Q9FB58 (UPPP_CORST) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Undecaprenyl-diphosphatase
EC=3.6.1.27

Alternative name(s):
Bacitracin resistance protein
Undecaprenyl pyrophosphate phosphatase

Gene names

Name:	uppP
Synonyms:	bacA, upk

Encoded on

Plasmid pTP10

Organism

Corynebacterium striatum

Taxonomic identifier

43770 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Actinobacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Corynebacteriaceae › Corynebacterium

Protein attributes

Sequence length	281 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin By similarity. HAMAP-Rule MF_01006
Catalytic activity	Ditrans,octacis-undecaprenyl diphosphate + H2O = ditrans,octacis-undecaprenyl phosphate + phosphate. HAMAP-Rule MF_01006
Subcellular location	Cell membrane; Multi-pass membrane protein By similarity HAMAP-Rule MF_01006.
Miscellaneous	Bacitracin is thought to be involved in the inhibition of peptidoglycan synthesis by sequestering undecaprenyl diphosphate, thereby reducing the pool of lipid carrier available. HAMAP-Rule MF_01006
Sequence similarities	Belongs to the UppP family.

Ontologies

Keywords
Biological process	Antibiotic resistance Cell shape Cell wall biogenesis/degradation Peptidoglycan synthesis
Cellular component	Cell membrane Membrane
Domain	Transmembrane Transmembrane helix
Molecular function	Hydrolase
Technical term	Plasmid
Gene Ontology (GO)
Biological_process	dephosphorylation Inferred from electronic annotation. Source: InterPro peptidoglycan biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW regulation of cell shape Inferred from electronic annotation. Source: UniProtKB-KW response to antibiotic Inferred from electronic annotation. Source: HAMAP
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	undecaprenyl-diphosphatase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 281	281	Undecaprenyl-diphosphatase HAMAP-Rule MF_01006		PRO_0000151141
Regions
	Transmembrane	12 – 32	21	Helical; Potential
	Transmembrane	50 – 70	21	Helical; Potential
	Transmembrane	99 – 119	21	Helical; Potential
	Transmembrane	123 – 143	21	Helical; Potential
	Transmembrane	156 – 176	21	Helical; Potential
	Transmembrane	199 – 219	21	Helical; Potential
	Transmembrane	231 – 251	21	Helical; Potential
	Transmembrane	260 – 280	21	Helical; Potential

Sequences

	Sequence		Length	Mass (Da)
	Q9FB58 [UniParc]. Last modified March 1, 2001. Version 1. Checksum: F82700075DB27EA9	FASTA	281	30,512
	10 20 30 40 50 60 MSFAMTDPAT TMSWVQVIVL SIVQGLTEFL PVSSSGHLRI VSQLFWGEDA GASFTAVIQL 70 80 90 100 110 120 GTELAVLVFF AKDIWRILTA WFAGLADKSK RNFDYRMGWM VIAGTIPVGL AGVLLKDLIR 130 140 150 160 170 180 ENFRNLWITA TVLILFSLVF ILAERRGKKT RGFEELTMKD AVVMGLWQCL ALIPGVSRSG 190 200 210 220 230 240 GTISGGLFLN LDREVATRFS FLLAIPAVLA SGLFSLPDAF DPQAGQAASG LQLLVGSGIG 250 260 270 280 FVVGYISIAW LLKFVSNHSF AWFAAYRIPL GLLVMALLGL A

References

[1]

"The 51,409-bp R-plasmid pTP10 from the multiresistant clinical isolate Corynebacterium striatum M82B is composed of DNA segments initially identified in soil bacteria and in plant, animal, and human pathogens." Tauch A., Krieft S., Kalinowski J., Puehler A. Mol. Gen. Genet. 263:1-11(2000) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: M82B.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF024666 Genomic DNA. Translation: AAG03365.1.
RefSeq	NP_862231.1. NC_004939.1.
3D structure databases
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	1403751.
Phylogenomic databases
ProtClustDB	PRK00281.
Family and domain databases
HAMAP	MF_01006. Undec_diphosphatase.
InterPro	IPR003824. Bacitracin-R_BacA. [Graphical view]
Pfam	PF02673. BacA. 1 hit. [Graphical view]
TIGRFAMs	TIGR00753. undec_PP_bacA. 1 hit.
ProtoNet	Search...

Entry information

Entry name

UPPP_CORST

Accession

Primary (citable) accession number: Q9FB58

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 5, 2002
Last sequence update:	March 1, 2001
Last modified:	April 3, 2013
This is version 60 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program