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Q9EYW9 (DCEB_LISMO) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 75. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Glutamate decarboxylase beta

Short name=GAD-beta
EC=4.1.1.15
Gene names
Name:gadB
Ordered Locus Names:lmo2363
OrganismListeria monocytogenes serovar 1/2a (strain ATCC BAA-679 / EGD-e) [Reference proteome] [HAMAP]
Taxonomic identifier169963 [NCBI]
Taxonomic lineageBacteriaFirmicutesBacilliBacillalesListeriaceaeListeria

Protein attributes

Sequence length464 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Converts internalized glutamate to GABA and increases the internal pH. Involved in glutamate-dependent acid resistance in gastric fluid.

Catalytic activity

L-glutamate = 4-aminobutanoate + CO2.

Cofactor

Pyridoxal phosphate By similarity.

Sequence similarities

Belongs to the group II decarboxylase family.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 464464Glutamate decarboxylase beta
PRO_0000146990

Amino acid modifications

Modified residue2751N6-(pyridoxal phosphate)lysine By similarity

Natural variations

Natural variant921A → P in strain: LO28.
Natural variant1241E → D in strain: LO28.
Natural variant2611F → L in strain: EGD5.
Natural variant3751C → R in strain: EGD5.
Natural variant380 – 3812DD → TT in strain: LO28.

Sequences

Sequence LengthMass (Da)Tools
Q9EYW9 [UniParc].

Last modified February 21, 2002. Version 2.
Checksum: F2E2778CFD1E2C36

FASTA46453,543
        10         20         30         40         50         60 
MLYSKENKES YLEPVFGSSA EDRDIPKYTL GKEPLEPRIA YRLVKDELLD EGSARQNLAT 

        70         80         90        100        110        120 
FCQTYMEDEA TKLMSETLEK NAIDKSEYPR TAELENRCVN IIADLWHAPK DQKFMGTSTI 

       130        140        150        160        170        180 
GSSEACMLGG MAMKFAWRKR AEKLGLDIYA KKPNLVISSG YQVCWEKFCV YWDIDMRVVP 

       190        200        210        220        230        240 
MDKEHMQLNT DQVLDYVDEY TIGVVGILGI TYTGRYDDIY ALNEKLEEYN SKTDYKVYIH 

       250        260        270        280        290        300 
VDAASGGFFT PFVEPDIIWD FRLKNVISIN TSGHKYGLVY PGIGWVLWKD ESYLPEELIF 

       310        320        330        340        350        360 
KVSYLGGEMP TMQINFSRSA SHIIGQYYNF LRYGFEGYRT IHQKTSDVAQ YLAHAVEQTG 

       370        380        390        400        410        420 
YFDIFNDGSH LPIVCYKLKD DANVNWTLYD LADRLQMRGW QVPAYPLPKS LENIIIQRYV 

       430        440        450        460 
CRADLGFNMA EEFIQDFQAS IQELNNAHIL FHDTQQSGVH GFTH 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF309077 Genomic DNA. Translation: AAG22562.1.
AF329447 Genomic DNA. Translation: AAK17187.1.
AL591983 Genomic DNA. Translation: CAD00441.1.
PIRAC1370.
RefSeqNP_465886.1. NC_003210.1.

3D structure databases

ProteinModelPortalQ9EYW9.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING169963.lmo2363.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaCAD00441; CAD00441; CAD00441.
GeneID985123.
KEGGlmo:lmo2363.
PATRIC20313958. VBILisMon69206_2421.

Organism-specific databases

GenoListLMO2363.

Phylogenomic databases

eggNOGCOG0076.
HOGENOMHOG000070228.
KOK01580.
OMAIADLWNA.
OrthoDBEOG6TFCPW.
ProtClustDBCLSK876864.

Enzyme and pathway databases

BioCycLMON169963:LMO2363-MONOMER.

Family and domain databases

Gene3D3.40.640.10. 1 hit.
InterProIPR010107. Glutamate_decarboxylase.
IPR002129. PyrdxlP-dep_de-COase.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PANTHERPTHR11999:SF1. PTHR11999:SF1. 1 hit.
PfamPF00282. Pyridoxal_deC. 1 hit.
[Graphical view]
SUPFAMSSF53383. SSF53383. 1 hit.
TIGRFAMsTIGR01788. Glu-decarb-GAD. 1 hit.
ProtoNetSearch...

Entry information

Entry nameDCEB_LISMO
AccessionPrimary (citable) accession number: Q9EYW9
Secondary accession number(s): Q8Y4S0, Q9AGQ0
Entry history
Integrated into UniProtKB/Swiss-Prot: February 21, 2002
Last sequence update: February 21, 2002
Last modified: February 19, 2014
This is version 75 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families