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Q9EY50

- Q9EY50_WEIVI

UniProt

Q9EY50 - Q9EY50_WEIVI

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Protein
Submitted name: FemX
Gene
femX
Organism
Weissella viridescens (Lactobacillus viridescens)
Status
Unreviewed - Annotation score: 2 out of 5 - Experimental evidence at protein leveli

Functioni

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei37 – 371Important for catalytic activityImported
Active sitei109 – 1091Proton donor/acceptorImported
Sitei212 – 2121Important for catalytic activityImported
Active sitei320 – 3201Proton donor/acceptorImported

GO - Molecular functioni

  1. transferase activity, transferring amino-acyl groups Source: InterPro
Complete GO annotation...

Enzyme and pathway databases

BioCyciMetaCyc:MONOMER-15493.
SABIO-RKQ9EY50.

Names & Taxonomyi

Protein namesi
Submitted name:
FemXImported
Gene namesi
Name:femXImported
OrganismiWeissella viridescens (Lactobacillus viridescens)Imported
Taxonomic identifieri1629 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesLeuconostocaceaeWeissella

Structurei

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1NE9X-ray1.70A2-336[»]
1P4NX-ray1.90A2-336[»]
1XE4X-ray1.95A2-336[»]
1XF8X-ray1.90A2-336[»]
1XIXX-ray2.00A2-336[»]
3GKRX-ray1.60A1-336[»]
4II9X-ray1.66A1-336[»]
ProteinModelPortaliQ9EY50.
SMRiQ9EY50. Positions 2-336.

Miscellaneous databases

EvolutionaryTraceiQ9EY50.

Family & Domainsi

Family and domain databases

Gene3Di3.40.630.30. 2 hits.
InterProiIPR016181. Acyl_CoA_acyltransferase.
IPR003447. FEMABX.
[Graphical view]
PfamiPF02388. FemAB. 2 hits.
[Graphical view]
SUPFAMiSSF55729. SSF55729. 2 hits.
PROSITEiPS51191. FEMABX. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9EY50-1 [UniParc]FASTAAdd to Basket

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MPVLNLNDPQ AVERYEEFMR QSPYGQVTQD LGWAKVKNNW EPVDVYLEDD    50
QGAIIAAMSM LLGDTPTDKK FAYASKGPVM DVTDVDLLDR LVDEAVKALD 100
GRAYVLRFDP EVAYSDEFNT TLQDHGYVTR NRNVADAGMH ATIQPRLNMV 150
LDLTKFPDAK TTLDLYPSKT KSKIKRPFRD GVEVHSGNSA TELDEFFKTY 200
TTMAERHGIT HRPIEYFQRM QAAFDADTMR IFVAEREGKL LSTGIALKYG 250
RKIWYMYAGS MDGNTYYAPY AVQSEMIQWA LDTNTDLYDL GGIESESTDD 300
SLYVFKHVFV KDAPREYIGE IDKVLDPEVY AELVKD 336
Length:336
Mass (Da):38,284
Last modified:March 1, 2001 - v1
Checksum:iAFB94A2718148C3C
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY008262 Genomic DNA. Translation: AAG21689.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY008262 Genomic DNA. Translation: AAG21689.1 .

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1NE9 X-ray 1.70 A 2-336 [» ]
1P4N X-ray 1.90 A 2-336 [» ]
1XE4 X-ray 1.95 A 2-336 [» ]
1XF8 X-ray 1.90 A 2-336 [» ]
1XIX X-ray 2.00 A 2-336 [» ]
3GKR X-ray 1.60 A 1-336 [» ]
4II9 X-ray 1.66 A 1-336 [» ]
ProteinModelPortali Q9EY50.
SMRi Q9EY50. Positions 2-336.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Enzyme and pathway databases

BioCyci MetaCyc:MONOMER-15493.
SABIO-RK Q9EY50.

Miscellaneous databases

EvolutionaryTracei Q9EY50.

Family and domain databases

Gene3Di 3.40.630.30. 2 hits.
InterProi IPR016181. Acyl_CoA_acyltransferase.
IPR003447. FEMABX.
[Graphical view ]
Pfami PF02388. FemAB. 2 hits.
[Graphical view ]
SUPFAMi SSF55729. SSF55729. 2 hits.
PROSITEi PS51191. FEMABX. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "FemABX family members are novel nonribosomal peptidyltransferases and important pathogen-specific drug targets."
    Hegde S.S., Shrader T.E.
    J. Biol. Chem. 276:6998-7003(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
  2. "Crystal structures of Weissella viridescens FemX and its complex with UDP-MurNAc-pentapeptide: insights into FemABX family substrates recognition."
    Biarrotte-Sorin S., Maillard A.P., Delettre J., Sougakoff W., Arthur M., Mayer C.
    Structure 12:257-267(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (1.70 ANGSTROMS) OF 2-336, ACTIVE SITE.
  3. "Structure-based site-directed mutagenesis of the UDP-MurNAc-pentapeptide-binding cavity of the FemX alanyl transferase from Weissella viridescens."
    Maillard A.P., Biarrotte-Sorin S., Villet R., Mesnage S., Bouhss A., Sougakoff W., Mayer C., Arthur M.
    J. Bacteriol. 187:3833-3838(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (1.90 ANGSTROMS) OF 2-336.
  4. "Structure of Weissella viridescens FemX with the UDP-MurNAc-hexapeptide product of the alanine transfer reaction."
    Delfosse V., Piton J., Villet R., Lecerf M., Arthur M., Mayer C.
    Submitted (MAR-2009) to the PDB data bank
    Cited for: X-RAY CRYSTALLOGRAPHY (1.60 ANGSTROMS).
  5. "The structure of FemX(Wv) in complex with a peptidyl-RNA conjugate: mechanism of aminoacyl transfer from Ala-tRNA(Ala) to peptidoglycan precursors."
    Fonvielle M., Li de La Sierra-Gallay I., El-Sagheer A.H., Lecerf M., Patin D., Mellal D., Mayer C., Blanot D., Gale N., Brown T., van Tilbeurgh H., Etheve-Quelquejeu M., Arthur M.
    Angew. Chem. Int. Ed. 52:7278-7281(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (1.66 ANGSTROMS).

Entry informationi

Entry nameiQ9EY50_WEIVI
AccessioniPrimary (citable) accession number: Q9EY50
Entry historyi
Integrated into UniProtKB/TrEMBL: March 1, 2001
Last sequence update: March 1, 2001
Last modified: September 3, 2014
This is version 52 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureImported

External Data

Dasty 3

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