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Protein

Low molecular weight protein-tyrosine-phosphatase Wzb

Gene

wzb

Organism
Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Dephosphorylates Wzc. Required for the extracellular polysaccharide colanic acid synthesis. Probably involved in the export of colanic acid from the cell to medium. Involved in protection of cells against contact-dependent growth inhibition (CDI).By similarity

Catalytic activityi

Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.

Pathwayi: exopolysaccharide biosynthesis

This protein is involved in the pathway exopolysaccharide biosynthesis, which is part of Glycan metabolism.
View all proteins of this organism that are known to be involved in the pathway exopolysaccharide biosynthesis and in Glycan metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei9NucleophileBy similarity1
Active sitei14By similarity1
Active sitei115Proton donorBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase, Protein phosphatase
Biological processExopolysaccharide synthesis

Enzyme and pathway databases

UniPathwayiUPA00631.

Names & Taxonomyi

Protein namesi
Recommended name:
Low molecular weight protein-tyrosine-phosphatase Wzb (EC:3.1.3.48)
Gene namesi
Name:wzb
Ordered Locus Names:STM2117
OrganismiSalmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)
Taxonomic identifieri99287 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeSalmonella
Proteomesi
  • UP000001014 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000465751 – 149Low molecular weight protein-tyrosine-phosphatase WzbAdd BLAST149

Proteomic databases

PaxDbiQ9F7B2.

Interactioni

Protein-protein interaction databases

STRINGi99287.STM2117.

Structurei

3D structure databases

ProteinModelPortaliQ9F7B2.
SMRiQ9F7B2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiENOG4105KJF. Bacteria.
COG0394. LUCA.
HOGENOMiHOG000273091.
KOiK01104.
OMAiENKWRID.
PhylomeDBiQ9F7B2.

Family and domain databases

InterProiView protein in InterPro
IPR023485. Ptyr_pPase_SF.
IPR017867. Tyr_phospatase_low_mol_wt.
PfamiView protein in Pfam
PF01451. LMWPc. 1 hit.
PRINTSiPR00719. LMWPTPASE.
SMARTiView protein in SMART
SM00226. LMWPc. 1 hit.
SUPFAMiSSF52788. SSF52788. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9F7B2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFNKILVVCV GNVCRSPTAE RLLKRFHPSL TVASAGLGAL VGKGADPAAA
60 70 80 90 100
SVASAHDLSL ENHCARQISA RLCREYDLIL TMEKRHIAAL CDIAPEMRGK
110 120 130 140
VMLFGHWDSE REIPDPYRKS RDAFEAVYTL LERSARQWAQ ALNAEQGKP
Length:149
Mass (Da):16,474
Last modified:March 1, 2001 - v1
Checksum:iDA5DF9B5699EF208
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF285084 Genomic DNA. Translation: AAG24805.1.
AE006468 Genomic DNA. Translation: AAL21021.1.
RefSeqiNP_461062.1. NC_003197.2.
WP_000482224.1. NC_003197.2.

Genome annotation databases

EnsemblBacteriaiAAL21021; AAL21021; STM2117.
GeneIDi1253638.
KEGGistm:STM2117.
PATRICifig|99287.12.peg.2239.

Similar proteinsi

Entry informationi

Entry nameiWZB_SALTY
AccessioniPrimary (citable) accession number: Q9F7B2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 3, 2002
Last sequence update: March 1, 2001
Last modified: August 30, 2017
This is version 95 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families