Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

tRNA (guanine-N(7)-)-methyltransferase

Gene

trmB

Organism
Mycoplasma hominis (strain ATCC 23114 / NBRC 14850 / NCTC 10111 / PG21)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the formation of N7-methylguanine at position 46 (m7G46) in tRNA.UniRule annotation

Catalytic activityi

S-adenosyl-L-methionine + guanine(46) in tRNA = S-adenosyl-L-homocysteine + N7-methylguanine(46) in tRNA.UniRule annotation

Pathwayi: N(7)-methylguanine-tRNA biosynthesis

This protein is involved in the pathway N(7)-methylguanine-tRNA biosynthesis, which is part of tRNA modification.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway N(7)-methylguanine-tRNA biosynthesis and in tRNA modification.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei34S-adenosyl-L-methionineUniRule annotation1
Binding sitei59S-adenosyl-L-methionineUniRule annotation1
Binding sitei86S-adenosyl-L-methionineUniRule annotation1
Active sitei107By similarity1
Binding sitei107S-adenosyl-L-methionineUniRule annotation1
Binding sitei111SubstrateUniRule annotation1
Binding sitei143SubstrateUniRule annotation1

GO - Molecular functioni

Keywordsi

Molecular functionMethyltransferase, Transferase
Biological processtRNA processing
LigandS-adenosyl-L-methionine

Enzyme and pathway databases

BioCyciMHOM347256:G1GK4-483-MONOMER
UniPathwayiUPA00989

Names & Taxonomyi

Protein namesi
Recommended name:
tRNA (guanine-N(7)-)-methyltransferaseUniRule annotation (EC:2.1.1.33UniRule annotation)
Alternative name(s):
tRNA (guanine(46)-N(7))-methyltransferaseUniRule annotation
tRNA(m7G46)-methyltransferaseUniRule annotation
Gene namesi
Name:trmBUniRule annotation
Ordered Locus Names:MHO_4250
OrganismiMycoplasma hominis (strain ATCC 23114 / NBRC 14850 / NCTC 10111 / PG21)
Taxonomic identifieri347256 [NCBI]
Taxonomic lineageiBacteriaTenericutesMollicutesMycoplasmataceaeMycoplasma
Proteomesi
  • UP000002631 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001713521 – 202tRNA (guanine-N(7)-)-methyltransferaseAdd BLAST202

Proteomic databases

PRIDEiQ9F411

Interactioni

Protein-protein interaction databases

STRINGi347256.MHO_4250

Structurei

3D structure databases

ProteinModelPortaliQ9F411
SMRiQ9F411
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni181 – 184Substrate bindingUniRule annotation4

Sequence similaritiesi

Belongs to the class I-like SAM-binding methyltransferase superfamily. TrmB family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4107T6Z Bacteria
COG0220 LUCA
HOGENOMiHOG000251689
KOiK03439
OMAiWITFPDP
OrthoDBiPOG091H015P

Family and domain databases

HAMAPiMF_01057 tRNA_methyltr_TrmB, 1 hit
InterProiView protein in InterPro
IPR029063 SAM-dependent_MTases
IPR003358 tRNA_(Gua-N-7)_MeTrfase_Trmb
PANTHERiPTHR23417 PTHR23417, 1 hit
SUPFAMiSSF53335 SSF53335, 1 hit
TIGRFAMsiTIGR00091 TIGR00091, 1 hit
PROSITEiView protein in PROSITE
PS51625 SAM_MT_TRMB, 1 hit

Sequencei

Sequence statusi: Complete.

Q9F411-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRLRFNKNAE TSLMASPMTF KDFPIDNKKN TILEIGMGRG TMLTKLALMH
60 70 80 90 100
PDIEYIGLEK YSTPAYSALK KAIDLNLENF HIIIGDAINL STYFKNKIKT
110 120 130 140 150
IWLTFSDPWP KKRHYKRRLV YRDFLKIYQN VLDKDGVVYF KTDNDMLYQF
160 170 180 190 200
AIDELKEINA KIIYQTSDLH HCNFKIENVF TDYEEKFNKL NKNINFIAFT

FN
Length:202
Mass (Da):23,951
Last modified:March 1, 2001 - v1
Checksum:iD8993C44B381BB0B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U59880 Genomic DNA Translation: AAG28841.1
FP236530 Genomic DNA Translation: CAX37560.1
RefSeqiWP_012855699.1, NC_013511.1

Genome annotation databases

EnsemblBacteriaiCAX37560; CAX37560; MHO_4250
GeneIDi25040506
KEGGimho:MHO_4250

Similar proteinsi

Entry informationi

Entry nameiTRMB_MYCHP
AccessioniPrimary (citable) accession number: Q9F411
Secondary accession number(s): D1J8L3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 1, 2001
Last sequence update: March 1, 2001
Last modified: May 23, 2018
This is version 91 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health