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Q9FB58

- UPPP_CORST

UniProt

Q9FB58 - UPPP_CORST

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Protein

Undecaprenyl-diphosphatase

Gene

uppP

Organism
Corynebacterium striatum
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity).By similarity

Catalytic activityi

Ditrans,octacis-undecaprenyl diphosphate + H2O = ditrans,octacis-undecaprenyl phosphate + phosphate.

GO - Molecular functioni

  1. undecaprenyl-diphosphatase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. cell wall organization Source: UniProtKB-KW
  2. dephosphorylation Source: InterPro
  3. peptidoglycan biosynthetic process Source: UniProtKB-KW
  4. regulation of cell shape Source: UniProtKB-KW
  5. response to antibiotic Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Antibiotic resistance, Cell shape, Cell wall biogenesis/degradation, Peptidoglycan synthesis

Names & Taxonomyi

Protein namesi
Recommended name:
Undecaprenyl-diphosphatase (EC:3.6.1.27)
Alternative name(s):
Bacitracin resistance protein
Undecaprenyl pyrophosphate phosphatase
Gene namesi
Name:uppP
Synonyms:bacA, upk
Encoded oniPlasmid pTP100 Publication
OrganismiCorynebacterium striatum
Taxonomic identifieri43770 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeCorynebacteriaceaeCorynebacterium

Subcellular locationi

Cell membrane By similarity; Multi-pass membrane protein By similarity

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei12 – 3221HelicalSequence AnalysisAdd
BLAST
Transmembranei50 – 7021HelicalSequence AnalysisAdd
BLAST
Transmembranei99 – 11921HelicalSequence AnalysisAdd
BLAST
Transmembranei123 – 14321HelicalSequence AnalysisAdd
BLAST
Transmembranei156 – 17621HelicalSequence AnalysisAdd
BLAST
Transmembranei199 – 21921HelicalSequence AnalysisAdd
BLAST
Transmembranei231 – 25121HelicalSequence AnalysisAdd
BLAST
Transmembranei260 – 28021HelicalSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 281281Undecaprenyl-diphosphatasePRO_0000151141Add
BLAST

Family & Domainsi

Sequence similaritiesi

Belongs to the UppP family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Family and domain databases

HAMAPiMF_01006. Undec_diphosphatase.
InterProiIPR003824. UppP.
[Graphical view]
PfamiPF02673. BacA. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00753. undec_PP_bacA. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9FB58-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSFAMTDPAT TMSWVQVIVL SIVQGLTEFL PVSSSGHLRI VSQLFWGEDA
60 70 80 90 100
GASFTAVIQL GTELAVLVFF AKDIWRILTA WFAGLADKSK RNFDYRMGWM
110 120 130 140 150
VIAGTIPVGL AGVLLKDLIR ENFRNLWITA TVLILFSLVF ILAERRGKKT
160 170 180 190 200
RGFEELTMKD AVVMGLWQCL ALIPGVSRSG GTISGGLFLN LDREVATRFS
210 220 230 240 250
FLLAIPAVLA SGLFSLPDAF DPQAGQAASG LQLLVGSGIG FVVGYISIAW
260 270 280
LLKFVSNHSF AWFAAYRIPL GLLVMALLGL A
Length:281
Mass (Da):30,512
Last modified:March 1, 2001 - v1
Checksum:iF82700075DB27EA9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF024666 Genomic DNA. Translation: AAG03365.1.
RefSeqiNP_862231.1. NC_004939.1.
WP_011116972.1. NC_004939.1.

Genome annotation databases

GeneIDi1403751.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF024666 Genomic DNA. Translation: AAG03365.1 .
RefSeqi NP_862231.1. NC_004939.1.
WP_011116972.1. NC_004939.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 1403751.

Family and domain databases

HAMAPi MF_01006. Undec_diphosphatase.
InterProi IPR003824. UppP.
[Graphical view ]
Pfami PF02673. BacA. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR00753. undec_PP_bacA. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "The 51,409-bp R-plasmid pTP10 from the multiresistant clinical isolate Corynebacterium striatum M82B is composed of DNA segments initially identified in soil bacteria and in plant, animal, and human pathogens."
    Tauch A., Krieft S., Kalinowski J., Puehler A.
    Mol. Gen. Genet. 263:1-11(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: M82B.

Entry informationi

Entry nameiUPPP_CORST
AccessioniPrimary (citable) accession number: Q9FB58
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 5, 2002
Last sequence update: March 1, 2001
Last modified: October 29, 2014
This is version 67 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Miscellaneous

Bacitracin is thought to be involved in the inhibition of peptidoglycan synthesis by sequestering undecaprenyl diphosphate, thereby reducing the pool of lipid carrier available.

Keywords - Technical termi

Plasmid

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3