Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Glutamate decarboxylase beta

Gene

gadB

Organism
Listeria monocytogenes serovar 1/2a (strain ATCC BAA-679 / EGD-e)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Converts internalized glutamate to GABA and increases the internal pH. Involved in glutamate-dependent acid resistance in gastric fluid.

Catalytic activityi

L-glutamate = 4-aminobutanoate + CO2.

Cofactori

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Decarboxylase, Lyase

Keywords - Ligandi

Pyridoxal phosphate

Enzyme and pathway databases

BioCyciLMON169963:LMO2363-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Glutamate decarboxylase beta (EC:4.1.1.15)
Short name:
GAD-beta
Gene namesi
Name:gadB
Ordered Locus Names:lmo2363
OrganismiListeria monocytogenes serovar 1/2a (strain ATCC BAA-679 / EGD-e)
Taxonomic identifieri169963 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesListeriaceaeListeria
ProteomesiUP000000817 Componenti: Chromosome

Organism-specific databases

GenoListiLMO2363.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 464464Glutamate decarboxylase betaPRO_0000146990Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei275 – 2751N6-(pyridoxal phosphate)lysineBy similarity

Interactioni

Protein-protein interaction databases

STRINGi169963.lmo2363.

Structurei

3D structure databases

ProteinModelPortaliQ9EYW9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the group II decarboxylase family.Curated

Phylogenomic databases

eggNOGiCOG0076.
HOGENOMiHOG000070228.
KOiK01580.
OMAiDPDLVWD.
OrthoDBiEOG6TFCPW.
PhylomeDBiQ9EYW9.

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
InterProiIPR010107. Glutamate_decarboxylase.
IPR002129. PyrdxlP-dep_de-COase.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PANTHERiPTHR11999:SF1. PTHR11999:SF1. 1 hit.
PfamiPF00282. Pyridoxal_deC. 1 hit.
[Graphical view]
SUPFAMiSSF53383. SSF53383. 1 hit.
TIGRFAMsiTIGR01788. Glu-decarb-GAD. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9EYW9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLYSKENKES YLEPVFGSSA EDRDIPKYTL GKEPLEPRIA YRLVKDELLD
60 70 80 90 100
EGSARQNLAT FCQTYMEDEA TKLMSETLEK NAIDKSEYPR TAELENRCVN
110 120 130 140 150
IIADLWHAPK DQKFMGTSTI GSSEACMLGG MAMKFAWRKR AEKLGLDIYA
160 170 180 190 200
KKPNLVISSG YQVCWEKFCV YWDIDMRVVP MDKEHMQLNT DQVLDYVDEY
210 220 230 240 250
TIGVVGILGI TYTGRYDDIY ALNEKLEEYN SKTDYKVYIH VDAASGGFFT
260 270 280 290 300
PFVEPDIIWD FRLKNVISIN TSGHKYGLVY PGIGWVLWKD ESYLPEELIF
310 320 330 340 350
KVSYLGGEMP TMQINFSRSA SHIIGQYYNF LRYGFEGYRT IHQKTSDVAQ
360 370 380 390 400
YLAHAVEQTG YFDIFNDGSH LPIVCYKLKD DANVNWTLYD LADRLQMRGW
410 420 430 440 450
QVPAYPLPKS LENIIIQRYV CRADLGFNMA EEFIQDFQAS IQELNNAHIL
460
FHDTQQSGVH GFTH
Length:464
Mass (Da):53,543
Last modified:February 21, 2002 - v2
Checksum:iF2E2778CFD1E2C36
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti92 – 921A → P in strain: LO28.
Natural varianti124 – 1241E → D in strain: LO28.
Natural varianti261 – 2611F → L in strain: EGD5.
Natural varianti375 – 3751C → R in strain: EGD5.
Natural varianti380 – 3812DD → TT in strain: LO28.

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF309077 Genomic DNA. Translation: AAG22562.1.
AF329447 Genomic DNA. Translation: AAK17187.1.
AL591983 Genomic DNA. Translation: CAD00441.1.
PIRiAC1370.
RefSeqiNP_465886.1. NC_003210.1.
WP_009931286.1. NC_003210.1.

Genome annotation databases

EnsemblBacteriaiCAD00441; CAD00441; CAD00441.
GeneIDi985123.
KEGGilmo:lmo2363.
PATRICi20313958. VBILisMon69206_2421.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF309077 Genomic DNA. Translation: AAG22562.1.
AF329447 Genomic DNA. Translation: AAK17187.1.
AL591983 Genomic DNA. Translation: CAD00441.1.
PIRiAC1370.
RefSeqiNP_465886.1. NC_003210.1.
WP_009931286.1. NC_003210.1.

3D structure databases

ProteinModelPortaliQ9EYW9.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi169963.lmo2363.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAD00441; CAD00441; CAD00441.
GeneIDi985123.
KEGGilmo:lmo2363.
PATRICi20313958. VBILisMon69206_2421.

Organism-specific databases

GenoListiLMO2363.

Phylogenomic databases

eggNOGiCOG0076.
HOGENOMiHOG000070228.
KOiK01580.
OMAiDPDLVWD.
OrthoDBiEOG6TFCPW.
PhylomeDBiQ9EYW9.

Enzyme and pathway databases

BioCyciLMON169963:LMO2363-MONOMER.

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
InterProiIPR010107. Glutamate_decarboxylase.
IPR002129. PyrdxlP-dep_de-COase.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PANTHERiPTHR11999:SF1. PTHR11999:SF1. 1 hit.
PfamiPF00282. Pyridoxal_deC. 1 hit.
[Graphical view]
SUPFAMiSSF53383. SSF53383. 1 hit.
TIGRFAMsiTIGR01788. Glu-decarb-GAD. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "A glutamate decarboxylase system protects Listeria monocytogenes in gastric fluid."
    Cotter P.D., Gahan C.G.M., Hill C.
    Mol. Microbiol. 40:465-475(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: EGD5 and LO28 / Serovar 1/2c.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC BAA-679 / EGD-e.

Entry informationi

Entry nameiDCEB_LISMO
AccessioniPrimary (citable) accession number: Q9EYW9
Secondary accession number(s): Q8Y4S0, Q9AGQ0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 21, 2002
Last sequence update: February 21, 2002
Last modified: May 27, 2015
This is version 82 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.