Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Probable DNA ligase

Gene

lig

Organism
Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair.UniRule annotation

Catalytic activityi

ATP + (deoxyribonucleotide)(n) + (deoxyribonucleotide)(m) = AMP + diphosphate + (deoxyribonucleotide)(n+m).UniRule annotation

Cofactori

Mg2+UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei208 – 2081ATPUniRule annotation
Active sitei210 – 2101N6-AMP-lysine intermediateUniRule annotation
Binding sitei215 – 2151ATPUniRule annotation
Binding sitei230 – 2301ATPUniRule annotation
Binding sitei259 – 2591ATPUniRule annotation
Binding sitei299 – 2991ATPUniRule annotation
Binding sitei374 – 3741ATPUniRule annotation
Binding sitei380 – 3801ATPUniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. DNA binding Source: InterPro
  3. DNA ligase (ATP) activity Source: GO_Central
  4. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. cell cycle Source: UniProtKB-KW
  2. cell division Source: UniProtKB-KW
  3. DNA biosynthetic process Source: InterPro
  4. DNA ligation Source: GO_Central
  5. DNA ligation involved in DNA repair Source: InterPro
  6. DNA recombination Source: UniProtKB-HAMAP
  7. lagging strand elongation Source: GO_Central
  8. nucleotide-excision repair Source: GO_Central
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

Cell cycle, Cell division, DNA damage, DNA recombination, DNA repair, DNA replication

Keywords - Ligandi

ATP-binding, Magnesium, Metal-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Probable DNA ligaseUniRule annotation (EC:6.5.1.1UniRule annotation)
Alternative name(s):
Polydeoxyribonucleotide synthase [ATP]UniRule annotation
Gene namesi
Name:ligUniRule annotation
Ordered Locus Names:SCO1202
ORF Names:2SCG58.02
OrganismiStreptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)
Taxonomic identifieri100226 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesStreptomycineaeStreptomycetaceaeStreptomycesStreptomyces albidoflavus group
ProteomesiUP000001973 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

  1. chromosome Source: GO_Central
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 512512Probable DNA ligasePRO_0000059624Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi100226.SCO1202.

Structurei

3D structure databases

ProteinModelPortaliQ9FCB1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ATP-dependent DNA ligase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG1793.
HOGENOMiHOG000036008.
InParanoidiQ9FCB1.
KOiK10747.
OMAiGRPRPFQ.
OrthoDBiEOG6Q8HXT.
PhylomeDBiQ9FCB1.

Family and domain databases

Gene3Di1.10.3260.10. 1 hit.
2.40.50.140. 1 hit.
HAMAPiMF_00407. DNA_ligase.
InterProiIPR022865. DNA_ligae_ATP-dep_bac/arc.
IPR000977. DNA_ligase_ATP-dep.
IPR012309. DNA_ligase_ATP-dep_C.
IPR012310. DNA_ligase_ATP-dep_cent.
IPR016059. DNA_ligase_ATP-dep_CS.
IPR012308. DNA_ligase_ATP-dep_N.
IPR012340. NA-bd_OB-fold.
[Graphical view]
PfamiPF04679. DNA_ligase_A_C. 1 hit.
PF01068. DNA_ligase_A_M. 1 hit.
PF04675. DNA_ligase_A_N. 1 hit.
[Graphical view]
SUPFAMiSSF117018. SSF117018. 1 hit.
SSF50249. SSF50249. 1 hit.
TIGRFAMsiTIGR00574. dnl1. 1 hit.
PROSITEiPS00697. DNA_LIGASE_A1. 1 hit.
PS50160. DNA_LIGASE_A3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9FCB1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLLARLAQVS REVAATSARS RKTVLLAELF REAEAADVPV VIPYLAGRLP
60 70 80 90 100
QGRIGVGWKV LSRRVPPADA PTLTVRDVDA RLTRLGAVSG AGSQAERTRL
110 120 130 140 150
VGELMGAATE DEQRFLIGLL TGEVRQGALD AAAVEGLAAA TDAPPADVRR
160 170 180 190 200
AVMLAGSLQT VAEALLADGP GALDRFRLTV GQPVLPMLAH SASSVAEAVG
210 220 230 240 250
KLGAAAVEEK LDGIRVQVHR DGGTVRIYTR TLDDITDRLP EVTEAALALP
260 270 280 290 300
GERFILDGEA ISLDADGRPR SFQETAGRVG SRTDVATAAR AVPVSAVFFD
310 320 330 340 350
VLSVDGRDLL DLPLTERHAE LARLVPEPLR VRRTLVHGPE DTGAAEEFLA
360 370 380 390 400
RTLARGHEGV VVKGLDAAYS AGRRGASWLK VKPVHTLDLV VLAAEWGHGR
410 420 430 440 450
RTGKLSNLHL GARTADGSFA MLGKTFKGMT DALLTWQTER LKELAVEEHG
460 470 480 490 500
WGVTVRPELV VEIAYDGLQR STRYPAGVTL RFARVVRYRE DKRPEDADTV
510
DTLLAAHPGV AP
Length:512
Mass (Da):54,696
Last modified:March 1, 2001 - v1
Checksum:i7A85CA68DC760FF9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL939108 Genomic DNA. Translation: CAC01484.1.
RefSeqiNP_625491.1. NC_003888.3.
WP_011027650.1. NC_003888.3.

Genome annotation databases

GeneIDi1096625.
KEGGisco:SCO1202.
PATRICi23731956. VBIStrCoe124346_1201.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL939108 Genomic DNA. Translation: CAC01484.1.
RefSeqiNP_625491.1. NC_003888.3.
WP_011027650.1. NC_003888.3.

3D structure databases

ProteinModelPortaliQ9FCB1.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi100226.SCO1202.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi1096625.
KEGGisco:SCO1202.
PATRICi23731956. VBIStrCoe124346_1201.

Phylogenomic databases

eggNOGiCOG1793.
HOGENOMiHOG000036008.
InParanoidiQ9FCB1.
KOiK10747.
OMAiGRPRPFQ.
OrthoDBiEOG6Q8HXT.
PhylomeDBiQ9FCB1.

Family and domain databases

Gene3Di1.10.3260.10. 1 hit.
2.40.50.140. 1 hit.
HAMAPiMF_00407. DNA_ligase.
InterProiIPR022865. DNA_ligae_ATP-dep_bac/arc.
IPR000977. DNA_ligase_ATP-dep.
IPR012309. DNA_ligase_ATP-dep_C.
IPR012310. DNA_ligase_ATP-dep_cent.
IPR016059. DNA_ligase_ATP-dep_CS.
IPR012308. DNA_ligase_ATP-dep_N.
IPR012340. NA-bd_OB-fold.
[Graphical view]
PfamiPF04679. DNA_ligase_A_C. 1 hit.
PF01068. DNA_ligase_A_M. 1 hit.
PF04675. DNA_ligase_A_N. 1 hit.
[Graphical view]
SUPFAMiSSF117018. SSF117018. 1 hit.
SSF50249. SSF50249. 1 hit.
TIGRFAMsiTIGR00574. dnl1. 1 hit.
PROSITEiPS00697. DNA_LIGASE_A1. 1 hit.
PS50160. DNA_LIGASE_A3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC BAA-471 / A3(2) / M145.

Entry informationi

Entry nameiDNLI_STRCO
AccessioniPrimary (citable) accession number: Q9FCB1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 20, 2001
Last sequence update: March 1, 2001
Last modified: April 1, 2015
This is version 99 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.