Q9EYG9 (SUCC_RHIME) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Succinyl-CoA ligase [ADP-forming] subunit beta
EC=6.2.1.5

Alternative name(s):
Succinyl-CoA synthetase subunit beta
Short name=SCS-beta

Gene names

Name:	sucC
Ordered Locus Names:	R03055
ORF Names:	SMc02480

Organism

Rhizobium meliloti (strain 1021) (Ensifer meliloti) (Sinorhizobium meliloti) [Complete proteome] [HAMAP]

Taxonomic identifier

266834 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Proteobacteria › Alphaproteobacteria › Rhizobiales › Rhizobiaceae › Sinorhizobium/Ensifer group › Sinorhizobium › Rhizobium meliloti

Protein attributes

Sequence length	398 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	ATP + succinate + CoA = ADP + phosphate + succinyl-CoA. HAMAP-Rule MF_00558
Cofactor	Binds 1 magnesium or manganese ion per subunit By similarity.
Pathway	Carbohydrate metabolism; tricarboxylic acid cycle; succinate from succinyl-CoA (ligase route): step 1/1. HAMAP-Rule MF_00558
Subunit structure	Heterotetramer of two alpha and two beta subunits By similarity.
Sequence similarities	Belongs to the succinate/malate CoA ligase beta subunit family. Contains 1 ATP-grasp domain.

Ontologies

Keywords
Biological process	Tricarboxylic acid cycle
Ligand	ATP-binding Magnesium Manganese Metal-binding Nucleotide-binding
Molecular function	Ligase
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	tricarboxylic acid cycle Inferred from electronic annotation. Source: HAMAP
Molecular_function	ATP binding Inferred from electronic annotation. Source: HAMAP magnesium ion binding Inferred from electronic annotation. Source: HAMAP manganese ion binding Inferred from electronic annotation. Source: HAMAP succinate-CoA ligase (ADP-forming) activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 398	398	Succinyl-CoA ligase [ADP-forming] subunit beta HAMAP-Rule MF_00558		PRO_0000102847
Regions
	Domain	9 – 254	246	ATP-grasp
	Nucleotide binding	35 – 118	84	ATP By similarity
Sites
	Metal binding	207	1	Magnesium or manganese By similarity
	Metal binding	209	1	Magnesium or manganese By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q9EYG9 [UniParc]. Last modified March 1, 2001. Version 1. Checksum: AAD705185C1D5A9E	FASTA	398	42,135
	10 20 30 40 50 60 MNIHEYQAKA LLKSYGAPVA EGVAIFSADE AEAAAKKLPG PLYVVKSQIH AGGRGKGKFK 70 80 90 100 110 120 ELGPDAKGGV RLAKSVDEVV ANAKDMLGNT LVTKQTGPAG KQVNRLYIED GADIDRELYL 130 140 150 160 170 180 SILVDRSVGQ VAFVVSTEGG MDIEAVAEHT PEKIVTVAID PEKGVTAENL KTLADALKLE 190 200 210 220 230 240 GEARADAEKL FPILYKAFVE KDMSLLEVNP LIVMTNGRMR VLDAKVSFDG NALFRHEDVV 250 260 270 280 290 300 ALRDTTEEDD KEIEASKYDL AYVALDGNIG CMVNGAGLAM ATMDIIKLYG AEPANFLDVG 310 320 330 340 350 360 GGASKEKVTQ AFKIITADPA VKGILVNIFG GIMKCDVIAE GVLAAVKEVG LKVPLVVRLE 370 380 390 GTNVELGKKI INESGLNVIS ADDLDDAAQK IVAAVKGA

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Isolation of a malate dehydrogenase mutant and genes encoding a putative TCA cycle operon of Sinorhizobium meliloti." Dymov S.I., Meek D.J., Driscoll B.T. Submitted (DEC-2000) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]	"Analysis of the chromosome sequence of the legume symbiont Sinorhizobium meliloti strain 1021." Capela D., Barloy-Hubler F., Gouzy J., Bothe G., Ampe F., Batut J., Boistard P., Becker A., Boutry M., Cadieu E., Dreano S., Gloux S., Godrie T., Goffeau A., Kahn D., Kiss E., Lelaure V., Masuy D. , Pohl T., Portetelle D., Puehler A., Purnelle B., Ramsperger U., Renard C., Thebault P., Vandenbol M., Weidner S., Galibert F. Proc. Natl. Acad. Sci. U.S.A. 98:9877-9882(2001) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: 1021.
[3]	"The composite genome of the legume symbiont Sinorhizobium meliloti." Galibert F., Finan T.M., Long S.R., Puehler A., Abola P., Ampe F., Barloy-Hubler F., Barnett M.J., Becker A., Boistard P., Bothe G., Boutry M., Bowser L., Buhrmester J., Cadieu E., Capela D., Chain P., Cowie A. , Davis R.W., Dreano S., Federspiel N.A., Fisher R.F., Gloux S., Godrie T., Goffeau A., Golding B., Gouzy J., Gurjal M., Hernandez-Lucas I., Hong A., Huizar L., Hyman R.W., Jones T., Kahn D., Kahn M.L., Kalman S., Keating D.H., Kiss E., Komp C., Lelaure V., Masuy D., Palm C., Peck M.C., Pohl T.M., Portetelle D., Purnelle B., Ramsperger U., Surzycki R., Thebault P., Vandenbol M., Vorhoelter F.J., Weidner S., Wells D.H., Wong K., Yeh K.-C., Batut J. Science 293:668-672(2001) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: 1021.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF326913 Genomic DNA. Translation: AAG42005.1. AL591688 Genomic DNA. Translation: CAC47634.1.
RefSeq	NP_387161.1. NC_003047.1.
3D structure databases
ProteinModelPortal	Q9EYG9.
SMR	Q9EYG9. Positions 1-395.
ModBase	Search...
Protein-protein interaction databases
STRING	266834.SMc02480.
Proteomic databases
PRIDE	Q9EYG9.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	CAC47634; CAC47634; SMc02480.
GeneID	1234739.
KEGG	sme:SMc02480.
PATRIC	23635732. VBISinMel96828_4589.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0045.
HOGENOM	HOG000007059.
KO	K01903.
OMA	QPVTKIL.
ProtClustDB	PRK00696.
Enzyme and pathway databases
BioCyc	SMEL266834:GJF6-3132-MONOMER.
UniPathway	UPA00223; UER00999.
Family and domain databases
Gene3D	3.30.1490.20. 1 hit. 3.30.470.20. 1 hit. 3.40.50.261. 1 hit.
HAMAP	MF_00558. Succ_CoA_beta.
InterPro	IPR011761. ATP-grasp. IPR013650. ATP-grasp_succ-CoA_synth-type. IPR013815. ATP_grasp_subdomain_1. IPR013816. ATP_grasp_subdomain_2. IPR005811. CoA_ligase. IPR017866. Succ-CoA_synthase_bsu_CS. IPR005809. Succ_CoA_synthase_bsu. IPR016102. Succinyl-CoA_synth-like. [Graphical view]
PANTHER	PTHR11815. PTHR11815. 1 hit.
Pfam	PF08442. ATP-grasp_2. 1 hit. PF00549. Ligase_CoA. 1 hit. [Graphical view]
PIRSF	PIRSF001554. SucCS_beta. 1 hit.
SUPFAM	SSF52210. CoA_ligase. 1 hit.
TIGRFAMs	TIGR01016. sucCoAbeta. 1 hit.
PROSITE	PS50975. ATP_GRASP. 1 hit. PS01217. SUCCINYL_COA_LIG_3. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

SUCC_RHIME

Accession

Primary (citable) accession number: Q9EYG9

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 27, 2002
Last sequence update:	March 1, 2001
Last modified:	May 1, 2013
This is version 85 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program