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Protein

Aspartate-semialdehyde dehydrogenase

Gene

asd

Organism
Yersinia pestis
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the NADPH-dependent formation of L-aspartate-semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl-4-phosphate.UniRule annotation

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.UniRule annotation

Catalytic activityi

L-aspartate 4-semialdehyde + phosphate + NADP+ = L-4-aspartyl phosphate + NADPH.UniRule annotation

Pathwayi: L-lysine biosynthesis via DAP pathway

This protein is involved in step 2 of the subpathway that synthesizes (S)-tetrahydrodipicolinate from L-aspartate.UniRule annotation
Proteins known to be involved in the 4 steps of the subpathway in this organism are:
  1. Aspartokinase (AU253_09460), Bifunctional aspartokinase/homoserine dehydrogenase (metL), Bifunctional aspartokinase/homoserine dehydrogenase (metL), Bifunctional aspartokinase/homoserine dehydrogenase (thrA), Aspartokinase (lysC2), Aspartokinase (apk), Bifunctional aspartokinase/homoserine dehydrogenase (thrA), Bifunctional aspartokinase/homoserine dehydrogenase (thrA)
  2. Aspartate-semialdehyde dehydrogenase (asd), Aspartate-semialdehyde dehydrogenase (asd)
  3. 4-hydroxy-tetrahydrodipicolinate synthase (dapA), 4-hydroxy-tetrahydrodipicolinate synthase (dapA)
  4. 4-hydroxy-tetrahydrodipicolinate reductase (dapB), 4-hydroxy-tetrahydrodipicolinate reductase (dapB)
This subpathway is part of the pathway L-lysine biosynthesis via DAP pathway, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes (S)-tetrahydrodipicolinate from L-aspartate, the pathway L-lysine biosynthesis via DAP pathway and in Amino-acid biosynthesis.

Pathwayi: L-methionine biosynthesis via de novo pathway

This protein is involved in step 2 of the subpathway that synthesizes L-homoserine from L-aspartate.UniRule annotation
Proteins known to be involved in the 3 steps of the subpathway in this organism are:
  1. Aspartokinase (AU253_09460), Bifunctional aspartokinase/homoserine dehydrogenase (metL), Bifunctional aspartokinase/homoserine dehydrogenase (metL), Bifunctional aspartokinase/homoserine dehydrogenase (thrA), Aspartokinase (lysC2), Aspartokinase (apk), Bifunctional aspartokinase/homoserine dehydrogenase (thrA), Bifunctional aspartokinase/homoserine dehydrogenase (thrA)
  2. Aspartate-semialdehyde dehydrogenase (asd), Aspartate-semialdehyde dehydrogenase (asd)
  3. Bifunctional aspartokinase/homoserine dehydrogenase (metL), Bifunctional aspartokinase/homoserine dehydrogenase (metL), Bifunctional aspartokinase/homoserine dehydrogenase (thrA), Bifunctional aspartokinase/homoserine dehydrogenase (thrA), Bifunctional aspartokinase/homoserine dehydrogenase (thrA)
This subpathway is part of the pathway L-methionine biosynthesis via de novo pathway, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-homoserine from L-aspartate, the pathway L-methionine biosynthesis via de novo pathway and in Amino-acid biosynthesis.

Pathwayi: L-threonine biosynthesis

This protein is involved in step 2 of the subpathway that synthesizes L-threonine from L-aspartate.UniRule annotation
Proteins known to be involved in the 5 steps of the subpathway in this organism are:
  1. Aspartokinase (AU253_09460), Bifunctional aspartokinase/homoserine dehydrogenase (metL), Bifunctional aspartokinase/homoserine dehydrogenase (metL), Bifunctional aspartokinase/homoserine dehydrogenase (thrA), Aspartokinase (lysC2), Aspartokinase (apk), Bifunctional aspartokinase/homoserine dehydrogenase (thrA), Bifunctional aspartokinase/homoserine dehydrogenase (thrA)
  2. Aspartate-semialdehyde dehydrogenase (asd), Aspartate-semialdehyde dehydrogenase (asd)
  3. Bifunctional aspartokinase/homoserine dehydrogenase (metL), Bifunctional aspartokinase/homoserine dehydrogenase (metL), Bifunctional aspartokinase/homoserine dehydrogenase (thrA), Bifunctional aspartokinase/homoserine dehydrogenase (thrA), Bifunctional aspartokinase/homoserine dehydrogenase (thrA)
  4. Homoserine kinase (thrB), Homoserine kinase (thrB)
  5. no protein annotated in this organism
This subpathway is part of the pathway L-threonine biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-threonine from L-aspartate, the pathway L-threonine biosynthesis and in Amino-acid biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei73NADPUniRule annotation1
Binding sitei102PhosphateUniRule annotation1
Active sitei135Acyl-thioester intermediateUniRule annotation1
Binding sitei162SubstrateUniRule annotation1
Binding sitei241SubstrateUniRule annotation1
Binding sitei244PhosphateUniRule annotation1
Binding sitei267SubstrateUniRule annotation1
Active sitei274Proton acceptorUniRule annotation1
Binding sitei350NADPUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi10 – 13NADPUniRule annotation4
Nucleotide bindingi37 – 38NADPUniRule annotation2
Nucleotide bindingi165 – 166NADPUniRule annotation2

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductaseUniRule annotation
Biological processAmino-acid biosynthesis, Diaminopimelate biosynthesisUniRule annotation, Lysine biosynthesisUniRule annotation, Methionine biosynthesisUniRule annotation, Threonine biosynthesisUniRule annotation
LigandNADPUniRule annotation

Enzyme and pathway databases

UniPathwayiUPA00034; UER00016
UPA00050; UER00463
UPA00051; UER00464

Names & Taxonomyi

Protein namesi
Recommended name:
Aspartate-semialdehyde dehydrogenaseUniRule annotation (EC:1.2.1.11UniRule annotation)
Short name:
ASA dehydrogenaseUniRule annotation
Short name:
ASADHUniRule annotation
Alternative name(s):
Aspartate-beta-semialdehyde dehydrogenaseUniRule annotation
Gene namesi
Name:asdUniRule annotationImported
Ordered Locus Names:YPO3949Imported
OrganismiYersinia pestisImported
Taxonomic identifieri632 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesYersiniaceaeYersinia
Proteomesi
  • UP000000815 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

PTM / Processingi

Proteomic databases

PaxDbiQ9ETB0

Interactioni

Subunit structurei

Homodimer.UniRule annotation

GO - Molecular functioni

Protein-protein interaction databases

STRINGi187410.y3880

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini3 – 122Semialdhyde_dhInterPro annotationAdd BLAST120

Sequence similaritiesi

Belongs to the aspartate-semialdehyde dehydrogenase family.UniRule annotationSAAS annotation

Phylogenomic databases

eggNOGiENOG4105CM3 Bacteria
COG0136 LUCA
HOGENOMiHOG000161376
KOiK00133
OMAiVGTDPTW

Family and domain databases

HAMAPiMF_02121 ASADH, 1 hit
InterProiView protein in InterPro
IPR000319 Asp-semialdehyde_DH_CS
IPR011534 Asp_ADH_gamma-type
IPR012080 Asp_semialdehyde_DH
IPR036291 NAD(P)-bd_dom_sf
IPR000534 Semialdehyde_DH_NAD-bd
IPR012280 Semialdhyde_DH_dimer_dom
PANTHERiPTHR10174:SF116 PTHR10174:SF116, 1 hit
PfamiView protein in Pfam
PF01118 Semialdhyde_dh, 1 hit
PF02774 Semialdhyde_dhC, 1 hit
SMARTiView protein in SMART
SM00859 Semialdhyde_dh, 1 hit
SUPFAMiSSF51735 SSF51735, 1 hit
TIGRFAMsiTIGR01745 asd_gamma, 1 hit
PROSITEiView protein in PROSITE
PS01103 ASD, 1 hit

Sequencei

Sequence statusi: Complete.

Q9ETB0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKNVGFIGWR GMVGSVLMQR MIEERDFDGI RPVFFSTSQH GQAAPAFAGH
60 70 80 90 100
QGTLQDAYDI DALSALDIII TCQGGDYTNQ IYPKLREIGW QGYWIDAASS
110 120 130 140 150
LRMQDDTIII LDPVNHDVIK QGLDKGIKTF AGGNCTVSLM LMSLGGLFAN
160 170 180 190 200
NLVEWASVAT YQAASGGGAR HMRELLTQMG MLHAGVAKEL QDPASAILDI
210 220 230 240 250
ERKVTSTTRS GTLPTDNFGV PLAGSLIPWI DKALDNGQSR EEWKGQAETN
260 270 280 290 300
KILSTSTLIP VDGLCVRVGA LRCHSQAFTL KLKKDVPLAE IEQMLATHND
310 320 330 340 350
WVRVIPNDRE LSMRELTPAA VTGTLNTPVG RLRKLNMGPE YLSAFTVGDQ
360
LLWGAAEPLR RMLRILL
Length:367
Mass (Da):40,191
Last modified:March 1, 2001 - v1
Checksum:iEFFEE5C4625B6DE4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF282318 Genomic DNA Translation: AAG22007.1
AL590842 Genomic DNA Translation: CAL22530.1
PIRiAG0480
RefSeqiWP_002209507.1, NZ_PDBR01000061.1
YP_002348820.1, NC_003143.1

Genome annotation databases

EnsemblBacteriaiAAM87425; AAM87425; y3880
AAS63476; AAS63476; YP_3311
GeneIDi1176788
KEGGiype:YPO3949
ypj:CH55_2628
ypl:CH46_1108
ypv:BZ15_3756
ypw:CH59_1896
PATRICifig|214092.21.peg.4477

Similar proteinsi

Entry informationi

Entry nameiQ9ETB0_YERPE
AccessioniPrimary (citable) accession number: Q9ETB0
Secondary accession number(s): Q74QZ1, Q7CFY8
Entry historyiIntegrated into UniProtKB/TrEMBL: March 1, 2001
Last sequence update: March 1, 2001
Last modified: May 23, 2018
This is version 144 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

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