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Q9EXQ1

- FNR_AGGAC

UniProt

Q9EXQ1 - FNR_AGGAC

Protein

Anaerobic regulatory protein

Gene

fnr

Organism
Aggregatibacter actinomycetemcomitans (Actinobacillus actinomycetemcomitans) (Haemophilus actinomycetemcomitans)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 70 (01 Oct 2014)
      Sequence version 1 (01 Mar 2001)
      Previous versions | rss
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    Functioni

    It is involved in the activation of genes necessary for anaerobic respiration. It probably also activates genes involved in the production of virulence factors.

    Cofactori

    Binds 1 4Fe-4S cluster per subunit.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi23 – 231Iron-sulfur (4Fe-4S)Sequence Analysis
    Metal bindingi26 – 261Iron-sulfur (4Fe-4S)Sequence Analysis
    Metal bindingi32 – 321Iron-sulfur (4Fe-4S)Sequence Analysis
    Metal bindingi125 – 1251Iron-sulfur (4Fe-4S)Sequence Analysis

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    DNA bindingi200 – 21920H-T-H motifPROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. 4 iron, 4 sulfur cluster binding Source: UniProtKB-KW
    2. DNA binding Source: UniProtKB-KW
    3. metal ion binding Source: UniProtKB-KW
    4. sequence-specific DNA binding transcription factor activity Source: InterPro

    GO - Biological processi

    1. pathogenesis Source: UniProtKB-KW
    2. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Molecular functioni

    Activator

    Keywords - Biological processi

    Transcription, Transcription regulation, Virulence

    Keywords - Ligandi

    4Fe-4S, DNA-binding, Iron, Iron-sulfur, Metal-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Anaerobic regulatory protein
    Gene namesi
    Name:fnr
    Synonyms:actX
    OrganismiAggregatibacter actinomycetemcomitans (Actinobacillus actinomycetemcomitans) (Haemophilus actinomycetemcomitans)
    Taxonomic identifieri714 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPasteurellalesPasteurellaceaeAggregatibacter

    Subcellular locationi

    GO - Cellular componenti

    1. intracellular Source: InterPro

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 257257Anaerobic regulatory proteinPRO_0000100172Add
    BLAST

    Expressioni

    Inductioni

    By anaerobiosis.

    Interactioni

    Subunit structurei

    Homodimer.By similarity

    Structurei

    3D structure databases

    ProteinModelPortaliQ9EXQ1.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini167 – 24074HTH crp-typePROSITE-ProRule annotationAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni23 – 3210Essential for the oxygen-regulated activityBy similarity

    Sequence similaritiesi

    Contains 1 cyclic nucleotide-binding domain.PROSITE-ProRule annotation
    Contains 1 HTH crp-type DNA-binding domain.PROSITE-ProRule annotation

    Family and domain databases

    Gene3Di1.10.10.10. 1 hit.
    2.60.120.10. 1 hit.
    InterProiIPR018490. cNMP-bd-like.
    IPR000595. cNMP-bd_dom.
    IPR012318. HTH_CRP_2.
    IPR014710. RmlC-like_jellyroll.
    IPR001808. Tscrpt_reg_HTH_Crp.
    IPR018335. Tscrpt_reg_HTH_Crp-type_CS.
    IPR011991. WHTH_DNA-bd_dom.
    [Graphical view]
    PfamiPF00027. cNMP_binding. 1 hit.
    PF00325. Crp. 1 hit.
    [Graphical view]
    PRINTSiPR00034. HTHCRP.
    SMARTiSM00100. cNMP. 1 hit.
    SM00419. HTH_CRP. 1 hit.
    [Graphical view]
    SUPFAMiSSF51206. SSF51206. 1 hit.
    PROSITEiPS50042. CNMP_BINDING_3. 1 hit.
    PS00042. HTH_CRP_1. 1 hit.
    PS51063. HTH_CRP_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9EXQ1-1 [UniParc]FASTAAdd to Basket

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    MKILATETKL GRRVQSGGCA IHCQNCSISQ LCIPFTLNQH ELDQLDNIIE    50
    RKKPIQKSQV LFKAGDELTS LYAIRSGTIK SYTISETGEE QITSFHLPGD 100
    LVGFDAIMNM QHPSFAQALE TAMVCEIPFD ILDDLSGKMP KLRQQIMRLM 150
    SNEIKSDQEM ILLLSKMNAE ERLAAFIYNL SQRYSARGFS AREFRLTMTR 200
    GDIGNYLGLT VETISRLLGR FQKLGVLSVQ GKYITINNMA ELIELSGTNK 250
    NKIQLII 257
    Length:257
    Mass (Da):28,929
    Last modified:March 1, 2001 - v1
    Checksum:iA4D82081369BD042
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti189 – 1891F → S in BAA11315. (PubMed:8998988)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D89096 Genomic DNA. Translation: BAB19627.1.
    D78251 Genomic DNA. Translation: BAA11315.1.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D89096 Genomic DNA. Translation: BAB19627.1 .
    D78251 Genomic DNA. Translation: BAA11315.1 .

    3D structure databases

    ProteinModelPortali Q9EXQ1.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Family and domain databases

    Gene3Di 1.10.10.10. 1 hit.
    2.60.120.10. 1 hit.
    InterProi IPR018490. cNMP-bd-like.
    IPR000595. cNMP-bd_dom.
    IPR012318. HTH_CRP_2.
    IPR014710. RmlC-like_jellyroll.
    IPR001808. Tscrpt_reg_HTH_Crp.
    IPR018335. Tscrpt_reg_HTH_Crp-type_CS.
    IPR011991. WHTH_DNA-bd_dom.
    [Graphical view ]
    Pfami PF00027. cNMP_binding. 1 hit.
    PF00325. Crp. 1 hit.
    [Graphical view ]
    PRINTSi PR00034. HTHCRP.
    SMARTi SM00100. cNMP. 1 hit.
    SM00419. HTH_CRP. 1 hit.
    [Graphical view ]
    SUPFAMi SSF51206. SSF51206. 1 hit.
    PROSITEi PS50042. CNMP_BINDING_3. 1 hit.
    PS00042. HTH_CRP_1. 1 hit.
    PS51063. HTH_CRP_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Molecular characterization of the hlyX-like gene of Actinobacillus actinomycetemcomitans Y4."
      Kokeguchi S., Hirosue M., Maeda H., Miyamoto M., Takashiba S., Murayama Y.
      Res. Microbiol. 151:721-725(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: ATCC 43718 / FDC Y4 / Serotype b.
    2. "Novel FNR homologues identified in four representative oral facultative anaerobes: Capnocytophaga ochracea, Capnocytophaga sputigena, Haemophilus aphrophilus, and Actinobacillus actinomycetemcomitans."
      Hattori T., Takahashi K., Nakanishi T., Ohta H., Fukui K., Taniguchi S., Takigawa M.
      FEMS Microbiol. Lett. 137:213-220(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 125-216.
      Strain: 301-b / Serotype a.

    Entry informationi

    Entry nameiFNR_AGGAC
    AccessioniPrimary (citable) accession number: Q9EXQ1
    Secondary accession number(s): Q46157
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 30, 2002
    Last sequence update: March 1, 2001
    Last modified: October 1, 2014
    This is version 70 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3