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Q9FDS0

- Q9FDS0_STRCS

UniProt

Q9FDS0 - Q9FDS0_STRCS

Protein
Submitted name:

Neutral proteinase inhibitor ScNPI

Gene

ScNPI

Organism
Streptomyces caespitosus
Status
Unreviewed - Annotation score: 1 out of 5- Experimental evidence at protein leveli
  1. Functioni

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei31 – 311CacodylateImported
    Binding sitei109 – 1091Acetate 3Imported
    Metal bindingi121 – 1211Potassium 1; via pros nitrogenImported
    Metal bindingi121 – 1211Potassium 2; via tele nitrogenImported
    Binding sitei121 – 1211Acetate 2Imported
    Metal bindingi132 – 1321Potassium 2Imported

    GO - Molecular functioni

    1. metal ion binding Source: UniProtKB-KW
    2. serine-type endopeptidase inhibitor activity Source: UniProtKB-KW

    Keywords - Molecular functioni

    Protease inhibitor, Serine protease inhibitorUniRule annotation

    Keywords - Ligandi

    Metal-bindingImported, PotassiumImported

    Protein family/group databases

    MEROPSiI16.017.

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    Neutral proteinase inhibitor ScNPIImported
    Gene namesi
    Name:ScNPIImported
    OrganismiStreptomyces caespitosusImported
    Taxonomic identifieri53502 [NCBI]
    Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesStreptomycineaeStreptomycetaceaeStreptomyces

    Structurei

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    4HWXX-ray1.90A29-141[»]
    4HX2X-ray2.25B/D29-141[»]
    4HX3X-ray2.70B/D/F/H/J/L29-141[»]
    ProteinModelPortaliQ9FDS0.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni30 – 312Acetate 1 bindingImported
    Regioni116 – 1194Acetate 3 bindingImported

    Sequence similaritiesi

    Belongs to the protease inhibitor I16 (SSI) family. [View classification]UniRule annotation

    Family and domain databases

    Gene3Di3.30.350.10. 1 hit.
    InterProiIPR000691. Prot_inh_I16_SSI.
    IPR023549. Subtilisin_inhibitor.
    [Graphical view]
    PfamiPF00720. SSI. 1 hit.
    [Graphical view]
    PRINTSiPR00294. SSBTLNINHBTR.
    ProDomiPD004028. Prot_inh_SSI. 1 hit.
    [Graphical view] [Entries sharing at least one domain]
    SUPFAMiSSF55399. SSF55399. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q9FDS0-1 [UniParc]FASTAAdd to Basket

    « Hide

    MRHHVIAVSA LSLLCLAGST GLAEAQPASA HGPSAMVFTV IQGSGEPTDT    50
    VLRATTLSCA YTAEGTHPAP RAACDALNAT DGELNRLLAA PDPSLVCPMY 100
    FDPVTVTADG VLNGRRVAWK HTFSNTCVMS ANLNSNPVYA F 141
    Length:141
    Mass (Da):14,657
    Last modified:March 1, 2001 - v1
    Checksum:iBEB8C40E3D22ECF6
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB042804 Genomic DNA. Translation: BAB11977.1.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB042804 Genomic DNA. Translation: BAB11977.1 .

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    4HWX X-ray 1.90 A 29-141 [» ]
    4HX2 X-ray 2.25 B/D 29-141 [» ]
    4HX3 X-ray 2.70 B/D/F/H/J/L 29-141 [» ]
    ProteinModelPortali Q9FDS0.
    ModBasei Search...
    MobiDBi Search...

    Protein family/group databases

    MEROPSi I16.017.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Family and domain databases

    Gene3Di 3.30.350.10. 1 hit.
    InterProi IPR000691. Prot_inh_I16_SSI.
    IPR023549. Subtilisin_inhibitor.
    [Graphical view ]
    Pfami PF00720. SSI. 1 hit.
    [Graphical view ]
    PRINTSi PR00294. SSBTLNINHBTR.
    ProDomi PD004028. Prot_inh_SSI. 1 hit.
    [Graphical view ] [Entries sharing at least one domain ]
    SUPFAMi SSF55399. SSF55399. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "A novel double-headed proteinaceous inhibitor for metalloproteinase and serine proteinase."
      Hiraga K., Suzuki T., Oda K.
      J. Biol. Chem. 275:25173-25179(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE.

    Entry informationi

    Entry nameiQ9FDS0_STRCS
    AccessioniPrimary (citable) accession number: Q9FDS0
    Entry historyi
    Integrated into UniProtKB/TrEMBL: March 1, 2001
    Last sequence update: March 1, 2001
    Last modified: October 1, 2014
    This is version 46 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    3D-structureImported

    External Data

    Dasty 3