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Q9F854

- HISX_VIBCH

UniProt

Q9F854 - HISX_VIBCH

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Protein

Histidinol dehydrogenase

Gene

hisD

Organism
Vibrio cholerae serotype O1 (strain ATCC 39315 / El Tor Inaba N16961)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the sequential NAD-dependent oxidations of L-histidinol to L-histidinaldehyde and then to L-histidine.UniRule annotation

Catalytic activityi

L-histidinol + H2O + 2 NAD+ = L-histidine + 2 NADH.UniRule annotation

Cofactori

Zn2+UniRule annotationNote: Binds 1 zinc ion per subunit.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei127 – 1271NADUniRule annotation
Binding sitei185 – 1851NADUniRule annotation
Binding sitei208 – 2081NADUniRule annotation
Binding sitei234 – 2341SubstrateUniRule annotation
Metal bindingi256 – 2561ZincUniRule annotation
Binding sitei256 – 2561SubstrateUniRule annotation
Metal bindingi259 – 2591ZincUniRule annotation
Binding sitei259 – 2591SubstrateUniRule annotation
Active sitei323 – 3231Proton acceptorUniRule annotation
Active sitei324 – 3241Proton acceptorUniRule annotation
Binding sitei324 – 3241SubstrateUniRule annotation
Metal bindingi357 – 3571ZincUniRule annotation
Binding sitei357 – 3571SubstrateUniRule annotation
Binding sitei411 – 4111SubstrateUniRule annotation
Metal bindingi416 – 4161ZincUniRule annotation
Binding sitei416 – 4161SubstrateUniRule annotation

GO - Molecular functioni

  1. histidinol dehydrogenase activity Source: TIGR
  2. NAD binding Source: InterPro
  3. zinc ion binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. histidine biosynthetic process Source: TIGR
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Amino-acid biosynthesis, Histidine biosynthesis

Keywords - Ligandi

Metal-binding, NAD, Zinc

Enzyme and pathway databases

BioCyciVCHO:VC1133-MONOMER.
UniPathwayiUPA00031; UER00014.

Names & Taxonomyi

Protein namesi
Recommended name:
Histidinol dehydrogenaseUniRule annotation (EC:1.1.1.23UniRule annotation)
Short name:
HDHUniRule annotation
Gene namesi
Name:hisDUniRule annotation
Ordered Locus Names:VC_1133
OrganismiVibrio cholerae serotype O1 (strain ATCC 39315 / El Tor Inaba N16961)
Taxonomic identifieri243277 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaVibrionalesVibrionaceaeVibrio
ProteomesiUP000000584: Chromosome 1

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 431431Histidinol dehydrogenasePRO_0000135874Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi243277.VC1133.

Structurei

3D structure databases

ProteinModelPortaliQ9F854.
SMRiQ9F854. Positions 6-429.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the histidinol dehydrogenase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0141.
KOiK00013.
OMAiYAAKLCG.
OrthoDBiEOG6CVVCR.

Family and domain databases

HAMAPiMF_01024. HisD.
InterProiIPR016161. Ald_DH/histidinol_DH.
IPR001692. Histidinol_DH_CS.
IPR022695. Histidinol_DH_monofunct.
IPR012131. Hstdl_DH.
[Graphical view]
PfamiPF00815. Histidinol_dh. 1 hit.
[Graphical view]
PIRSFiPIRSF000099. Histidinol_dh. 1 hit.
PRINTSiPR00083. HOLDHDRGNASE.
SUPFAMiSSF53720. SSF53720. 1 hit.
TIGRFAMsiTIGR00069. hisD. 1 hit.
PROSITEiPS00611. HISOL_DEHYDROGENASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9F854-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MRTVVWQSLS EAQQESILER PAITEGANIT AAVAQVIAKV RSEGDAALFE
60 70 80 90 100
LTEKFDRVKP ASLRVSREEM DAAAARLSET MKQALEQAYN NISKFHKAQK
110 120 130 140 150
AQPIKVETMP GVVCEQVTRP INKVGLYIPG GSAPLPSTVL MLGVPAQIAG
160 170 180 190 200
CRKVVLCSPP PIADEILYVA KLCNIDEVYN LGGGQAIAAM AYGTETVTKV
210 220 230 240 250
DKIFGPGNAY VTEAKRQVSN DFRGAAIDMP AGPSEVLVIA DETADANFIA
260 270 280 290 300
ADLLSQAEHG PDSQVVLVTP SPVLADQVTD AVQKQLKVLS RASIAEKALA
310 320 330 340 350
SSLIIIAESL TQAVSISNYY GPEHLIVQTR NPRELVPLLD NAGSIFLGDW
360 370 380 390 400
SPESVGDYAS GTNHVLPTYG YTRTYSSLGL ADFSKRMTVQ ELTADGLQLL
410 420 430
APTVVTMAEA EGLDAHKRAV TIRVEKLQKA Q
Length:431
Mass (Da):46,127
Last modified:March 25, 2003 - v2
Checksum:i435CDAF188C4926C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE003852 Genomic DNA. Translation: AAF94292.1.
AF261153 Genomic DNA. Translation: AAG16130.1.
PIRiH82237.
RefSeqiNP_230778.1. NC_002505.1.

Genome annotation databases

EnsemblBacteriaiAAF94292; AAF94292; VC_1133.
GeneIDi2614403.
KEGGivch:VC1133.
PATRICi20081358. VBIVibCho83274_1082.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE003852 Genomic DNA. Translation: AAF94292.1 .
AF261153 Genomic DNA. Translation: AAG16130.1 .
PIRi H82237.
RefSeqi NP_230778.1. NC_002505.1.

3D structure databases

ProteinModelPortali Q9F854.
SMRi Q9F854. Positions 6-429.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 243277.VC1133.

Protocols and materials databases

DNASUi 2614403.
Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAF94292 ; AAF94292 ; VC_1133 .
GeneIDi 2614403.
KEGGi vch:VC1133.
PATRICi 20081358. VBIVibCho83274_1082.

Phylogenomic databases

eggNOGi COG0141.
KOi K00013.
OMAi YAAKLCG.
OrthoDBi EOG6CVVCR.

Enzyme and pathway databases

UniPathwayi UPA00031 ; UER00014 .
BioCyci VCHO:VC1133-MONOMER.

Family and domain databases

HAMAPi MF_01024. HisD.
InterProi IPR016161. Ald_DH/histidinol_DH.
IPR001692. Histidinol_DH_CS.
IPR022695. Histidinol_DH_monofunct.
IPR012131. Hstdl_DH.
[Graphical view ]
Pfami PF00815. Histidinol_dh. 1 hit.
[Graphical view ]
PIRSFi PIRSF000099. Histidinol_dh. 1 hit.
PRINTSi PR00083. HOLDHDRGNASE.
SUPFAMi SSF53720. SSF53720. 1 hit.
TIGRFAMsi TIGR00069. hisD. 1 hit.
PROSITEi PS00611. HISOL_DEHYDROGENASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 39315 / El Tor Inaba N16961.
  2. Haralalka S., Roychoudhury S., Chaudhuri K.
    Submitted (APR-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-337.
    Strain: ATCC 25870 / Classical Inaba 569B / Serotype O1.

Entry informationi

Entry nameiHISX_VIBCH
AccessioniPrimary (citable) accession number: Q9F854
Secondary accession number(s): Q9KSX3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 25, 2003
Last sequence update: March 25, 2003
Last modified: November 26, 2014
This is version 92 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3