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Protein

Phosphoribosyl-ATP pyrophosphatase

Gene

hisE

Organism
Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

1-(5-phospho-beta-D-ribosyl)-ATP + H2O = 1-(5-phospho-beta-D-ribosyl)-AMP + diphosphate.

Pathwayi: L-histidine biosynthesis

This protein is involved in step 2 of the subpathway that synthesizes L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate.
Proteins known to be involved in the 9 steps of the subpathway in this organism are:
  1. ATP phosphoribosyltransferase (hisG)
  2. Phosphoribosyl-ATP pyrophosphatase (hisE)
  3. Phosphoribosyl-AMP cyclohydrolase (hisI)
  4. Phosphoribosyl isomerase A (priA)
  5. Imidazole glycerol phosphate synthase subunit HisF (hisF), Imidazole glycerol phosphate synthase subunit HisH (hisH)
  6. Imidazoleglycerol-phosphate dehydratase (hisB)
  7. Histidinol-phosphate aminotransferase (hisC)
  8. Histidinol-phosphatase (hisN)
  9. Histidinol dehydrogenase (hisD)
This subpathway is part of the pathway L-histidine biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate, the pathway L-histidine biosynthesis and in Amino-acid biosynthesis.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Amino-acid biosynthesis, Histidine biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

UniPathwayiUPA00031; UER00007.

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphoribosyl-ATP pyrophosphatase (EC:3.6.1.31)
Short name:
PRA-PH
Gene namesi
Name:hisE
Ordered Locus Names:SCO1439
ORF Names:SC6D7A.02c
OrganismiStreptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)
Taxonomic identifieri100226 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaStreptomycetalesStreptomycetaceaeStreptomycesStreptomyces albidoflavus group
Proteomesi
  • UP000001973 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001363881 – 90Phosphoribosyl-ATP pyrophosphataseAdd BLAST90

Proteomic databases

PRIDEiQ9EWK0.

Interactioni

Protein-protein interaction databases

STRINGi100226.SCO1439.

Structurei

Secondary structure

190
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi6 – 16Combined sources11
Helixi30 – 33Combined sources4
Helixi35 – 55Combined sources21
Helixi58 – 78Combined sources21
Helixi83 – 89Combined sources7

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1YXBX-ray2.60A/B/C/D/E/F/G/H1-90[»]
ProteinModelPortaliQ9EWK0.
SMRiQ9EWK0.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9EWK0.

Family & Domainsi

Sequence similaritiesi

Belongs to the PRA-PH family.Curated

Phylogenomic databases

eggNOGiENOG4105M0N. Bacteria.
COG0140. LUCA.
HOGENOMiHOG000220966.
InParanoidiQ9EWK0.
KOiK01523.
OMAiVMMVARG.
OrthoDBiPOG091H09PQ.
PhylomeDBiQ9EWK0.

Family and domain databases

HAMAPiMF_01020. HisE. 1 hit.
InterProiIPR008179. HisE.
IPR021130. PRib-ATP_PPHydrolase-like.
[Graphical view]
PfamiPF01503. PRA-PH. 1 hit.
[Graphical view]
TIGRFAMsiTIGR03188. histidine_hisI. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9EWK0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSKKTFEELF TELQHKAANG DPATSRTAEL VDKGVHAIGK KVVEEAAEVW
60 70 80 90
MAAEYEGKDA AAEEISQLLY HVQVMMVARG ISLDDVYAHL
Length:90
Mass (Da):9,919
Last modified:March 1, 2001 - v1
Checksum:i50CACC42A8D97F55
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL939108 Genomic DNA. Translation: CAC17557.1.
RefSeqiNP_625720.1. NC_003888.3.
WP_011027788.1. NC_003888.3.

Genome annotation databases

EnsemblBacteriaiCAC17557; CAC17557; CAC17557.
GeneIDi1096865.
KEGGisco:SCO1439.
PATRICi23732456. VBIStrCoe124346_1449.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL939108 Genomic DNA. Translation: CAC17557.1.
RefSeqiNP_625720.1. NC_003888.3.
WP_011027788.1. NC_003888.3.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1YXBX-ray2.60A/B/C/D/E/F/G/H1-90[»]
ProteinModelPortaliQ9EWK0.
SMRiQ9EWK0.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi100226.SCO1439.

Proteomic databases

PRIDEiQ9EWK0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAC17557; CAC17557; CAC17557.
GeneIDi1096865.
KEGGisco:SCO1439.
PATRICi23732456. VBIStrCoe124346_1449.

Phylogenomic databases

eggNOGiENOG4105M0N. Bacteria.
COG0140. LUCA.
HOGENOMiHOG000220966.
InParanoidiQ9EWK0.
KOiK01523.
OMAiVMMVARG.
OrthoDBiPOG091H09PQ.
PhylomeDBiQ9EWK0.

Enzyme and pathway databases

UniPathwayiUPA00031; UER00007.

Miscellaneous databases

EvolutionaryTraceiQ9EWK0.

Family and domain databases

HAMAPiMF_01020. HisE. 1 hit.
InterProiIPR008179. HisE.
IPR021130. PRib-ATP_PPHydrolase-like.
[Graphical view]
PfamiPF01503. PRA-PH. 1 hit.
[Graphical view]
TIGRFAMsiTIGR03188. histidine_hisI. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiHIS2_STRCO
AccessioniPrimary (citable) accession number: Q9EWK0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 27, 2002
Last sequence update: March 1, 2001
Last modified: November 2, 2016
This is version 96 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.