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Q9F305

- TRMB_STRCO

UniProt

Q9F305 - TRMB_STRCO

Protein

tRNA (guanine-N(7)-)-methyltransferase

Gene

trmB

Organism
Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 82 (01 Oct 2014)
      Sequence version 1 (01 Mar 2001)
      Previous versions | rss
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    Functioni

    Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA.UniRule annotation

    Catalytic activityi

    S-adenosyl-L-methionine + guanine(46) in tRNA = S-adenosyl-L-homocysteine + N(7)-methylguanine(46) in tRNA.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei93 – 931S-adenosyl-L-methionineUniRule annotation
    Binding sitei118 – 1181S-adenosyl-L-methionineUniRule annotation
    Binding sitei145 – 1451S-adenosyl-L-methionineUniRule annotation
    Active sitei168 – 1681By similarity
    Binding sitei168 – 1681S-adenosyl-L-methionineUniRule annotation
    Binding sitei172 – 1721SubstrateUniRule annotation
    Binding sitei204 – 2041SubstrateUniRule annotation

    GO - Molecular functioni

    1. tRNA (guanine-N7-)-methyltransferase activity Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Methyltransferase, Transferase

    Keywords - Biological processi

    tRNA processing

    Keywords - Ligandi

    S-adenosyl-L-methionine

    Enzyme and pathway databases

    UniPathwayiUPA00989.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    tRNA (guanine-N(7)-)-methyltransferaseUniRule annotation (EC:2.1.1.33UniRule annotation)
    Alternative name(s):
    tRNA (guanine(46)-N(7))-methyltransferaseUniRule annotation
    tRNA(m7G46)-methyltransferaseUniRule annotation
    Gene namesi
    Name:trmBUniRule annotation
    Ordered Locus Names:SCO4111
    ORF Names:SCD17A.03c
    OrganismiStreptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)
    Taxonomic identifieri100226 [NCBI]
    Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesStreptomycineaeStreptomycetaceaeStreptomycesStreptomyces albidoflavus group
    ProteomesiUP000001973: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 271271tRNA (guanine-N(7)-)-methyltransferasePRO_0000171401Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi100226.SCO4111.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9F305.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni241 – 2444Substrate bindingUniRule annotation

    Sequence similaritiesi

    Belongs to the class I-like SAM-binding methyltransferase superfamily. TrmB family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0220.
    HOGENOMiHOG000073968.
    KOiK03439.
    OMAiHSTLEMA.
    OrthoDBiEOG6K6VBC.
    PhylomeDBiQ9F305.

    Family and domain databases

    Gene3Di3.40.50.150. 1 hit.
    HAMAPiMF_01057. tRNA_methyltr_TrmB.
    InterProiIPR029063. SAM-dependent_MTases-like.
    IPR003358. tRNA_(Gua-N-7)_MeTrfase.
    [Graphical view]
    PfamiPF02390. Methyltransf_4. 1 hit.
    [Graphical view]
    SUPFAMiSSF53335. SSF53335. 1 hit.
    TIGRFAMsiTIGR00091. TIGR00091. 1 hit.
    PROSITEiPS51625. SAM_MT_TRMB. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9F305-1 [UniParc]FASTAAdd to Basket

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    MSDSHHTPEA ASASLRHVRA KGEPRFPDGP KADPAGSHFE RRIRSFQPRR    50
    SRVTAGQADA LQRLWPLWGL DIDGRRVVDL AELFGNARPV VLEIGFGMGE 100
    TTARMAAADP DTNILAADVH TPGQGNLLGL AERQELPNIR VANGDAIILL 150
    REMLAPGSLA GLRVYFPDPW PKKRHHKRRL IQPEFLTLAA TRLAPGAVVH 200
    CATDWEPYAE QMLDVLTAHP DFENTVPGGG FAPRPEHRPL TRFEGQGLDK 250
    GHVVNDLLFR RVQHKEPPPN G 271
    Length:271
    Mass (Da):29,912
    Last modified:March 1, 2001 - v1
    Checksum:i8E9A7A05BA6E2829
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL939118 Genomic DNA. Translation: CAC08407.1.
    RefSeqiNP_628290.1. NC_003888.3.

    Genome annotation databases

    EnsemblBacteriaiCAC08407; CAC08407; CAC08407.
    GeneIDi1099548.
    KEGGisco:SCO4111.
    PATRICi23738006. VBIStrCoe124346_4171.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL939118 Genomic DNA. Translation: CAC08407.1 .
    RefSeqi NP_628290.1. NC_003888.3.

    3D structure databases

    ProteinModelPortali Q9F305.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 100226.SCO4111.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CAC08407 ; CAC08407 ; CAC08407 .
    GeneIDi 1099548.
    KEGGi sco:SCO4111.
    PATRICi 23738006. VBIStrCoe124346_4171.

    Phylogenomic databases

    eggNOGi COG0220.
    HOGENOMi HOG000073968.
    KOi K03439.
    OMAi HSTLEMA.
    OrthoDBi EOG6K6VBC.
    PhylomeDBi Q9F305.

    Enzyme and pathway databases

    UniPathwayi UPA00989 .

    Family and domain databases

    Gene3Di 3.40.50.150. 1 hit.
    HAMAPi MF_01057. tRNA_methyltr_TrmB.
    InterProi IPR029063. SAM-dependent_MTases-like.
    IPR003358. tRNA_(Gua-N-7)_MeTrfase.
    [Graphical view ]
    Pfami PF02390. Methyltransf_4. 1 hit.
    [Graphical view ]
    SUPFAMi SSF53335. SSF53335. 1 hit.
    TIGRFAMsi TIGR00091. TIGR00091. 1 hit.
    PROSITEi PS51625. SAM_MT_TRMB. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC BAA-471 / A3(2) / M145.

    Entry informationi

    Entry nameiTRMB_STRCO
    AccessioniPrimary (citable) accession number: Q9F305
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 1, 2001
    Last sequence update: March 1, 2001
    Last modified: October 1, 2014
    This is version 82 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3