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Q9EXQ1 (FNR_AGGAC) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 68. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Anaerobic regulatory protein
Gene names
Name:fnr
Synonyms:actX
OrganismAggregatibacter actinomycetemcomitans (Actinobacillus actinomycetemcomitans) (Haemophilus actinomycetemcomitans)
Taxonomic identifier714 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaPasteurellalesPasteurellaceaeAggregatibacter

Protein attributes

Sequence length257 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

It is involved in the activation of genes necessary for anaerobic respiration. It probably also activates genes involved in the production of virulence factors.

Cofactor

Binds 1 4Fe-4S cluster per subunit By similarity.

Subunit structure

Homodimer By similarity.

Induction

By anaerobiosis.

Sequence similarities

Contains 1 cyclic nucleotide-binding domain.

Contains 1 HTH crp-type DNA-binding domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 257257Anaerobic regulatory protein
PRO_0000100172

Regions

Domain167 – 24074HTH crp-type
DNA binding200 – 21920H-T-H motif By similarity
Region23 – 3210Essential for the oxygen-regulated activity By similarity

Sites

Metal binding231Iron-sulfur (4Fe-4S) Potential
Metal binding261Iron-sulfur (4Fe-4S) Potential
Metal binding321Iron-sulfur (4Fe-4S) Potential
Metal binding1251Iron-sulfur (4Fe-4S) Potential

Experimental info

Sequence conflict1891F → S in BAA11315. Ref.2

Sequences

Sequence LengthMass (Da)Tools
Q9EXQ1 [UniParc].

Last modified March 1, 2001. Version 1.
Checksum: A4D82081369BD042

FASTA25728,929
        10         20         30         40         50         60 
MKILATETKL GRRVQSGGCA IHCQNCSISQ LCIPFTLNQH ELDQLDNIIE RKKPIQKSQV 

        70         80         90        100        110        120 
LFKAGDELTS LYAIRSGTIK SYTISETGEE QITSFHLPGD LVGFDAIMNM QHPSFAQALE 

       130        140        150        160        170        180 
TAMVCEIPFD ILDDLSGKMP KLRQQIMRLM SNEIKSDQEM ILLLSKMNAE ERLAAFIYNL 

       190        200        210        220        230        240 
SQRYSARGFS AREFRLTMTR GDIGNYLGLT VETISRLLGR FQKLGVLSVQ GKYITINNMA 

       250 
ELIELSGTNK NKIQLII 

« Hide

References

[1]"Molecular characterization of the hlyX-like gene of Actinobacillus actinomycetemcomitans Y4."
Kokeguchi S., Hirosue M., Maeda H., Miyamoto M., Takashiba S., Murayama Y.
Res. Microbiol. 151:721-725(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: ATCC 43718 / FDC Y4 / Serotype b.
[2]"Novel FNR homologues identified in four representative oral facultative anaerobes: Capnocytophaga ochracea, Capnocytophaga sputigena, Haemophilus aphrophilus, and Actinobacillus actinomycetemcomitans."
Hattori T., Takahashi K., Nakanishi T., Ohta H., Fukui K., Taniguchi S., Takigawa M.
FEMS Microbiol. Lett. 137:213-220(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 125-216.
Strain: 301-b / Serotype a.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
D89096 Genomic DNA. Translation: BAB19627.1.
D78251 Genomic DNA. Translation: BAA11315.1.

3D structure databases

ProteinModelPortalQ9EXQ1.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Family and domain databases

Gene3D1.10.10.10. 1 hit.
2.60.120.10. 1 hit.
InterProIPR018490. cNMP-bd-like.
IPR000595. cNMP-bd_dom.
IPR012318. HTH_CRP_2.
IPR014710. RmlC-like_jellyroll.
IPR001808. Tscrpt_reg_HTH_Crp.
IPR018335. Tscrpt_reg_HTH_Crp-type_CS.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamPF00027. cNMP_binding. 1 hit.
PF00325. Crp. 1 hit.
[Graphical view]
PRINTSPR00034. HTHCRP.
SMARTSM00100. cNMP. 1 hit.
SM00419. HTH_CRP. 1 hit.
[Graphical view]
SUPFAMSSF51206. SSF51206. 1 hit.
PROSITEPS50042. CNMP_BINDING_3. 1 hit.
PS00042. HTH_CRP_1. 1 hit.
PS51063. HTH_CRP_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameFNR_AGGAC
AccessionPrimary (citable) accession number: Q9EXQ1
Secondary accession number(s): Q46157
Entry history
Integrated into UniProtKB/Swiss-Prot: August 30, 2002
Last sequence update: March 1, 2001
Last modified: February 19, 2014
This is version 68 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families