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Protein

Uracil-DNA glycosylase 1

Gene

ung1

Organism
Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine.By similarity

Catalytic activityi

Hydrolyzes single-stranded DNA or mismatched double-stranded DNA and polynucleotides, releasing free uracil.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei68Proton acceptorBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase
Biological processDNA damage, DNA repair

Names & Taxonomyi

Protein namesi
Recommended name:
Uracil-DNA glycosylase 1 (EC:3.2.2.27)
Short name:
UDG 1
Gene namesi
Name:ung1
Ordered Locus Names:SCO1114
ORF Names:2SCG38.07
OrganismiStreptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)
Taxonomic identifieri100226 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaStreptomycetalesStreptomycetaceaeStreptomycesStreptomyces albidoflavus group
Proteomesi
  • UP000001973 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001761491 – 225Uracil-DNA glycosylase 1Add BLAST225

Proteomic databases

PRIDEiQ9EX12

Interactioni

Protein-protein interaction databases

STRINGi100226.SCO1114

Structurei

3D structure databases

ProteinModelPortaliQ9EX12
SMRiQ9EX12
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiENOG4105D5S Bacteria
COG0692 LUCA
HOGENOMiHOG000229528
InParanoidiQ9EX12
KOiK03648
OMAiQANGLCF
OrthoDBiPOG091H03VL
PhylomeDBiQ9EX12

Family and domain databases

CDDicd10027 UDG_F1, 1 hit
Gene3Di3.40.470.10, 1 hit
HAMAPiMF_00148 UDG, 1 hit
InterProiView protein in InterPro
IPR002043 UDG_fam1
IPR018085 Ura-DNA_Glyclase_AS
IPR005122 Uracil-DNA_glycosylase-like
IPR036895 Uracil-DNA_glycosylase-like_sf
PANTHERiPTHR11264 PTHR11264, 1 hit
PfamiView protein in Pfam
PF03167 UDG, 1 hit
SMARTiView protein in SMART
SM00986 UDG, 1 hit
SUPFAMiSSF52141 SSF52141, 1 hit
PROSITEiView protein in PROSITE
PS00130 U_DNA_GLYCOSYLASE, 1 hit

Sequencei

Sequence statusi: Complete.

Q9EX12-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAPRPLNEIV EAGWAKALEP VAGQITSMGE FLRAEIAAGR TYLPAGANVL
60 70 80 90 100
RAFQQPFDDV RVLIVGQDPY PTPGHAVGLS FSVAPEVRPL PGSLVNIFRE
110 120 130 140 150
LNTDLNLPQP ANGDLTPWTR QGVLLLNRAL TTAPRKPAAH RGKGWEEVTE
160 170 180 190 200
QAIRALAARG KPMVSILWGR DARNLRPLLG DLPALESAHP SPMSADRGFF
210 220
GSRPFSRAND LLMRLGGQPV DWRLP
Length:225
Mass (Da):24,456
Last modified:March 1, 2001 - v1
Checksum:iB370AE819B12D144
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL939107 Genomic DNA Translation: CAC13066.1
RefSeqiNP_625407.1, NC_003888.3
WP_011027583.1, NC_003888.3

Genome annotation databases

EnsemblBacteriaiCAC13066; CAC13066; CAC13066
GeneIDi1096537
KEGGisco:SCO1114
PATRICifig|100226.15.peg.1111

Similar proteinsi

Entry informationi

Entry nameiUNG1_STRCO
AccessioniPrimary (citable) accession number: Q9EX12
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 8, 2002
Last sequence update: March 1, 2001
Last modified: May 23, 2018
This is version 97 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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