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Q9F854

- HISX_VIBCH

UniProt

Q9F854 - HISX_VIBCH

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Protein
Histidinol dehydrogenase
Gene
hisD, VC_1133
Organism
Vibrio cholerae serotype O1 (strain ATCC 39315 / El Tor Inaba N16961)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the sequential NAD-dependent oxidations of L-histidinol to L-histidinaldehyde and then to L-histidine By similarity.UniRule annotation

Catalytic activityi

L-histidinol + H2O + 2 NAD+ = L-histidine + 2 NADH.UniRule annotation

Cofactori

Binds 1 zinc ion per subunit By similarity.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei127 – 1271NAD By similarity
Binding sitei185 – 1851NAD By similarity
Binding sitei208 – 2081NAD By similarity
Binding sitei234 – 2341Substrate By similarity
Metal bindingi256 – 2561Zinc By similarity
Binding sitei256 – 2561Substrate By similarity
Metal bindingi259 – 2591Zinc By similarity
Binding sitei259 – 2591Substrate By similarity
Active sitei323 – 3231Proton acceptor By similarity
Active sitei324 – 3241Proton acceptor By similarity
Binding sitei324 – 3241Substrate By similarity
Metal bindingi357 – 3571Zinc By similarity
Binding sitei357 – 3571Substrate By similarity
Binding sitei411 – 4111Substrate By similarity
Metal bindingi416 – 4161Zinc By similarity
Binding sitei416 – 4161Substrate By similarity

GO - Molecular functioni

  1. NAD binding Source: InterPro
  2. histidinol dehydrogenase activity Source: TIGR
  3. zinc ion binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. histidine biosynthetic process Source: TIGR
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Amino-acid biosynthesis, Histidine biosynthesis

Keywords - Ligandi

Metal-binding, NAD, Zinc

Enzyme and pathway databases

BioCyciVCHO:VC1133-MONOMER.
UniPathwayiUPA00031; UER00014.

Names & Taxonomyi

Protein namesi
Recommended name:
Histidinol dehydrogenase (EC:1.1.1.23)
Short name:
HDH
Gene namesi
Name:hisD
Ordered Locus Names:VC_1133
OrganismiVibrio cholerae serotype O1 (strain ATCC 39315 / El Tor Inaba N16961)
Taxonomic identifieri243277 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaVibrionalesVibrionaceaeVibrio
ProteomesiUP000000584: Chromosome 1

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 431431Histidinol dehydrogenaseUniRule annotation
PRO_0000135874Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi243277.VC1133.

Structurei

3D structure databases

ProteinModelPortaliQ9F854.
SMRiQ9F854. Positions 6-429.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0141.
KOiK00013.
OMAiYAAKLCG.
OrthoDBiEOG6CVVCR.

Family and domain databases

HAMAPiMF_01024. HisD.
InterProiIPR016161. Ald_DH/histidinol_DH.
IPR001692. Histidinol_DH_CS.
IPR022695. Histidinol_DH_monofunct.
IPR012131. Hstdl_DH.
[Graphical view]
PfamiPF00815. Histidinol_dh. 1 hit.
[Graphical view]
PIRSFiPIRSF000099. Histidinol_dh. 1 hit.
PRINTSiPR00083. HOLDHDRGNASE.
SUPFAMiSSF53720. SSF53720. 1 hit.
TIGRFAMsiTIGR00069. hisD. 1 hit.
PROSITEiPS00611. HISOL_DEHYDROGENASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9F854-1 [UniParc]FASTAAdd to Basket

« Hide

MRTVVWQSLS EAQQESILER PAITEGANIT AAVAQVIAKV RSEGDAALFE    50
LTEKFDRVKP ASLRVSREEM DAAAARLSET MKQALEQAYN NISKFHKAQK 100
AQPIKVETMP GVVCEQVTRP INKVGLYIPG GSAPLPSTVL MLGVPAQIAG 150
CRKVVLCSPP PIADEILYVA KLCNIDEVYN LGGGQAIAAM AYGTETVTKV 200
DKIFGPGNAY VTEAKRQVSN DFRGAAIDMP AGPSEVLVIA DETADANFIA 250
ADLLSQAEHG PDSQVVLVTP SPVLADQVTD AVQKQLKVLS RASIAEKALA 300
SSLIIIAESL TQAVSISNYY GPEHLIVQTR NPRELVPLLD NAGSIFLGDW 350
SPESVGDYAS GTNHVLPTYG YTRTYSSLGL ADFSKRMTVQ ELTADGLQLL 400
APTVVTMAEA EGLDAHKRAV TIRVEKLQKA Q 431
Length:431
Mass (Da):46,127
Last modified:March 25, 2003 - v2
Checksum:i435CDAF188C4926C
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE003852 Genomic DNA. Translation: AAF94292.1.
AF261153 Genomic DNA. Translation: AAG16130.1.
PIRiH82237.
RefSeqiNP_230778.1. NC_002505.1.

Genome annotation databases

EnsemblBacteriaiAAF94292; AAF94292; VC_1133.
GeneIDi2614403.
KEGGivch:VC1133.
PATRICi20081358. VBIVibCho83274_1082.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE003852 Genomic DNA. Translation: AAF94292.1 .
AF261153 Genomic DNA. Translation: AAG16130.1 .
PIRi H82237.
RefSeqi NP_230778.1. NC_002505.1.

3D structure databases

ProteinModelPortali Q9F854.
SMRi Q9F854. Positions 6-429.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 243277.VC1133.

Protocols and materials databases

DNASUi 2614403.
Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAF94292 ; AAF94292 ; VC_1133 .
GeneIDi 2614403.
KEGGi vch:VC1133.
PATRICi 20081358. VBIVibCho83274_1082.

Phylogenomic databases

eggNOGi COG0141.
KOi K00013.
OMAi YAAKLCG.
OrthoDBi EOG6CVVCR.

Enzyme and pathway databases

UniPathwayi UPA00031 ; UER00014 .
BioCyci VCHO:VC1133-MONOMER.

Family and domain databases

HAMAPi MF_01024. HisD.
InterProi IPR016161. Ald_DH/histidinol_DH.
IPR001692. Histidinol_DH_CS.
IPR022695. Histidinol_DH_monofunct.
IPR012131. Hstdl_DH.
[Graphical view ]
Pfami PF00815. Histidinol_dh. 1 hit.
[Graphical view ]
PIRSFi