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Protein

1D-myo-inositol 2-acetamido-2-deoxy-alpha-D-glucopyranoside deacetylase

Gene

mshB

Organism
Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Catalyzes the deacetylation of 1D-myo-inositol 2-acetamido-2-deoxy-alpha-D-glucopyranoside (GlcNAc-Ins) in the mycothiol biosynthesis pathway.UniRule annotation

Catalytic activityi

1-O-(2-acetamido-2-deoxy-alpha-D-glucopyranosyl)-1D-myo-inositol + H2O = 1-O-(2-amino-2-deoxy-alpha-D-glucopyranosyl)-1D-myo-inositol + acetate.UniRule annotation

Cofactori

Zn2+UniRule annotationNote: Binds 1 zinc ion per subunit.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi15ZincUniRule annotation1
Metal bindingi18ZincUniRule annotation1
Metal bindingi147ZincUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Ligandi

Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
1D-myo-inositol 2-acetamido-2-deoxy-alpha-D-glucopyranoside deacetylaseUniRule annotation (EC:3.5.1.103UniRule annotation)
Short name:
GlcNAc-Ins deacetylaseUniRule annotation
Alternative name(s):
N-acetyl-1-D-myo-inositol 2-amino-2-deoxy-alpha-D-glucopyranoside deacetylase
Gene namesi
Name:mshBUniRule annotation
Ordered Locus Names:SCO5126
ORF Names:SC9E12.11
OrganismiStreptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)
Taxonomic identifieri100226 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaStreptomycetalesStreptomycetaceaeStreptomycesStreptomyces albidoflavus group
Proteomesi
  • UP000001973 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004002261 – 2951D-myo-inositol 2-acetamido-2-deoxy-alpha-D-glucopyranoside deacetylaseAdd BLAST295

Expressioni

Inductioni

Gradually induced by thiol-oxidant diamide, under (probably indirect) control of SigR.1 Publication

Interactioni

Protein-protein interaction databases

STRINGi100226.SCO5126.

Structurei

3D structure databases

ProteinModelPortaliQ9F344.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the MshB deacetylase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG2120. LUCA.
HOGENOMiHOG000241173.
InParanoidiQ9F344.
KOiK15525.
OMAiMMGLATN.
OrthoDBiPOG091H08W5.
PhylomeDBiQ9F344.

Family and domain databases

Gene3Di3.40.50.10320. 1 hit.
HAMAPiMF_01696. MshB. 1 hit.
InterProiIPR003737. GlcNAc_PI_deacetylase-related.
IPR024078. LmbE-like_dom.
IPR017810. Mycothiol_biosynthesis_MshB.
[Graphical view]
PANTHERiPTHR12993. PTHR12993. 1 hit.
PfamiPF02585. PIG-L. 1 hit.
[Graphical view]
SUPFAMiSSF102588. SSF102588. 1 hit.
TIGRFAMsiTIGR03445. mycothiol_MshB. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9F344-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTDLPGRRLL LVHAHPDDES INNGVTMARY AAEGAHVTLV TCTLGERGEV
60 70 80 90 100
IPPALAHLSG AALGGHRRGE LADAMRALGV DDFRLLGGPG RYADSGMLGL
110 120 130 140 150
SDNDDPGCLW QADVDAAAAL LVDVIREVRP QVLVTYDPNG GYGHPDHIQA
160 170 180 190 200
HRIAMRAAEL AAEAGCPVAK VYWNRVPRSR VEDAFARLRD DLPGLPFEKA
210 220 230 240 250
AGVEDVPGVV DDERITTEIR GEGTAYAAAK AAAMRAHATQ ITVAEPYFVL
260 270 280 290
SNDLAQPILT TEYYELVRGE RGGEGRENDL FAGIAGTFDT GEATS
Length:295
Mass (Da):31,433
Last modified:March 1, 2001 - v1
Checksum:i0EBA7027EF891ED8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL939122 Genomic DNA. Translation: CAC05756.1.
RefSeqiNP_629275.1. NC_003888.3.
WP_011030070.1. NC_003888.3.

Genome annotation databases

EnsemblBacteriaiCAC05756; CAC05756; CAC05756.
GeneIDi1100567.
KEGGisco:SCO5126.
PATRICi23740098. VBIStrCoe124346_5209.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL939122 Genomic DNA. Translation: CAC05756.1.
RefSeqiNP_629275.1. NC_003888.3.
WP_011030070.1. NC_003888.3.

3D structure databases

ProteinModelPortaliQ9F344.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi100226.SCO5126.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAC05756; CAC05756; CAC05756.
GeneIDi1100567.
KEGGisco:SCO5126.
PATRICi23740098. VBIStrCoe124346_5209.

Phylogenomic databases

eggNOGiCOG2120. LUCA.
HOGENOMiHOG000241173.
InParanoidiQ9F344.
KOiK15525.
OMAiMMGLATN.
OrthoDBiPOG091H08W5.
PhylomeDBiQ9F344.

Family and domain databases

Gene3Di3.40.50.10320. 1 hit.
HAMAPiMF_01696. MshB. 1 hit.
InterProiIPR003737. GlcNAc_PI_deacetylase-related.
IPR024078. LmbE-like_dom.
IPR017810. Mycothiol_biosynthesis_MshB.
[Graphical view]
PANTHERiPTHR12993. PTHR12993. 1 hit.
PfamiPF02585. PIG-L. 1 hit.
[Graphical view]
SUPFAMiSSF102588. SSF102588. 1 hit.
TIGRFAMsiTIGR03445. mycothiol_MshB. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiMSHB_STRCO
AccessioniPrimary (citable) accession number: Q9F344
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 2, 2010
Last sequence update: March 1, 2001
Last modified: September 7, 2016
This is version 68 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.