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Protein

Urease subunit alpha 1

Gene

ureC1

Organism
Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

Urea + H2O = CO2 + 2 NH3.UniRule annotation

Cofactori

Ni cationUniRule annotationNote: Binds 2 nickel ions per subunit.UniRule annotation

Pathwayi: urea degradation

This protein is involved in step 1 of the subpathway that synthesizes CO(2) and NH(3) from urea (urease route).UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Urease subunit gamma/beta (ureAB), Urease subunit alpha 1 (ureC1), Urease subunit alpha 2 (ureC2), Urease subunit gamma (ureA), Urease subunit beta (ureB)
This subpathway is part of the pathway urea degradation, which is itself part of Nitrogen metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes CO(2) and NH(3) from urea (urease route), the pathway urea degradation and in Nitrogen metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi141Nickel 1; via tele nitrogenUniRule annotation1
Metal bindingi143Nickel 1; via tele nitrogenUniRule annotation1
Metal bindingi224Nickel 1; via carbamate groupUniRule annotation1
Metal bindingi224Nickel 2; via carbamate groupUniRule annotation1
Binding sitei226SubstrateUniRule annotation1
Metal bindingi253Nickel 2; via pros nitrogenUniRule annotation1
Metal bindingi279Nickel 2; via tele nitrogenUniRule annotation1
Active sitei327Proton donorUniRule annotation1
Metal bindingi367Nickel 1UniRule annotation1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Ligandi

Metal-binding, Nickel

Enzyme and pathway databases

UniPathwayiUPA00258; UER00370.

Names & Taxonomyi

Protein namesi
Recommended name:
Urease subunit alpha 1UniRule annotation (EC:3.5.1.5UniRule annotation)
Alternative name(s):
Urea amidohydrolase subunit alpha 1UniRule annotation
Gene namesi
Name:ureC1UniRule annotation
Ordered Locus Names:SCO1234
ORF Names:2SCG1.09c
OrganismiStreptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)
Taxonomic identifieri100226 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaStreptomycetalesStreptomycetaceaeStreptomycesStreptomyces albidoflavus group
Proteomesi
  • UP000001973 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002341871 – 573Urease subunit alpha 1Add BLAST573

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei224N6-carboxylysineUniRule annotation1

Post-translational modificationi

Carbamylation allows a single lysine to coordinate two nickel ions.UniRule annotation

Proteomic databases

PRIDEiQ9FCD3.

Interactioni

Subunit structurei

May form a heterohexamer of 3 UreC (alpha) and 3 UreAB (gamma/beta) subunits. May also form a heterotrimer of UreA (gamma), UreB (beta) and UreC (alpha) subunits. Three heterotrimers associate to form the active enzyme.UniRule annotation

Protein-protein interaction databases

STRINGi100226.SCO1234.

Structurei

3D structure databases

ProteinModelPortaliQ9FCD3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini136 – 573UreaseUniRule annotationAdd BLAST438

Sequence similaritiesi

Belongs to the urease family.UniRule annotation
Contains 1 urease domain.UniRule annotation

Phylogenomic databases

eggNOGiCOG0804. LUCA.
HOGENOMiHOG000075064.
InParanoidiQ9FCD3.
KOiK01428.
OMAiFDSHIHF.
OrthoDBiPOG091H0ARR.
PhylomeDBiQ9FCD3.

Family and domain databases

CDDicd00375. Urease_alpha. 1 hit.
Gene3Di2.30.40.10. 1 hit.
HAMAPiMF_01953. Urease_alpha. 1 hit.
InterProiIPR006680. Amidohydro-rel.
IPR011059. Metal-dep_hydrolase_composite.
IPR032466. Metal_Hydrolase.
IPR011612. Urease_alpha_N_dom.
IPR017950. Urease_AS.
IPR005848. Urease_asu.
IPR017951. Urease_asu_c.
IPR029754. Urease_Ni-bd.
[Graphical view]
PfamiPF01979. Amidohydro_1. 1 hit.
PF00449. Urease_alpha. 1 hit.
[Graphical view]
PRINTSiPR01752. UREASE.
SUPFAMiSSF51338. SSF51338. 2 hits.
SSF51556. SSF51556. 2 hits.
TIGRFAMsiTIGR01792. urease_alph. 1 hit.
PROSITEiPS01120. UREASE_1. 1 hit.
PS00145. UREASE_2. 1 hit.
PS51368. UREASE_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9FCD3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPELSRTAYA DLFGPTTGDR VRLADTDLFV EIEEDRSGGP GRSGDEAVFG
60 70 80 90 100
GGKVLRESMG QGRTTRAQGA PDTVITGALI IDHWGIVKAD IGIRDGRITG
110 120 130 140 150
IGKAGNPDTM DGVHPDLVIG PETEIVAGNG KIVTAGGIDT HVHFIAPGAV
160 170 180 190 200
DEALASGVTT LIGGGTGPAE GSKATTVTPG AWHLAWMFAA LESSPVNIGF
210 220 230 240 250
LGKGSTMSKE SMRDQLRAGV LGFKIHEDWG ATPAVISACL DVCEESGVQL
260 270 280 290 300
AVHSDTLNEA GFVGDTFDAV AGRTLHAFHV EGAGGGHAPD MITAVSLPNM
310 320 330 340 350
LPASTNPTRP HTVNTVEEHL DMLMVCHHLN PAVPEDLAFA ESRIRPSTIA
360 370 380 390 400
AEDILHDMGA ISIMSSDAQA MGRIGEVILR TWQTAHVMKR RRGFLPGDTR
410 420 430 440 450
ADNLRARRYV AKYTINPAVA QGIEHEVGSV ETGKLADLVL WDPRFFGAKP
460 470 480 490 500
QLVIKGGQIA YAQMGDANAS IPTPQPVLPR PMYGALGTAP ATNSVNFVSE
510 520 530 540 550
QAVEDGLPER LGLGRAFVPI RSTRGRTKAD MRQNDALPRV EVAADSFAVT
560 570
IDGELVEPAP VTELPLAQRY FLF
Length:573
Mass (Da):60,551
Last modified:March 1, 2001 - v1
Checksum:iEE035EEA30B18456
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL939108 Genomic DNA. Translation: CAC01458.1.
RefSeqiNP_625522.1. NC_003888.3.
WP_003977597.1. NC_003888.3.

Genome annotation databases

EnsemblBacteriaiCAC01458; CAC01458; CAC01458.
GeneIDi1096657.
KEGGisco:SCO1234.
PATRICi23732020. VBIStrCoe124346_1233.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL939108 Genomic DNA. Translation: CAC01458.1.
RefSeqiNP_625522.1. NC_003888.3.
WP_003977597.1. NC_003888.3.

3D structure databases

ProteinModelPortaliQ9FCD3.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi100226.SCO1234.

Proteomic databases

PRIDEiQ9FCD3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAC01458; CAC01458; CAC01458.
GeneIDi1096657.
KEGGisco:SCO1234.
PATRICi23732020. VBIStrCoe124346_1233.

Phylogenomic databases

eggNOGiCOG0804. LUCA.
HOGENOMiHOG000075064.
InParanoidiQ9FCD3.
KOiK01428.
OMAiFDSHIHF.
OrthoDBiPOG091H0ARR.
PhylomeDBiQ9FCD3.

Enzyme and pathway databases

UniPathwayiUPA00258; UER00370.

Family and domain databases

CDDicd00375. Urease_alpha. 1 hit.
Gene3Di2.30.40.10. 1 hit.
HAMAPiMF_01953. Urease_alpha. 1 hit.
InterProiIPR006680. Amidohydro-rel.
IPR011059. Metal-dep_hydrolase_composite.
IPR032466. Metal_Hydrolase.
IPR011612. Urease_alpha_N_dom.
IPR017950. Urease_AS.
IPR005848. Urease_asu.
IPR017951. Urease_asu_c.
IPR029754. Urease_Ni-bd.
[Graphical view]
PfamiPF01979. Amidohydro_1. 1 hit.
PF00449. Urease_alpha. 1 hit.
[Graphical view]
PRINTSiPR01752. UREASE.
SUPFAMiSSF51338. SSF51338. 2 hits.
SSF51556. SSF51556. 2 hits.
TIGRFAMsiTIGR01792. urease_alph. 1 hit.
PROSITEiPS01120. UREASE_1. 1 hit.
PS00145. UREASE_2. 1 hit.
PS51368. UREASE_3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiURE11_STRCO
AccessioniPrimary (citable) accession number: Q9FCD3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 2, 2006
Last sequence update: March 1, 2001
Last modified: October 5, 2016
This is version 95 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.