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Q9F411

- TRMB_MYCHP

UniProt

Q9F411 - TRMB_MYCHP

Protein

tRNA (guanine-N(7)-)-methyltransferase

Gene

trmB

Organism
Mycoplasma hominis (strain ATCC 23114 / NBRC 14850 / NCTC 10111 / PG21)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 76 (01 Oct 2014)
      Sequence version 1 (01 Mar 2001)
      Previous versions | rss
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    Functioni

    Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA.UniRule annotation

    Catalytic activityi

    S-adenosyl-L-methionine + guanine(46) in tRNA = S-adenosyl-L-homocysteine + N(7)-methylguanine(46) in tRNA.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei34 – 341S-adenosyl-L-methionineUniRule annotation
    Binding sitei59 – 591S-adenosyl-L-methionineUniRule annotation
    Binding sitei86 – 861S-adenosyl-L-methionineUniRule annotation
    Active sitei107 – 1071By similarity
    Binding sitei107 – 1071S-adenosyl-L-methionineUniRule annotation
    Binding sitei111 – 1111SubstrateUniRule annotation
    Binding sitei143 – 1431SubstrateUniRule annotation

    GO - Molecular functioni

    1. tRNA (guanine-N7-)-methyltransferase activity Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Methyltransferase, Transferase

    Keywords - Biological processi

    tRNA processing

    Keywords - Ligandi

    S-adenosyl-L-methionine

    Enzyme and pathway databases

    BioCyciMHOM347256:GBZD-466-MONOMER.
    UniPathwayiUPA00989.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    tRNA (guanine-N(7)-)-methyltransferaseUniRule annotation (EC:2.1.1.33UniRule annotation)
    Alternative name(s):
    tRNA (guanine(46)-N(7))-methyltransferaseUniRule annotation
    tRNA(m7G46)-methyltransferaseUniRule annotation
    Gene namesi
    Name:trmBUniRule annotation
    Ordered Locus Names:MHO_4250
    OrganismiMycoplasma hominis (strain ATCC 23114 / NBRC 14850 / NCTC 10111 / PG21)
    Taxonomic identifieri347256 [NCBI]
    Taxonomic lineageiBacteriaTenericutesMollicutesMycoplasmataceaeMycoplasma
    ProteomesiUP000002631: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 202202tRNA (guanine-N(7)-)-methyltransferasePRO_0000171352Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi2098.MHO_4250.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9F411.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni181 – 1844Substrate bindingUniRule annotation

    Sequence similaritiesi

    Belongs to the class I-like SAM-binding methyltransferase superfamily. TrmB family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0220.
    HOGENOMiHOG000251689.
    KOiK03439.
    OMAiGCGKGEY.
    OrthoDBiEOG6K6VBC.

    Family and domain databases

    Gene3Di3.40.50.150. 1 hit.
    HAMAPiMF_01057. tRNA_methyltr_TrmB.
    InterProiIPR029063. SAM-dependent_MTases-like.
    IPR003358. tRNA_(Gua-N-7)_MeTrfase.
    [Graphical view]
    PfamiPF02390. Methyltransf_4. 1 hit.
    [Graphical view]
    SUPFAMiSSF53335. SSF53335. 1 hit.
    TIGRFAMsiTIGR00091. TIGR00091. 1 hit.
    PROSITEiPS51625. SAM_MT_TRMB. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9F411-1 [UniParc]FASTAAdd to Basket

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    MRLRFNKNAE TSLMASPMTF KDFPIDNKKN TILEIGMGRG TMLTKLALMH    50
    PDIEYIGLEK YSTPAYSALK KAIDLNLENF HIIIGDAINL STYFKNKIKT 100
    IWLTFSDPWP KKRHYKRRLV YRDFLKIYQN VLDKDGVVYF KTDNDMLYQF 150
    AIDELKEINA KIIYQTSDLH HCNFKIENVF TDYEEKFNKL NKNINFIAFT 200
    FN 202
    Length:202
    Mass (Da):23,951
    Last modified:March 1, 2001 - v1
    Checksum:iD8993C44B381BB0B
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U59880 Genomic DNA. Translation: AAG28841.1.
    FP236530 Genomic DNA. Translation: CAX37560.1.
    RefSeqiWP_012855699.1. NC_013511.1.
    YP_003302963.1. NC_013511.1.

    Genome annotation databases

    EnsemblBacteriaiCAX37560; CAX37560; MHO_4250.
    GeneIDi8595146.
    KEGGimho:MHO_4250.
    PATRICi32274019. VBIMycHom120329_0443.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U59880 Genomic DNA. Translation: AAG28841.1 .
    FP236530 Genomic DNA. Translation: CAX37560.1 .
    RefSeqi WP_012855699.1. NC_013511.1.
    YP_003302963.1. NC_013511.1.

    3D structure databases

    ProteinModelPortali Q9F411.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 2098.MHO_4250.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CAX37560 ; CAX37560 ; MHO_4250 .
    GeneIDi 8595146.
    KEGGi mho:MHO_4250.
    PATRICi 32274019. VBIMycHom120329_0443.

    Phylogenomic databases

    eggNOGi COG0220.
    HOGENOMi HOG000251689.
    KOi K03439.
    OMAi GCGKGEY.
    OrthoDBi EOG6K6VBC.

    Enzyme and pathway databases

    UniPathwayi UPA00989 .
    BioCyci MHOM347256:GBZD-466-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.150. 1 hit.
    HAMAPi MF_01057. tRNA_methyltr_TrmB.
    InterProi IPR029063. SAM-dependent_MTases-like.
    IPR003358. tRNA_(Gua-N-7)_MeTrfase.
    [Graphical view ]
    Pfami PF02390. Methyltransf_4. 1 hit.
    [Graphical view ]
    SUPFAMi SSF53335. SSF53335. 1 hit.
    TIGRFAMsi TIGR00091. TIGR00091. 1 hit.
    PROSITEi PS51625. SAM_MT_TRMB. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Cloning and nucleotide sequence of the DNA gyrase (gyrA) gene from Mycoplasma hominis and characterization of quinolone-resistant mutants selected In vitro with trovafloxacin."
      Bebear C.M., Grau O., Charron A., Renaudin H., Gruson D., Bebear C.
      Antimicrob. Agents Chemother. 44:2719-2727(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. "Life on arginine for Mycoplasma hominis: clues from its minimal genome and comparison with other human urogenital mycoplasmas."
      Pereyre S., Sirand-Pugnet P., Beven L., Charron A., Renaudin H., Barre A., Avenaud P., Jacob D., Couloux A., Barbe V., de Daruvar A., Blanchard A., Bebear C.
      PLoS Genet. 5:E1000677-E1000677(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 23114 / NBRC 14850 / NCTC 10111 / PG21.

    Entry informationi

    Entry nameiTRMB_MYCHP
    AccessioniPrimary (citable) accession number: Q9F411
    Secondary accession number(s): D1J8L3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 1, 2001
    Last sequence update: March 1, 2001
    Last modified: October 1, 2014
    This is version 76 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3