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Protein

Auxin transporter-like protein 3

Gene

LAX3

Organism
Medicago truncatula (Barrel medic) (Medicago tribuloides)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Carrier protein involved in proton-driven auxin influx. Mediates the formation of auxin gradient from developing leaves (site of auxin biosynthesis) to tips by contributing to the loading of auxin in vascular tissues and facilitating acropetal (base to tip) auxin transport within inner tissues of the root apex, and basipetal (tip to base) auxin transport within outer tissues of the root apex (By similarity). May be involved in lateral roots and nodules formation.By similarity1 Publication

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processAmino-acid transport, Auxin signaling pathway, Symport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Auxin transporter-like protein 3
Alternative name(s):
AUX1-like protein 3
MtLAX3
Gene namesi
Name:LAX3
OrganismiMedicago truncatula (Barrel medic) (Medicago tribuloides)
Taxonomic identifieri3880 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsfabidsFabalesFabaceaePapilionoideaeTrifolieaeMedicago

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 52CytoplasmicSequence analysisAdd BLAST52
Transmembranei53 – 70HelicalSequence analysisAdd BLAST18
Topological domaini71 – 72ExtracellularSequence analysis2
Transmembranei73 – 93HelicalSequence analysisAdd BLAST21
Topological domaini94 – 129CytoplasmicSequence analysisAdd BLAST36
Transmembranei130 – 150HelicalSequence analysisAdd BLAST21
Topological domaini151 – 165ExtracellularSequence analysisAdd BLAST15
Transmembranei166 – 186HelicalSequence analysisAdd BLAST21
Topological domaini187 – 189CytoplasmicSequence analysis3
Transmembranei190 – 210HelicalSequence analysisAdd BLAST21
Topological domaini211 – 225ExtracellularSequence analysisAdd BLAST15
Transmembranei226 – 246HelicalSequence analysisAdd BLAST21
Topological domaini247 – 259CytoplasmicSequence analysisAdd BLAST13
Transmembranei260 – 280HelicalSequence analysisAdd BLAST21
Topological domaini281 – 307ExtracellularSequence analysisAdd BLAST27
Transmembranei308 – 328HelicalSequence analysisAdd BLAST21
Topological domaini329 – 349CytoplasmicSequence analysisAdd BLAST21
Transmembranei350 – 370HelicalSequence analysisAdd BLAST21
Topological domaini371 – 374ExtracellularSequence analysis4
Transmembranei375 – 395HelicalSequence analysisAdd BLAST21
Topological domaini396 – 421CytoplasmicSequence analysisAdd BLAST26
Transmembranei422 – 442HelicalSequence analysisAdd BLAST21
Topological domaini443 – 465ExtracellularSequence analysisAdd BLAST23

GO - Cellular componenti

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000938471 – 465Auxin transporter-like protein 3Add BLAST465

Expressioni

Tissue specificityi

Shoots and roots of nodulating plants. Low levels in roots, nodules, stems, petioles, leaves, shoot apices and flowers.2 Publications

Developmental stagei

In primary roots, mostly localized in tips and to a lower extent in vasculature of older regions. In root tips, mostly expressed in the central tissues of the elongating zone (developing vasculature), in the starch-filled cells of the root cap and in some cortical cells. During lateral root development, striking expression in the proximal region of the primordium, close to the primary root central cylinder, and then in elongating cells of the developing vasculature and in developing root cap. During nodule formation, expressed in young elongated primordium, mostly in cells close to the root vasculature. In later stages, confined in small cells rich in amyloplasts with small nuclei. Near the periphery of developing nodules strong expression at the base that tapers off toward the apex. Not expressed in mature nodules.1 Publication

Gene expression databases

ExpressionAtlasiQ9FEL6. differential.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

KOiK13946.
OMAiPSFLGGW.
OrthoDBiEOG09360AGA.

Family and domain databases

InterProiView protein in InterPro
IPR013057. AA_transpt_TM.
PfamiView protein in Pfam
PF01490. Aa_trans. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9FEL6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTSEKVETVV AGNYLEMERE EEGSKSTTGK LSKFFWHGGS VYDAWFSCAS
60 70 80 90 100
NQVAQVLLTL PYSFSQLGML SGILFQIFYG LMGSWTAYII SVLYVEYRTR
110 120 130 140 150
KEREKVDFRN HVIQWFEVLD GLLGKHWRNL GLFFNCTFLL FGSVIQLIAC
160 170 180 190 200
ASNIYYINDH LDKRTWTYIF GACCATTVFI PSFHNYRIWS FLGLVMTTYT
210 220 230 240 250
AWYMTIASIL HGQAEDVKHS GPTKLVLYFT GATNILYTFG GHAVTVEIMH
260 270 280 290 300
AMWKPQKFKM IYLIATLYVM TLTLPSAAAV YWAFGDNLLT HSNALSLLPR
310 320 330 340 350
TGFRDTAVIL MLIHQFITFG FACTPLYFVW EKFLGVHETK SLLKRALVRL
360 370 380 390 400
PVVIPIWFLA IIFPFFGPIN STVGSLLVSF TVYIIPALAH MVTFASAPAR
410 420 430 440 450
ENAVERPPSF LGGWVGLYSV NVFVAVWVLV VGFGLGGWAS MLNFVHQIKT
460
FGLFAKCFQC PPHKA
Length:465
Mass (Da):52,597
Last modified:March 1, 2001 - v1
Checksum:iD20E5C8AA0B20593
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ299399 mRNA. Translation: CAC12997.1.
AY115842 Genomic DNA. Translation: AAM55303.1.
RefSeqiXP_003601086.1. XM_003601038.2.
UniGeneiMtr.123.

Genome annotation databases

EnsemblPlantsiAES71337; AES71337; MTR_3g072870.
GeneIDi11411395.
GrameneiAES71337; AES71337; MTR_3g072870.
KEGGimtr:MTR_3g072870.

Similar proteinsi

Entry informationi

Entry nameiLAX3_MEDTR
AccessioniPrimary (citable) accession number: Q9FEL6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 22, 2005
Last sequence update: March 1, 2001
Last modified: February 15, 2017
This is version 67 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Caution

Because of the similarity in sequence, the probe used to describe the developmental stages did not discriminate among the various MtLAX mRNAs.Curated

Documents

  1. SIMILARITY comments
    Index of protein domains and families