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Q9F323 (SYD_STRCO) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 70. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Aspartate--tRNA ligase
EC=6.1.1.12
Alternative name(s):
Aspartyl-tRNA synthetase
Short name=AspRS
Gene names
Name:aspS
Ordered Locus Names:SCO3795
ORF Names:SCAC2.03c
OrganismStreptomyces coelicolor
Taxonomic identifier1902 [NCBI]
Taxonomic lineageBacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Streptomycineae › Streptomycetaceae › Streptomyces

Protein attributes

Sequence length587 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + L-aspartate + tRNA(Asp) = AMP + diphosphate + L-aspartyl-tRNA(Asp). HAMAP MF_00044_B

Subunit structure

Homodimer By similarity. HAMAP MF_00044_B

Subcellular location

Cytoplasm HAMAP MF_00044_B.

Sequence similarities

Belongs to the class-II aminoacyl-tRNA synthetase family.

Ontologies

Keywords
   Biological processProtein biosynthesis
   Cellular componentCytoplasm
   LigandATP-binding
Nucleotide-binding
   Molecular functionAminoacyl-tRNA synthetase
Ligase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological processtRNA aminoacylation for protein translation

Inferred from electronic annotation. Source: InterPro

   Cellular componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular functionATP binding

Inferred from electronic annotation. Source: UniProtKB-KW

aspartate-tRNA ligase activity

Inferred from electronic annotation. Source: EC

nucleic acid binding

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 587587Aspartate--tRNA ligase HAMAP MF_00044_B
PRO_0000110952

Sequences

Sequence LengthMass (Da)Tools
Q9F323 [UniParc].

Last modified March 1, 2001. Version 1.
Checksum: BE6381432C8D9BC3

FASTA58766,002
        10         20         30         40         50         60 
MHRYRSHTCG ELRSSDVGTD VRLSGWLHNR RDLGGILFID LRDHYGITQL VARPGTEAYE 

        70         80         90        100        110        120 
ALDKLTKEST VRVDGKVVSR GADNINPDLP TGEVEVEVGE VELLGAAQPL PFTINTEDGV 

       130        140        150        160        170        180 
NEERRLEYRF LDLRRERMHR NIMLRTSVIS SIRSKMVALG FNEMATPILT ATSPEGARDF 

       190        200        210        220        230        240 
VVPSRLHAGR FYALPQAPQQ FKQLLMISGF DRYFQIAPCF RDEDARADRS PGEFYQLDVE 

       250        260        270        280        290        300 
MSFVEQEDVF RPIEQLMTEL FEEFGNGRHV TSPFPRIPFR EAMLKYGSDK PDLRAQLELV 

       310        320        330        340        350        360 
DITDVFEGSE FKAFAGKHVR ALPVPDVSGQ PRRFFDQLGD YAVSQGAKGL AWVRVGEDGK 

       370        380        390        400        410        420 
LSGPIAKFLT EENVAELTKR LSLAPGHAVF FGAGEFDEVS KIMGAVRVEA AKRAGHFEEN 

       430        440        450        460        470        480 
VFRFCWIVDF PMYEKDEETG KIDFSHNPFS MPQGGMDALE NQDPLDILAW QYDIVCNGVE 

       490        500        510        520        530        540 
LSSGAIRNHE PEIMLKAFEI AGYDAETVER EFAGMLRAFR FGAPPHGGIA PGVDRIVMLL 

       550        560        570        580 
ADEPNIRETI AFPLNGNAQD LMMGAPTELD ESRLRELHLT VRKPQPK

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AL939117 Genomic DNA. Translation: CAC08476.1.
RefSeqNP_627985.1. NC_003888.3.

3D structure databases

ProteinModelPortalQ9F323.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID1099231.
GenomeReviewsGene locus SCO3795 in contig AL645882_GR.
KEGGsco:SCO3795.
NMPDRfig|100226.1.peg.3752.
PATRIC23737350. VBIStrCoe124346_3857.

Phylogenomic databases

HOGENOMHBG396032.
OMAYQLDVEM.
PhylomeDBQ9F323.
ProtClustDBPRK00476.

Family and domain databases

HAMAPMF_00044_B. Asp_tRNA_synth_B.
[Tree]
InterProIPR004364. aa-tRNA-synt_II.
IPR018150. aa-tRNA-synt_II-like.
IPR006195. aa-tRNA-synth_II.
IPR004524. Asp-tRNA-synth_IIb_bac/mt.
IPR002312. Asp/Asn-tRNA-synth_IIb.
IPR004115. GAD_dom.
IPR012340. NA-bd_OB-fold.
IPR016027. NA-bd_OB-fold-like.
IPR004365. NA-bd_OB_tRNA-helicase.
[Graphical view]
Gene3DG3DSA:3.30.1360.30. GAD_dom. 1 hit.
G3DSA:2.40.50.140. OB_NA_bd_sub. 1 hit.
KOK01876.
PANTHERPTHR22594. aa-tRNA-synt_II. 1 hit.
PTHR22594:SF5. AspS_bac. 1 hit.
PfamPF02938. GAD. 1 hit.
PF00152. tRNA-synt_2. 1 hit.
PF01336. tRNA_anti. 1 hit.
[Graphical view]
PRINTSPR01042. TRNASYNTHASP.
SUPFAMSSF50249. Nucleic_acid_OB. 1 hit.
SSF55261. SSF55261. 1 hit.
TIGRFAMsTIGR00459. AspS_bact. 1 hit.
PROSITEPS50862. AA_TRNA_LIGASE_II. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameSYD_STRCO
AccessionPrimary (citable) accession number: Q9F323
Entry history
Integrated into UniProtKB/Swiss-Prot: October 19, 2002
Last sequence update: March 1, 2001
Last modified: January 25, 2012
This is version 70 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

Aminoacyl-tRNA synthetases

List of aminoacyl-tRNA synthetase entries

SIMILARITY comments

Index of protein domains and families

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