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Q9F5P3 (DCEA_LISMO) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 77. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Glutamate decarboxylase alpha

Short name=GAD-alpha
EC=4.1.1.15
Gene names
Name:gadA
Ordered Locus Names:lmo0447
OrganismListeria monocytogenes serovar 1/2a (strain ATCC BAA-679 / EGD-e) [Reference proteome] [HAMAP]
Taxonomic identifier169963 [NCBI]
Taxonomic lineageBacteriaFirmicutesBacilliBacillalesListeriaceaeListeria

Protein attributes

Sequence length462 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Converts internalized glutamate to GABA and increases the internal pH. Involved in glutamate-dependent acid resistance in gastric fluid.

Catalytic activity

L-glutamate = 4-aminobutanoate + CO2.

Cofactor

Pyridoxal phosphate By similarity.

Sequence similarities

Belongs to the group II decarboxylase family.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 462462Glutamate decarboxylase alpha
PRO_0000146988

Amino acid modifications

Modified residue2731N6-(pyridoxal phosphate)lysine By similarity

Experimental info

Sequence conflict1521S → N in AAG22560. Ref.1

Sequences

Sequence LengthMass (Da)Tools
Q9F5P3 [UniParc].

Last modified February 21, 2002. Version 2.
Checksum: EA1A442E3E1CE2FA

FASTA46252,498
        10         20         30         40         50         60 
MFKTNVEQNN VPVFGSFESG QDLPEKRMNK ESVDPRIAYQ LVKDQLIDEG SARQNLATFC 

        70         80         90        100        110        120 
QTYMEPEAEQ IMAETMEKNA IDKSEYPQTA KLESSCVNML ADLWNVDESE HYMGTSTVGS 

       130        140        150        160        170        180 
SEACMLGGMA MKFRWRSAAL KNGLDIHAKK PSLVISSGYQ VCWEKFCVYW DIELREVPMS 

       190        200        210        220        230        240 
EEHLSINTDI IMDYVDEYTI GIVGILGITY TGKFDDIMTL NDLVEDYNNT HDNEVVIHVD 

       250        260        270        280        290        300 
GASGAMFTPF VEPGLEWDFR LPNVVSINTS GHKYGLVYPG VGWILWRDKE YLPEELVFDV 

       310        320        330        340        350        360 
SYLGGHMPTM AINFSRSASQ IIGQYYNFLR FGYEGYRQIH MRTRDGALQL SQAVAETGLF 

       370        380        390        400        410        420 
EIYNDGANLP IVCYKLKDDA NVAWTLYDLA DRLQMKGWQV PAYPLPKEMG NTIIQRYVCR 

       430        440        450        460 
GDLGQNMVTA FKNDLSESIE ELNNAHILYH DVNTSKTHGF TH 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF309076 Genomic DNA. Translation: AAG22560.1.
AL591975 Genomic DNA. Translation: CAC98526.1.
PIRAH1130.
RefSeqNP_463976.1. NC_003210.1.

3D structure databases

ProteinModelPortalQ9F5P3.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING169963.lmo0447.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaCAC98526; CAC98526; CAC98526.
GeneID986724.
KEGGlmo:lmo0447.
PATRIC20309953. VBILisMon69206_0462.

Organism-specific databases

GenoListLMO0447.

Phylogenomic databases

eggNOGCOG0076.
HOGENOMHOG000070228.
KOK01580.
OMAAQYYTFL.
OrthoDBEOG618QPT.
PhylomeDBQ9F5P3.

Enzyme and pathway databases

BioCycLMON169963:LMO0447-MONOMER.

Family and domain databases

Gene3D3.40.640.10. 1 hit.
InterProIPR010107. Glutamate_decarboxylase.
IPR002129. PyrdxlP-dep_de-COase.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PANTHERPTHR11999:SF1. PTHR11999:SF1. 1 hit.
PfamPF00282. Pyridoxal_deC. 1 hit.
[Graphical view]
SUPFAMSSF53383. SSF53383. 1 hit.
TIGRFAMsTIGR01788. Glu-decarb-GAD. 1 hit.
ProtoNetSearch...

Entry information

Entry nameDCEA_LISMO
AccessionPrimary (citable) accession number: Q9F5P3
Secondary accession number(s): Q8Y9S6
Entry history
Integrated into UniProtKB/Swiss-Prot: February 21, 2002
Last sequence update: February 21, 2002
Last modified: July 9, 2014
This is version 77 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families