Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q9F5P3

- DCEA_LISMO

UniProt

Q9F5P3 - DCEA_LISMO

Protein

Glutamate decarboxylase alpha

Gene

gadA

Organism
Listeria monocytogenes serovar 1/2a (strain ATCC BAA-679 / EGD-e)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 79 (01 Oct 2014)
      Sequence version 2 (21 Feb 2002)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Converts internalized glutamate to GABA and increases the internal pH. Involved in glutamate-dependent acid resistance in gastric fluid.

    Catalytic activityi

    L-glutamate = 4-aminobutanoate + CO2.

    Cofactori

    Pyridoxal phosphate.By similarity

    GO - Molecular functioni

    1. glutamate decarboxylase activity Source: UniProtKB-EC
    2. pyridoxal phosphate binding Source: InterPro

    GO - Biological processi

    1. glutamate metabolic process Source: InterPro

    Keywords - Molecular functioni

    Decarboxylase, Lyase

    Keywords - Ligandi

    Pyridoxal phosphate

    Enzyme and pathway databases

    BioCyciLMON169963:LMO0447-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Glutamate decarboxylase alpha (EC:4.1.1.15)
    Short name:
    GAD-alpha
    Gene namesi
    Name:gadA
    Ordered Locus Names:lmo0447
    OrganismiListeria monocytogenes serovar 1/2a (strain ATCC BAA-679 / EGD-e)
    Taxonomic identifieri169963 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesListeriaceaeListeria
    ProteomesiUP000000817: Chromosome

    Organism-specific databases

    GenoListiLMO0447.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 462462Glutamate decarboxylase alphaPRO_0000146988Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei273 – 2731N6-(pyridoxal phosphate)lysineBy similarity

    Interactioni

    Protein-protein interaction databases

    STRINGi169963.lmo0447.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9F5P3.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the group II decarboxylase family.Curated

    Phylogenomic databases

    eggNOGiCOG0076.
    HOGENOMiHOG000070228.
    KOiK01580.
    OMAiAQYYTFL.
    OrthoDBiEOG618QPT.
    PhylomeDBiQ9F5P3.

    Family and domain databases

    Gene3Di3.40.640.10. 1 hit.
    InterProiIPR010107. Glutamate_decarboxylase.
    IPR002129. PyrdxlP-dep_de-COase.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    [Graphical view]
    PANTHERiPTHR11999:SF1. PTHR11999:SF1. 1 hit.
    PfamiPF00282. Pyridoxal_deC. 1 hit.
    [Graphical view]
    SUPFAMiSSF53383. SSF53383. 1 hit.
    TIGRFAMsiTIGR01788. Glu-decarb-GAD. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q9F5P3-1 [UniParc]FASTAAdd to Basket

    « Hide

    MFKTNVEQNN VPVFGSFESG QDLPEKRMNK ESVDPRIAYQ LVKDQLIDEG    50
    SARQNLATFC QTYMEPEAEQ IMAETMEKNA IDKSEYPQTA KLESSCVNML 100
    ADLWNVDESE HYMGTSTVGS SEACMLGGMA MKFRWRSAAL KNGLDIHAKK 150
    PSLVISSGYQ VCWEKFCVYW DIELREVPMS EEHLSINTDI IMDYVDEYTI 200
    GIVGILGITY TGKFDDIMTL NDLVEDYNNT HDNEVVIHVD GASGAMFTPF 250
    VEPGLEWDFR LPNVVSINTS GHKYGLVYPG VGWILWRDKE YLPEELVFDV 300
    SYLGGHMPTM AINFSRSASQ IIGQYYNFLR FGYEGYRQIH MRTRDGALQL 350
    SQAVAETGLF EIYNDGANLP IVCYKLKDDA NVAWTLYDLA DRLQMKGWQV 400
    PAYPLPKEMG NTIIQRYVCR GDLGQNMVTA FKNDLSESIE ELNNAHILYH 450
    DVNTSKTHGF TH 462
    Length:462
    Mass (Da):52,498
    Last modified:February 21, 2002 - v2
    Checksum:iEA1A442E3E1CE2FA
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti152 – 1521S → N in AAG22560. (PubMed:11309128)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF309076 Genomic DNA. Translation: AAG22560.1.
    AL591975 Genomic DNA. Translation: CAC98526.1.
    PIRiAH1130.
    RefSeqiNP_463976.1. NC_003210.1.
    WP_010989470.1. NC_003210.1.

    Genome annotation databases

    EnsemblBacteriaiCAC98526; CAC98526; CAC98526.
    GeneIDi986724.
    KEGGilmo:lmo0447.
    PATRICi20309953. VBILisMon69206_0462.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF309076 Genomic DNA. Translation: AAG22560.1 .
    AL591975 Genomic DNA. Translation: CAC98526.1 .
    PIRi AH1130.
    RefSeqi NP_463976.1. NC_003210.1.
    WP_010989470.1. NC_003210.1.

    3D structure databases

    ProteinModelPortali Q9F5P3.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 169963.lmo0447.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CAC98526 ; CAC98526 ; CAC98526 .
    GeneIDi 986724.
    KEGGi lmo:lmo0447.
    PATRICi 20309953. VBILisMon69206_0462.

    Organism-specific databases

    GenoListi LMO0447.

    Phylogenomic databases

    eggNOGi COG0076.
    HOGENOMi HOG000070228.
    KOi K01580.
    OMAi AQYYTFL.
    OrthoDBi EOG618QPT.
    PhylomeDBi Q9F5P3.

    Enzyme and pathway databases

    BioCyci LMON169963:LMO0447-MONOMER.

    Family and domain databases

    Gene3Di 3.40.640.10. 1 hit.
    InterProi IPR010107. Glutamate_decarboxylase.
    IPR002129. PyrdxlP-dep_de-COase.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    [Graphical view ]
    PANTHERi PTHR11999:SF1. PTHR11999:SF1. 1 hit.
    Pfami PF00282. Pyridoxal_deC. 1 hit.
    [Graphical view ]
    SUPFAMi SSF53383. SSF53383. 1 hit.
    TIGRFAMsi TIGR01788. Glu-decarb-GAD. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "A glutamate decarboxylase system protects Listeria monocytogenes in gastric fluid."
      Cotter P.D., Gahan C.G.M., Hill C.
      Mol. Microbiol. 40:465-475(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: LO28 / Serovar 1/2c.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC BAA-679 / EGD-e.

    Entry informationi

    Entry nameiDCEA_LISMO
    AccessioniPrimary (citable) accession number: Q9F5P3
    Secondary accession number(s): Q8Y9S6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 21, 2002
    Last sequence update: February 21, 2002
    Last modified: October 1, 2014
    This is version 79 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3