Q9F3E6 (COMB_STRCO) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Probable 2-phosphosulfolactate phosphatase
EC=3.1.3.71

Gene names

Name:	comB
Ordered Locus Names:	SCO7611
ORF Names:	SC2H2.09

Organism

Streptomyces coelicolor

Taxonomic identifier

1902 [NCBI]

Taxonomic lineage

Bacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Streptomycineae › Streptomycetaceae › Streptomyces

Protein attributes

Sequence length	237 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	(2R)-2-phospho-3-sulfolactate + H2O = (2R)-3-sulfolactate + phosphate. HAMAP MF_00490
Cofactor	Magnesium By similarity. HAMAP MF_00490
Sequence similarities	Belongs to the ComB family.

Ontologies

Keywords
Ligand	Magnesium
Molecular function	Hydrolase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	coenzyme M biosynthetic process Inferred from electronic annotation. Source: InterPro
Molecular function	2-phosphosulfolactate phosphatase activity Inferred from electronic annotation. Source: EC magnesium ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 237	237	Probable 2-phosphosulfolactate phosphatase HAMAP MF_00490		PRO_0000081472

Sequences

	Sequence		Length	Mass (Da)
	Q9F3E6 [UniParc]. Last modified January 17, 2003. Version 3. Checksum: 91B50DF45D6F7017	FASTA	237	24,800
	10 20 30 40 50 60 MLPGVRDHDG MDTRFVGIPE VGEAPAVAVV VDVMRAFTVA AWAFARGAEK IVLAGSLDEA 70 80 90 100 110 120 LALKERDPAR VALKDGPLTP GFDLVNSPGL LRSADLAGRT VVQKTTAGTV GALAVRDASL 130 140 150 160 170 180 VLCAGFVVAE ATARVLRARA PEHVTFVVTG EDGRADEDLA CARYIARRAA GHDADAAGFL 190 200 210 220 230 GRAAESRAAT ELVQGVRQGV HPDDVALCLE LDRFPFAMVA APEDSLMVLR PCAVPRP

References

[1]

"Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2)." Bentley S.D., Chater K.F., Cerdeno-Tarraga A.-M., Challis G.L., Thomson N.R., James K.D., Harris D.E., Quail M.A., Kieser H., Harper D., Bateman A., Brown S., Chandra G., Chen C.W., Collins M., Cronin A., Fraser A., Goble A. , Hidalgo J., Hornsby T., Howarth S., Huang C.-H., Kieser T., Larke L., Murphy L.D., Oliver K., O'Neil S., Rabbinowitsch E., Rajandream M.A., Rutherford K.M., Rutter S., Seeger K., Saunders D., Sharp S., Squares R., Squares S., Taylor K., Warren T., Wietzorrek A., Woodward J.R., Barrell B.G., Parkhill J., Hopwood D.A. Nature 417:141-147(2002) [PubMed: 12000953] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC BAA-471 / A3(2) / M145.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AL939132 Genomic DNA. Translation: CAC16713.1.
RefSeq	NP_631652.1. NC_003888.3.
3D structure databases
ProteinModelPortal	Q9F3E6.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	1103049.
GenomeReviews	Gene locus SCO7611 in contig AL645882_GR.
KEGG	sco:SCO7611.
NMPDR	fig|100226.1.peg.7542.
PATRIC	23745171. VBIStrCoe124346_7728.
Phylogenomic databases
HOGENOM	HBG696993.
OMA	AFTVAAW.
PhylomeDB	Q9F3E6.
ProtClustDB	CLSK2502801.
Family and domain databases
HAMAP	MF_00490. ComB. [Tree]
InterPro	IPR005238. 2-PSlactate_phosphatase. IPR022995. Pase_ComB. [Graphical view]
Gene3D	G3DSA:3.90.1560.10. 2-PSlactate_phosphatase. 1 hit.
KO	K05979.
Pfam	PF04029. 2-ph_phosp. 1 hit. [Graphical view]
SUPFAM	SSF142823. SSF142823. 1 hit.
ProtoNet	Search...

Entry information

Entry name

COMB_STRCO

Accession

Primary (citable) accession number: Q9F3E6

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 5, 2001
Last sequence update:	January 17, 2003
Last modified:	January 25, 2012
This is version 58 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program