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Protein

Glutamate decarboxylase alpha

Gene

gadA

Organism
Listeria monocytogenes serovar 1/2a (strain ATCC BAA-679 / EGD-e)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Converts internalized glutamate to GABA and increases the internal pH. Involved in glutamate-dependent acid resistance in gastric fluid.

Catalytic activityi

L-glutamate = 4-aminobutanoate + CO2.

Cofactori

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDecarboxylase, Lyase
LigandPyridoxal phosphate

Enzyme and pathway databases

BioCyciLMON169963:G1GTA-480-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Glutamate decarboxylase alpha (EC:4.1.1.15)
Short name:
GAD-alpha
Gene namesi
Name:gadA
Ordered Locus Names:lmo0447
OrganismiListeria monocytogenes serovar 1/2a (strain ATCC BAA-679 / EGD-e)
Taxonomic identifieri169963 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesListeriaceaeListeria
Proteomesi
  • UP000000817 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001469881 – 462Glutamate decarboxylase alphaAdd BLAST462

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei273N6-(pyridoxal phosphate)lysineBy similarity1

Proteomic databases

PaxDbiQ9F5P3

Interactioni

Protein-protein interaction databases

STRINGi169963.lmo0447

Structurei

3D structure databases

ProteinModelPortaliQ9F5P3
SMRiQ9F5P3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the group II decarboxylase family.Curated

Phylogenomic databases

eggNOGiENOG4105CVK Bacteria
COG0076 LUCA
HOGENOMiHOG000070228
KOiK01580
OMAiSTFRMPE
PhylomeDBiQ9F5P3

Family and domain databases

Gene3Di3.40.640.10, 1 hit
InterProiView protein in InterPro
IPR010107 Glutamate_decarboxylase
IPR002129 PyrdxlP-dep_de-COase
IPR015424 PyrdxlP-dep_Trfase
IPR015421 PyrdxlP-dep_Trfase_major
PANTHERiPTHR43321 PTHR43321, 1 hit
PfamiView protein in Pfam
PF00282 Pyridoxal_deC, 1 hit
SUPFAMiSSF53383 SSF53383, 1 hit
TIGRFAMsiTIGR01788 Glu-decarb-GAD, 1 hit

Sequencei

Sequence statusi: Complete.

Q9F5P3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFKTNVEQNN VPVFGSFESG QDLPEKRMNK ESVDPRIAYQ LVKDQLIDEG
60 70 80 90 100
SARQNLATFC QTYMEPEAEQ IMAETMEKNA IDKSEYPQTA KLESSCVNML
110 120 130 140 150
ADLWNVDESE HYMGTSTVGS SEACMLGGMA MKFRWRSAAL KNGLDIHAKK
160 170 180 190 200
PSLVISSGYQ VCWEKFCVYW DIELREVPMS EEHLSINTDI IMDYVDEYTI
210 220 230 240 250
GIVGILGITY TGKFDDIMTL NDLVEDYNNT HDNEVVIHVD GASGAMFTPF
260 270 280 290 300
VEPGLEWDFR LPNVVSINTS GHKYGLVYPG VGWILWRDKE YLPEELVFDV
310 320 330 340 350
SYLGGHMPTM AINFSRSASQ IIGQYYNFLR FGYEGYRQIH MRTRDGALQL
360 370 380 390 400
SQAVAETGLF EIYNDGANLP IVCYKLKDDA NVAWTLYDLA DRLQMKGWQV
410 420 430 440 450
PAYPLPKEMG NTIIQRYVCR GDLGQNMVTA FKNDLSESIE ELNNAHILYH
460
DVNTSKTHGF TH
Length:462
Mass (Da):52,498
Last modified:February 21, 2002 - v2
Checksum:iEA1A442E3E1CE2FA
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti152S → N in AAG22560 (PubMed:11309128).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF309076 Genomic DNA Translation: AAG22560.1
AL591975 Genomic DNA Translation: CAC98526.1
PIRiAH1130
RefSeqiNP_463976.1, NC_003210.1
WP_010989470.1, NC_003210.1

Genome annotation databases

EnsemblBacteriaiCAC98526; CAC98526; CAC98526
GeneIDi986724
KEGGilmo:lmo0447
PATRICifig|169963.11.peg.462

Similar proteinsi

Entry informationi

Entry nameiDCEA_LISMO
AccessioniPrimary (citable) accession number: Q9F5P3
Secondary accession number(s): Q8Y9S6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 21, 2002
Last sequence update: February 21, 2002
Last modified: March 28, 2018
This is version 95 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health