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Protein

Undecaprenyl-diphosphatase 1

Gene

uppP1

Organism
Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin.UniRule annotation

Catalytic activityi

Ditrans,octacis-undecaprenyl diphosphate + H2O = ditrans,octacis-undecaprenyl phosphate + phosphate.UniRule annotation

GO - Molecular functioni

  1. undecaprenyl-diphosphatase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. cell wall organization Source: UniProtKB-KW
  2. dephosphorylation Source: InterPro
  3. peptidoglycan biosynthetic process Source: UniProtKB-KW
  4. regulation of cell shape Source: UniProtKB-KW
  5. response to antibiotic Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Antibiotic resistance, Cell shape, Cell wall biogenesis/degradation, Peptidoglycan synthesis

Names & Taxonomyi

Protein namesi
Recommended name:
Undecaprenyl-diphosphatase 1UniRule annotation (EC:3.6.1.27UniRule annotation)
Alternative name(s):
Bacitracin resistance protein 1UniRule annotation
Undecaprenyl pyrophosphate phosphatase 1UniRule annotation
Gene namesi
Name:uppP1UniRule annotation
Synonyms:bacA1, upk1
Ordered Locus Names:SCO7047
ORF Names:SC4G1.13
OrganismiStreptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)
Taxonomic identifieri100226 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesStreptomycineaeStreptomycetaceaeStreptomycesStreptomyces albidoflavus group
ProteomesiUP000001973 Componenti: Chromosome

Subcellular locationi

Cell membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei45 – 6521HelicalUniRule annotationAdd
BLAST
Transmembranei95 – 11521HelicalUniRule annotationAdd
BLAST
Transmembranei119 – 13921HelicalUniRule annotationAdd
BLAST
Transmembranei191 – 21121HelicalUniRule annotationAdd
BLAST
Transmembranei225 – 24521HelicalUniRule annotationAdd
BLAST
Transmembranei256 – 27621HelicalUniRule annotationAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 278278Undecaprenyl-diphosphatase 1PRO_0000151211Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi100226.SCO7047.

Family & Domainsi

Sequence similaritiesi

Belongs to the UppP family.UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG1968.
HOGENOMiHOG000218357.
InParanoidiQ9FC36.
KOiK06153.
OMAiHKRGEDD.
OrthoDBiEOG6QP13M.
PhylomeDBiQ9FC36.

Family and domain databases

HAMAPiMF_01006. Undec_diphosphatase.
InterProiIPR003824. UppP.
[Graphical view]
PfamiPF02673. BacA. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00753. undec_PP_bacA. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9FC36-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSAISIGQAV VLGAVEGVTE FLPVSSTGHL KIVEGLMGIP VDDDAVIGFS
60 70 80 90 100
AVIQVGAIAA VLVYFSKDIM RIVSAWGRGL RDREERYHHD YRFAWWVIYA
110 120 130 140 150
TIPIVLVGLA AKPLIKGPLA SLWVVAGSLI VGSGVMWWAD RTGRHKRGED
160 170 180 190 200
DTSFKDAMLV GGSQILALLF PGFSRSGATM STALMLDLDR VAATRLSFFL
210 220 230 240 250
GIPALTGAGL YELKDALGTG AGAAPLAVGT LVSFVVAYAS IAWLLKFVAK
260 270
HTFNSFVVYR IAVGVLLFGL LGTGVLHS
Length:278
Mass (Da):29,480
Last modified:March 1, 2001 - v1
Checksum:i522A6F040FA67458
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL939130 Genomic DNA. Translation: CAC01545.1.
RefSeqiNP_631109.1. NC_003888.3.

Genome annotation databases

GeneIDi1102485.
KEGGisco:SCO7047.
PATRICi23744017. VBIStrCoe124346_7151.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL939130 Genomic DNA. Translation: CAC01545.1.
RefSeqiNP_631109.1. NC_003888.3.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi100226.SCO7047.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi1102485.
KEGGisco:SCO7047.
PATRICi23744017. VBIStrCoe124346_7151.

Phylogenomic databases

eggNOGiCOG1968.
HOGENOMiHOG000218357.
InParanoidiQ9FC36.
KOiK06153.
OMAiHKRGEDD.
OrthoDBiEOG6QP13M.
PhylomeDBiQ9FC36.

Family and domain databases

HAMAPiMF_01006. Undec_diphosphatase.
InterProiIPR003824. UppP.
[Graphical view]
PfamiPF02673. BacA. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00753. undec_PP_bacA. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC BAA-471 / A3(2) / M145.

Entry informationi

Entry nameiUPPP1_STRCO
AccessioniPrimary (citable) accession number: Q9FC36
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 5, 2002
Last sequence update: March 1, 2001
Last modified: April 1, 2015
This is version 87 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Miscellaneous

Bacitracin is thought to be involved in the inhibition of peptidoglycan synthesis by sequestering undecaprenyl diphosphate, thereby reducing the pool of lipid carrier available.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.