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Q9FAB3

- SPKA_SYNY3

UniProt

Q9FAB3 - SPKA_SYNY3

Protein

Serine/threonine-protein kinase A

Gene

spkA

Organism
Synechocystis sp. (strain PCC 6803 / Kazusa)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 93 (01 Oct 2014)
      Sequence version 1 (01 Mar 2001)
      Previous versions | rss
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    Functioni

    Protein kinase that regulates cellular motility via phosphorylation of membrane proteins.

    Catalytic activityi

    ATP + a protein = ADP + a phosphoprotein.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei45 – 451ATPPROSITE-ProRule annotation
    Active sitei148 – 1481Proton acceptorPROSITE-ProRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi21 – 299ATPPROSITE-ProRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. protein serine/threonine kinase activity Source: UniProtKB-KW

    Keywords - Molecular functioni

    Kinase, Serine/threonine-protein kinase, Transferase

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Serine/threonine-protein kinase A (EC:2.7.11.1)
    Gene namesi
    Name:spkA
    Ordered Locus Names:sll1574/sll1575
    OrganismiSynechocystis sp. (strain PCC 6803 / Kazusa)
    Taxonomic identifieri1111708 [NCBI]
    Taxonomic lineageiBacteriaCyanobacteriaOscillatoriophycideaeChroococcalesSynechocystis
    ProteomesiUP000001425: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 521521Serine/threonine-protein kinase APRO_0000171239Add
    BLAST

    Post-translational modificationi

    Autophosphorylated.

    Keywords - PTMi

    Phosphoprotein

    Interactioni

    Protein-protein interaction databases

    IntActiQ9FAB3. 3 interactions.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9FAB3.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini15 – 289275Protein kinasePROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.PROSITE-ProRule annotation
    Contains 1 protein kinase domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiCOG0515.
    KOiK08884.
    OrthoDBiEOG6B35XT.
    PhylomeDBiQ9FAB3.

    Family and domain databases

    InterProiIPR011009. Kinase-like_dom.
    IPR000719. Prot_kinase_dom.
    IPR017441. Protein_kinase_ATP_BS.
    IPR008271. Ser/Thr_kinase_AS.
    [Graphical view]
    PfamiPF00069. Pkinase. 1 hit.
    [Graphical view]
    SUPFAMiSSF56112. SSF56112. 1 hit.
    PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
    PS50011. PROTEIN_KINASE_DOM. 1 hit.
    PS00108. PROTEIN_KINASE_ST. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9FAB3-1 [UniParc]FASTAAdd to Basket

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    MTPDSRHRRL LANRYQLVEL VGSGAMGQVY RAEDKLLGGV TVAVKFLSQA    50
    LLNPRMKERF EREATISALL GEKSIHIVRV RDYGLDEKEI PFYVMEYLQG 100
    ENISDVIKYR PLKVERFLKI ARQICFGLDC AHKGIIYQGE ACPVVHRDIK 150
    PSNVLLVEDP ALGELVKILD FGIAKLVQAA EESKTQAFMG TLAYCSPEQM 200
    EGKELDSRSD IYSLGVMMYE MLTGEMPLFP DNSSFGGWYE AHHHTKPHPF 250
    SARYKIPASL EALVMNCLAK SPKGRPQSVD VIIRAIDAIE AEIKAPPISD 300
    TEKTQIAPHL LNTDMEATVV AQRGPGIVPE TRLPLVSELC KQLEWPSDKP 350
    KQKIVFPYVL NAAEGKLASL WVMLNQEDIL TRMSSIRYNQ FLLMTSPHPM 400
    VLWITVLYHR EYGPRWLPCY LDLKTRSGQS FAQMLGESGT YWLLFFALEN 450
    PTRCQHMLTA TVAPNQCKLL KEWAQTSQSM PGGKPQVTKR LLKQELDRLK 500
    PKIEAKLSQV KPSFNKEVSG L 521
    Length:521
    Mass (Da):58,875
    Last modified:March 1, 2001 - v1
    Checksum:i5FEC16F80D369C91
    GO

    Sequence cautioni

    The sequence BAA17235.1 differs from that shown. Reason: Frameshift at position 103. sll1574 and sll1575 have been merged into one gene.
    The sequence BAA17236.1 differs from that shown. Reason: Frameshift at position 103. sll1574 and sll1575 have been merged into one gene.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB046597 Genomic DNA. Translation: BAB17033.1.
    BA000022 Genomic DNA. Translation: BAA17235.1. Frameshift.
    BA000022 Genomic DNA. Translation: BAA17236.1. Frameshift.
    PIRiS75321.
    S75322.
    RefSeqiNP_440555.1. NC_000911.1.
    NP_440556.1. NC_000911.1.
    YP_005650613.1. NC_017277.1.
    YP_005650614.1. NC_017277.1.
    YP_007450439.1. NC_020286.1.

    Genome annotation databases

    EnsemblBacteriaiBAA17235; BAA17235; BAA17235.
    BAA17236; BAA17236; BAA17236.
    GeneIDi953856.
    953857.
    KEGGisyn:sll1574.
    syn:sll1575.
    syy:SYNGTS_0660.
    syy:SYNGTS_0661.
    syz:MYO_16670.
    PATRICi23838296. VBISynSp132158_0715.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB046597 Genomic DNA. Translation: BAB17033.1 .
    BA000022 Genomic DNA. Translation: BAA17235.1 . Frameshift.
    BA000022 Genomic DNA. Translation: BAA17236.1 . Frameshift.
    PIRi S75321.
    S75322.
    RefSeqi NP_440555.1. NC_000911.1.
    NP_440556.1. NC_000911.1.
    YP_005650613.1. NC_017277.1.
    YP_005650614.1. NC_017277.1.
    YP_007450439.1. NC_020286.1.

    3D structure databases

    ProteinModelPortali Q9FAB3.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi Q9FAB3. 3 interactions.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai BAA17235 ; BAA17235 ; BAA17235 .
    BAA17236 ; BAA17236 ; BAA17236 .
    GeneIDi 953856.
    953857.
    KEGGi syn:sll1574.
    syn:sll1575.
    syy:SYNGTS_0660.
    syy:SYNGTS_0661.
    syz:MYO_16670.
    PATRICi 23838296. VBISynSp132158_0715.

    Phylogenomic databases

    eggNOGi COG0515.
    KOi K08884.
    OrthoDBi EOG6B35XT.
    PhylomeDBi Q9FAB3.

    Family and domain databases

    InterProi IPR011009. Kinase-like_dom.
    IPR000719. Prot_kinase_dom.
    IPR017441. Protein_kinase_ATP_BS.
    IPR008271. Ser/Thr_kinase_AS.
    [Graphical view ]
    Pfami PF00069. Pkinase. 1 hit.
    [Graphical view ]
    SUPFAMi SSF56112. SSF56112. 1 hit.
    PROSITEi PS00107. PROTEIN_KINASE_ATP. 1 hit.
    PS50011. PROTEIN_KINASE_DOM. 1 hit.
    PS00108. PROTEIN_KINASE_ST. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "A eukaryotic-type protein kinase, SpkA, is required for normal motility of the unicellular Cyanobacterium synechocystis sp. strain PCC 6803."
      Kamei A., Yuasa T., Orikawa K., Geng X.X., Ikeuchi M.
      J. Bacteriol. 183:1505-1510(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], CHARACTERIZATION.
    2. "Sequence analysis of the genome of the unicellular cyanobacterium Synechocystis sp. strain PCC6803. II. Sequence determination of the entire genome and assignment of potential protein-coding regions."
      Kaneko T., Sato S., Kotani H., Tanaka A., Asamizu E., Nakamura Y., Miyajima N., Hirosawa M., Sugiura M., Sasamoto S., Kimura T., Hosouchi T., Matsuno A., Muraki A., Nakazaki N., Naruo K., Okumura S., Shimpo S.
      , Takeuchi C., Wada T., Watanabe A., Yamada M., Yasuda M., Tabata S.
      DNA Res. 3:109-136(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: PCC 6803 / Kazusa.

    Entry informationi

    Entry nameiSPKA_SYNY3
    AccessioniPrimary (citable) accession number: Q9FAB3
    Secondary accession number(s): P73208, P73209
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 14, 2001
    Last sequence update: March 1, 2001
    Last modified: October 1, 2014
    This is version 93 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families
    2. Synechocystis PCC 6803
      Synechocystis (strain PCC 6803): entries and gene names

    External Data

    Dasty 3