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Q9F1S9 (PUR2_STRSU) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 60. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Phosphoribosylamine--glycine ligase

EC=6.3.4.13
Alternative name(s):
GARS
Glycinamide ribonucleotide synthetase
Phosphoribosylglycinamide synthetase
Gene names
Name:purD
OrganismStreptococcus suis
Taxonomic identifier1307 [NCBI]
Taxonomic lineageBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus

Protein attributes

Sequence length420 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + 5-phospho-D-ribosylamine + glycine = ADP + phosphate + N(1)-(5-phospho-D-ribosyl)glycinamide. HAMAP-Rule MF_00138

Cofactor

Binds 1 magnesium or manganese ion per subunit By similarity.

Pathway

Purine metabolism; IMP biosynthesis via de novo pathway; N(1)-(5-phospho-D-ribosyl)glycinamide from 5-phospho-alpha-D-ribose 1-diphosphate: step 2/2. HAMAP-Rule MF_00138

Sequence similarities

Belongs to the GARS family.

Contains 1 ATP-grasp domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 420420Phosphoribosylamine--glycine ligase HAMAP-Rule MF_00138
PRO_0000151493

Regions

Domain108 – 314207ATP-grasp
Nucleotide binding134 – 19562ATP By similarity

Sites

Metal binding2841Magnesium or manganese By similarity
Metal binding2861Magnesium or manganese By similarity

Sequences

Sequence LengthMass (Da)Tools
Q9F1S9 [UniParc].

Last modified March 1, 2001. Version 1.
Checksum: 14E9C2D29CDF6B9F

FASTA42045,333
        10         20         30         40         50         60 
MKLLVVGSGG REHAIAKKLL ESEQVEQVFV APGNDGMTLD GIELINIGIS EHSALINFAK 

        70         80         90        100        110        120 
ENDIAWTFVG PDDALAAGIV DDFEQAGLKA FGPSRLAAEL EWSKDFAKQI MVKYGIPTAA 

       130        140        150        160        170        180 
FGTFSNFEEA KAYIEEQGAP IVVKADGLAL GKGVVVAETV EQAVEAAREM LLDNKFGDSG 

       190        200        210        220        230        240 
ARVVIEEFLA GEEFSLFALV NGDQFYILPT AQDHKRAFDG DQGPNTGGMG AYVHVPHLPQ 

       250        260        270        280        290        300 
SVVDTAVDTI VKPILEGMIT EGRSYLGVLY AGLILTDQGP KVIEFNARFG DPETQIILPR 

       310        320        330        340        350        360 
LTSDFAQNID DILHKRPTQL TWLNSGVTLG VVVASNGYPL DYEKGVTLPA KTEGDITTYY 

       370        380        390        400        410        420 
AGARFAENSR ALLSNGGRVY MLVTTADTVQ DAQEKIYSEL KNQDTTGLFY RTDIGSKAVK 

« Hide

References

[1]"Evidence for horizontal transfer of the SsuDAT1I restriction-modification genes to the Streptococcus suis genome."
Sekizaki T., Otani Y., Osaki M., Takamatsu D., Shimoji Y.
J. Bacteriol. 183:500-511(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: DAT1 / Serotype 2.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AB045609 Genomic DNA. Translation: BAB20832.1.

3D structure databases

ProteinModelPortalQ9F1S9.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Enzyme and pathway databases

UniPathwayUPA00074; UER00125.

Family and domain databases

Gene3D3.30.1490.20. 1 hit.
3.30.470.20. 1 hit.
3.40.50.20. 1 hit.
3.90.600.10. 1 hit.
HAMAPMF_00138. GARS.
InterProIPR011761. ATP-grasp.
IPR013815. ATP_grasp_subdomain_1.
IPR013816. ATP_grasp_subdomain_2.
IPR016185. PreATP-grasp_dom.
IPR020561. PRibGlycinamid_synth_ATP-grasp.
IPR000115. PRibGlycinamide_synth.
IPR020560. PRibGlycinamide_synth_C-dom.
IPR020559. PRibGlycinamide_synth_CS.
IPR020562. PRibGlycinamide_synth_N.
IPR011054. Rudment_hybrid_motif.
[Graphical view]
PfamPF01071. GARS_A. 1 hit.
PF02843. GARS_C. 1 hit.
PF02844. GARS_N. 1 hit.
[Graphical view]
SUPFAMSSF51246. SSF51246. 1 hit.
SSF52440. SSF52440. 1 hit.
TIGRFAMsTIGR00877. purD. 1 hit.
PROSITEPS50975. ATP_GRASP. 1 hit.
PS00184. GARS. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry namePUR2_STRSU
AccessionPrimary (citable) accession number: Q9F1S9
Entry history
Integrated into UniProtKB/Swiss-Prot: May 16, 2003
Last sequence update: March 1, 2001
Last modified: February 19, 2014
This is version 60 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways