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Q9F411

- TRMB_MYCHP

UniProt

Q9F411 - TRMB_MYCHP

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Protein
tRNA (guanine-N(7)-)-methyltransferase
Gene
trmB, MHO_4250
Organism
Mycoplasma hominis (strain ATCC 23114 / NBRC 14850 / NCTC 10111 / PG21)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA By similarity.UniRule annotation

Catalytic activityi

S-adenosyl-L-methionine + guanine(46) in tRNA = S-adenosyl-L-homocysteine + N(7)-methylguanine(46) in tRNA.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei34 – 341S-adenosyl-L-methionine By similarity
Binding sitei59 – 591S-adenosyl-L-methionine By similarity
Binding sitei86 – 861S-adenosyl-L-methionine By similarity
Active sitei107 – 1071 By similarity
Binding sitei107 – 1071S-adenosyl-L-methionine By similarity
Binding sitei111 – 1111Substrate By similarity
Binding sitei143 – 1431Substrate By similarity

GO - Molecular functioni

  1. tRNA (guanine-N7-)-methyltransferase activity Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Methyltransferase, Transferase

Keywords - Biological processi

tRNA processing

Keywords - Ligandi

S-adenosyl-L-methionine

Enzyme and pathway databases

BioCyciMHOM347256:GBZD-466-MONOMER.
UniPathwayiUPA00989.

Names & Taxonomyi

Protein namesi
Recommended name:
tRNA (guanine-N(7)-)-methyltransferase (EC:2.1.1.33)
Alternative name(s):
tRNA (guanine(46)-N(7))-methyltransferase
tRNA(m7G46)-methyltransferase
Gene namesi
Name:trmB
Ordered Locus Names:MHO_4250
OrganismiMycoplasma hominis (strain ATCC 23114 / NBRC 14850 / NCTC 10111 / PG21)
Taxonomic identifieri347256 [NCBI]
Taxonomic lineageiBacteriaTenericutesMollicutesMycoplasmataceaeMycoplasma
ProteomesiUP000002631: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 202202tRNA (guanine-N(7)-)-methyltransferaseUniRule annotation
PRO_0000171352Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi2098.MHO_4250.

Structurei

3D structure databases

ProteinModelPortaliQ9F411.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni181 – 1844Substrate binding Reviewed prediction

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0220.
HOGENOMiHOG000251689.
KOiK03439.
OMAiGCGKGEY.
OrthoDBiEOG6K6VBC.

Family and domain databases

Gene3Di3.40.50.150. 1 hit.
HAMAPiMF_01057. tRNA_methyltr_TrmB.
InterProiIPR029063. SAM-dependent_MTases-like.
IPR003358. tRNA_(Gua-N-7)_MeTrfase.
[Graphical view]
PfamiPF02390. Methyltransf_4. 1 hit.
[Graphical view]
SUPFAMiSSF53335. SSF53335. 1 hit.
TIGRFAMsiTIGR00091. TIGR00091. 1 hit.
PROSITEiPS51625. SAM_MT_TRMB. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9F411-1 [UniParc]FASTAAdd to Basket

« Hide

MRLRFNKNAE TSLMASPMTF KDFPIDNKKN TILEIGMGRG TMLTKLALMH    50
PDIEYIGLEK YSTPAYSALK KAIDLNLENF HIIIGDAINL STYFKNKIKT 100
IWLTFSDPWP KKRHYKRRLV YRDFLKIYQN VLDKDGVVYF KTDNDMLYQF 150
AIDELKEINA KIIYQTSDLH HCNFKIENVF TDYEEKFNKL NKNINFIAFT 200
FN 202
Length:202
Mass (Da):23,951
Last modified:March 1, 2001 - v1
Checksum:iD8993C44B381BB0B
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U59880 Genomic DNA. Translation: AAG28841.1.
FP236530 Genomic DNA. Translation: CAX37560.1.
RefSeqiWP_012855699.1. NC_013511.1.
YP_003302963.1. NC_013511.1.

Genome annotation databases

EnsemblBacteriaiCAX37560; CAX37560; MHO_4250.
GeneIDi8595146.
KEGGimho:MHO_4250.
PATRICi32274019. VBIMycHom120329_0443.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U59880 Genomic DNA. Translation: AAG28841.1 .
FP236530 Genomic DNA. Translation: CAX37560.1 .
RefSeqi WP_012855699.1. NC_013511.1.
YP_003302963.1. NC_013511.1.

3D structure databases

ProteinModelPortali Q9F411.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 2098.MHO_4250.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAX37560 ; CAX37560 ; MHO_4250 .
GeneIDi 8595146.
KEGGi mho:MHO_4250.
PATRICi 32274019. VBIMycHom120329_0443.

Phylogenomic databases

eggNOGi COG0220.
HOGENOMi HOG000251689.
KOi K03439.
OMAi GCGKGEY.
OrthoDBi EOG6K6VBC.

Enzyme and pathway databases

UniPathwayi UPA00989 .
BioCyci MHOM347256:GBZD-466-MONOMER.

Family and domain databases

Gene3Di 3.40.50.150. 1 hit.
HAMAPi MF_01057. tRNA_methyltr_TrmB.
InterProi IPR029063. SAM-dependent_MTases-like.
IPR003358. tRNA_(Gua-N-7)_MeTrfase.
[Graphical view ]
Pfami PF02390. Methyltransf_4. 1 hit.
[Graphical view ]
SUPFAMi SSF53335. SSF53335. 1 hit.
TIGRFAMsi TIGR00091. TIGR00091. 1 hit.
PROSITEi PS51625. SAM_MT_TRMB. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning and nucleotide sequence of the DNA gyrase (gyrA) gene from Mycoplasma hominis and characterization of quinolone-resistant mutants selected In vitro with trovafloxacin."
    Bebear C.M., Grau O., Charron A., Renaudin H., Gruson D., Bebear C.
    Antimicrob. Agents Chemother. 44:2719-2727(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "Life on arginine for Mycoplasma hominis: clues from its minimal genome and comparison with other human urogenital mycoplasmas."
    Pereyre S., Sirand-Pugnet P., Beven L., Charron A., Renaudin H., Barre A., Avenaud P., Jacob D., Couloux A., Barbe V., de Daruvar A., Blanchard A., Bebear C.
    PLoS Genet. 5:E1000677-E1000677(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 23114 / NBRC 14850 / NCTC 10111 / PG21.

Entry informationi

Entry nameiTRMB_MYCHP
AccessioniPrimary (citable) accession number: Q9F411
Secondary accession number(s): D1J8L3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 1, 2001
Last sequence update: March 1, 2001
Last modified: September 3, 2014
This is version 75 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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