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Protein

Carbapenem-hydrolyzing beta-lactamase KPC

Gene

bla

Organism
Klebsiella pneumoniae
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Hydrolyzes carbapenems, penicillins, cephalosporins and monobactams with varying efficiency.

Miscellaneous

Initially two different KPC beta-lactamases were identified from two different Klebsiella (KPC-1 and KPC-2); they were later shown to be identical.

Catalytic activityi

A beta-lactam + H2O = a substituted beta-amino acid.

Enzyme regulationi

Not inhibited by EDTA, inhibited by clavulanic acid and tazobactam.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei69Acyl-ester intermediateBy similarity1
Active sitei167Proton acceptorBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase
Biological processAntibiotic resistance

Names & Taxonomyi

Protein namesi
Recommended name:
Carbapenem-hydrolyzing beta-lactamase KPC (EC:3.5.2.6)
Alternative name(s):
Carbapenem-hydrolyzing beta-lactamase KPC-1
Gene namesi
Name:bla
Synonyms:kpc, kpc1
Encoded oniPlasmid nonconjugative 50kb0 Publication
OrganismiKlebsiella pneumoniae
Taxonomic identifieri573 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeKlebsiella

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL6132
DrugBankiDB09060 Avibactam

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 24Sequence analysisAdd BLAST24
ChainiPRO_000034914325 – 293Carbapenem-hydrolyzing beta-lactamase KPCAdd BLAST269

Interactioni

Chemistry databases

BindingDBiQ9F663

Structurei

Secondary structure

1293
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Turni28 – 30Combined sources3
Helixi33 – 40Combined sources8
Beta strandi42 – 50Combined sources9
Turni51 – 53Combined sources3
Beta strandi56 – 60Combined sources5
Helixi68 – 70Combined sources3
Helixi71 – 85Combined sources15
Turni87 – 91Combined sources5
Helixi98 – 100Combined sources3
Helixi108 – 111Combined sources4
Turni112 – 114Combined sources3
Helixi118 – 127Combined sources10
Helixi131 – 140Combined sources10
Helixi144 – 153Combined sources10
Helixi167 – 169Combined sources3
Helixi182 – 193Combined sources12
Beta strandi195 – 198Combined sources4
Helixi200 – 211Combined sources12
Turni217 – 219Combined sources3
Helixi220 – 223Combined sources4
Beta strandi228 – 236Combined sources9
Helixi239 – 241Combined sources3
Beta strandi243 – 250Combined sources8
Beta strandi257 – 264Combined sources8
Helixi274 – 287Combined sources14

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2OV5X-ray1.85A/B/C30-290[»]
3E2KX-ray2.10A/B30-293[»]
3E2LX-ray1.87A/B30-293[»]
3RXWX-ray1.26A26-289[»]
3RXXX-ray1.62A26-289[»]
4ZBEX-ray1.80A26-289[»]
5EECX-ray1.87A/B25-293[»]
5UJ3X-ray1.45A25-293[»]
5UJ4X-ray1.40A25-293[»]
5UL8X-ray1.15A25-293[»]
ProteinModelPortaliQ9F663
SMRiQ9F663
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9F663

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni233 – 235Substrate bindingBy similarity3

Sequence similaritiesi

Belongs to the class-A beta-lactamase family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

KOiK18768

Family and domain databases

InterProiView protein in InterPro
IPR012338 Beta-lactam/transpept-like
IPR000871 Beta-lactam_class-A
PRINTSiPR00118 BLACTAMASEA
SUPFAMiSSF56601 SSF56601, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9F663-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSLYRRLVLL SCLSWPLAGF SATALTNLVA EPFAKLEQDF GGSIGVYAMD
60 70 80 90 100
TGSGATVSYR AEERFPLCSS FKGFLAAAVL ARSQQQAGLL DTPIRYGKNA
110 120 130 140 150
LVPWSPISEK YLTTGMTVAE LSAAAVQYSD NAAANLLLKE LGGPAGLTAF
160 170 180 190 200
MRSIGDTTFR LDRWELELNS AIPGDARDTS SPRAVTESLQ KLTLGSALAA
210 220 230 240 250
PQRQQFVDWL KGNTTGNHRI RAAVPADWAV GDKTGTCGVY GTANDYAVVW
260 270 280 290
PTGRAPIVLA VYTRAPNKDD KHSEAVIAAA ARLALEGLGV NGQ
Length:293
Mass (Da):31,115
Last modified:September 2, 2008 - v2
Checksum:i13EB2FC28005EE5F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF297554 Genomic DNA Translation: AAG13410.1 Sequence problems.
RefSeqiWP_004199234.1, NZ_PJPU01000065.1
YP_002286834.1, NC_011382.1
YP_002286844.1, NC_011383.1
YP_002286855.1, NC_011383.1
YP_003754012.1, NC_014312.1
YP_006958635.1, NC_019152.1
YP_006959213.1, NC_019161.1
YP_006959400.1, NC_019165.1
YP_006971133.1, NC_019384.1
YP_007366474.1, NC_020132.1
YP_007688776.1, NC_020893.1
YP_008003445.1, NC_021238.1
YP_008998912.1, NC_023331.1
YP_009022511.1, NC_023903.1
YP_009022618.1, NC_023904.1
YP_009022725.1, NC_023905.1
YP_009022831.1, NC_023906.1
YP_009070099.1, NC_025166.1
YP_009071849.1, NC_025187.1
YP_009328785.1, NC_032103.1

Genome annotation databases

GeneIDi13914015
13914300
13914665
13923837
14458347
15077276
15564405
18261808
18983479
18983482
18983485
18985416
20493883
20494301
30522711
32364923
6993854
6993864
6993875
9389494
KEGGiag:AAG13410

Similar proteinsi

Entry informationi

Entry nameiBLKPC_KLEPN
AccessioniPrimary (citable) accession number: Q9F663
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 2, 2008
Last sequence update: September 2, 2008
Last modified: April 25, 2018
This is version 84 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Plasmid
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Main funding by: National Institutes of Health