Q9F931 (Q9F931_CLODI) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Submitted name:
Cytotoxin B EMBL AAG18011.1

Gene names

Name:

tcdB EMBL AAG18011.1

Organism

Clostridium difficile EMBL AAG18011.1

Taxonomic identifier

1496 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Clostridia › Clostridiales › Clostridiaceae › Clostridium

Protein attributes

Sequence length	2367 AA.
Sequence status	Complete.
Protein existence	Predicted

Ontologies

Gene Ontology (GO)
Biological process	pathogenesis Inferred from electronic annotation. Source: InterPro
Molecular function	transferase activity, transferring glycosyl groups Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	Q9F931 [UniParc]. Last modified March 1, 2001. Version 1. Checksum: D5EE715E5BD41E2F	FASTA	2,367	269,340
	10 20 30 40 50 60 MSLVNRKQLE KMANVRFRVQ EDEYVAILDA LEEYHNMSEN TVVEKYLKLK DINSLTDTYI 70 80 90 100 110 120 DTYKKSGRNK ALKKFKEYLV IEILELENSN LTPVEKNLHF IWIGGQINDT AINYINQWKD 130 140 150 160 170 180 VNSDYNVNVF YDSNAFLINT LKKTIIESAS NDTLESFREN LNDPEFNHTA FFRKRMQIIY 190 200 210 220 230 240 DKQQNFINYY KAQKEENPDL IIDDIVKTYL SNEYSKDIDE LNAYIEESLN KVTENSGNDV 250 260 270 280 290 300 RNFEEFKTGE VFNLYEQELV ERWNLAGASD ILRVAILKNI GGVYLDVDML PGIHPDLFKD 310 320 330 340 350 360 INKPDSVKTA VDWEEMQLEA IMKHKEYIPE YTSKHFDTLD EEVQSSFESV LASKSDKSEI 370 380 390 400 410 420 FLPLGDIEVS PLEVKIAFAK GSIINQALIS AKDSYCSDLL IKQIQNRYKI LNDTLGPIIS 430 440 450 460 470 480 QGNDFNTTMN NFGESLGAIA NEENISFIAK IGSYLRVGFY PEANTTVTLS GPTIYAGAYK 490 500 510 520 530 540 DLLTFKEMSI DTSILSSELR NFEFPKVNIS QATEQEKNSL WQFNEERAKI QFEEYKKNYF 550 560 570 580 590 600 EGALGEDDNL DFSQNTVTDK EYLLEKISSS TKSSERGYVH YIVQLQGDKI SYEAACNLFA 610 620 630 640 650 660 KNPYDSILFQ KNIEDSEVAY YYNPTDSEIQ EIDKYRIPDR ISDRPKIKLT FIGHGKAEFN 670 680 690 700 710 720 TDIFAGLDVD SLSSEIETAI GLAKEDISPK SIEINLLGCN MFSYSVNVEE TYPGKLLLRV 730 740 750 760 770 780 KDKVSELMPS MSQDSIIVSA NQYEVRINSE GRRELLDHSG EWINKEESII KDISSKEYIS 790 800 810 820 830 840 FNPKENKVIV KSKNLPELST LLQEIRNNSN SSDIELEEKV MLAECEINVI SNIETQVVEE 850 860 870 880 890 900 RIEEAKSLTS DSINYIKNEF KLIESISDAL CDLKQQNELE DSHFISFEDI SETDEGFSIR 910 920 930 940 950 960 FINKETGESI FVETEKTIFS EYANHITEEI SKIKGTIFDT VNGKLVKKVN LDTTHEVNTL 970 980 990 1000 1010 1020 NAAFFIQSLI EYNSSKESLS NLSVAMKVQV YAQLFSTGLN TITDAARVVE LVSTALDETI 1030 1040 1050 1060 1070 1080 DLLPTLSEGL PIIATIIDGV SLGAAIKELS ETSDPLLRQE IEAKIGIMAV NLTTATTAII 1090 1100 1110 1120 1130 1140 TSSLGIASGF SILLVPLAGI SAGIPSLVNN ELVLRDKATK VVDYFKHVSL VETEGVFTLL 1150 1160 1170 1180 1190 1200 DDKVMMPQDD LVISEIDFNN NSIVLGKCEI WRMEGGSGHT VTDDIDHFFS APSITYREPH 1210 1220 1230 1240 1250 1260 LSIYDVLEVQ KEELDLSKDL MVLPNAPNRV FAWETGWTPG LRSLENDGTK LLDRIRDNYE 1270 1280 1290 1300 1310 1320 GEFYWRYFAF IADALITTLK PRYEDTNIRI NLDSNTRSFI VPIITTEYIR EKLSYSFYGS 1330 1340 1350 1360 1370 1380 GGTYALSLSQ YNMGINIELS ESDVWIIDVD NVVRDVTIES DKIKKGDLIE GILSTLSIEE 1390 1400 1410 1420 1430 1440 NKIILNSHEI NFSGEVNGSN GFVSLTFSIL EGINAIIEVD LLSKSYKLLI SGELKILMLN 1450 1460 1470 1480 1490 1500 SNHIQQKIDY IGFNSELQKN IPYSFVDSEG KENGFINGST KEGLFVSELP DVVLISKVYM 1510 1520 1530 1540 1550 1560 DDSKPSFGYY SNNLKDVKVI TKDNVNILTG YYLKDDIKIS LSLTLQDEKT IKLNSVHLDE 1570 1580 1590 1600 1610 1620 SGVAEILKFM NRKGSTNTSD SLMSFLESMN IKSIFVNFLQ SNIKFILDAN FIISGTTSIG 1630 1640 1650 1660 1670 1680 QFEFICDENN NIQPYFIKFN TLETNYTLYV GNRQNMIVEP NYDLDDSGDI SSTVINFSQK 1690 1700 1710 1720 1730 1740 YLYGIDSCVN KVVISPNIYT DEINITPVYE TNNTYPEVIV LDANYINEKI NVNINDLSIR 1750 1760 1770 1780 1790 1800 YVWSNDGNDF ILMSTSEENK VSQVKIRFVN VFKDKTLANK LSFNFSDKQD VPVSEIILSF 1810 1820 1830 1840 1850 1860 TPSYYEDGLI GYDLGLVSLY NEKFYINNFG MMVSGLIYIN DSLYYFKPPV NNLITGFVTV 1870 1880 1890 1900 1910 1920 GDDKYYFNPI NGGAASIGET IIDDKNYYFN QSGVLQTGVF STEDGFKYFA PANTLDENLE 1930 1940 1950 1960 1970 1980 GEAIDFTGKL IIDENIYYFE DNYRGAVEWK ELDGEMHYFS PETGKAFKGL NQIGDDKYYF 1990 2000 2010 2020 2030 2040 NSDGVMQKGF VSINDNKHYF DDSGVMKVGY TEIDGKHFYF AENGEMQIGV FNTEDGFKYF 2050 2060 2070 2080 2090 2100 AHHNEDLGNE EGEEISYSGI LNFNNKIYYF DDSFTAVVGW KDLEDGSKYY FDEDTAEAYI 2110 2120 2130 2140 2150 2160 GLSLINDGQY YFNDDGIMQV GFVTINDKVF YFSDSGIIES GVQNIDDNYF YIDDNGIVQI 2170 2180 2190 2200 2210 2220 GVFDTSDGYK YFAPANTVND NIYGQAVEYS GLVRVGEDVY YFGETYTIET GWIYDMENES 2230 2240 2250 2260 2270 2280 DKYYFDPETK KACKGINLID DIKYYFDEKG IMRTGLISFE NNNYYFNENG EMQFGYINIE 2290 2300 2310 2320 2330 2340 DKMFYFGEDG DMQIGVFNTP DGFKYFAHQN TLDENFEGES INYTGWLDLD EKRYYFTDEY 2350 2360 IAATGSVIID GEEYYFDPDT AQLVISE

References

[1]	"Toxin gene analysis of a variant strain of Clostridium difficile that causes human clinical disease." Sambol S.P., Merrigan M.M., Lyerly D., Gerding D.N., Johnson S. Infect. Immun. 68:5480-5487(2000) [PubMed: 10992443] [Abstract] Cited for: NUCLEOTIDE SEQUENCE.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF217292 Genomic DNA. Translation: AAG18011.1.
PIR	A27636.
3D structure databases
HSSP	HSSP built from PDB template 1GVM based on UniProtKB P06653.
ProteinModelPortal	Q9F931.
SMR	Q9F931. Positions 1-544.
ModBase	Search...
Protein family/group databases
CAZy	GT44. Glycosyltransferase Family 44.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Family and domain databases
InterPro	IPR018337. Cell_wall/Cho-bd_repeat. IPR020974. Pept_C80_RTX_self_cleaving. IPR024770. TcdA/TcdB_cat. IPR024772. TcdA/TcdB_N. IPR024769. TcdA/TcdB_pore_forming. [Graphical view]
Pfam	PF01473. CW_binding_1. 4 hits. PF11713. Peptidase_C80. 1 hit. PF12919. TcdA_TcdB. 1 hit. PF12920. TcdA_TcdB_pore. 1 hit. PF12918. TcdB_N. 1 hit. [Graphical view]
PROSITE	PS51170. CW. 18 hits. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

Q9F931_CLODI

Accession

Primary (citable) accession number: Q9F931

Entry history

Integrated into UniProtKB/TrEMBL:	March 1, 2001
Last sequence update:	March 1, 2001
Last modified:	December 14, 2011
This is version 33 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)