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Protein

Transcription factor MYB75

Gene

MYB75

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Transcription activator, when associated with BHLH12/MYC1, EGL3, or GL3. Promotes the synthesis of. phenylpropanoid-derived compounds such as anthocyanins and proanthocyanidin, probably together with GL3 and BHLH2. Regulates the expression of CHS, DFRA, LDOX, and BAN.6 Publications

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi33 – 5725H-T-H motifPROSITE-ProRule annotationAdd
BLAST
DNA bindingi85 – 10824H-T-H motifPROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  • DNA binding Source: UniProtKB-KW
  • transcription factor activity, sequence-specific DNA binding Source: TAIR

GO - Biological processi

  • anthocyanin-containing compound biosynthetic process Source: TAIR
  • defense response to fungus Source: TAIR
  • regulation of anthocyanin biosynthetic process Source: TAIR
  • removal of superoxide radicals Source: TAIR
  • response to auxin Source: TAIR
  • response to ethylene Source: TAIR
  • response to jasmonic acid Source: TAIR
  • response to salt stress Source: TAIR
  • sucrose mediated signaling Source: TAIR
  • transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Activator

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Transcription factor MYB75
Alternative name(s):
Myb-related protein 75
Short name:
AtMYB75
Production of anthocyanin pigment 1 protein
Suc-induced anthocyanin accumulation locus 1
Gene namesi
Name:MYB75
Synonyms:PAP1, SIAA1
Ordered Locus Names:At1g56650
ORF Names:F25P12.92
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 1

Organism-specific databases

TAIRiAT1G56650.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 248248Transcription factor MYB75PRO_0000285730Add
BLAST

Proteomic databases

PaxDbiQ9FE25.
PRIDEiQ9FE25.

Expressioni

Tissue specificityi

Mostly expressed in mature plant aerial part. Detected ubiquitously, with higher levels in rosette leaves and flowers.2 Publications

Inductioni

By jasmonic acid (JA), NaCl, sucrose, UV light, nitrogen deficiency and drought.3 Publications

Gene expression databases

GenevisibleiQ9FE25. AT.

Interactioni

Subunit structurei

Interacts with BHLH12/MYC1, BHLH1/GL3/MYC6, BHLH2/EGL3/MYC146, and BHLH42/TT8.2 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
BHLH12Q8W2F13EBI-1545177,EBI-1546379
BHLH2Q9CAD05EBI-1545177,EBI-533398
GL3Q9FN692EBI-1545177,EBI-533348
TT8Q9FT813EBI-1545177,EBI-395790

Protein-protein interaction databases

BioGridi27345. 15 interactions.
IntActiQ9FE25. 4 interactions.
STRINGi3702.AT1G56650.1.

Structurei

3D structure databases

ProteinModelPortaliQ9FE25.
SMRiQ9FE25. Positions 8-111.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini5 – 5753HTH myb-type 1PROSITE-ProRule annotationAdd
BLAST
Domaini58 – 11255HTH myb-type 2PROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 2 HTH myb-type DNA-binding domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG0048. Eukaryota.
COG5147. LUCA.
HOGENOMiHOG000237600.
InParanoidiQ9FE25.
KOiK16166.
OMAiNVCDNSI.
PhylomeDBiQ9FE25.

Family and domain databases

Gene3Di1.10.10.60. 2 hits.
InterProiIPR009057. Homeodomain-like.
IPR017930. Myb_dom.
IPR001005. SANT/Myb.
[Graphical view]
PfamiPF00249. Myb_DNA-binding. 2 hits.
[Graphical view]
SMARTiSM00717. SANT. 2 hits.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS51294. HTH_MYB. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9FE25-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEGSSKGLRK GAWTTEEDSL LRQCINKYGE GKWHQVPVRA GLNRCRKSCR
60 70 80 90 100
LRWLNYLKPS IKRGKLSSDE VDLLLRLHRL LGNRWSLIAG RLPGRTANDV
110 120 130 140 150
KNYWNTHLSK KHEPCCKIKM KKRDITPIPT TPALKNNVYK PRPRSFTVNN
160 170 180 190 200
DCNHLNAPPK VDVNPPCLGL NINNVCDNSI IYNKDKKKDQ LVNNLIDGDN
210 220 230 240
MWLEKFLEES QEVDILVPEA TTTEKGDTLA FDVDQLWSLF DGETVKFD
Length:248
Mass (Da):28,470
Last modified:March 1, 2001 - v1
Checksum:iB86103A9AB5CF442
GO

Sequence cautioni

The sequence AAC83630.1 differs from that shown. Reason: Frameshift at position 207. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti246 – 2472KF → EL in AAS10033 (Ref. 4) Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti37 – 371P → H in strain: cv. cvi-1. 1 Publication
Natural varianti60 – 601S → N in strain: cv. Landsberg erecta. 1 Publication
Natural varianti136 – 1361N → T in strain: cv. C24 and cv. Landsberg erecta. 1 Publication
Natural varianti147 – 1482TV → SG in strain: cv. Landsberg erecta.
Natural varianti147 – 1471T → S in strain: cv. C24. 1 Publication
Natural varianti160 – 1601K → N in strain: cv. cvi-1. 1 Publication
Natural varianti167 – 1671C → R in strain: cv. C24. 1 Publication
Natural varianti172 – 1721I → T in strain: cv. C24 and cv. Landsberg erecta. 1 Publication
Natural varianti179 – 1791S → N in strain: cv. C24 and cv. Landsberg erecta. 1 Publication
Natural varianti215 – 2151I → M in strain: cv. C24 and cv. Landsberg erecta. 1 Publication
Natural varianti220 – 2201A → T in strain: cv. C24 and cv. Landsberg erecta. 1 Publication

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF062908 mRNA. Translation: AAC83630.1. Frameshift.
AF325123 Genomic DNA. Translation: AAG42001.1.
DQ222404 Genomic DNA. Translation: ABB03877.1.
DQ222405 Genomic DNA. Translation: ABB03878.1.
DQ222406 Genomic DNA. Translation: ABB03879.1.
AY519563 mRNA. Translation: AAS10033.1.
AC009323 Genomic DNA. Translation: AAG09100.1.
CP002684 Genomic DNA. Translation: AEE33419.1.
AK221639 mRNA. Translation: BAD95284.1.
PIRiB96608.
T51680.
RefSeqiNP_176057.1. NM_104541.3.
UniGeneiAt.20447.

Genome annotation databases

EnsemblPlantsiAT1G56650.1; AT1G56650.1; AT1G56650.
GeneIDi842120.
GrameneiAT1G56650.1; AT1G56650.1; AT1G56650.
KEGGiath:AT1G56650.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF062908 mRNA. Translation: AAC83630.1. Frameshift.
AF325123 Genomic DNA. Translation: AAG42001.1.
DQ222404 Genomic DNA. Translation: ABB03877.1.
DQ222405 Genomic DNA. Translation: ABB03878.1.
DQ222406 Genomic DNA. Translation: ABB03879.1.
AY519563 mRNA. Translation: AAS10033.1.
AC009323 Genomic DNA. Translation: AAG09100.1.
CP002684 Genomic DNA. Translation: AEE33419.1.
AK221639 mRNA. Translation: BAD95284.1.
PIRiB96608.
T51680.
RefSeqiNP_176057.1. NM_104541.3.
UniGeneiAt.20447.

3D structure databases

ProteinModelPortaliQ9FE25.
SMRiQ9FE25. Positions 8-111.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi27345. 15 interactions.
IntActiQ9FE25. 4 interactions.
STRINGi3702.AT1G56650.1.

Proteomic databases

PaxDbiQ9FE25.
PRIDEiQ9FE25.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsiAT1G56650.1; AT1G56650.1; AT1G56650.
GeneIDi842120.
GrameneiAT1G56650.1; AT1G56650.1; AT1G56650.
KEGGiath:AT1G56650.

Organism-specific databases

TAIRiAT1G56650.

Phylogenomic databases

eggNOGiKOG0048. Eukaryota.
COG5147. LUCA.
HOGENOMiHOG000237600.
InParanoidiQ9FE25.
KOiK16166.
OMAiNVCDNSI.
PhylomeDBiQ9FE25.

Miscellaneous databases

PROiQ9FE25.

Gene expression databases

GenevisibleiQ9FE25. AT.

Family and domain databases

Gene3Di1.10.10.60. 2 hits.
InterProiIPR009057. Homeodomain-like.
IPR017930. Myb_dom.
IPR001005. SANT/Myb.
[Graphical view]
PfamiPF00249. Myb_DNA-binding. 2 hits.
[Graphical view]
SMARTiSM00717. SANT. 2 hits.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS51294. HTH_MYB. 2 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Towards functional characterisation of the members of the R2R3-MYB gene family from Arabidopsis thaliana."
    Kranz H.D., Denekamp M., Greco R., Jin H.-L., Leyva A., Meissner R.C., Petroni K., Urzainqui A., Bevan M., Martin C., Smeekens S., Tonelli C., Paz-Ares J., Weisshaar B.
    Plant J. 16:263-276(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, INDUCTION BY SUCROSE; UV LIGHT AND DROUGHT.
    Strain: cv. Columbia.
  2. "Activation tagging identifies a conserved MYB regulator of phenylpropanoid biosynthesis."
    Borevitz J.O., Xia Y., Blount J., Dixon R.A., Lamb C.
    Plant Cell 12:2383-2393(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION.
    Strain: cv. Columbia.
  3. "Sucrose-specific induction of anthocyanin biosynthesis in Arabidopsis requires the MYB75/PAP1 gene."
    Teng S., Keurentjes J., Bentsink L., Koornneef M., Smeekens S.
    Plant Physiol. 139:1840-1852(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION, VARIANTS HIS-37; ASN-60; THR-136; SER-147; 147-SER-GLY-148; ASN-160; ARG-167; THR-172; ASN-179; MET-215 AND THR-220.
    Strain: cv. C24, cv. Cvi-1 and cv. Landsberg erecta.
  4. "The MYB transcription factor family in Arabidopsis: a genome-wide cloning and expression pattern analysis."
    Qu L.-J., Gu H.
    Submitted (JAN-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  5. "Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana."
    Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O., Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E., Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K.
    , Conn L., Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P., Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D., Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J., Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L., Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A., Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A., Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M., Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M., Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P., Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D., Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D., Yu G., Fraser C.M., Venter J.C., Davis R.W.
    Nature 408:816-820(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: cv. Columbia.
  6. The Arabidopsis Information Resource (TAIR)
    Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases
    Cited for: GENOME REANNOTATION.
    Strain: cv. Columbia.
  7. "Large-scale analysis of RIKEN Arabidopsis full-length (RAFL) cDNAs."
    Totoki Y., Seki M., Ishida J., Nakajima M., Enju A., Kamiya A., Narusaka M., Shin-i T., Nakagawa M., Sakamoto N., Oishi K., Kohara Y., Kobayashi M., Toyoda A., Sakaki Y., Sakurai T., Iida K., Akiyama K.
    , Satou M., Toyoda T., Konagaya A., Carninci P., Kawai J., Hayashizaki Y., Shinozaki K.
    Submitted (MAR-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: cv. Columbia.
  8. "The R2R3-MYB gene family in Arabidopsis thaliana."
    Stracke R., Werber M., Weisshaar B.
    Curr. Opin. Plant Biol. 4:447-456(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: GENE FAMILY, NOMENCLATURE.
  9. "A network of redundant bHLH proteins functions in all TTG1-dependent pathways of Arabidopsis."
    Zhang F., Gonzalez A., Zhao M., Payne C.T., Lloyd A.M.
    Development 130:4859-4869(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INTERACTION WITH BHLH2.
  10. "Suppression of the biosynthesis of proanthocyanidin in Arabidopsis by a chimeric PAP1 repressor."
    Matsui K., Tanaka H., Ohme-Takagi M.
    Plant Biotechnol. J. 2:487-493(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, TISSUE SPECIFICITY.
  11. "Comprehensive identification of Arabidopsis thaliana MYB transcription factors interacting with R/B-like BHLH proteins."
    Zimmermann I.M., Heim M.A., Weisshaar B., Uhrig J.F.
    Plant J. 40:22-34(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INTERACTION WITH BHLH12; BHLH1; BHLH2 AND BHLH42.
  12. "Functional genomics by integrated analysis of metabolome and transcriptome of Arabidopsis plants over-expressing an MYB transcription factor."
    Tohge T., Nishiyama Y., Hirai M.Y., Yano M., Nakajima J., Awazuhara M., Inoue E., Takahashi H., Goodenowe D.B., Kitayama M., Noji M., Yamazaki M., Saito K.
    Plant J. 42:218-235(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  13. "The MYB transcription factor superfamily of Arabidopsis: expression analysis and phylogenetic comparison with the rice MYB family."
    Chen Y., Yang X., He K., Liu M., Li J., Gao Z., Lin Z., Zhang Y., Wang X., Qiu X., Shen Y., Zhang L., Deng X., Luo J., Deng X.-W., Chen Z., Gu H., Qu L.-J.
    Plant Mol. Biol. 60:107-124(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: GENE FAMILY, INDUCTION BY JA AND NACL.
  14. "Nitrogen deficiency enhances expression of specific MYB and bHLH transcription factors and accumulation of end products in the flavonoid pathway."
    Lea U.S., Slimestad R., Smedvig P., Lillo C.
    Planta 225:1245-1253(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: INDUCTION BY NITROGEN DEFICIENCY.

Entry informationi

Entry nameiMYB75_ARATH
AccessioniPrimary (citable) accession number: Q9FE25
Secondary accession number(s): Q38JL3
, Q38JL4, Q38JL5, Q6R0B5, Q9ZTC7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 1, 2007
Last sequence update: March 1, 2001
Last modified: February 17, 2016
This is version 116 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Miscellaneous

This protein has reduced anthocyanins induction activity in cv C24 and cv cvi-1 backgrounds.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.