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Q9EYJ6

- MDH_RHIME

UniProt

Q9EYJ6 - MDH_RHIME

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Protein
Malate dehydrogenase
Gene
mdh, R03056, SMc02479
Organism
Rhizobium meliloti (strain 1021) (Ensifer meliloti) (Sinorhizobium meliloti)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

Catalyzes the reversible oxidation of malate to oxaloacetate By similarity.UniRule annotation

Catalytic activityi

(S)-malate + NAD+ = oxaloacetate + NADH.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei34 – 341NAD By similarity
Binding sitei83 – 831Substrate By similarity
Binding sitei89 – 891Substrate By similarity
Binding sitei96 – 961NAD By similarity
Binding sitei121 – 1211Substrate By similarity
Binding sitei152 – 1521Substrate By similarity
Active sitei176 – 1761Proton acceptor By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi10 – 156NAD By similarity
Nucleotide bindingi119 – 1213NAD By similarity

GO - Molecular functioni

  1. L-malate dehydrogenase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. cellular carbohydrate metabolic process Source: InterPro
  2. malate metabolic process Source: InterPro
  3. tricarboxylic acid cycle Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Tricarboxylic acid cycle

Keywords - Ligandi

NAD

Enzyme and pathway databases

BioCyciSMEL266834:GJF6-3133-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Malate dehydrogenase (EC:1.1.1.37)
Gene namesi
Name:mdh
Ordered Locus Names:R03056
ORF Names:SMc02479
OrganismiRhizobium meliloti (strain 1021) (Ensifer meliloti) (Sinorhizobium meliloti)
Taxonomic identifieri266834 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesRhizobiaceaeSinorhizobium/Ensifer groupSinorhizobium
ProteomesiUP000001976: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 320320Malate dehydrogenaseUniRule annotation
PRO_0000113463Add
BLAST

Proteomic databases

ProMEXiQ9EYJ6.

Interactioni

Protein-protein interaction databases

STRINGi266834.SMc02479.

Structurei

3D structure databases

ProteinModelPortaliQ9EYJ6.
SMRiQ9EYJ6. Positions 1-311.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0039.
HOGENOMiHOG000213794.
KOiK00024.
OMAiYAPSAFV.
OrthoDBiEOG6091FG.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
3.90.110.10. 1 hit.
HAMAPiMF_00487. Malate_dehydrog_3.
InterProiIPR001557. L-lactate/malate_DH.
IPR022383. Lactate/malate_DH_C.
IPR001236. Lactate/malate_DH_N.
IPR015955. Lactate_DH/Glyco_Ohase_4_C.
IPR011275. Malate_DH_type3.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PANTHERiPTHR11540. PTHR11540. 1 hit.
PfamiPF02866. Ldh_1_C. 1 hit.
PF00056. Ldh_1_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000102. Lac_mal_DH. 1 hit.
PRINTSiPR00086. LLDHDRGNASE.
SUPFAMiSSF56327. SSF56327. 1 hit.
TIGRFAMsiTIGR01763. MalateDH_bact. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9EYJ6-1 [UniParc]FASTAAdd to Basket

« Hide

MARNKIALIG SGMIGGTLAH LAGLKELGDI VLFDIADGIP QGKGLDIAQS    50
SPVEGFDASL TGASDYSAIE GADVCIVTAG VPRKPGMSRD DLLGINLKVM 100
EQVGAGIKKY APNAFVICIT NPLDAMVWAL QKFSGLPKNK VVGMAGVLDS 150
SRFRLFLAEE FNVSVKDITA FVLGGHGDTM VPLARYSTVA GIPLPDLIQM 200
GWTTKEKLDQ IIQRTRDGGA EIVGLLKTGS AYYAPAASAI EMAEAYLKDK 250
KRVLPCAAHL SGQYGVKDMY VGVPTVIGAG GIERIIEIDL NKGEKEAFDK 300
SVAAVAGLCE ACINIAPSLK 320
Length:320
Mass (Da):33,611
Last modified:March 1, 2001 - v1
Checksum:i3CF1514C7211F9FA
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF322647 Genomic DNA. Translation: AAG41996.1.
AL591688 Genomic DNA. Translation: CAC47635.1.
RefSeqiNP_387162.1. NC_003047.1.
WP_003530257.1. NC_003047.1.

Genome annotation databases

EnsemblBacteriaiCAC47635; CAC47635; SMc02479.
GeneIDi1234740.
KEGGisme:SMc02479.
PATRICi23635734. VBISinMel96828_4590.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF322647 Genomic DNA. Translation: AAG41996.1 .
AL591688 Genomic DNA. Translation: CAC47635.1 .
RefSeqi NP_387162.1. NC_003047.1.
WP_003530257.1. NC_003047.1.

3D structure databases

ProteinModelPortali Q9EYJ6.
SMRi Q9EYJ6. Positions 1-311.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 266834.SMc02479.

Proteomic databases

ProMEXi Q9EYJ6.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAC47635 ; CAC47635 ; SMc02479 .
GeneIDi 1234740.
KEGGi sme:SMc02479.
PATRICi 23635734. VBISinMel96828_4590.

Phylogenomic databases

eggNOGi COG0039.
HOGENOMi HOG000213794.
KOi K00024.
OMAi YAPSAFV.
OrthoDBi EOG6091FG.

Enzyme and pathway databases

BioCyci SMEL266834:GJF6-3133-MONOMER.

Family and domain databases

Gene3Di 3.40.50.720. 1 hit.
3.90.110.10. 1 hit.
HAMAPi MF_00487. Malate_dehydrog_3.
InterProi IPR001557. L-lactate/malate_DH.
IPR022383. Lactate/malate_DH_C.
IPR001236. Lactate/malate_DH_N.
IPR015955. Lactate_DH/Glyco_Ohase_4_C.
IPR011275. Malate_DH_type3.
IPR016040. NAD(P)-bd_dom.
[Graphical view ]
PANTHERi PTHR11540. PTHR11540. 1 hit.
Pfami PF02866. Ldh_1_C. 1 hit.
PF00056. Ldh_1_N. 1 hit.
[Graphical view ]
PIRSFi PIRSF000102. Lac_mal_DH. 1 hit.
PRINTSi PR00086. LLDHDRGNASE.
SUPFAMi SSF56327. SSF56327. 1 hit.
TIGRFAMsi TIGR01763. MalateDH_bact. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Isolation of a malate dehydrogenase mutant and genes encoding a putative TCA cycle operon of Sinorhizobium meliloti."
    Dymov S.I., Meek D.J., Driscoll B.T.
    Submitted (NOV-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 1021.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 1021.

Entry informationi

Entry nameiMDH_RHIME
AccessioniPrimary (citable) accession number: Q9EYJ6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 1, 2001
Last sequence update: March 1, 2001
Last modified: September 3, 2014
This is version 99 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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