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Protein

23S rRNA (guanine(2535)-N(1))-methyltransferase

Gene

aviRa

Organism
Streptomyces viridochromogenes
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Specifically methylates the guanine-2535 in 23S ribosomal RNA. Confers resistance to antibiotic avilamycin, an orthosomycin antibiotic.2 Publications

Catalytic activityi

S-adenosyl-L-methionine + guanine(2535) in 23S rRNA = S-adenosyl-L-homocysteine + N1-methylguanine(2535) in 23S rRNA.1 Publication

GO - Molecular functioni

  • rRNA (guanine-N1-)-methyltransferase activity Source: UniProtKB

GO - Biological processi

  • methylation Source: UniProtKB
  • response to antibiotic Source: UniProtKB
  • rRNA methylation Source: UniProtKB

Keywordsi

Molecular functionMethyltransferase, Transferase
Biological processAntibiotic resistance
LigandS-adenosyl-L-methionine

Enzyme and pathway databases

BioCyciMetaCyc:MONOMER-16329.
BRENDAi2.1.1.209. 6116.

Names & Taxonomyi

Protein namesi
Recommended name:
23S rRNA (guanine(2535)-N(1))-methyltransferase (EC:2.1.1.209)
Alternative name(s):
Avilamycin resistance protein A
Gene namesi
Name:aviRa
OrganismiStreptomyces viridochromogenes
Taxonomic identifieri1938 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaStreptomycetalesStreptomycetaceaeStreptomyces

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004184601 – 25023S rRNA (guanine(2535)-N(1))-methyltransferaseAdd BLAST250

Structurei

Secondary structure

1250
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi5 – 7Combined sources3
Helixi14 – 16Combined sources3
Turni18 – 20Combined sources3
Helixi33 – 45Combined sources13
Beta strandi47 – 49Combined sources3
Beta strandi53 – 57Combined sources5
Helixi64 – 72Combined sources9
Helixi74 – 76Combined sources3
Beta strandi77 – 85Combined sources9
Helixi87 – 98Combined sources12
Helixi102 – 119Combined sources18
Helixi122 – 140Combined sources19
Beta strandi147 – 151Combined sources5
Helixi157 – 159Combined sources3
Helixi160 – 164Combined sources5
Beta strandi170 – 175Combined sources6
Helixi178 – 180Combined sources3
Beta strandi181 – 186Combined sources6
Helixi190 – 203Combined sources14
Beta strandi209 – 217Combined sources9
Beta strandi227 – 232Combined sources6
Beta strandi235 – 241Combined sources7
Helixi242 – 247Combined sources6

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1O9GX-ray1.50A1-250[»]
1O9HX-ray2.40A1-250[»]
ProteinModelPortaliQ9F5K5.
SMRiQ9F5K5.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9F5K5.

Family & Domainsi

Family and domain databases

InterProiView protein in InterPro
IPR024268. AviRa.
IPR029063. SAM-dependent_MTases.
PfamiView protein in Pfam
PF11599. AviRa. 1 hit.
SUPFAMiSSF53335. SSF53335. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9F5K5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSAYRHAVER IDSSDLACGV VLHSAPGYPA FPVRLATEIF QRALARLPGD
60 70 80 90 100
GPVTLWDPCC GSGYLLTVLG LLHRRSLRQV IASDVDPAPL ELAAKNLALL
110 120 130 140 150
SPAGLTAREL ERREQSERFG KPSYLEAAQA ARRLRERLTA EGGALPCAIR
160 170 180 190 200
TADVFDPRAL SAVLAGSAPD VVLTDLPYGE RTHWEGQVPA QPVAGLLRSL
210 220 230 240 250
ASALPAHAVI AVTDRSRKIP VAPVKALERL KIGTRSAVLV RAADVLEAGP
Length:250
Mass (Da):26,636
Last modified:July 5, 2004 - v2
Checksum:iE2F972770DA5A853
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF333038 Genomic DNA. Translation: AAG32067.2.

Genome annotation databases

KEGGiag:AAG32067.

Similar proteinsi

Entry informationi

Entry nameiAVRA_STRVR
AccessioniPrimary (citable) accession number: Q9F5K5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 5, 2012
Last sequence update: July 5, 2004
Last modified: May 10, 2017
This is version 54 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references