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Q9EYV3

- PYRF_RHIFH

UniProt

Q9EYV3 - PYRF_RHIFH

Protein

Orotidine 5'-phosphate decarboxylase

Gene

pyrF

Organism
Rhizobium fredii (strain HH103) (Sinorhizobium fredii)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 65 (01 Oct 2014)
      Sequence version 1 (01 Mar 2001)
      Previous versions | rss
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    Functioni

    Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP).UniRule annotation

    Catalytic activityi

    Orotidine 5'-phosphate = UMP + CO2.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei14 – 141SubstrateUniRule annotation
    Binding sitei36 – 361SubstrateUniRule annotation
    Active sitei65 – 651Proton donorUniRule annotation
    Binding sitei118 – 1181SubstrateUniRule annotation
    Binding sitei179 – 1791SubstrateUniRule annotation
    Binding sitei188 – 1881SubstrateUniRule annotation
    Binding sitei209 – 2091SubstrateUniRule annotation

    GO - Molecular functioni

    1. orotidine-5'-phosphate decarboxylase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. 'de novo' pyrimidine nucleobase biosynthetic process Source: InterPro
    2. 'de novo' UMP biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Decarboxylase, Lyase

    Keywords - Biological processi

    Pyrimidine biosynthesis

    Enzyme and pathway databases

    BioCyciSFRE1117943:GJT5-3958-MONOMER.
    UniPathwayiUPA00070; UER00120.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Orotidine 5'-phosphate decarboxylaseUniRule annotation (EC:4.1.1.23UniRule annotation)
    Alternative name(s):
    OMP decarboxylaseUniRule annotation
    Short name:
    OMPDCaseUniRule annotation
    Short name:
    OMPdecaseUniRule annotation
    Gene namesi
    Name:pyrFUniRule annotation
    Ordered Locus Names:SFHH103_03903
    OrganismiRhizobium fredii (strain HH103) (Sinorhizobium fredii)
    Taxonomic identifieri1117943 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesRhizobiaceaeSinorhizobium/Ensifer groupSinorhizobium
    ProteomesiUP000007735: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 234234Orotidine 5'-phosphate decarboxylasePRO_0000134567Add
    BLAST

    Interactioni

    Subunit structurei

    Homodimer.UniRule annotation

    Structurei

    3D structure databases

    ProteinModelPortaliQ9EYV3.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni63 – 7210Substrate bindingUniRule annotation

    Sequence similaritiesi

    Belongs to the OMP decarboxylase family. Type 1 subfamily.UniRule annotation

    Phylogenomic databases

    KOiK01591.

    Family and domain databases

    Gene3Di3.20.20.70. 1 hit.
    HAMAPiMF_01200_B. OMPdecase_type1_B.
    InterProiIPR013785. Aldolase_TIM.
    IPR014732. OMPdecase.
    IPR018089. OMPdecase_AS.
    IPR001754. OMPdeCOase_dom.
    IPR011060. RibuloseP-bd_barrel.
    [Graphical view]
    PfamiPF00215. OMPdecase. 1 hit.
    [Graphical view]
    SMARTiSM00934. OMPdecase. 1 hit.
    [Graphical view]
    SUPFAMiSSF51366. SSF51366. 1 hit.
    TIGRFAMsiTIGR01740. pyrF. 1 hit.
    PROSITEiPS00156. OMPDECASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9EYV3-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSTSARDRLI VGLDLPTIAE AERIVSTLGD DVAFYKIGYQ LAFAGGLEFA    50
    RDLAASGKKV FLDMKLLDID NTVAKGVENI VRMGMSMLTL HAYPKAMKAA 100
    VDAAKGSDLC LLGVTVLTSM DAQDVIDAGY GSDPHTLVLR RAEQARAAGM 150
    GGIVCSAEEA TAVRRIIGAE MAVVTPGIRP TGAEKGDQKR VMTPAEAIRA 200
    GSSHLVVARP IVKAADPLSA SRAILAEMEG VLSA 234
    Length:234
    Mass (Da):24,468
    Last modified:March 1, 2001 - v1
    Checksum:i4ECA2249DF40F7FB
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF311321 Genomic DNA. Translation: AAG42471.1.
    HE616890 Genomic DNA. Translation: CCE98394.1.
    RefSeqiWP_014330760.1. NC_016812.1.
    YP_005191219.1. NC_016812.1.

    Genome annotation databases

    EnsemblBacteriaiCCE98394; CCE98394; SFHH103_03903.
    GeneIDi11815797.
    KEGGisfh:SFHH103_03903.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF311321 Genomic DNA. Translation: AAG42471.1 .
    HE616890 Genomic DNA. Translation: CCE98394.1 .
    RefSeqi WP_014330760.1. NC_016812.1.
    YP_005191219.1. NC_016812.1.

    3D structure databases

    ProteinModelPortali Q9EYV3.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CCE98394 ; CCE98394 ; SFHH103_03903 .
    GeneIDi 11815797.
    KEGGi sfh:SFHH103_03903.

    Phylogenomic databases

    KOi K01591.

    Enzyme and pathway databases

    UniPathwayi UPA00070 ; UER00120 .
    BioCyci SFRE1117943:GJT5-3958-MONOMER.

    Family and domain databases

    Gene3Di 3.20.20.70. 1 hit.
    HAMAPi MF_01200_B. OMPdecase_type1_B.
    InterProi IPR013785. Aldolase_TIM.
    IPR014732. OMPdecase.
    IPR018089. OMPdecase_AS.
    IPR001754. OMPdeCOase_dom.
    IPR011060. RibuloseP-bd_barrel.
    [Graphical view ]
    Pfami PF00215. OMPdecase. 1 hit.
    [Graphical view ]
    SMARTi SM00934. OMPdecase. 1 hit.
    [Graphical view ]
    SUPFAMi SSF51366. SSF51366. 1 hit.
    TIGRFAMsi TIGR01740. pyrF. 1 hit.
    PROSITEi PS00156. OMPDECASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "pyrF gene of Sinorhizobium fredii HH103."
      Buendia A.M., Ollero F.J., Ruiz-Sainz J.E.
      Submitted (OCT-2000) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: HH103.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: HH103.

    Entry informationi

    Entry nameiPYRF_RHIFH
    AccessioniPrimary (citable) accession number: Q9EYV3
    Secondary accession number(s): G9A684
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 23, 2002
    Last sequence update: March 1, 2001
    Last modified: October 1, 2014
    This is version 65 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3