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Protein

Malate dehydrogenase

Gene

mdh

Organism
Rhizobium meliloti (strain 1021) (Ensifer meliloti) (Sinorhizobium meliloti)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the reversible oxidation of malate to oxaloacetate.

Catalytic activityi

(S)-malate + NAD+ = oxaloacetate + NADH.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei34NAD1
Binding sitei83Substrate1
Binding sitei89Substrate1
Binding sitei96NAD1
Binding sitei121Substrate1
Binding sitei152Substrate1
Active sitei176Proton acceptor1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi10 – 15NAD6
Nucleotide bindingi119 – 121NAD3

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
Biological processTricarboxylic acid cycle
LigandNAD

Names & Taxonomyi

Protein namesi
Recommended name:
Malate dehydrogenase (EC:1.1.1.37)
Gene namesi
Name:mdh
Ordered Locus Names:R03056
ORF Names:SMc02479
OrganismiRhizobium meliloti (strain 1021) (Ensifer meliloti) (Sinorhizobium meliloti)
Taxonomic identifieri266834 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesRhizobiaceaeSinorhizobium/Ensifer groupSinorhizobium
Proteomesi
  • UP000001976 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001134631 – 320Malate dehydrogenaseAdd BLAST320

Interactioni

Protein-protein interaction databases

STRINGi266834.SMc02479.

Structurei

3D structure databases

ProteinModelPortaliQ9EYJ6.
SMRiQ9EYJ6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the LDH/MDH superfamily. MDH type 3 family.

Phylogenomic databases

eggNOGiENOG4105C80. Bacteria.
COG0039. LUCA.
HOGENOMiHOG000213794.
KOiK00024.
OMAiMDLMQTA.

Family and domain databases

CDDicd01339. LDH-like_MDH. 1 hit.
Gene3Di3.90.110.10. 1 hit.
HAMAPiMF_00487. Malate_dehydrog_3. 1 hit.
InterProiView protein in InterPro
IPR001557. L-lactate/malate_DH.
IPR022383. Lactate/malate_DH_C.
IPR001236. Lactate/malate_DH_N.
IPR015955. Lactate_DH/Glyco_Ohase_4_C.
IPR011275. Malate_DH_type3.
IPR036291. NAD(P)-bd_dom_sf.
PfamiView protein in Pfam
PF02866. Ldh_1_C. 1 hit.
PF00056. Ldh_1_N. 1 hit.
PIRSFiPIRSF000102. Lac_mal_DH. 1 hit.
PRINTSiPR00086. LLDHDRGNASE.
SUPFAMiSSF51735. SSF51735. 1 hit.
SSF56327. SSF56327. 1 hit.
TIGRFAMsiTIGR01763. MalateDH_bact. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9EYJ6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MARNKIALIG SGMIGGTLAH LAGLKELGDI VLFDIADGIP QGKGLDIAQS
60 70 80 90 100
SPVEGFDASL TGASDYSAIE GADVCIVTAG VPRKPGMSRD DLLGINLKVM
110 120 130 140 150
EQVGAGIKKY APNAFVICIT NPLDAMVWAL QKFSGLPKNK VVGMAGVLDS
160 170 180 190 200
SRFRLFLAEE FNVSVKDITA FVLGGHGDTM VPLARYSTVA GIPLPDLIQM
210 220 230 240 250
GWTTKEKLDQ IIQRTRDGGA EIVGLLKTGS AYYAPAASAI EMAEAYLKDK
260 270 280 290 300
KRVLPCAAHL SGQYGVKDMY VGVPTVIGAG GIERIIEIDL NKGEKEAFDK
310 320
SVAAVAGLCE ACINIAPSLK
Length:320
Mass (Da):33,611
Last modified:March 1, 2001 - v1
Checksum:i3CF1514C7211F9FA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF322647 Genomic DNA. Translation: AAG41996.1.
AL591688 Genomic DNA. Translation: CAC47635.1.
RefSeqiNP_387162.1. NC_003047.1.
WP_003530257.1. NC_003047.1.

Genome annotation databases

EnsemblBacteriaiCAC47635; CAC47635; SMc02479.
GeneIDi1234740.
KEGGisme:SMc02479.
PATRICifig|266834.11.peg.4590.

Similar proteinsi

Entry informationi

Entry nameiMDH_RHIME
AccessioniPrimary (citable) accession number: Q9EYJ6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 1, 2001
Last sequence update: March 1, 2001
Last modified: October 25, 2017
This is version 120 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families