Q9FB24 (Q9FB24_9ACTO) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Submitted name:
Peptide synthetase NRPS6 EMBL AAG02358.1

Gene names

Name:

blmVII EMBL AAG02358.1

Organism

Streptomyces verticillus EMBL AAG02358.1

Taxonomic identifier

29309 [NCBI]

Taxonomic lineage

Bacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Streptomycineae › Streptomycetaceae › Streptomyces

Protein attributes

Sequence length	1218 AA.
Sequence status	Complete.
Protein existence	Predicted

Ontologies

Gene Ontology (GO)
Molecular function	acyl carrier activity Inferred from electronic annotation. Source: InterPro cofactor binding Inferred from electronic annotation. Source: InterPro ligase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	Q9FB24 [UniParc]. Last modified March 1, 2001. Version 1. Checksum: F8678E8624753910	FASTA	1,218	129,640
	10 20 30 40 50 60 MTTPRITDLL TELRGRQVTL TADGDRLHCR APRGALTDEL LATIRARRDE LLAHLRADRR 70 80 90 100 110 120 IPRHDGPAPL SFAQERLWLL HQFHPHDSAY NIPLHIALRG PLNPAALRAA LAEVVRRHDV 130 140 150 160 170 180 LRTRYAISRG LPRPVVEPAH TPPLPLTDLT GLPAHHRDAE LARLAAQEAR RPFDLAQGPV 190 200 210 220 230 240 LRARLLRTAP EEHRLLLTRH HIASDGWSLD ILLRELGTFY RAGRDGTPAG LDALPLRYAD 250 260 270 280 290 300 FAAYQREQAE RPETAERSTR WARHLRGAPA TLDVLGPPPA EPSHAPAGTV RTDLPAALVT 310 320 330 340 350 360 GLRQLGGRAR TTLFPLLLSA FGLALAGPPG PYDVMVGIPV AGRPRTELEP LIGCFATIAP 370 380 390 400 410 420 MRLTSDGTEP LTRLAARAQQ HVQDALDGPD VPFERLVHAL RPERDLAENP LFSASFAFQN 430 440 450 460 470 480 TPRTAVRLPG LDAEVLPSPP VAPKFPLALT ATARADGGMG LELEFDRDRI AEPVARGILT 490 500 510 520 530 540 SFHAALARAV ADPEAPAAPV PAAAVDRRPG REGHECLHEP VARAAARHPD AVAVSCGGTQ 550 560 570 580 590 600 LSYGALDTRA ERLAAVLRAH GAGPERLVAL CLPTGPEWVV GALAILKSGA AYLPLDPGDP 610 620 630 640 650 660 AERRASVAAD AGATLIVSDT ALPPLHRVDV TATLPDGAPE PTARAVLPGN LAYAVYTSGS 670 680 690 700 710 720 TGGPKGVLVT HANVTGLLAA CREALPALDA PRTWSATHSP AFDFSVWEVW GPLTAGGRLV 730 740 750 760 770 780 LVPPDVARAP DELWDTLRDE QVEVLSQTPS AFHHLLPTAV RRAAQATALE LVVLGGEACE 790 800 810 820 830 840 PARLTPWWDA LGDRRPAVVN MYGITENTIH VTVRRMTAAD RSGSPVGRPL PGQRADLLDP 850 860 870 880 890 900 HGRPVAPGGR GELFVGGVGL ARGYLGRPGL TARSFLPDDT PGWPGARRYR SGDLARLLPD 910 920 930 940 950 960 GGLDYAGRSD AQVKVRGYRV EPAETEAAAL THPAVRHCVV VPRGDGDRRH LAAYVVADTR 970 980 990 1000 1010 1020 ACDGPGLRTH LAERLPRHLV PASVVFLKRI PLTRNGKLDV AALPDPAAHR APARERPRTA 1030 1040 1050 1060 1070 1080 TERTLTRLLA ALLKAPPETI GTHDNLFDLG GDSLTVTQFH SRVVEEFAVD LPVRRVYQAL 1090 1100 1110 1120 1130 1140 DIATLAVTVD DFRRRAERTA VLRALAAAEA MEPGGTAGES GGNPEESAAT ARGPAVAANE 1150 1160 1170 1180 1190 1200 PGAAARESGA APVEPAVAVQ ESAATKGEPG TAANELGAEA REPGTAAQEP GTDPRPPAAT 1210 PQDPRTTPQE GQPCPRPE

References

[1]	"An oxidation domain in the BlmIII non-ribosomal peptide synthetase probably catalyzing thiazole formation in the biosynthesis of the anti-tumor drug bleomycin in Streptomyces verticillus ATCC15003." Du L., Chen M., Sanchez C., Shen B. FEMS Microbiol. Lett. 189:171-175(2000) [PubMed: 10930733] [Abstract] Cited for: NUCLEOTIDE SEQUENCE. Strain: ATCC15003 EMBL AAG02358.1.
[2]	"The biosynthetic gene cluster for the antitumor drug bleomycin from Streptomyces verticillus ATCC15003 supporting functional interactions between nonribosomal peptide synthetases and a polyketide synthase." Du L., Sanchez C., Chen M., Edwards D.J., Shen B. Chem. Biol. 7:623-642(2000) [PubMed: 11048953] [Abstract] Cited for: NUCLEOTIDE SEQUENCE. Strain: ATCC15003 EMBL AAG02358.1.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF210249 Genomic DNA. Translation: AAG02358.1.
3D structure databases
HSSP	HSSP built from PDB template 1AMU based on UniProtKB P14687.
ProteinModelPortal	Q9FB24.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Family and domain databases
InterPro	IPR010071. AA_adenyl_domain. IPR009081. Acyl_carrier_prot-like. IPR000873. AMP-dep_Synth/Lig. IPR001242. Condensatn. IPR006163. Phsphopanteth-bd. [Graphical view]
Gene3D	G3DSA:1.10.1200.10. ACP_like. 1 hit.
Pfam	PF00501. AMP-binding. 1 hit. PF00668. Condensation. 1 hit. PF00550. PP-binding. 1 hit. [Graphical view]
SUPFAM	SSF47336. ACP_like. 1 hit.
TIGRFAMs	TIGR01733. AA-adenyl-dom. 1 hit.
PROSITE	PS50075. ACP_DOMAIN. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

Q9FB24_9ACTO

Accession

Primary (citable) accession number: Q9FB24

Entry history

Integrated into UniProtKB/TrEMBL:	March 1, 2001
Last sequence update:	March 1, 2001
Last modified:	September 21, 2011
This is version 44 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)