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Q9F305

- TRMB_STRCO

UniProt

Q9F305 - TRMB_STRCO

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Protein

tRNA (guanine-N(7)-)-methyltransferase

Gene

trmB

Organism
Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA.UniRule annotation

Catalytic activityi

S-adenosyl-L-methionine + guanine(46) in tRNA = S-adenosyl-L-homocysteine + N(7)-methylguanine(46) in tRNA.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei93 – 931S-adenosyl-L-methionineUniRule annotation
Binding sitei118 – 1181S-adenosyl-L-methionineUniRule annotation
Binding sitei145 – 1451S-adenosyl-L-methionineUniRule annotation
Active sitei168 – 1681By similarity
Binding sitei168 – 1681S-adenosyl-L-methionineUniRule annotation
Binding sitei172 – 1721SubstrateUniRule annotation
Binding sitei204 – 2041SubstrateUniRule annotation

GO - Molecular functioni

  1. tRNA (guanine-N7-)-methyltransferase activity Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Methyltransferase, Transferase

Keywords - Biological processi

tRNA processing

Keywords - Ligandi

S-adenosyl-L-methionine

Enzyme and pathway databases

UniPathwayiUPA00989.

Names & Taxonomyi

Protein namesi
Recommended name:
tRNA (guanine-N(7)-)-methyltransferaseUniRule annotation (EC:2.1.1.33UniRule annotation)
Alternative name(s):
tRNA (guanine(46)-N(7))-methyltransferaseUniRule annotation
tRNA(m7G46)-methyltransferaseUniRule annotation
Gene namesi
Name:trmBUniRule annotation
Ordered Locus Names:SCO4111
ORF Names:SCD17A.03c
OrganismiStreptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)
Taxonomic identifieri100226 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesStreptomycineaeStreptomycetaceaeStreptomycesStreptomyces albidoflavus group
ProteomesiUP000001973: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 271271tRNA (guanine-N(7)-)-methyltransferasePRO_0000171401Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi100226.SCO4111.

Structurei

3D structure databases

ProteinModelPortaliQ9F305.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni241 – 2444Substrate bindingUniRule annotation

Sequence similaritiesi

Belongs to the class I-like SAM-binding methyltransferase superfamily. TrmB family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0220.
HOGENOMiHOG000073968.
InParanoidiQ9F305.
KOiK03439.
OMAiHSTLEMA.
OrthoDBiEOG6K6VBC.
PhylomeDBiQ9F305.

Family and domain databases

Gene3Di3.40.50.150. 1 hit.
HAMAPiMF_01057. tRNA_methyltr_TrmB.
InterProiIPR029063. SAM-dependent_MTases-like.
IPR003358. tRNA_(Gua-N-7)_MeTrfase.
[Graphical view]
PfamiPF02390. Methyltransf_4. 1 hit.
[Graphical view]
SUPFAMiSSF53335. SSF53335. 1 hit.
TIGRFAMsiTIGR00091. TIGR00091. 1 hit.
PROSITEiPS51625. SAM_MT_TRMB. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9F305-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSDSHHTPEA ASASLRHVRA KGEPRFPDGP KADPAGSHFE RRIRSFQPRR
60 70 80 90 100
SRVTAGQADA LQRLWPLWGL DIDGRRVVDL AELFGNARPV VLEIGFGMGE
110 120 130 140 150
TTARMAAADP DTNILAADVH TPGQGNLLGL AERQELPNIR VANGDAIILL
160 170 180 190 200
REMLAPGSLA GLRVYFPDPW PKKRHHKRRL IQPEFLTLAA TRLAPGAVVH
210 220 230 240 250
CATDWEPYAE QMLDVLTAHP DFENTVPGGG FAPRPEHRPL TRFEGQGLDK
260 270
GHVVNDLLFR RVQHKEPPPN G
Length:271
Mass (Da):29,912
Last modified:March 1, 2001 - v1
Checksum:i8E9A7A05BA6E2829
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL939118 Genomic DNA. Translation: CAC08407.1.
RefSeqiNP_628290.1. NC_003888.3.

Genome annotation databases

EnsemblBacteriaiCAC08407; CAC08407; CAC08407.
GeneIDi1099548.
KEGGisco:SCO4111.
PATRICi23738006. VBIStrCoe124346_4171.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL939118 Genomic DNA. Translation: CAC08407.1 .
RefSeqi NP_628290.1. NC_003888.3.

3D structure databases

ProteinModelPortali Q9F305.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 100226.SCO4111.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAC08407 ; CAC08407 ; CAC08407 .
GeneIDi 1099548.
KEGGi sco:SCO4111.
PATRICi 23738006. VBIStrCoe124346_4171.

Phylogenomic databases

eggNOGi COG0220.
HOGENOMi HOG000073968.
InParanoidi Q9F305.
KOi K03439.
OMAi HSTLEMA.
OrthoDBi EOG6K6VBC.
PhylomeDBi Q9F305.

Enzyme and pathway databases

UniPathwayi UPA00989 .

Family and domain databases

Gene3Di 3.40.50.150. 1 hit.
HAMAPi MF_01057. tRNA_methyltr_TrmB.
InterProi IPR029063. SAM-dependent_MTases-like.
IPR003358. tRNA_(Gua-N-7)_MeTrfase.
[Graphical view ]
Pfami PF02390. Methyltransf_4. 1 hit.
[Graphical view ]
SUPFAMi SSF53335. SSF53335. 1 hit.
TIGRFAMsi TIGR00091. TIGR00091. 1 hit.
PROSITEi PS51625. SAM_MT_TRMB. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC BAA-471 / A3(2) / M145.

Entry informationi

Entry nameiTRMB_STRCO
AccessioniPrimary (citable) accession number: Q9F305
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 1, 2001
Last sequence update: March 1, 2001
Last modified: October 29, 2014
This is version 83 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3