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Q9FCB1 (DNLI_STRCO) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 90. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Probable DNA ligase

EC=6.5.1.1
Alternative name(s):
Polydeoxyribonucleotide synthase [ATP]
Gene names
Name:lig
Ordered Locus Names:SCO1202
ORF Names:2SCG58.02
OrganismStreptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145) [Reference proteome] [HAMAP]
Taxonomic identifier100226 [NCBI]
Taxonomic lineageBacteriaActinobacteriaActinobacteridaeActinomycetalesStreptomycineaeStreptomycetaceaeStreptomyces

Protein attributes

Sequence length512 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair By similarity. HAMAP-Rule MF_00407

Catalytic activity

ATP + (deoxyribonucleotide)(n) + (deoxyribonucleotide)(m) = AMP + diphosphate + (deoxyribonucleotide)(n+m). HAMAP-Rule MF_00407

Cofactor

Divalent metal cations By similarity. HAMAP-Rule MF_00407

Sequence similarities

Belongs to the ATP-dependent DNA ligase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 512512Probable DNA ligase HAMAP-Rule MF_00407
PRO_0000059624

Sites

Active site2101N6-AMP-lysine intermediate By similarity
Binding site2081ATP By similarity
Binding site2151ATP By similarity
Binding site2301ATP By similarity
Binding site2591ATP By similarity
Binding site2991ATP By similarity
Binding site3741ATP By similarity
Binding site3801ATP By similarity

Sequences

Sequence LengthMass (Da)Tools
Q9FCB1 [UniParc].

Last modified March 1, 2001. Version 1.
Checksum: 7A85CA68DC760FF9

FASTA51254,696
        10         20         30         40         50         60 
MLLARLAQVS REVAATSARS RKTVLLAELF REAEAADVPV VIPYLAGRLP QGRIGVGWKV 

        70         80         90        100        110        120 
LSRRVPPADA PTLTVRDVDA RLTRLGAVSG AGSQAERTRL VGELMGAATE DEQRFLIGLL 

       130        140        150        160        170        180 
TGEVRQGALD AAAVEGLAAA TDAPPADVRR AVMLAGSLQT VAEALLADGP GALDRFRLTV 

       190        200        210        220        230        240 
GQPVLPMLAH SASSVAEAVG KLGAAAVEEK LDGIRVQVHR DGGTVRIYTR TLDDITDRLP 

       250        260        270        280        290        300 
EVTEAALALP GERFILDGEA ISLDADGRPR SFQETAGRVG SRTDVATAAR AVPVSAVFFD 

       310        320        330        340        350        360 
VLSVDGRDLL DLPLTERHAE LARLVPEPLR VRRTLVHGPE DTGAAEEFLA RTLARGHEGV 

       370        380        390        400        410        420 
VVKGLDAAYS AGRRGASWLK VKPVHTLDLV VLAAEWGHGR RTGKLSNLHL GARTADGSFA 

       430        440        450        460        470        480 
MLGKTFKGMT DALLTWQTER LKELAVEEHG WGVTVRPELV VEIAYDGLQR STRYPAGVTL 

       490        500        510 
RFARVVRYRE DKRPEDADTV DTLLAAHPGV AP 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AL939108 Genomic DNA. Translation: CAC01484.1.
RefSeqNP_625491.1. NC_003888.3.

3D structure databases

ProteinModelPortalQ9FCB1.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING100226.SCO1202.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaCAC01484; CAC01484; CAC01484.
GeneID1096625.
KEGGsco:SCO1202.
PATRIC23731956. VBIStrCoe124346_1201.

Phylogenomic databases

eggNOGCOG1793.
HOGENOMHOG000036008.
KOK01971.
OMAGRPRPFQ.
OrthoDBEOG6Q8HXT.
PhylomeDBQ9FCB1.
ProtClustDBPRK03180.

Family and domain databases

Gene3D1.10.3260.10. 1 hit.
2.40.50.140. 1 hit.
HAMAPMF_00407. DNA_ligase.
InterProIPR022865. DNA_ligae_ATP-dep_bac/arc.
IPR000977. DNA_ligase_ATP-dep.
IPR012309. DNA_ligase_ATP-dep_C.
IPR012310. DNA_ligase_ATP-dep_cent.
IPR016059. DNA_ligase_ATP-dep_CS.
IPR012308. DNA_ligase_ATP-dep_N.
IPR012340. NA-bd_OB-fold.
[Graphical view]
PfamPF04679. DNA_ligase_A_C. 1 hit.
PF01068. DNA_ligase_A_M. 1 hit.
PF04675. DNA_ligase_A_N. 1 hit.
[Graphical view]
SUPFAMSSF117018. SSF117018. 1 hit.
SSF50249. SSF50249. 1 hit.
TIGRFAMsTIGR00574. dnl1. 1 hit.
PROSITEPS00697. DNA_LIGASE_A1. 1 hit.
PS50160. DNA_LIGASE_A3. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameDNLI_STRCO
AccessionPrimary (citable) accession number: Q9FCB1
Entry history
Integrated into UniProtKB/Swiss-Prot: June 20, 2001
Last sequence update: March 1, 2001
Last modified: April 16, 2014
This is version 90 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families