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Q9EV38

- LACG_STRGC

UniProt

Q9EV38 - LACG_STRGC

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Protein
6-phospho-beta-galactosidase
Gene
lacG, SGO_1512
Organism
Streptococcus gordonii (strain Challis / ATCC 35105 / CH1 / DL1 / V288)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

A 6-phospho-beta-D-galactoside + H2O = 6-phospho-D-galactose + an alcohol.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei160 – 1601Proton donor By similarity
Active sitei375 – 3751Nucleophile By similarity

GO - Molecular functioni

  1. 6-phospho-beta-galactosidase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. lactose catabolic process via tagatose-6-phosphate Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Glycosidase, Hydrolase

Enzyme and pathway databases

BioCyciSGOR467705:GH3R-1511-MONOMER.
UniPathwayiUPA00542; UER00605.

Protein family/group databases

CAZyiGH1. Glycoside Hydrolase Family 1.

Names & Taxonomyi

Protein namesi
Recommended name:
6-phospho-beta-galactosidase (EC:3.2.1.85)
Alternative name(s):
Beta-D-phosphogalactoside galactohydrolase
Short name:
PGALase
P-beta-Gal
Short name:
PBG
Gene namesi
Name:lacG
Ordered Locus Names:SGO_1512
OrganismiStreptococcus gordonii (strain Challis / ATCC 35105 / CH1 / DL1 / V288)
Taxonomic identifieri29390 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus
ProteomesiUP000001131: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 4684686-phospho-beta-galactosidaseUniRule annotation
PRO_0000260729Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi467705.SGO_1512.

Structurei

3D structure databases

ProteinModelPortaliQ9EV38.
SMRiQ9EV38. Positions 1-468.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG2723.
HOGENOMiHOG000088632.
KOiK01220.
OMAiNRWYLDP.
OrthoDBiEOG60658J.

Family and domain databases

Gene3Di3.20.20.80. 1 hit.
HAMAPiMF_01574. LacG.
InterProiIPR005928. 6P-beta-galactosidase.
IPR001360. Glyco_hydro_1.
IPR018120. Glyco_hydro_1_AS.
IPR013781. Glyco_hydro_catalytic_dom.
IPR017853. Glycoside_hydrolase_SF.
[Graphical view]
PANTHERiPTHR10353. PTHR10353. 1 hit.
PfamiPF00232. Glyco_hydro_1. 1 hit.
[Graphical view]
PRINTSiPR00131. GLHYDRLASE1.
SUPFAMiSSF51445. SSF51445. 1 hit.
TIGRFAMsiTIGR01233. lacG. 1 hit.
PROSITEiPS00572. GLYCOSYL_HYDROL_F1_1. 1 hit.
PS00653. GLYCOSYL_HYDROL_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9EV38-1 [UniParc]FASTAAdd to Basket

« Hide

MTKSLPKDFI FGGATAAYQA EGATHTDGKG PVAWDKYLED NYWYTAEPAS    50
DFYHKYPVDL KLAEEYGVNG IRISIAWSRI FPTGYGEVNP KGVEFYHNLF 100
AECHKRHVEP FVTLHHFDTP EALHSNGDFL NRDNIEHFVD YAAFCFEEFP 150
EVRYWTTFNE IGPIGDGQYL VGKFPPGIQY DLAKVFQSHH NMMVSHARAV 200
KLYKDKGYKG EIGVVHALPT KYPYDPENPA DVRAAELEDI IHNKFILDAT 250
YLGHYSDVTL AGVNHILKVN GGQLDLRDED FAALEAAKDL NDFLGINYYM 300
SDWMRDFDGE TEIIHNGKGE KGSSKYQIKG VGRRESPTHI PKTDWDWIIY 350
PQGLYDQIMR IKKDYPNYKK IYITENGLGY KDEFVDNTVY DDARIDYVKQ 400
HLEVLSDAIA DGANVKGYFI WSLMDVFSWS NGYEKRYGLF YVDFETQERY 450
PKKSAHWYRR LAETQMIE 468
Length:468
Mass (Da):54,111
Last modified:February 26, 2008 - v2
Checksum:i86A4A0301682873E
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti459 – 4602RR → KK in AAG39001. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF210773 Genomic DNA. Translation: AAG39001.1.
CP000725 Genomic DNA. Translation: ABV10357.1.
RefSeqiYP_001450791.1. NC_009785.1.

Genome annotation databases

EnsemblBacteriaiABV10357; ABV10357; SGO_1512.
GeneIDi5598019.
KEGGisgo:SGO_1512.
PATRICi19660976. VBIStrGor124371_1489.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF210773 Genomic DNA. Translation: AAG39001.1 .
CP000725 Genomic DNA. Translation: ABV10357.1 .
RefSeqi YP_001450791.1. NC_009785.1.

3D structure databases

ProteinModelPortali Q9EV38.
SMRi Q9EV38. Positions 1-468.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 467705.SGO_1512.

Protein family/group databases

CAZyi GH1. Glycoside Hydrolase Family 1.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABV10357 ; ABV10357 ; SGO_1512 .
GeneIDi 5598019.
KEGGi sgo:SGO_1512.
PATRICi 19660976. VBIStrGor124371_1489.

Phylogenomic databases

eggNOGi COG2723.
HOGENOMi HOG000088632.
KOi K01220.
OMAi NRWYLDP.
OrthoDBi EOG60658J.

Enzyme and pathway databases

UniPathwayi UPA00542 ; UER00605 .
BioCyci SGOR467705:GH3R-1511-MONOMER.

Family and domain databases

Gene3Di 3.20.20.80. 1 hit.
HAMAPi MF_01574. LacG.
InterProi IPR005928. 6P-beta-galactosidase.
IPR001360. Glyco_hydro_1.
IPR018120. Glyco_hydro_1_AS.
IPR013781. Glyco_hydro_catalytic_dom.
IPR017853. Glycoside_hydrolase_SF.
[Graphical view ]
PANTHERi PTHR10353. PTHR10353. 1 hit.
Pfami PF00232. Glyco_hydro_1. 1 hit.
[Graphical view ]
PRINTSi PR00131. GLHYDRLASE1.
SUPFAMi SSF51445. SSF51445. 1 hit.
TIGRFAMsi TIGR01233. lacG. 1 hit.
PROSITEi PS00572. GLYCOSYL_HYDROL_F1_1. 1 hit.
PS00653. GLYCOSYL_HYDROL_F1_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Identification of new intergenic and intragenic integration sites for foreign gene expression in recombinant Streptococcus gordonii strains."
    Bolken T.C., Franke C.A., Hruby D.E., Zeller G.O.
    Submitted (DEC-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "Genome-wide transcriptional changes in Streptococcus gordonii in response to competence signaling peptide."
    Vickerman M.M., Iobst S., Jesionowski A.M., Gill S.R.
    J. Bacteriol. 189:7799-7807(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Challis / ATCC 35105 / CH1 / DL1 / V288.

Entry informationi

Entry nameiLACG_STRGC
AccessioniPrimary (citable) accession number: Q9EV38
Secondary accession number(s): A8AYD1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 28, 2006
Last sequence update: February 26, 2008
Last modified: May 14, 2014
This is version 76 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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