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Q9F5P3

- DCEA_LISMO

UniProt

Q9F5P3 - DCEA_LISMO

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Protein

Glutamate decarboxylase alpha

Gene

gadA

Organism
Listeria monocytogenes serovar 1/2a (strain ATCC BAA-679 / EGD-e)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Converts internalized glutamate to GABA and increases the internal pH. Involved in glutamate-dependent acid resistance in gastric fluid.

Catalytic activityi

L-glutamate = 4-aminobutanoate + CO2.

Cofactori

GO - Molecular functioni

  1. glutamate decarboxylase activity Source: UniProtKB-EC
  2. pyridoxal phosphate binding Source: InterPro

GO - Biological processi

  1. glutamate metabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Decarboxylase, Lyase

Keywords - Ligandi

Pyridoxal phosphate

Enzyme and pathway databases

BioCyciLMON169963:LMO0447-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Glutamate decarboxylase alpha (EC:4.1.1.15)
Short name:
GAD-alpha
Gene namesi
Name:gadA
Ordered Locus Names:lmo0447
OrganismiListeria monocytogenes serovar 1/2a (strain ATCC BAA-679 / EGD-e)
Taxonomic identifieri169963 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesListeriaceaeListeria
ProteomesiUP000000817: Chromosome

Organism-specific databases

GenoListiLMO0447.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 462462Glutamate decarboxylase alphaPRO_0000146988Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei273 – 2731N6-(pyridoxal phosphate)lysineBy similarity

Interactioni

Protein-protein interaction databases

STRINGi169963.lmo0447.

Structurei

3D structure databases

ProteinModelPortaliQ9F5P3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the group II decarboxylase family.Curated

Phylogenomic databases

eggNOGiCOG0076.
HOGENOMiHOG000070228.
KOiK01580.
OMAiAQYYTFL.
OrthoDBiEOG618QPT.
PhylomeDBiQ9F5P3.

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
InterProiIPR010107. Glutamate_decarboxylase.
IPR002129. PyrdxlP-dep_de-COase.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PANTHERiPTHR11999:SF1. PTHR11999:SF1. 1 hit.
PfamiPF00282. Pyridoxal_deC. 1 hit.
[Graphical view]
SUPFAMiSSF53383. SSF53383. 1 hit.
TIGRFAMsiTIGR01788. Glu-decarb-GAD. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9F5P3-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MFKTNVEQNN VPVFGSFESG QDLPEKRMNK ESVDPRIAYQ LVKDQLIDEG
60 70 80 90 100
SARQNLATFC QTYMEPEAEQ IMAETMEKNA IDKSEYPQTA KLESSCVNML
110 120 130 140 150
ADLWNVDESE HYMGTSTVGS SEACMLGGMA MKFRWRSAAL KNGLDIHAKK
160 170 180 190 200
PSLVISSGYQ VCWEKFCVYW DIELREVPMS EEHLSINTDI IMDYVDEYTI
210 220 230 240 250
GIVGILGITY TGKFDDIMTL NDLVEDYNNT HDNEVVIHVD GASGAMFTPF
260 270 280 290 300
VEPGLEWDFR LPNVVSINTS GHKYGLVYPG VGWILWRDKE YLPEELVFDV
310 320 330 340 350
SYLGGHMPTM AINFSRSASQ IIGQYYNFLR FGYEGYRQIH MRTRDGALQL
360 370 380 390 400
SQAVAETGLF EIYNDGANLP IVCYKLKDDA NVAWTLYDLA DRLQMKGWQV
410 420 430 440 450
PAYPLPKEMG NTIIQRYVCR GDLGQNMVTA FKNDLSESIE ELNNAHILYH
460
DVNTSKTHGF TH
Length:462
Mass (Da):52,498
Last modified:February 21, 2002 - v2
Checksum:iEA1A442E3E1CE2FA
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti152 – 1521S → N in AAG22560. (PubMed:11309128)Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF309076 Genomic DNA. Translation: AAG22560.1.
AL591975 Genomic DNA. Translation: CAC98526.1.
PIRiAH1130.
RefSeqiNP_463976.1. NC_003210.1.
WP_010989470.1. NC_003210.1.

Genome annotation databases

EnsemblBacteriaiCAC98526; CAC98526; CAC98526.
GeneIDi986724.
KEGGilmo:lmo0447.
PATRICi20309953. VBILisMon69206_0462.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF309076 Genomic DNA. Translation: AAG22560.1 .
AL591975 Genomic DNA. Translation: CAC98526.1 .
PIRi AH1130.
RefSeqi NP_463976.1. NC_003210.1.
WP_010989470.1. NC_003210.1.

3D structure databases

ProteinModelPortali Q9F5P3.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 169963.lmo0447.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAC98526 ; CAC98526 ; CAC98526 .
GeneIDi 986724.
KEGGi lmo:lmo0447.
PATRICi 20309953. VBILisMon69206_0462.

Organism-specific databases

GenoListi LMO0447.

Phylogenomic databases

eggNOGi COG0076.
HOGENOMi HOG000070228.
KOi K01580.
OMAi AQYYTFL.
OrthoDBi EOG618QPT.
PhylomeDBi Q9F5P3.

Enzyme and pathway databases

BioCyci LMON169963:LMO0447-MONOMER.

Family and domain databases

Gene3Di 3.40.640.10. 1 hit.
InterProi IPR010107. Glutamate_decarboxylase.
IPR002129. PyrdxlP-dep_de-COase.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view ]
PANTHERi PTHR11999:SF1. PTHR11999:SF1. 1 hit.
Pfami PF00282. Pyridoxal_deC. 1 hit.
[Graphical view ]
SUPFAMi SSF53383. SSF53383. 1 hit.
TIGRFAMsi TIGR01788. Glu-decarb-GAD. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "A glutamate decarboxylase system protects Listeria monocytogenes in gastric fluid."
    Cotter P.D., Gahan C.G.M., Hill C.
    Mol. Microbiol. 40:465-475(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: LO28 / Serovar 1/2c.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC BAA-679 / EGD-e.

Entry informationi

Entry nameiDCEA_LISMO
AccessioniPrimary (citable) accession number: Q9F5P3
Secondary accession number(s): Q8Y9S6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 21, 2002
Last sequence update: February 21, 2002
Last modified: November 26, 2014
This is version 81 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3