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Q9FCB1

- DNLI_STRCO

UniProt

Q9FCB1 - DNLI_STRCO

Protein

Probable DNA ligase

Gene

lig

Organism
Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 93 (01 Oct 2014)
      Sequence version 1 (01 Mar 2001)
      Previous versions | rss
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    Functioni

    DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair.By similarity

    Catalytic activityi

    ATP + (deoxyribonucleotide)(n) + (deoxyribonucleotide)(m) = AMP + diphosphate + (deoxyribonucleotide)(n+m).

    Cofactori

    Divalent metal cations.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei208 – 2081ATPBy similarity
    Active sitei210 – 2101N6-AMP-lysine intermediateBy similarity
    Binding sitei215 – 2151ATPBy similarity
    Binding sitei230 – 2301ATPBy similarity
    Binding sitei259 – 2591ATPBy similarity
    Binding sitei299 – 2991ATPBy similarity
    Binding sitei374 – 3741ATPBy similarity
    Binding sitei380 – 3801ATPBy similarity

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-HAMAP
    2. DNA binding Source: InterPro
    3. DNA ligase (ATP) activity Source: RefGenome
    4. metal ion binding Source: UniProtKB-KW

    GO - Biological processi

    1. cell cycle Source: UniProtKB-KW
    2. cell division Source: UniProtKB-KW
    3. DNA ligation Source: RefGenome
    4. DNA ligation involved in DNA repair Source: InterPro
    5. DNA recombination Source: UniProtKB-HAMAP
    6. lagging strand elongation Source: RefGenome
    7. nucleotide-excision repair Source: RefGenome

    Keywords - Molecular functioni

    Ligase

    Keywords - Biological processi

    Cell cycle, Cell division, DNA damage, DNA recombination, DNA repair, DNA replication

    Keywords - Ligandi

    ATP-binding, Metal-binding, Nucleotide-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Probable DNA ligase (EC:6.5.1.1)
    Alternative name(s):
    Polydeoxyribonucleotide synthase [ATP]
    Gene namesi
    Name:lig
    Ordered Locus Names:SCO1202
    ORF Names:2SCG58.02
    OrganismiStreptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)
    Taxonomic identifieri100226 [NCBI]
    Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesStreptomycineaeStreptomycetaceaeStreptomycesStreptomyces albidoflavus group
    ProteomesiUP000001973: Chromosome

    Subcellular locationi

    GO - Cellular componenti

    1. chromosome Source: RefGenome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 512512Probable DNA ligasePRO_0000059624Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi100226.SCO1202.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9FCB1.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the ATP-dependent DNA ligase family.Curated

    Phylogenomic databases

    eggNOGiCOG1793.
    HOGENOMiHOG000036008.
    KOiK01971.
    OMAiARVQVHK.
    OrthoDBiEOG6Q8HXT.
    PhylomeDBiQ9FCB1.

    Family and domain databases

    Gene3Di1.10.3260.10. 1 hit.
    2.40.50.140. 1 hit.
    HAMAPiMF_00407. DNA_ligase.
    InterProiIPR022865. DNA_ligae_ATP-dep_bac/arc.
    IPR000977. DNA_ligase_ATP-dep.
    IPR012309. DNA_ligase_ATP-dep_C.
    IPR012310. DNA_ligase_ATP-dep_cent.
    IPR016059. DNA_ligase_ATP-dep_CS.
    IPR012308. DNA_ligase_ATP-dep_N.
    IPR012340. NA-bd_OB-fold.
    [Graphical view]
    PfamiPF04679. DNA_ligase_A_C. 1 hit.
    PF01068. DNA_ligase_A_M. 1 hit.
    PF04675. DNA_ligase_A_N. 1 hit.
    [Graphical view]
    SUPFAMiSSF117018. SSF117018. 1 hit.
    SSF50249. SSF50249. 1 hit.
    TIGRFAMsiTIGR00574. dnl1. 1 hit.
    PROSITEiPS00697. DNA_LIGASE_A1. 1 hit.
    PS50160. DNA_LIGASE_A3. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9FCB1-1 [UniParc]FASTAAdd to Basket

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    MLLARLAQVS REVAATSARS RKTVLLAELF REAEAADVPV VIPYLAGRLP    50
    QGRIGVGWKV LSRRVPPADA PTLTVRDVDA RLTRLGAVSG AGSQAERTRL 100
    VGELMGAATE DEQRFLIGLL TGEVRQGALD AAAVEGLAAA TDAPPADVRR 150
    AVMLAGSLQT VAEALLADGP GALDRFRLTV GQPVLPMLAH SASSVAEAVG 200
    KLGAAAVEEK LDGIRVQVHR DGGTVRIYTR TLDDITDRLP EVTEAALALP 250
    GERFILDGEA ISLDADGRPR SFQETAGRVG SRTDVATAAR AVPVSAVFFD 300
    VLSVDGRDLL DLPLTERHAE LARLVPEPLR VRRTLVHGPE DTGAAEEFLA 350
    RTLARGHEGV VVKGLDAAYS AGRRGASWLK VKPVHTLDLV VLAAEWGHGR 400
    RTGKLSNLHL GARTADGSFA MLGKTFKGMT DALLTWQTER LKELAVEEHG 450
    WGVTVRPELV VEIAYDGLQR STRYPAGVTL RFARVVRYRE DKRPEDADTV 500
    DTLLAAHPGV AP 512
    Length:512
    Mass (Da):54,696
    Last modified:March 1, 2001 - v1
    Checksum:i7A85CA68DC760FF9
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL939108 Genomic DNA. Translation: CAC01484.1.
    RefSeqiNP_625491.1. NC_003888.3.
    WP_011027650.1. NC_003888.3.

    Genome annotation databases

    EnsemblBacteriaiCAC01484; CAC01484; CAC01484.
    GeneIDi1096625.
    KEGGisco:SCO1202.
    PATRICi23731956. VBIStrCoe124346_1201.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL939108 Genomic DNA. Translation: CAC01484.1 .
    RefSeqi NP_625491.1. NC_003888.3.
    WP_011027650.1. NC_003888.3.

    3D structure databases

    ProteinModelPortali Q9FCB1.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 100226.SCO1202.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CAC01484 ; CAC01484 ; CAC01484 .
    GeneIDi 1096625.
    KEGGi sco:SCO1202.
    PATRICi 23731956. VBIStrCoe124346_1201.

    Phylogenomic databases

    eggNOGi COG1793.
    HOGENOMi HOG000036008.
    KOi K01971.
    OMAi ARVQVHK.
    OrthoDBi EOG6Q8HXT.
    PhylomeDBi Q9FCB1.

    Family and domain databases

    Gene3Di 1.10.3260.10. 1 hit.
    2.40.50.140. 1 hit.
    HAMAPi MF_00407. DNA_ligase.
    InterProi IPR022865. DNA_ligae_ATP-dep_bac/arc.
    IPR000977. DNA_ligase_ATP-dep.
    IPR012309. DNA_ligase_ATP-dep_C.
    IPR012310. DNA_ligase_ATP-dep_cent.
    IPR016059. DNA_ligase_ATP-dep_CS.
    IPR012308. DNA_ligase_ATP-dep_N.
    IPR012340. NA-bd_OB-fold.
    [Graphical view ]
    Pfami PF04679. DNA_ligase_A_C. 1 hit.
    PF01068. DNA_ligase_A_M. 1 hit.
    PF04675. DNA_ligase_A_N. 1 hit.
    [Graphical view ]
    SUPFAMi SSF117018. SSF117018. 1 hit.
    SSF50249. SSF50249. 1 hit.
    TIGRFAMsi TIGR00574. dnl1. 1 hit.
    PROSITEi PS00697. DNA_LIGASE_A1. 1 hit.
    PS50160. DNA_LIGASE_A3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC BAA-471 / A3(2) / M145.

    Entry informationi

    Entry nameiDNLI_STRCO
    AccessioniPrimary (citable) accession number: Q9FCB1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 20, 2001
    Last sequence update: March 1, 2001
    Last modified: October 1, 2014
    This is version 93 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3