Q9FB18 (Q9FB18_9ACTO) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Submitted name:
Peptide synthetase NRPS2-1 EMBL AAG02364.1

Gene names

Name:

blmIV EMBL AAG02364.1

Organism

Streptomyces verticillus EMBL AAG02364.1

Taxonomic identifier

29309 [NCBI]

Taxonomic lineage

Bacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Streptomycineae › Streptomycetaceae › Streptomyces

Protein attributes

Sequence length	2626 AA.
Sequence status	Complete.
Protein existence	Predicted

Ontologies

Gene Ontology (GO)
Molecular function	acyl carrier activity Inferred from electronic annotation. Source: InterPro cofactor binding Inferred from electronic annotation. Source: InterPro ligase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	Q9FB18 [UniParc]. Last modified March 1, 2001. Version 1. Checksum: 6579B49BEEE0299D	FASTA	2,626	284,285
	10 20 30 40 50 60 MLHGAAHPRP GIPRRGATAA PASYGQERLW LLTGLLPTAY NYATALRLRG DLSVPALRGA 70 80 90 100 110 120 LRGIVRRHEV LRTTFRLDGD DLIQVVHPTA DVPVRLADLT GRSADTGRLM REEARRPFDL 130 140 150 160 170 180 EHGPLLRLTL FRLGPRDHLA LLAVHHAVTD GWSNGVLVTE LATGYRELRA GRPDRRPAPP 190 200 210 220 230 240 VQYGDYAHWQ RERLTGPELR ALEDYWRTAV RDLPRTDLPT DRPRPAARRG EGANHALLLS 250 260 270 280 290 300 PELTGRLADL RRREGGSLFM LVLSALLVVL RGTGGRDRLA VGTLVAGRTR PELEPLIGYF 310 320 330 340 350 360 VNVLLLPFET GGRTSFAELW RRVRGRLVEA YAHQELPLEK ALELLRADGT APADPPVGVV 370 380 390 400 410 420 CVAQQPAPAI TLPGLDASVE DVDLGTAQFD LVVEVRERPE GVQIAFQYDR DLFDAATVRL 430 440 450 460 470 480 LADHVHAVLD QAAADPTLPC AELPAPPAPA APARTAGATT LHALFESRAA KSPDAVALVD 490 500 510 520 530 540 GGHRVTYRTL NTRANRLARH LRAVGVRTED RVALRLPRGT DAVTATLAAL KAGAAYVPLD 550 560 570 580 590 600 PALPEERLTR VLADARPAVV LTPAYLHDRS AEITAHAGHD LNLPVHPDNL AYLLHTSGST 610 620 630 640 650 660 GTPKGVLGTH RGAVNRVDWM STAYPFRTGD VAVARTAPGF VDAVWELFGP LAAGVPLVLL 670 680 690 700 710 720 PTDEARDPAL LTAALERHRV SRMVTVPSLL TMLLDESARA TDLGTRLACL RTWITSGEPL 730 740 750 760 770 780 PPALARRFHD RLPGRTLLNL YGSSETAADA TAARIDPAPG TALPERSPIG TPITGVSALV 790 800 810 820 830 840 RGPDLRPLPA LMPGELYAGG ACVARGYHAR PAETAAAFPP DPDGGPGARM FRTGDRARLR 850 860 870 880 890 900 ADGRLELLGR VDRQVQIRGQ RAEPGEVEHA LLAHPAVRAA AVTANPDATG LWAYVRLAPG 910 920 930 940 950 960 PFAAGSPQTE LTAFLRRTLP AHLVPTAVTV LDELPVTAHG KTDHARLPAP DPRAGRPAPT 970 980 990 1000 1010 1020 APRTPTERTV ADVFAGVLGL EGPVGAHDDF FLLGGHSLLA ARSRGGTPRP PRRPDRAERR 1030 1040 1050 1060 1070 1080 LRGPHRRRSV AARTDAARPG TGPEHTPFVT DPGARHEPFP LTDVQRAYYV GREGGFALGG 1090 1100 1110 1120 1130 1140 VSTHAYLEIE APRIDVARFT GALRGVIARH PMLRAVIRPD GLQQVLTDVP PYDVAVHDLR 1150 1160 1170 1180 1190 1200 DLDEPARQRR RAALREEMSH QVVPADLWPL FDVRVSLGPT DALVHVGVDA LICDAHSFGL 1210 1220 1230 1240 1250 1260 VLAELAARYA DPARRFPPLT ADFRDHVLHQ EALRGTAEYA AAERYWRERL PELPPGPELP 1270 1280 1290 1300 1310 1320 LAVAPETLGT PRFTRRSGRL DAASWTAVKD RARRAGLSPS GVLLAAFAEV ITAWSGRPRY 1330 1340 1350 1360 1370 1380 SLMLTVFDRP PLHPDLGRIV GDFTSLSLLE VDHSRPGDFT DRARALQRRL WQDLDHLAVG 1390 1400 1410 1420 1430 1440 GVTVTRERAL RHDARPGLLT PVVFTSDLPV GETAAEDADG GEGWALGEPV YGVSQTPQVH 1450 1460 1470 1480 1490 1500 LDHQVAEDRG ELVFNWDAVE DLFAPGALDA MFAAYTASLT RLARSPEAWR RPGTPPLPTA 1510 1520 1530 1540 1550 1560 QAAVRRRTAA TEAPLPARLL HEAVGDAARR HADLTALVDG DTRMTYRRLT EHARRVGRTL 1570 1580 1590 1600 1610 1620 RRLGARPGRL VPVVARKGWR QAVAALGVLE SGAAYLPLDP ELPAERLVHL VRRAEAALLL 1630 1640 1650 1660 1670 1680 TERALLDTLA VPVGVTVLAV DDDAALDADG GPLQSVQNLT DLAYTIFTSG STGEPKGVMI 1690 1700 1710 1720 1730 1740 DHLGAANTLE CVNRRFGTGP GDAVLAVSSP SFDLAVYDLF GVLAAGGTVV VPAHDRRRDP 1750 1760 1770 1780 1790 1800 GHWAELIRRE RVTLWNSVPA LGTLLTEYAE ALAPDALRTL RAVLLSGDWI PLGLPDRIRA 1810 1820 1830 1840 1850 1860 LSAPGATVMS LGGATEASIW SVWYEIGKVH EAWSSIPYGT PMANQRLEVL DEQLRPRPDW 1870 1880 1890 1900 1910 1920 VPGELYIGGT GVAKGYWRDP EQTSLRFPVH PGSGQRLYRT GDFARHLPDG TLEFLGRQDD 1930 1940 1950 1960 1970 1980 QVKIGGFRVE LGEVEAALGR LPDVAAGAVI ATGDPRGDRR LVGFAVPARE GGFDAAGLRR 1990 2000 2010 2020 2030 2040 QLARRLPAYM VPTTLLPLDR LPLTANGKVD RAALQRLVPG RAPAPAEPAT APPARSRAVP 2050 2060 2070 2080 2090 2100 VPGWLADLWC ELLDVPEADP DANFFALGGT SRVAITLVTR IEARLAVRVP LARLFDARTL 2110 2120 2130 2140 2150 2160 GGLAETIAEL SAAAEEEPAP AEPVYAPDPA TRHEPFPLTD IQRAYWLGRH RSLSLGGVAT 2170 2180 2190 2200 2210 2220 HTYLELDVED LDPGRLQTAL RRLIDRHDAL RLVVLPDGRQ QILGDVPPYL LAHTDLRGRA 2230 2240 2250 2260 2270 2280 DAEAELARVR EHMSHEVRDA SRWPLFDVRT HRLDDVRTRL HLSLDLLIAD AHSVHVLTGD 2290 2300 2310 2320 2330 2340 LLTFYADPDA ALPPLGCSFR DYVLAVRAHA EGEPRRRALD HWRARLADLP GPPGLPLRCR 2350 2360 2370 2380 2390 2400 PEELTAPRFA RLTTGLGPDA WARLRRAAAA AELTPAALIC AAFCDVLAQW SDTPRFTLNL 2410 2420 2430 2440 2450 2460 TTFHRPALLP GVDDLVGDFT TTTLLGVDGE GDTFRDRARR LQDRIWEDLE HRVVSGVEVL 2470 2480 2490 2500 2510 2520 RMLRRERGTH DAVRMPVVFT STLRAAGPAP RTAPPAWRVR PGYAISQTPQ VLLDHQVSES 2530 2540 2550 2560 2570 2580 DGRLVCTWDY VADAYPPGLI EAMFGAFEAL LASLAGHDDD AGHDDDAGHD DGPGHDDGPG 2590 2600 2610 2620 HDDGPGHDDG PGHDDGPGRD DSADHGHSAT HDDSAARNDR EGGGPE

References

[1]	"An oxidation domain in the BlmIII non-ribosomal peptide synthetase probably catalyzing thiazole formation in the biosynthesis of the anti-tumor drug bleomycin in Streptomyces verticillus ATCC15003." Du L., Chen M., Sanchez C., Shen B. FEMS Microbiol. Lett. 189:171-175(2000) [PubMed: 10930733] [Abstract] Cited for: NUCLEOTIDE SEQUENCE. Strain: ATCC15003 EMBL AAG02364.1.
[2]	"The biosynthetic gene cluster for the antitumor drug bleomycin from Streptomyces verticillus ATCC15003 supporting functional interactions between nonribosomal peptide synthetases and a polyketide synthase." Du L., Sanchez C., Chen M., Edwards D.J., Shen B. Chem. Biol. 7:623-642(2000) [PubMed: 11048953] [Abstract] Cited for: NUCLEOTIDE SEQUENCE. Strain: ATCC15003 EMBL AAG02364.1.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF210249 Genomic DNA. Translation: AAG02364.1.
3D structure databases
HSSP	HSSP built from PDB template 1AMU based on UniProtKB P14687.
ProteinModelPortal	Q9FB18.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Family and domain databases
InterPro	IPR010071. AA_adenyl_domain. IPR009081. Acyl_carrier_prot-like. IPR020845. AMP-binding_CS. IPR000873. AMP-dep_Synth/Lig. IPR001242. Condensatn. IPR013624. NRPS. IPR006163. Phsphopanteth-bd. [Graphical view]
Gene3D	G3DSA:1.10.1200.10. ACP_like. 2 hits.
Pfam	PF00501. AMP-binding. 2 hits. PF00668. Condensation. 3 hits. PF08415. NRPS. 2 hits. PF00550. PP-binding. 1 hit. [Graphical view]
SUPFAM	SSF47336. ACP_like. 1 hit.
TIGRFAMs	TIGR01733. AA-adenyl-dom. 2 hits.
PROSITE	PS50075. ACP_DOMAIN. 2 hits. PS00455. AMP_BINDING. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

Q9FB18_9ACTO

Accession

Primary (citable) accession number: Q9FB18

Entry history

Integrated into UniProtKB/TrEMBL:	March 1, 2001
Last sequence update:	March 1, 2001
Last modified:	September 21, 2011
This is version 50 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)