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Q9FC36 (UPPP1_STRCO) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 82. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Undecaprenyl-diphosphatase 1

EC=3.6.1.27
Alternative name(s):
Bacitracin resistance protein 1
Undecaprenyl pyrophosphate phosphatase 1
Gene names
Name:uppP1
Synonyms:bacA1, upk1
Ordered Locus Names:SCO7047
ORF Names:SC4G1.13
OrganismStreptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145) [Reference proteome] [HAMAP]
Taxonomic identifier100226 [NCBI]
Taxonomic lineageBacteriaActinobacteriaActinobacteridaeActinomycetalesStreptomycineaeStreptomycetaceaeStreptomyces

Protein attributes

Sequence length278 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin By similarity. HAMAP-Rule MF_01006

Catalytic activity

Ditrans,octacis-undecaprenyl diphosphate + H2O = ditrans,octacis-undecaprenyl phosphate + phosphate. HAMAP-Rule MF_01006

Subcellular location

Cell membrane; Multi-pass membrane protein By similarity HAMAP-Rule MF_01006.

Miscellaneous

Bacitracin is thought to be involved in the inhibition of peptidoglycan synthesis by sequestering undecaprenyl diphosphate, thereby reducing the pool of lipid carrier available.

Sequence similarities

Belongs to the UppP family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 278278Undecaprenyl-diphosphatase 1 HAMAP-Rule MF_01006
PRO_0000151211

Regions

Transmembrane45 – 6521Helical; Potential
Transmembrane95 – 11521Helical; Potential
Transmembrane119 – 13921Helical; Potential
Transmembrane191 – 21121Helical; Potential
Transmembrane225 – 24521Helical; Potential
Transmembrane256 – 27621Helical; Potential

Sequences

Sequence LengthMass (Da)Tools
Q9FC36 [UniParc].

Last modified March 1, 2001. Version 1.
Checksum: 522A6F040FA67458

FASTA27829,480
        10         20         30         40         50         60 
MSAISIGQAV VLGAVEGVTE FLPVSSTGHL KIVEGLMGIP VDDDAVIGFS AVIQVGAIAA 

        70         80         90        100        110        120 
VLVYFSKDIM RIVSAWGRGL RDREERYHHD YRFAWWVIYA TIPIVLVGLA AKPLIKGPLA 

       130        140        150        160        170        180 
SLWVVAGSLI VGSGVMWWAD RTGRHKRGED DTSFKDAMLV GGSQILALLF PGFSRSGATM 

       190        200        210        220        230        240 
STALMLDLDR VAATRLSFFL GIPALTGAGL YELKDALGTG AGAAPLAVGT LVSFVVAYAS 

       250        260        270 
IAWLLKFVAK HTFNSFVVYR IAVGVLLFGL LGTGVLHS 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AL939130 Genomic DNA. Translation: CAC01545.1.
RefSeqNP_631109.1. NC_003888.3.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING100226.SCO7047.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaCAC01545; CAC01545; CAC01545.
GeneID1102485.
KEGGsco:SCO7047.
PATRIC23744017. VBIStrCoe124346_7151.

Phylogenomic databases

eggNOGCOG1968.
HOGENOMHOG000218357.
KOK06153.
OMAWVIYATI.
OrthoDBEOG6QP13M.
PhylomeDBQ9FC36.
ProtClustDBPRK00281.

Family and domain databases

HAMAPMF_01006. Undec_diphosphatase.
InterProIPR003824. UppP.
[Graphical view]
PfamPF02673. BacA. 1 hit.
[Graphical view]
TIGRFAMsTIGR00753. undec_PP_bacA. 1 hit.
ProtoNetSearch...

Entry information

Entry nameUPPP1_STRCO
AccessionPrimary (citable) accession number: Q9FC36
Entry history
Integrated into UniProtKB/Swiss-Prot: March 5, 2002
Last sequence update: March 1, 2001
Last modified: April 16, 2014
This is version 82 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families