Reviewed, UniProtKB/Swiss-Prot Q9FC36 (UPPP1_STRCO)

Names and origin

Protein names

Recommended name:
    Undecaprenyl-diphosphatase 1
    EC=3.6.1.27
Alternative name(s):
    Undecaprenyl pyrophosphate phosphatase 1
    Bacitracin resistance protein 1

Gene names

Name:	uppP1
Synonyms:	bacA1, upk1
Ordered Locus Names:	SCO7047
ORF Names:	SC4G1.13

Organism

Streptomyces coelicolor [Complete proteome] [HAMAP]

Taxonomic identifier

1902 [NCBI]

Taxonomic lineage

Bacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Streptomycineae › Streptomycetaceae › Streptomyces

Protein attributes

Sequence length	278 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin By similarity.
Catalytic activity	Undecaprenyl diphosphate + H2O = undecaprenyl phosphate + phosphate. HAMAP MF_01006
Subcellular location	Cell membrane; Multi-pass membrane protein By similarity.
Miscellaneous	Bacitracin is thought to be involved in the inhibition of peptidoglycan synthesis by sequestering undecaprenyl diphosphate, thereby reducing the pool of lipid carrier available. HAMAP MF_01006
Sequence similarities	Belongs to the uppP family.

Ontologies

Keywords
Biological process	Antibiotic resistance Cell shape Cell wall biogenesis/degradation Peptidoglycan synthesis
Cellular component	Cell membrane Membrane
Domain	Transmembrane
Molecular function	Hydrolase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	cell wall organization Inferred from electronic annotation. Source: UniProtKB-KW dephosphorylation Inferred from electronic annotation. Source: InterPro peptidoglycan biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW regulation of cell shape Inferred from electronic annotation. Source: UniProtKB-KW response to antibiotic Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-SubCell plasma membrane Inferred from electronic annotation. Source: HAMAP
Molecular function	undecaprenyl-diphosphatase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 278	278	Undecaprenyl-diphosphatase 1 HAMAP MF_01006		PRO_0000151211
Regions
	Transmembrane	45 – 65	21	Potential
	Transmembrane	95 – 115	21	Potential
	Transmembrane	119 – 139	21	Potential
	Transmembrane	191 – 211	21	Potential
	Transmembrane	225 – 245	21	Potential
	Transmembrane	256 – 276	21	Potential

Sequences

	Sequence		Length	Mass (Da)
	Q9FC36-1 [UniParc]. Last modified March 1, 2001. Version 1. Checksum: 522A6F040FA67458	FASTA	278	29,480
	10 20 30 40 50 60 MSAISIGQAV VLGAVEGVTE FLPVSSTGHL KIVEGLMGIP VDDDAVIGFS AVIQVGAIAA 70 80 90 100 110 120 VLVYFSKDIM RIVSAWGRGL RDREERYHHD YRFAWWVIYA TIPIVLVGLA AKPLIKGPLA 130 140 150 160 170 180 SLWVVAGSLI VGSGVMWWAD RTGRHKRGED DTSFKDAMLV GGSQILALLF PGFSRSGATM 190 200 210 220 230 240 STALMLDLDR VAATRLSFFL GIPALTGAGL YELKDALGTG AGAAPLAVGT LVSFVVAYAS 250 260 270 IAWLLKFVAK HTFNSFVVYR IAVGVLLFGL LGTGVLHS

References

[1]

"Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2)." Bentley S.D., Chater K.F., Cerdeno-Tarraga A.-M., Challis G.L., Thomson N.R., James K.D., Harris D.E., Quail M.A., Kieser H., Harper D., Bateman A., Brown S., Chandra G., Chen C.W., Collins M., Cronin A., Fraser A., Goble A. , Hidalgo J., Hornsby T., Howarth S., Huang C.-H., Kieser T., Larke L., Murphy L.D., Oliver K., O'Neil S., Rabbinowitsch E., Rajandream M.A., Rutherford K.M., Rutter S., Seeger K., Saunders D., Sharp S., Squares R., Squares S., Taylor K., Warren T., Wietzorrek A., Woodward J.R., Barrell B.G., Parkhill J., Hopwood D.A. Nature 417:141-147(2002) [PubMed: 12000953] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC BAA-471 / A3(2) / M145.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AL939130 Genomic DNA. Translation: CAC01545.1.
RefSeq	NP_631109.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	1102485.
GenomeReviews	Gene locus SCO7047 in contig AL645882_GR.
KEGG	sco:SCO7047.
NMPDR	fig|100226.1.peg.6982.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q9FC36.
OMA	AYASIAW.
Enzyme and pathway databases
BioCyc	SCOE100226:SCO7047-MON.
BRENDA	3.6.1.27. 1084.
Family and domain databases
HAMAP	MF_01006. [Tree]
InterPro	IPR003824. Bacitracin-R_BacA. [Graphical view]
Pfam	PF02673. BacA. 1 hit. [Graphical view]
TIGRFAMs	TIGR00753. undec_PP_bacA. 1 hit.
ProtoNet	Search...

Entry information

Entry name

UPPP1_STRCO

Accession

Primary (citable) accession number: Q9FC36

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 5, 2002
Last sequence update:	March 1, 2001
Last modified:	November 3, 2009
This is version 54 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)