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Q9FCB1

- DNLI_STRCO

UniProt

Q9FCB1 - DNLI_STRCO

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Protein

Probable DNA ligase

Gene

lig

Organism
Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair.By similarity

Catalytic activityi

ATP + (deoxyribonucleotide)(n) + (deoxyribonucleotide)(m) = AMP + diphosphate + (deoxyribonucleotide)(n+m).

Cofactori

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei208 – 2081ATPBy similarity
Active sitei210 – 2101N6-AMP-lysine intermediateBy similarity
Binding sitei215 – 2151ATPBy similarity
Binding sitei230 – 2301ATPBy similarity
Binding sitei259 – 2591ATPBy similarity
Binding sitei299 – 2991ATPBy similarity
Binding sitei374 – 3741ATPBy similarity
Binding sitei380 – 3801ATPBy similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. DNA binding Source: InterPro
  3. DNA ligase (ATP) activity Source: RefGenome
  4. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. cell cycle Source: UniProtKB-KW
  2. cell division Source: UniProtKB-KW
  3. DNA biosynthetic process Source: InterPro
  4. DNA ligation Source: RefGenome
  5. DNA ligation involved in DNA repair Source: InterPro
  6. DNA recombination Source: UniProtKB-HAMAP
  7. lagging strand elongation Source: RefGenome
  8. nucleotide-excision repair Source: RefGenome
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

Cell cycle, Cell division, DNA damage, DNA recombination, DNA repair, DNA replication

Keywords - Ligandi

ATP-binding, Metal-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Probable DNA ligase (EC:6.5.1.1)
Alternative name(s):
Polydeoxyribonucleotide synthase [ATP]
Gene namesi
Name:lig
Ordered Locus Names:SCO1202
ORF Names:2SCG58.02
OrganismiStreptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)
Taxonomic identifieri100226 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesStreptomycineaeStreptomycetaceaeStreptomycesStreptomyces albidoflavus group
ProteomesiUP000001973: Chromosome

Subcellular locationi

GO - Cellular componenti

  1. chromosome Source: RefGenome
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 512512Probable DNA ligasePRO_0000059624Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi100226.SCO1202.

Structurei

3D structure databases

ProteinModelPortaliQ9FCB1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ATP-dependent DNA ligase family.Curated

Phylogenomic databases

eggNOGiCOG1793.
HOGENOMiHOG000036008.
InParanoidiQ9FCB1.
KOiK01971.
OMAiARVQVHK.
OrthoDBiEOG6Q8HXT.
PhylomeDBiQ9FCB1.

Family and domain databases

Gene3Di1.10.3260.10. 1 hit.
2.40.50.140. 1 hit.
HAMAPiMF_00407. DNA_ligase.
InterProiIPR022865. DNA_ligae_ATP-dep_bac/arc.
IPR000977. DNA_ligase_ATP-dep.
IPR012309. DNA_ligase_ATP-dep_C.
IPR012310. DNA_ligase_ATP-dep_cent.
IPR016059. DNA_ligase_ATP-dep_CS.
IPR012308. DNA_ligase_ATP-dep_N.
IPR012340. NA-bd_OB-fold.
[Graphical view]
PfamiPF04679. DNA_ligase_A_C. 1 hit.
PF01068. DNA_ligase_A_M. 1 hit.
PF04675. DNA_ligase_A_N. 1 hit.
[Graphical view]
SUPFAMiSSF117018. SSF117018. 1 hit.
SSF50249. SSF50249. 1 hit.
TIGRFAMsiTIGR00574. dnl1. 1 hit.
PROSITEiPS00697. DNA_LIGASE_A1. 1 hit.
PS50160. DNA_LIGASE_A3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9FCB1-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MLLARLAQVS REVAATSARS RKTVLLAELF REAEAADVPV VIPYLAGRLP
60 70 80 90 100
QGRIGVGWKV LSRRVPPADA PTLTVRDVDA RLTRLGAVSG AGSQAERTRL
110 120 130 140 150
VGELMGAATE DEQRFLIGLL TGEVRQGALD AAAVEGLAAA TDAPPADVRR
160 170 180 190 200
AVMLAGSLQT VAEALLADGP GALDRFRLTV GQPVLPMLAH SASSVAEAVG
210 220 230 240 250
KLGAAAVEEK LDGIRVQVHR DGGTVRIYTR TLDDITDRLP EVTEAALALP
260 270 280 290 300
GERFILDGEA ISLDADGRPR SFQETAGRVG SRTDVATAAR AVPVSAVFFD
310 320 330 340 350
VLSVDGRDLL DLPLTERHAE LARLVPEPLR VRRTLVHGPE DTGAAEEFLA
360 370 380 390 400
RTLARGHEGV VVKGLDAAYS AGRRGASWLK VKPVHTLDLV VLAAEWGHGR
410 420 430 440 450
RTGKLSNLHL GARTADGSFA MLGKTFKGMT DALLTWQTER LKELAVEEHG
460 470 480 490 500
WGVTVRPELV VEIAYDGLQR STRYPAGVTL RFARVVRYRE DKRPEDADTV
510
DTLLAAHPGV AP
Length:512
Mass (Da):54,696
Last modified:March 1, 2001 - v1
Checksum:i7A85CA68DC760FF9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL939108 Genomic DNA. Translation: CAC01484.1.
RefSeqiNP_625491.1. NC_003888.3.

Genome annotation databases

EnsemblBacteriaiCAC01484; CAC01484; CAC01484.
GeneIDi1096625.
KEGGisco:SCO1202.
PATRICi23731956. VBIStrCoe124346_1201.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL939108 Genomic DNA. Translation: CAC01484.1 .
RefSeqi NP_625491.1. NC_003888.3.

3D structure databases

ProteinModelPortali Q9FCB1.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 100226.SCO1202.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAC01484 ; CAC01484 ; CAC01484 .
GeneIDi 1096625.
KEGGi sco:SCO1202.
PATRICi 23731956. VBIStrCoe124346_1201.

Phylogenomic databases

eggNOGi COG1793.
HOGENOMi HOG000036008.
InParanoidi Q9FCB1.
KOi K01971.
OMAi ARVQVHK.
OrthoDBi EOG6Q8HXT.
PhylomeDBi Q9FCB1.

Family and domain databases

Gene3Di 1.10.3260.10. 1 hit.
2.40.50.140. 1 hit.
HAMAPi MF_00407. DNA_ligase.
InterProi IPR022865. DNA_ligae_ATP-dep_bac/arc.
IPR000977. DNA_ligase_ATP-dep.
IPR012309. DNA_ligase_ATP-dep_C.
IPR012310. DNA_ligase_ATP-dep_cent.
IPR016059. DNA_ligase_ATP-dep_CS.
IPR012308. DNA_ligase_ATP-dep_N.
IPR012340. NA-bd_OB-fold.
[Graphical view ]
Pfami PF04679. DNA_ligase_A_C. 1 hit.
PF01068. DNA_ligase_A_M. 1 hit.
PF04675. DNA_ligase_A_N. 1 hit.
[Graphical view ]
SUPFAMi SSF117018. SSF117018. 1 hit.
SSF50249. SSF50249. 1 hit.
TIGRFAMsi TIGR00574. dnl1. 1 hit.
PROSITEi PS00697. DNA_LIGASE_A1. 1 hit.
PS50160. DNA_LIGASE_A3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC BAA-471 / A3(2) / M145.

Entry informationi

Entry nameiDNLI_STRCO
AccessioniPrimary (citable) accession number: Q9FCB1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 20, 2001
Last sequence update: March 1, 2001
Last modified: November 26, 2014
This is version 95 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3