Q9FD08 (SPLA1_STAAU) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Serine protease SplA
EC=3.4.21.-

Gene names

Name:

splA

Organism

Staphylococcus aureus

Taxonomic identifier

1280 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Firmicutes › Bacilli › Bacillales › Staphylococcaceae › Staphylococcus

Protein attributes

Sequence length	235 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Inferred from homology

General annotation (Comments)

Subcellular location	Secreted By similarity.
Sequence similarities	Belongs to the peptidase S1B family.

Ontologies

Keywords
Cellular component	Secreted
Domain	Signal
Molecular function	Hydrolase Protease Serine protease
Gene Ontology (GO)
Biological_process	proteolysis Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	extracellular region Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	serine-type endopeptidase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 35	35	By similarity
	Chain	36 – 235	200	Serine protease SplA		PRO_0000359525
Sites
	Active site	74	1	Charge relay system By similarity
	Active site	113	1	Charge relay system By similarity
	Active site	189	1	Charge relay system By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q9FD08 [UniParc]. Last modified March 1, 2001. Version 1. Checksum: 6DE1C607B559C96B	FASTA	235	25,514
	10 20 30 40 50 60 MNKNVMIKGL TALTILTSLG FAENISDQPH SIAKAEKNIK EVTDATKAPY NSVVAFAGGT 70 80 90 100 110 120 GVVVGKNTIV TNKHIAKSND IFKNRVSAHH SSKGKGGGNY DVKDIVEYPG KEDLAIVHVH 130 140 150 160 170 180 ETSTEGLNFN KNVSYTKFAE GAKMKDRISV IGYPKGAQTK YKMFESTGTI NHINGTFMEF 190 200 210 220 230 DAYAQPGNSG SPVLNSKNEL VGILYAGSGK DESEKNFGVY FTPQLKEFIQ NNIEK

References

[1]	"Cloning and expression of two genes from a novel Staphylococcus aureus operon encoding serine protease like exoproteins." Nair S.P., Williams R.J. Submitted (AUG-2000) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: FRI326.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF295600 Genomic DNA. Translation: AAG02238.1.
3D structure databases
HSSP	HSSP built from PDB template 2AS9 based on UniProtKB Q53782.
ProteinModelPortal	Q9FD08.
SMR	Q9FD08. Positions 36-235.
ModBase	Search...
Protein family/group databases
MEROPS	S01.503.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Phylogenomic databases
eggNOG	COG3591.
Family and domain databases
InterPro	IPR000126. Pept_S1B_AS. IPR001254. Peptidase_S1. IPR008256. Peptidase_S1B. IPR008353. Peptidase_S1B_tx. IPR009003. Trypsin-like_Pept_dom. [Graphical view]
Pfam	PF00089. Trypsin. 1 hit. [Graphical view]
PRINTS	PR01774. EXFOLTOXIN. PR00839. V8PROTEASE.
SUPFAM	SSF50494. Pept_Ser_Cys. 1 hit.
PROSITE	PS00672. V8_HIS. 1 hit. PS00673. V8_SER. False negative. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

SPLA1_STAAU

Accession

Primary (citable) accession number: Q9FD08

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 20, 2009
Last sequence update:	March 1, 2001
Last modified:	March 6, 2013
This is version 41 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program