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Protein

Orotidine 5'-phosphate decarboxylase

Gene

pyrF

Organism
Rhizobium fredii (strain HH103) (Sinorhizobium fredii)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP).UniRule annotation

Catalytic activityi

Orotidine 5'-phosphate = UMP + CO2.UniRule annotation

Pathwayi: UMP biosynthesis via de novo pathway

This protein is involved in step 2 of the subpathway that synthesizes UMP from orotate.UniRule annotation
Proteins known to be involved in the 2 steps of the subpathway in this organism are:
  1. Orotate phosphoribosyltransferase (pyrE)
  2. Orotidine 5'-phosphate decarboxylase (pyrF)
This subpathway is part of the pathway UMP biosynthesis via de novo pathway, which is itself part of Pyrimidine metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes UMP from orotate, the pathway UMP biosynthesis via de novo pathway and in Pyrimidine metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei14SubstrateUniRule annotation1
Binding sitei36SubstrateUniRule annotation1
Active sitei65Proton donorUniRule annotation1
Binding sitei118SubstrateUniRule annotation1
Binding sitei179SubstrateUniRule annotation1
Binding sitei188SubstrateUniRule annotation1
Binding sitei209SubstrateUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDecarboxylase, Lyase
Biological processPyrimidine biosynthesis

Enzyme and pathway databases

UniPathwayiUPA00070; UER00120

Names & Taxonomyi

Protein namesi
Recommended name:
Orotidine 5'-phosphate decarboxylaseUniRule annotation (EC:4.1.1.23UniRule annotation)
Alternative name(s):
OMP decarboxylaseUniRule annotation
Short name:
OMPDCaseUniRule annotation
Short name:
OMPdecaseUniRule annotation
Gene namesi
Name:pyrFUniRule annotation
Ordered Locus Names:SFHH103_03903
OrganismiRhizobium fredii (strain HH103) (Sinorhizobium fredii)
Taxonomic identifieri1117943 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesRhizobiaceaeSinorhizobium/Ensifer groupSinorhizobium
Proteomesi
  • UP000007735 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001345671 – 234Orotidine 5'-phosphate decarboxylaseAdd BLAST234

Proteomic databases

PRIDEiQ9EYV3

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi1117943.SFHH103_03903

Structurei

3D structure databases

ProteinModelPortaliQ9EYV3
SMRiQ9EYV3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni63 – 72Substrate bindingUniRule annotation10

Sequence similaritiesi

Belongs to the OMP decarboxylase family. Type 1 subfamily.UniRule annotation

Phylogenomic databases

eggNOGiENOG4106EG9 Bacteria
COG0284 LUCA
KOiK01591
OMAiNFKIFLD
OrthoDBiPOG091H0256

Family and domain databases

Gene3Di3.20.20.70, 1 hit
HAMAPiMF_01200_B OMPdecase_type1_B, 1 hit
InterProiView protein in InterPro
IPR013785 Aldolase_TIM
IPR014732 OMPdecase
IPR018089 OMPdecase_AS
IPR001754 OMPdeCOase_dom
IPR011060 RibuloseP-bd_barrel
PANTHERiPTHR32119:SF2 PTHR32119:SF2, 1 hit
PfamiView protein in Pfam
PF00215 OMPdecase, 1 hit
SMARTiView protein in SMART
SM00934 OMPdecase, 1 hit
SUPFAMiSSF51366 SSF51366, 1 hit
TIGRFAMsiTIGR01740 pyrF, 1 hit
PROSITEiView protein in PROSITE
PS00156 OMPDECASE, 1 hit

Sequencei

Sequence statusi: Complete.

Q9EYV3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSTSARDRLI VGLDLPTIAE AERIVSTLGD DVAFYKIGYQ LAFAGGLEFA
60 70 80 90 100
RDLAASGKKV FLDMKLLDID NTVAKGVENI VRMGMSMLTL HAYPKAMKAA
110 120 130 140 150
VDAAKGSDLC LLGVTVLTSM DAQDVIDAGY GSDPHTLVLR RAEQARAAGM
160 170 180 190 200
GGIVCSAEEA TAVRRIIGAE MAVVTPGIRP TGAEKGDQKR VMTPAEAIRA
210 220 230
GSSHLVVARP IVKAADPLSA SRAILAEMEG VLSA
Length:234
Mass (Da):24,468
Last modified:March 1, 2001 - v1
Checksum:i4ECA2249DF40F7FB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF311321 Genomic DNA Translation: AAG42471.1
HE616890 Genomic DNA Translation: CCE98394.1
RefSeqiWP_014330760.1, NC_016812.1

Genome annotation databases

GeneIDi34334571
KEGGisfh:SFHH103_03903
PATRICifig|380.5.peg.4125

Similar proteinsi

Entry informationi

Entry nameiPYRF_RHIFH
AccessioniPrimary (citable) accession number: Q9EYV3
Secondary accession number(s): G9A684
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 23, 2002
Last sequence update: March 1, 2001
Last modified: May 23, 2018
This is version 78 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

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