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Protein

Uracil-DNA glycosylase 1

Gene

ung1

Organism
Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine.By similarity

Catalytic activityi

Hydrolyzes single-stranded DNA or mismatched double-stranded DNA and polynucleotides, releasing free uracil.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei68 – 681Proton acceptorBy similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Glycosidase, Hydrolase

Keywords - Biological processi

DNA damage, DNA repair

Names & Taxonomyi

Protein namesi
Recommended name:
Uracil-DNA glycosylase 1 (EC:3.2.2.27)
Short name:
UDG 1
Gene namesi
Name:ung1
Ordered Locus Names:SCO1114
ORF Names:2SCG38.07
OrganismiStreptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)
Taxonomic identifieri100226 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaStreptomycetalesStreptomycetaceaeStreptomycesStreptomyces albidoflavus group
Proteomesi
  • UP000001973 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 225225Uracil-DNA glycosylase 1PRO_0000176149Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi100226.SCO1114.

Structurei

3D structure databases

ProteinModelPortaliQ9EX12.
SMRiQ9EX12. Positions 4-225.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the uracil-DNA glycosylase family.Curated

Phylogenomic databases

eggNOGiENOG4105D5S. Bacteria.
COG0692. LUCA.
HOGENOMiHOG000229528.
InParanoidiQ9EX12.
KOiK03648.
OMAiEIVEAGW.
OrthoDBiEOG6MSS63.
PhylomeDBiQ9EX12.

Family and domain databases

Gene3Di3.40.470.10. 1 hit.
HAMAPiMF_00148. UDG.
InterProiIPR018085. Ura-DNA_Glyclase_AS.
IPR002043. Ura_DNA_glycsylse.
IPR005122. Uracil-DNA_glycosylase-like.
[Graphical view]
PANTHERiPTHR11264. PTHR11264. 1 hit.
PfamiPF03167. UDG. 1 hit.
[Graphical view]
SMARTiSM00986. UDG. 1 hit.
[Graphical view]
SUPFAMiSSF52141. SSF52141. 1 hit.
PROSITEiPS00130. U_DNA_GLYCOSYLASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9EX12-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAPRPLNEIV EAGWAKALEP VAGQITSMGE FLRAEIAAGR TYLPAGANVL
60 70 80 90 100
RAFQQPFDDV RVLIVGQDPY PTPGHAVGLS FSVAPEVRPL PGSLVNIFRE
110 120 130 140 150
LNTDLNLPQP ANGDLTPWTR QGVLLLNRAL TTAPRKPAAH RGKGWEEVTE
160 170 180 190 200
QAIRALAARG KPMVSILWGR DARNLRPLLG DLPALESAHP SPMSADRGFF
210 220
GSRPFSRAND LLMRLGGQPV DWRLP
Length:225
Mass (Da):24,456
Last modified:March 1, 2001 - v1
Checksum:iB370AE819B12D144
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL939107 Genomic DNA. Translation: CAC13066.1.
RefSeqiNP_625407.1. NC_003888.3.
WP_011027583.1. NC_003888.3.

Genome annotation databases

EnsemblBacteriaiCAC13066; CAC13066; CAC13066.
GeneIDi1096537.
KEGGisco:SCO1114.
PATRICi23731776. VBIStrCoe124346_1111.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL939107 Genomic DNA. Translation: CAC13066.1.
RefSeqiNP_625407.1. NC_003888.3.
WP_011027583.1. NC_003888.3.

3D structure databases

ProteinModelPortaliQ9EX12.
SMRiQ9EX12. Positions 4-225.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi100226.SCO1114.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAC13066; CAC13066; CAC13066.
GeneIDi1096537.
KEGGisco:SCO1114.
PATRICi23731776. VBIStrCoe124346_1111.

Phylogenomic databases

eggNOGiENOG4105D5S. Bacteria.
COG0692. LUCA.
HOGENOMiHOG000229528.
InParanoidiQ9EX12.
KOiK03648.
OMAiEIVEAGW.
OrthoDBiEOG6MSS63.
PhylomeDBiQ9EX12.

Family and domain databases

Gene3Di3.40.470.10. 1 hit.
HAMAPiMF_00148. UDG.
InterProiIPR018085. Ura-DNA_Glyclase_AS.
IPR002043. Ura_DNA_glycsylse.
IPR005122. Uracil-DNA_glycosylase-like.
[Graphical view]
PANTHERiPTHR11264. PTHR11264. 1 hit.
PfamiPF03167. UDG. 1 hit.
[Graphical view]
SMARTiSM00986. UDG. 1 hit.
[Graphical view]
SUPFAMiSSF52141. SSF52141. 1 hit.
PROSITEiPS00130. U_DNA_GLYCOSYLASE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC BAA-471 / A3(2) / M145.

Entry informationi

Entry nameiUNG1_STRCO
AccessioniPrimary (citable) accession number: Q9EX12
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 8, 2002
Last sequence update: March 1, 2001
Last modified: November 11, 2015
This is version 88 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.