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Protein

Serine/threonine-protein kinase A

Gene

spkA

Organism
Synechocystis sp. (strain PCC 6803 / Kazusa)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Protein kinase that regulates cellular motility via phosphorylation of membrane proteins.

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei45 – 451ATPPROSITE-ProRule annotation
Active sitei148 – 1481Proton acceptorPROSITE-ProRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi21 – 299ATPPROSITE-ProRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Kinase, Serine/threonine-protein kinase, Transferase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Serine/threonine-protein kinase A (EC:2.7.11.1)
Gene namesi
Name:spkA
Ordered Locus Names:sll1574/sll1575
OrganismiSynechocystis sp. (strain PCC 6803 / Kazusa)
Taxonomic identifieri1111708 [NCBI]
Taxonomic lineageiBacteriaCyanobacteriaOscillatoriophycideaeChroococcalesSynechocystis
ProteomesiUP000001425 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 521521Serine/threonine-protein kinase APRO_0000171239Add
BLAST

Post-translational modificationi

Autophosphorylated.

Keywords - PTMi

Phosphoprotein

Interactioni

Protein-protein interaction databases

IntActiQ9FAB3. 3 interactions.
STRINGi1148.SYNGTS_0660.

Structurei

3D structure databases

ProteinModelPortaliQ9FAB3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini15 – 289275Protein kinasePROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.PROSITE-ProRule annotation
Contains 1 protein kinase domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiCOG0515.
InParanoidiQ9FAB3.
KOiK08884.
OrthoDBiEOG6XHCB8.
PhylomeDBiQ9FAB3.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9FAB3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTPDSRHRRL LANRYQLVEL VGSGAMGQVY RAEDKLLGGV TVAVKFLSQA
60 70 80 90 100
LLNPRMKERF EREATISALL GEKSIHIVRV RDYGLDEKEI PFYVMEYLQG
110 120 130 140 150
ENISDVIKYR PLKVERFLKI ARQICFGLDC AHKGIIYQGE ACPVVHRDIK
160 170 180 190 200
PSNVLLVEDP ALGELVKILD FGIAKLVQAA EESKTQAFMG TLAYCSPEQM
210 220 230 240 250
EGKELDSRSD IYSLGVMMYE MLTGEMPLFP DNSSFGGWYE AHHHTKPHPF
260 270 280 290 300
SARYKIPASL EALVMNCLAK SPKGRPQSVD VIIRAIDAIE AEIKAPPISD
310 320 330 340 350
TEKTQIAPHL LNTDMEATVV AQRGPGIVPE TRLPLVSELC KQLEWPSDKP
360 370 380 390 400
KQKIVFPYVL NAAEGKLASL WVMLNQEDIL TRMSSIRYNQ FLLMTSPHPM
410 420 430 440 450
VLWITVLYHR EYGPRWLPCY LDLKTRSGQS FAQMLGESGT YWLLFFALEN
460 470 480 490 500
PTRCQHMLTA TVAPNQCKLL KEWAQTSQSM PGGKPQVTKR LLKQELDRLK
510 520
PKIEAKLSQV KPSFNKEVSG L
Length:521
Mass (Da):58,875
Last modified:March 1, 2001 - v1
Checksum:i5FEC16F80D369C91
GO

Sequence cautioni

The sequence BAA17235.1 differs from that shown. Reason: Frameshift at position 103. sll1574 and sll1575 have been merged into one gene.Curated
The sequence BAA17236.1 differs from that shown. Reason: Frameshift at position 103. sll1574 and sll1575 have been merged into one gene.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB046597 Genomic DNA. Translation: BAB17033.1.
BA000022 Genomic DNA. Translation: BAA17235.1. Frameshift.
BA000022 Genomic DNA. Translation: BAA17236.1. Frameshift.
PIRiS75321.
S75322.
RefSeqiYP_005650613.1. NC_017277.1.
YP_005650614.1. NC_017277.1.
YP_007450439.1. NC_020286.1.

Genome annotation databases

EnsemblBacteriaiBAA17235; BAA17235; BAA17235.
BAA17236; BAA17236; BAA17236.
KEGGisyn:sll1574.
syn:sll1575.
PATRICi23838296. VBISynSp132158_0715.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB046597 Genomic DNA. Translation: BAB17033.1.
BA000022 Genomic DNA. Translation: BAA17235.1. Frameshift.
BA000022 Genomic DNA. Translation: BAA17236.1. Frameshift.
PIRiS75321.
S75322.
RefSeqiYP_005650613.1. NC_017277.1.
YP_005650614.1. NC_017277.1.
YP_007450439.1. NC_020286.1.

3D structure databases

ProteinModelPortaliQ9FAB3.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ9FAB3. 3 interactions.
STRINGi1148.SYNGTS_0660.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiBAA17235; BAA17235; BAA17235.
BAA17236; BAA17236; BAA17236.
KEGGisyn:sll1574.
syn:sll1575.
PATRICi23838296. VBISynSp132158_0715.

Phylogenomic databases

eggNOGiCOG0515.
InParanoidiQ9FAB3.
KOiK08884.
OrthoDBiEOG6XHCB8.
PhylomeDBiQ9FAB3.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "A eukaryotic-type protein kinase, SpkA, is required for normal motility of the unicellular Cyanobacterium synechocystis sp. strain PCC 6803."
    Kamei A., Yuasa T., Orikawa K., Geng X.X., Ikeuchi M.
    J. Bacteriol. 183:1505-1510(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], CHARACTERIZATION.
  2. "Sequence analysis of the genome of the unicellular cyanobacterium Synechocystis sp. strain PCC6803. II. Sequence determination of the entire genome and assignment of potential protein-coding regions."
    Kaneko T., Sato S., Kotani H., Tanaka A., Asamizu E., Nakamura Y., Miyajima N., Hirosawa M., Sugiura M., Sasamoto S., Kimura T., Hosouchi T., Matsuno A., Muraki A., Nakazaki N., Naruo K., Okumura S., Shimpo S.
    , Takeuchi C., Wada T., Watanabe A., Yamada M., Yasuda M., Tabata S.
    DNA Res. 3:109-136(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: PCC 6803 / Kazusa.

Entry informationi

Entry nameiSPKA_SYNY3
AccessioniPrimary (citable) accession number: Q9FAB3
Secondary accession number(s): P73208, P73209
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 14, 2001
Last sequence update: March 1, 2001
Last modified: June 24, 2015
This is version 99 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Synechocystis PCC 6803
    Synechocystis (strain PCC 6803): entries and gene names

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.