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Q9F1T6 (PUR5_STRSU) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 57. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Phosphoribosylformylglycinamidine cyclo-ligase

EC=6.3.3.1
Alternative name(s):
AIR synthase
AIRS
Phosphoribosyl-aminoimidazole synthetase
Gene names
Name:purM
OrganismStreptococcus suis
Taxonomic identifier1307 [NCBI]
Taxonomic lineageBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus

Protein attributes

Sequence length340 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + 2-(formamido)-N(1)-(5-phospho-D-ribosyl)acetamidine = ADP + phosphate + 5-amino-1-(5-phospho-D-ribosyl)imidazole. HAMAP-Rule MF_00741

Pathway

Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole from N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide: step 2/2. HAMAP-Rule MF_00741

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00741.

Sequence similarities

Belongs to the AIR synthase family.

Ontologies

Keywords
   Biological processPurine biosynthesis
   Cellular componentCytoplasm
   LigandATP-binding
Nucleotide-binding
   Molecular functionLigase
Gene Ontology (GO)
   Biological_process'de novo' IMP biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-UniPathway

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-KW

phosphoribosylformylglycinamidine cyclo-ligase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 340340Phosphoribosylformylglycinamidine cyclo-ligase HAMAP-Rule MF_00741
PRO_0000148265

Sequences

Sequence LengthMass (Da)Tools
Q9F1T6 [UniParc].

Last modified March 1, 2001. Version 1.
Checksum: E043F5BD1BE19288

FASTA34036,358
        10         20         30         40         50         60 
MTNKNAYAQS GVDVEAGYEV VERIKKHVAR TERLGVMGAL GGFGGMFDLT KLDVKEPVLV 

        70         80         90        100        110        120 
SGTDGVGTKL MLAIQYDKHD TIGQDCVAMC VNDIIAAGAE PLYFLDYIAT GKNEPAKLEQ 

       130        140        150        160        170        180 
VVAGVAEGCV QAGCGLIGGE TAEMPGMYGE DDYDLAGFAV GIAEKYQIID GSKVKEGDIL 

       190        200        210        220        230        240 
LGLASSGIHS NGYSLVRRVF ADVSGDALLP ELNGRALKDV LLEPTRIYVQ QVLPLVKAGL 

       250        260        270        280        290        300 
VNGIAHITGG GFIENVPRMF ADNLAAEIEE DKIPVLPIFT ALEKYGKIKH EEMFEIFNMG 

       310        320        330        340 
IGLVLAVSPD KVDSVCQLVD EEVYTIGRII AKEDKSVVIK 

« Hide

References

[1]"Evidence for horizontal transfer of the SsuDAT1I restriction-modification genes to the Streptococcus suis genome."
Sekizaki T., Otani Y., Osaki M., Takamatsu D., Shimoji Y.
J. Bacteriol. 183:500-511(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: DAT1 / Serotype 2.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AB045609 Genomic DNA. Translation: BAB20825.1.

3D structure databases

ProteinModelPortalQ9F1T6.
SMRQ9F1T6. Positions 15-332.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Enzyme and pathway databases

UniPathwayUPA00074; UER00129.

Family and domain databases

Gene3D3.30.1330.10. 1 hit.
3.90.650.10. 1 hit.
HAMAPMF_00741_B. AIRS_B.
InterProIPR010918. AIR_synth_C_dom.
IPR000728. AIR_synth_N_dom.
IPR004733. PurM_cligase.
IPR016188. PurM_N-like.
[Graphical view]
PfamPF00586. AIRS. 1 hit.
PF02769. AIRS_C. 1 hit.
[Graphical view]
SUPFAMSSF55326. SSF55326. 1 hit.
SSF56042. SSF56042. 1 hit.
TIGRFAMsTIGR00878. purM. 1 hit.
ProtoNetSearch...

Entry information

Entry namePUR5_STRSU
AccessionPrimary (citable) accession number: Q9F1T6
Entry history
Integrated into UniProtKB/Swiss-Prot: November 28, 2003
Last sequence update: March 1, 2001
Last modified: April 16, 2014
This is version 57 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways