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Q9EYV3 (PYRF_RHIFH) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 63. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Orotidine 5'-phosphate decarboxylase

EC=4.1.1.23
Alternative name(s):
OMP decarboxylase
Short name=OMPDCase
Short name=OMPdecase
Gene names
Name:pyrF
Ordered Locus Names:SFHH103_03903
OrganismRhizobium fredii (strain HH103) (Sinorhizobium fredii) [Complete proteome] [HAMAP]
Taxonomic identifier1117943 [NCBI]
Taxonomic lineageBacteriaProteobacteriaAlphaproteobacteriaRhizobialesRhizobiaceaeSinorhizobium/Ensifer groupSinorhizobium

Protein attributes

Sequence length234 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP) By similarity. HAMAP-Rule MF_01200

Catalytic activity

Orotidine 5'-phosphate = UMP + CO2. HAMAP-Rule MF_01200

Pathway

Pyrimidine metabolism; UMP biosynthesis via de novo pathway; UMP from orotate: step 2/2. HAMAP-Rule MF_01200

Subunit structure

Homodimer By similarity. HAMAP-Rule MF_01200

Sequence similarities

Belongs to the OMP decarboxylase family. Type 1 subfamily.

Ontologies

Keywords
   Biological processPyrimidine biosynthesis
   Molecular functionDecarboxylase
Lyase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_process'de novo' UMP biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-UniPathway

'de novo' pyrimidine nucleobase biosynthetic process

Inferred from electronic annotation. Source: InterPro

   Molecular_functionorotidine-5'-phosphate decarboxylase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 234234Orotidine 5'-phosphate decarboxylase HAMAP-Rule MF_01200
PRO_0000134567

Regions

Region63 – 7210Substrate binding By similarity

Sites

Active site651Proton donor By similarity
Binding site141Substrate By similarity
Binding site361Substrate By similarity
Binding site1181Substrate By similarity
Binding site1791Substrate By similarity
Binding site1881Substrate By similarity
Binding site2091Substrate By similarity

Sequences

Sequence LengthMass (Da)Tools
Q9EYV3 [UniParc].

Last modified March 1, 2001. Version 1.
Checksum: 4ECA2249DF40F7FB

FASTA23424,468
        10         20         30         40         50         60 
MSTSARDRLI VGLDLPTIAE AERIVSTLGD DVAFYKIGYQ LAFAGGLEFA RDLAASGKKV 

        70         80         90        100        110        120 
FLDMKLLDID NTVAKGVENI VRMGMSMLTL HAYPKAMKAA VDAAKGSDLC LLGVTVLTSM 

       130        140        150        160        170        180 
DAQDVIDAGY GSDPHTLVLR RAEQARAAGM GGIVCSAEEA TAVRRIIGAE MAVVTPGIRP 

       190        200        210        220        230 
TGAEKGDQKR VMTPAEAIRA GSSHLVVARP IVKAADPLSA SRAILAEMEG VLSA 

« Hide

References

« Hide 'large scale' references
[1]"pyrF gene of Sinorhizobium fredii HH103."
Buendia A.M., Ollero F.J., Ruiz-Sainz J.E.
Submitted (OCT-2000) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: HH103.
[2]"Genome sequence of the soybean symbiont Sinorhizobium fredii HH103."
Weidner S., Becker A., Bonilla I., Jaenicke S., Lloret J., Margaret I., Puhler A., Ruiz-Sainz J.E., Schneiker-Bekel S., Szczepanowski R., Vinardell J.M., Zehner S., Gottfert M.
J. Bacteriol. 194:1617-1618(2012) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: HH103.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF311321 Genomic DNA. Translation: AAG42471.1.
HE616890 Genomic DNA. Translation: CCE98394.1.
RefSeqYP_005191219.1. NC_016812.1.

3D structure databases

ProteinModelPortalQ9EYV3.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaCCE98394; CCE98394; SFHH103_03903.
GeneID11815797.
KEGGsfh:SFHH103_03903.

Organism-specific databases

CMRSearch...

Phylogenomic databases

KOK01591.

Enzyme and pathway databases

BioCycSFRE1117943:GJT5-3958-MONOMER.
UniPathwayUPA00070; UER00120.

Family and domain databases

Gene3D3.20.20.70. 1 hit.
HAMAPMF_01200_B. OMPdecase_type1_B.
InterProIPR013785. Aldolase_TIM.
IPR014732. OMPdecase.
IPR018089. OMPdecase_AS.
IPR001754. OMPdeCOase_dom.
IPR011060. RibuloseP-bd_barrel.
[Graphical view]
PfamPF00215. OMPdecase. 1 hit.
[Graphical view]
SMARTSM00934. OMPdecase. 1 hit.
[Graphical view]
SUPFAMSSF51366. SSF51366. 1 hit.
TIGRFAMsTIGR01740. pyrF. 1 hit.
PROSITEPS00156. OMPDECASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry namePYRF_RHIFH
AccessionPrimary (citable) accession number: Q9EYV3
Secondary accession number(s): G9A684
Entry history
Integrated into UniProtKB/Swiss-Prot: January 23, 2002
Last sequence update: March 1, 2001
Last modified: February 19, 2014
This is version 63 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways