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Q9FCA2 (DEF2_STRCO) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 71. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Peptide deformylase 2

Short name=PDF 2
EC=3.5.1.88
Alternative name(s):
Polypeptide deformylase 2
Gene names
Name:def2
Ordered Locus Names:SCO1211
ORF Names:2SCG58.11c
OrganismStreptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145) [Reference proteome] [HAMAP]
Taxonomic identifier100226 [NCBI]
Taxonomic lineageBacteriaActinobacteriaActinobacteridaeActinomycetalesStreptomycineaeStreptomycetaceaeStreptomyces

Protein attributes

Sequence length179 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions By similarity. HAMAP-Rule MF_00163

Catalytic activity

Formyl-L-methionyl peptide + H2O = formate + methionyl peptide. HAMAP-Rule MF_00163

Cofactor

Binds 1 Fe2+ ion By similarity. HAMAP-Rule MF_00163

Sequence similarities

Belongs to the polypeptide deformylase family.

Sequence caution

The sequence CAC01493.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
   Biological processProtein biosynthesis
   LigandIron
Metal-binding
   Molecular functionHydrolase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processtranslation

Inferred from electronic annotation. Source: UniProtKB-HAMAP

   Molecular_functioniron ion binding

Inferred from electronic annotation. Source: InterPro

peptide deformylase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 179179Peptide deformylase 2 HAMAP-Rule MF_00163
PRO_0000082853

Sites

Active site1471 By similarity
Metal binding1041Iron By similarity
Metal binding1461Iron By similarity
Metal binding1501Iron By similarity

Sequences

Sequence LengthMass (Da)Tools
Q9FCA2 [UniParc].

Last modified September 19, 2002. Version 2.
Checksum: 8ABB3827812788F2

FASTA17919,476
        10         20         30         40         50         60 
MRQGSIPGAH GRVRPLGLLG DPVLHARCAE VTDFGPELAA LVEDLFATMY AAHGVGLAAN 

        70         80         90        100        110        120 
QVGEAVRVFV YDCPDDEDER HLGHVVNPRL VETGGVVVRG PEGCLSLPGL EAGTERYDEA 

       130        140        150        160        170 
VVTGFTVAGE PVTVRGTGFF ARCLQHECDH LEGRVYADRL TGRRHRKLMR QVARASWHR 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AL939108 Genomic DNA. Translation: CAC01493.1. Different initiation.
RefSeqNP_625500.1. NC_003888.3.

3D structure databases

ProteinModelPortalQ9FCA2.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING100226.SCO1211.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaCAC01493; CAC01493; CAC01493.
GeneID1096634.
KEGGsco:SCO1211.
PATRIC23731974. VBIStrCoe124346_1210.

Phylogenomic databases

eggNOGCOG0242.
HOGENOMHOG000243508.
KOK01462.
OrthoDBEOG664CMF.
PhylomeDBQ9FCA2.
ProtClustDBCLSK378633.

Family and domain databases

Gene3D3.90.45.10. 1 hit.
HAMAPMF_00163. Pep_deformylase.
InterProIPR000181. Fmet_deformylase.
IPR023635. Peptide_deformylase.
[Graphical view]
PANTHERPTHR10458. PTHR10458. 1 hit.
PfamPF01327. Pep_deformylase. 1 hit.
[Graphical view]
PIRSFPIRSF004749. Pep_def. 1 hit.
PRINTSPR01576. PDEFORMYLASE.
SUPFAMSSF56420. SSF56420. 1 hit.
TIGRFAMsTIGR00079. pept_deformyl. 1 hit.
ProtoNetSearch...

Entry information

Entry nameDEF2_STRCO
AccessionPrimary (citable) accession number: Q9FCA2
Entry history
Integrated into UniProtKB/Swiss-Prot: September 19, 2002
Last sequence update: September 19, 2002
Last modified: April 16, 2014
This is version 71 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families