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Q9EYW9

- DCEB_LISMO

UniProt

Q9EYW9 - DCEB_LISMO

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Protein

Glutamate decarboxylase beta

Gene
gadB, lmo2363
Organism
Listeria monocytogenes serovar 1/2a (strain ATCC BAA-679 / EGD-e)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Converts internalized glutamate to GABA and increases the internal pH. Involved in glutamate-dependent acid resistance in gastric fluid.

Catalytic activityi

L-glutamate = 4-aminobutanoate + CO2.

Cofactori

Pyridoxal phosphate By similarity.

GO - Molecular functioni

  1. glutamate decarboxylase activity Source: UniProtKB-EC
  2. pyridoxal phosphate binding Source: InterPro

GO - Biological processi

  1. glutamate metabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Decarboxylase, Lyase

Keywords - Ligandi

Pyridoxal phosphate

Enzyme and pathway databases

BioCyciLMON169963:LMO2363-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Glutamate decarboxylase beta (EC:4.1.1.15)
Short name:
GAD-beta
Gene namesi
Name:gadB
Ordered Locus Names:lmo2363
OrganismiListeria monocytogenes serovar 1/2a (strain ATCC BAA-679 / EGD-e)
Taxonomic identifieri169963 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesListeriaceaeListeria
ProteomesiUP000000817: Chromosome

Organism-specific databases

GenoListiLMO2363.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 464464Glutamate decarboxylase betaPRO_0000146990Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei275 – 2751N6-(pyridoxal phosphate)lysine By similarity

Interactioni

Protein-protein interaction databases

STRINGi169963.lmo2363.

Structurei

3D structure databases

ProteinModelPortaliQ9EYW9.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0076.
HOGENOMiHOG000070228.
KOiK01580.
OMAiPTFQINF.
OrthoDBiEOG6TFCPW.
PhylomeDBiQ9EYW9.

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
InterProiIPR010107. Glutamate_decarboxylase.
IPR002129. PyrdxlP-dep_de-COase.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PANTHERiPTHR11999:SF1. PTHR11999:SF1. 1 hit.
PfamiPF00282. Pyridoxal_deC. 1 hit.
[Graphical view]
SUPFAMiSSF53383. SSF53383. 1 hit.
TIGRFAMsiTIGR01788. Glu-decarb-GAD. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9EYW9-1 [UniParc]FASTAAdd to Basket

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MLYSKENKES YLEPVFGSSA EDRDIPKYTL GKEPLEPRIA YRLVKDELLD    50
EGSARQNLAT FCQTYMEDEA TKLMSETLEK NAIDKSEYPR TAELENRCVN 100
IIADLWHAPK DQKFMGTSTI GSSEACMLGG MAMKFAWRKR AEKLGLDIYA 150
KKPNLVISSG YQVCWEKFCV YWDIDMRVVP MDKEHMQLNT DQVLDYVDEY 200
TIGVVGILGI TYTGRYDDIY ALNEKLEEYN SKTDYKVYIH VDAASGGFFT 250
PFVEPDIIWD FRLKNVISIN TSGHKYGLVY PGIGWVLWKD ESYLPEELIF 300
KVSYLGGEMP TMQINFSRSA SHIIGQYYNF LRYGFEGYRT IHQKTSDVAQ 350
YLAHAVEQTG YFDIFNDGSH LPIVCYKLKD DANVNWTLYD LADRLQMRGW 400
QVPAYPLPKS LENIIIQRYV CRADLGFNMA EEFIQDFQAS IQELNNAHIL 450
FHDTQQSGVH GFTH 464
Length:464
Mass (Da):53,543
Last modified:February 21, 2002 - v2
Checksum:iF2E2778CFD1E2C36
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti92 – 921A → P in strain: LO28.
Natural varianti124 – 1241E → D in strain: LO28.
Natural varianti261 – 2611F → L in strain: EGD5.
Natural varianti375 – 3751C → R in strain: EGD5.
Natural varianti380 – 3812DD → TT in strain: LO28.

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF309077 Genomic DNA. Translation: AAG22562.1.
AF329447 Genomic DNA. Translation: AAK17187.1.
AL591983 Genomic DNA. Translation: CAD00441.1.
PIRiAC1370.
RefSeqiNP_465886.1. NC_003210.1.

Genome annotation databases

EnsemblBacteriaiCAD00441; CAD00441; CAD00441.
GeneIDi985123.
KEGGilmo:lmo2363.
PATRICi20313958. VBILisMon69206_2421.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF309077 Genomic DNA. Translation: AAG22562.1 .
AF329447 Genomic DNA. Translation: AAK17187.1 .
AL591983 Genomic DNA. Translation: CAD00441.1 .
PIRi AC1370.
RefSeqi NP_465886.1. NC_003210.1.

3D structure databases

ProteinModelPortali Q9EYW9.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 169963.lmo2363.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAD00441 ; CAD00441 ; CAD00441 .
GeneIDi 985123.
KEGGi lmo:lmo2363.
PATRICi 20313958. VBILisMon69206_2421.

Organism-specific databases

GenoListi LMO2363.

Phylogenomic databases

eggNOGi COG0076.
HOGENOMi HOG000070228.
KOi K01580.
OMAi PTFQINF.
OrthoDBi EOG6TFCPW.
PhylomeDBi Q9EYW9.

Enzyme and pathway databases

BioCyci LMON169963:LMO2363-MONOMER.

Family and domain databases

Gene3Di 3.40.640.10. 1 hit.
InterProi IPR010107. Glutamate_decarboxylase.
IPR002129. PyrdxlP-dep_de-COase.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view ]
PANTHERi PTHR11999:SF1. PTHR11999:SF1. 1 hit.
Pfami PF00282. Pyridoxal_deC. 1 hit.
[Graphical view ]
SUPFAMi SSF53383. SSF53383. 1 hit.
TIGRFAMsi TIGR01788. Glu-decarb-GAD. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "A glutamate decarboxylase system protects Listeria monocytogenes in gastric fluid."
    Cotter P.D., Gahan C.G.M., Hill C.
    Mol. Microbiol. 40:465-475(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: EGD5 and LO28 / Serovar 1/2c.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC BAA-679 / EGD-e.

Entry informationi

Entry nameiDCEB_LISMO
AccessioniPrimary (citable) accession number: Q9EYW9
Secondary accession number(s): Q8Y4S0, Q9AGQ0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 21, 2002
Last sequence update: February 21, 2002
Last modified: July 9, 2014
This is version 77 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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