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Q9EY50 (Q9EY50_WEIVI) Unreviewed, UniProtKB/TrEMBL

Last modified July 9, 2014. Version 51. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein names
Gene names
Name:femX EMBL AAG21689.1
OrganismWeissella viridescens (Lactobacillus viridescens) EMBL AAG21689.1
Taxonomic identifier1629 [NCBI]
Taxonomic lineageBacteriaFirmicutesBacilliLactobacillalesLeuconostocaceaeWeissella

Protein attributes

Sequence length336 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Sites

Active site1091Proton donor/acceptor PDB 1P4N
Active site3201Proton donor/acceptor PDB 1P4N
Site371Important for catalytic activity PDB 1P4N
Site2121Important for catalytic activity PDB 1P4N

Sequences

Sequence LengthMass (Da)Tools
Q9EY50 [UniParc].

Last modified March 1, 2001. Version 1.
Checksum: AFB94A2718148C3C

FASTA33638,284
        10         20         30         40         50         60 
MPVLNLNDPQ AVERYEEFMR QSPYGQVTQD LGWAKVKNNW EPVDVYLEDD QGAIIAAMSM 

        70         80         90        100        110        120 
LLGDTPTDKK FAYASKGPVM DVTDVDLLDR LVDEAVKALD GRAYVLRFDP EVAYSDEFNT 

       130        140        150        160        170        180 
TLQDHGYVTR NRNVADAGMH ATIQPRLNMV LDLTKFPDAK TTLDLYPSKT KSKIKRPFRD 

       190        200        210        220        230        240 
GVEVHSGNSA TELDEFFKTY TTMAERHGIT HRPIEYFQRM QAAFDADTMR IFVAEREGKL 

       250        260        270        280        290        300 
LSTGIALKYG RKIWYMYAGS MDGNTYYAPY AVQSEMIQWA LDTNTDLYDL GGIESESTDD 

       310        320        330 
SLYVFKHVFV KDAPREYIGE IDKVLDPEVY AELVKD 

« Hide

References

[1]"FemABX family members are novel nonribosomal peptidyltransferases and important pathogen-specific drug targets."
Hegde S.S., Shrader T.E.
J. Biol. Chem. 276:6998-7003(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE.
[2]"Crystal structures of Weissella viridescens FemX and its complex with UDP-MurNAc-pentapeptide: insights into FemABX family substrates recognition."
Biarrotte-Sorin S., Maillard A.P., Delettre J., Sougakoff W., Arthur M., Mayer C.
Structure 12:257-267(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (1.70 ANGSTROMS) OF 2-336, ACTIVE SITE.
[3]"Structure-based site-directed mutagenesis of the UDP-MurNAc-pentapeptide-binding cavity of the FemX alanyl transferase from Weissella viridescens."
Maillard A.P., Biarrotte-Sorin S., Villet R., Mesnage S., Bouhss A., Sougakoff W., Mayer C., Arthur M.
J. Bacteriol. 187:3833-3838(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (1.90 ANGSTROMS) OF 2-336.
[4]"Structure of Weissella viridescens FemX with the UDP-MurNAc-hexapeptide product of the alanine transfer reaction."
Delfosse V., Piton J., Villet R., Lecerf M., Arthur M., Mayer C.
Submitted (MAR-2009) to the PDB data bank
Cited for: X-RAY CRYSTALLOGRAPHY (1.60 ANGSTROMS).
[5]"The structure of FemX(Wv) in complex with a peptidyl-RNA conjugate: mechanism of aminoacyl transfer from Ala-tRNA(Ala) to peptidoglycan precursors."
Fonvielle M., Li de La Sierra-Gallay I., El-Sagheer A.H., Lecerf M., Patin D., Mellal D., Mayer C., Blanot D., Gale N., Brown T., van Tilbeurgh H., Etheve-Quelquejeu M., Arthur M.
Angew. Chem. Int. Ed. 52:7278-7281(2013) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (1.66 ANGSTROMS).

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AY008262 Genomic DNA. Translation: AAG21689.1.

3D structure databases

PDBe
RCSB-PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
1NE9X-ray1.70A2-336[»]
1P4NX-ray1.90A2-336[»]
1XE4X-ray1.95A2-336[»]
1XF8X-ray1.90A2-336[»]
1XIXX-ray2.00A2-336[»]
3GKRX-ray1.60A1-336[»]
4II9X-ray1.66A1-336[»]
ProteinModelPortalQ9EY50.
SMRQ9EY50. Positions 2-336.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Enzyme and pathway databases

BioCycMetaCyc:MONOMER-15493.
SABIO-RKQ9EY50.

Family and domain databases

Gene3D3.40.630.30. 2 hits.
InterProIPR016181. Acyl_CoA_acyltransferase.
IPR003447. Methicillin-R.
[Graphical view]
PfamPF02388. FemAB. 2 hits.
[Graphical view]
SUPFAMSSF55729. SSF55729. 2 hits.
PROSITEPS51191. FEMABX. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

EvolutionaryTraceQ9EY50.

Entry information

Entry nameQ9EY50_WEIVI
AccessionPrimary (citable) accession number: Q9EY50
Entry history
Integrated into UniProtKB/TrEMBL: March 1, 2001
Last sequence update: March 1, 2001
Last modified: July 9, 2014
This is version 51 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)