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Q9FB58 (UPPP_CORST) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 64. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Undecaprenyl-diphosphatase

EC=3.6.1.27
Alternative name(s):
Bacitracin resistance protein
Undecaprenyl pyrophosphate phosphatase
Gene names
Name:uppP
Synonyms:bacA, upk
Encoded onPlasmid pTP10
OrganismCorynebacterium striatum
Taxonomic identifier43770 [NCBI]
Taxonomic lineageBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeCorynebacteriaceaeCorynebacterium

Protein attributes

Sequence length281 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin By similarity. HAMAP-Rule MF_01006

Catalytic activity

Ditrans,octacis-undecaprenyl diphosphate + H2O = ditrans,octacis-undecaprenyl phosphate + phosphate. HAMAP-Rule MF_01006

Subcellular location

Cell membrane; Multi-pass membrane protein By similarity HAMAP-Rule MF_01006.

Miscellaneous

Bacitracin is thought to be involved in the inhibition of peptidoglycan synthesis by sequestering undecaprenyl diphosphate, thereby reducing the pool of lipid carrier available.

Sequence similarities

Belongs to the UppP family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 281281Undecaprenyl-diphosphatase HAMAP-Rule MF_01006
PRO_0000151141

Regions

Transmembrane12 – 3221Helical; Potential
Transmembrane50 – 7021Helical; Potential
Transmembrane99 – 11921Helical; Potential
Transmembrane123 – 14321Helical; Potential
Transmembrane156 – 17621Helical; Potential
Transmembrane199 – 21921Helical; Potential
Transmembrane231 – 25121Helical; Potential
Transmembrane260 – 28021Helical; Potential

Sequences

Sequence LengthMass (Da)Tools
Q9FB58 [UniParc].

Last modified March 1, 2001. Version 1.
Checksum: F82700075DB27EA9

FASTA28130,512
        10         20         30         40         50         60 
MSFAMTDPAT TMSWVQVIVL SIVQGLTEFL PVSSSGHLRI VSQLFWGEDA GASFTAVIQL 

        70         80         90        100        110        120 
GTELAVLVFF AKDIWRILTA WFAGLADKSK RNFDYRMGWM VIAGTIPVGL AGVLLKDLIR 

       130        140        150        160        170        180 
ENFRNLWITA TVLILFSLVF ILAERRGKKT RGFEELTMKD AVVMGLWQCL ALIPGVSRSG 

       190        200        210        220        230        240 
GTISGGLFLN LDREVATRFS FLLAIPAVLA SGLFSLPDAF DPQAGQAASG LQLLVGSGIG 

       250        260        270        280 
FVVGYISIAW LLKFVSNHSF AWFAAYRIPL GLLVMALLGL A 

« Hide

References

[1]"The 51,409-bp R-plasmid pTP10 from the multiresistant clinical isolate Corynebacterium striatum M82B is composed of DNA segments initially identified in soil bacteria and in plant, animal, and human pathogens."
Tauch A., Krieft S., Kalinowski J., Puehler A.
Mol. Gen. Genet. 263:1-11(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: M82B.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF024666 Genomic DNA. Translation: AAG03365.1.
RefSeqNP_862231.1. NC_004939.1.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID1403751.

Family and domain databases

HAMAPMF_01006. Undec_diphosphatase.
InterProIPR003824. UppP.
[Graphical view]
PfamPF02673. BacA. 1 hit.
[Graphical view]
TIGRFAMsTIGR00753. undec_PP_bacA. 1 hit.
ProtoNetSearch...

Entry information

Entry nameUPPP_CORST
AccessionPrimary (citable) accession number: Q9FB58
Entry history
Integrated into UniProtKB/Swiss-Prot: March 5, 2002
Last sequence update: March 1, 2001
Last modified: May 14, 2014
This is version 64 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families