Q9EWA3 (Q9EWA3_9ACTO) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Submitted name:
PimS4 protein EMBL CAC20919.1

Gene names

Name:

pimS4 EMBL CAC20919.1

Organism

Streptomyces natalensis EMBL CAC20919.1

Taxonomic identifier

68242 [NCBI]

Taxonomic lineage

Bacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Streptomycineae › Streptomycetaceae › Streptomyces

Protein attributes

Sequence length	2024 AA.
Sequence status	Complete.
Protein existence	Predicted

Ontologies

Keywords
Ligand	Phosphopantetheine RuleBase RU000721
Molecular function	Transferase RuleBase RU000693
Gene Ontology (GO)
Biological process	biosynthetic process Inferred from electronic annotation. Source: InterPro
Molecular function	acyl carrier activity Inferred from electronic annotation. Source: InterPro cofactor binding Inferred from electronic annotation. Source: InterPro hydrolase activity, acting on ester bonds Inferred from electronic annotation. Source: InterPro nucleotide binding Inferred from electronic annotation. Source: InterPro phosphopantetheine binding Inferred from electronic annotation. Source: InterPro transferase activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	Q9EWA3 [UniParc]. Last modified March 1, 2001. Version 1. Checksum: 7751312CBE95C228	FASTA	2,024	212,175
	10 20 30 40 50 60 MPNDKPNDKK LVDYLKWVTN DLHQTRQRLR EVESAKQEPI AIVGMSCRLP GGVRSPEEFW 70 80 90 100 110 120 QLLKDGRDGI STFPTDRGWD LDLLAGDGSG SSATAEGGFI DAASFDAGFF GISPREAVTM 130 140 150 160 170 180 DPQQRILLES SWEALERAGI DPVSLRGTET GVFVGTSGID YINTVMNSRE DIEGHGSTGL 190 200 210 220 230 240 IASILSGRVS YTFGLEGPAV TVDTACSSSL VSLHLAAQAL RVGECSLALA GGVTAISTPM 250 260 270 280 290 300 SFVGFSRQGG LAPDGRCKAF SDTADGTAWS EGVGVLVVER LSDARRNGHP VLAVVRGSAV 310 320 330 340 350 360 NQDGASNGLT APSGPSQQRV IRQALAAAGL SASDVDVVEA HGTGTALGDP IEAQALLATY 370 380 390 400 410 420 GRDRDPERPL LLGSVKSNLG HTQAAAGAAG LIKMILAMRH GVLPRTLHVE APSSHVDWSS 430 440 450 460 470 480 GALQLLTEPQ EWPKADRPWR AGVSSFAISG TNAHIILEQP PAAEEPEDEE GPHTSPSAVP 490 500 510 520 530 540 WLVSAKSEEA LTAQLDRISA LTDRSPLDLG LSLATTRAHL EHRAVLLSEG GETVEVARGH 550 560 570 580 590 600 AEHTAGKLAV LFSGQGAQRV GMGRELYGRF PVFAEALDGV LAHFDAGLRD VMFGEAEGLD 610 620 630 640 650 660 ETGFTQPALF AIEVALFRLS ESLGVRPDFV AGHSIGEIAA AHVAGVFSLA DACALVAARA 670 680 690 700 710 720 RLMQALPAGG AMVAVQAAES EVAARLVDGV SIAAVNGPEA VVIAGEEREV LRIAEEFTGL 730 740 750 760 770 780 GRKTRRLPVS HAFHSPLMEP MLEDFRRVAE GLSYEAPRIA LVSNLTGELA TEDLVRSAEY 790 800 810 820 830 840 WVRHVRETVR FADGVSALAA EGASVFLELG PDGVLTAMAQ HTLDGTATTV PALRKDRSEE 850 860 870 880 890 900 TALLTALAQL HVAGVGVDWS GIFAGTGARR VDLPTYPFQH ERYWPRPAVL SGDVVGAGLR 910 920 930 940 950 960 SAEHPLLGAT LTLAESGEVV LTGRLSLQAY PWLTDHTMGG SVLFPATGFL ELAMRAADQV 970 980 990 1000 1010 1020 GCDRVDEFVL MTPLVLAEES GTQVQVLVGP ADEAGTRTIS IHARPDGDPD QPWMQHAGGT 1030 1040 1050 1060 1070 1080 LTSGERIVDF GSTVWPPQGA EAVDLEGFYD TTGYGPAFQG LRSVWQCEDG AYVEVALPDQ 1090 1100 1110 1120 1130 1140 VAEDAGAFGL HPVLLDAVLQ SRRMAGIGAA GDTFLPFAWR GVSLHAGGAS VLRARVIKTG 1150 1160 1170 1180 1190 1200 EDTLSLVAVD AEGAPVLSVE ELVLRTQLTH TDAPLTARRG AERDALLSLE WVSGPEVPPA 1210 1220 1230 1240 1250 1260 GVRCVSLGAD ELGVGASVAT LADLSGDEDF VVVPVSGVGG DVPAAAHELT ARTLGLLQEW 1270 1280 1290 1300 1310 1320 SGREGTSASR LVFVTRNAVS ADGGESVRDV AAAAVWGLVR SAQSESPGRI ALVDLEADSG 1330 1340 1350 1360 1370 1380 DLAEVLAGLP GLLAAGDAQF VVREGAVRVG RLVESNEGAG VSPREWDADG TVLVTGGTGG 1390 1400 1410 1420 1430 1440 LGRELARHLV VERGVRHLLL VSRSGPEASG VGELRDELAA HGAEIAVRAC DVADRAAVEA 1450 1460 1470 1480 1490 1500 VVGAVDAAHP LTAVIHTAGV LDDGVIASLT PERLSAVLRP KVDAAWNLHE ATKDLDLAAF 1510 1520 1530 1540 1550 1560 VLYSSISGVL GSLGQGNYAA GNVFLDALAG HRAGLGLPAQ SLAWGAWTQG GGMTATLSDA 1570 1580 1590 1600 1610 1620 DMQRMASYGT APLSPERGLA LFDAATAGSA THLVAVGRVS GPVRAQGPVP SMLRGLVKGA 1630 1640 1650 1660 1670 1680 RRTAVNTTGE TAVSLADRLR AARPEERTQL MTDVVRTEAA AVLGHASSQN VDARREFYEL 1690 1700 1710 1720 1730 1740 GFDSLTSVEL RNRLSTVTGL RLSATVVFDS KNPTDLAARL YADLAAQSAL DGSASQAGFL 1750 1760 1770 1780 1790 1800 PVAAPETDSL ERMFLDALDS GKVPEAQRML SALGALRPSF ENTAELEDLP LPATLAEGPG 1810 1820 1830 1840 1850 1860 TPRLICVSTP TANGGVHEYA RLAASFRGER HVSALPLVGF ATGERLPATA ETAVRVIAES 1870 1880 1890 1900 1910 1920 ALRASDGNPF VLVGHSSAGA FAYLAAALLE NTWGIRPEAV VLLDTLSLRH EQNESIDYAG 1930 1940 1950 1960 1970 1980 LMRRHFMVDE VSPVRMTNSR LSAMARWMGM LNQLEVRHTT VPVLIIRATK ETFGIGTDTG 1990 2000 2010 2020 IYGEDHGSPV DVRSVDADHF SMVRDDAPET ARIVREWLDS LGNA

References

[1]	"A complex multienzyme system encoded by five polyketide synthase genes is involved in the biosynthesis of the 26-membered polyene macrolide pimaricin in Streptomyces natalensis." Aparicio J.F., Fouces R., Mendes M.V., Olivera N., Martin J.F. Chem. Biol. 7:895-905(2000) [PubMed: 11094342] [Abstract] Cited for: NUCLEOTIDE SEQUENCE.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AJ278573 Genomic DNA. Translation: CAC20919.1.
3D structure databases
HSSP	HSSP built from PDB template 1LQ9 based on UniProtKB Q53908.
ProteinModelPortal	Q9EWA3.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Family and domain databases
InterPro	IPR001227. Ac_transferase_dom. IPR009081. Acyl_carrier_prot-like. IPR014043. Acyl_transferase. IPR016035. Acyl_Trfase/lysoPLipase. IPR000794. Beta-ketoacyl_synthase. IPR018201. Ketoacyl_synth_AS. IPR014031. Ketoacyl_synth_C. IPR014030. Ketoacyl_synth_N. IPR016036. Malonyl_transacylase_ACP-bd. IPR016040. NAD(P)-bd_dom. IPR006163. Phsphopanteth-bd. IPR020842. PKS/FAS_KR. IPR020801. PKS_acyl_transferase. IPR020841. PKS_Beta-ketoAc_synthase_dom. IPR020807. PKS_dehydratase. IPR013968. PKS_KR. IPR020806. PKS_PP-bd. IPR020802. PKS_thioesterase. IPR015083. Polyketide_synth_docking. IPR006162. PPantetheine_attach_site. IPR001031. Thioesterase. IPR016039. Thiolase-like. IPR016038. Thiolase-like_subgr. [Graphical view]
Gene3D	G3DSA:3.40.366.10. Ac_transferase_reg. 2 hits. G3DSA:1.10.1200.10. ACP_like. 1 hit. G3DSA:3.40.50.720. NAD(P)-bd. 1 hit. G3DSA:3.40.47.10. Thiolase-like_subgr. 2 hits.
PANTHER	PTHR11712. Ketoacyl_synth. 1 hit.
Pfam	PF00698. Acyl_transf_1. 1 hit. PF08990. Docking. 1 hit. PF00109. ketoacyl-synt. 1 hit. PF02801. Ketoacyl-synt_C. 1 hit. PF08659. KR. 1 hit. PF00550. PP-binding. 1 hit. PF00975. Thioesterase. 1 hit. [Graphical view]
SMART	SM00827. PKS_AT. 1 hit. SM00826. PKS_DH. 1 hit. SM00822. PKS_KR. 1 hit. SM00825. PKS_KS. 1 hit. SM00823. PKS_PP. 1 hit. SM00824. PKS_TE. 1 hit. [Graphical view]
SUPFAM	SSF47336. ACP_like. 1 hit. SSF52151. Acyl_Trfase/lysoPlipase. 1 hit. SSF55048. Malonyl_transacylase_ACP-bd. 1 hit. SSF53901. Thiolase-like. 1 hit.
PROSITE	PS50075. ACP_DOMAIN. 1 hit. PS00606. B_KETOACYL_SYNTHASE. 1 hit. PS00012. PHOSPHOPANTETHEINE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

Q9EWA3_9ACTO

Accession

Primary (citable) accession number: Q9EWA3

Entry history

Integrated into UniProtKB/TrEMBL:	March 1, 2001
Last sequence update:	March 1, 2001
Last modified:	December 14, 2011
This is version 69 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)