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Q9ETB0

- Q9ETB0_YERPE

UniProt

Q9ETB0 - Q9ETB0_YERPE

Protein

Aspartate-semialdehyde dehydrogenase

Gene

asd

Organism
Yersinia pestis
Status
Unreviewed - Annotation score: 4 out of 5- Protein inferred from homologyi
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    • History
      Entry version 110 (01 Oct 2014)
      Sequence version 1 (01 Mar 2001)
      Previous versions | rss
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    Functioni

    Catalyzes the NADPH-dependent formation of L-aspartate-semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl-4-phosphate.UniRule annotation

    Catalytic activityi

    L-aspartate 4-semialdehyde + phosphate + NADP+ = L-4-aspartyl phosphate + NADPH.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei73 – 731NADPUniRule annotation
    Binding sitei102 – 1021PhosphateUniRule annotation
    Active sitei135 – 1351Acyl-thioester intermediateUniRule annotation
    Binding sitei162 – 1621SubstrateUniRule annotation
    Binding sitei193 – 1931NADP; via carbonyl oxygenUniRule annotation
    Binding sitei241 – 2411SubstrateUniRule annotation
    Binding sitei244 – 2441PhosphateUniRule annotation
    Binding sitei267 – 2671SubstrateUniRule annotation
    Active sitei274 – 2741Proton acceptorUniRule annotation
    Binding sitei350 – 3501NADPUniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi10 – 134NADPUniRule annotation
    Nucleotide bindingi37 – 382NADPUniRule annotation
    Nucleotide bindingi165 – 1662NADPUniRule annotation

    GO - Molecular functioni

    1. aspartate-semialdehyde dehydrogenase activity Source: UniProtKB-HAMAP
    2. N-acetyl-gamma-glutamyl-phosphate reductase activity Source: InterPro
    3. NAD binding Source: InterPro
    4. NADP binding Source: UniProtKB-HAMAP

    GO - Biological processi

    1. 'de novo' L-methionine biosynthetic process Source: UniProtKB-HAMAP
    2. diaminopimelate biosynthetic process Source: UniProtKB-HAMAP
    3. isoleucine biosynthetic process Source: InterPro
    4. lysine biosynthetic process via diaminopimelate Source: UniProtKB-HAMAP
    5. threonine biosynthetic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    OxidoreductaseUniRule annotation

    Keywords - Biological processi

    Amino-acid biosynthesis, Diaminopimelate biosynthesisUniRule annotation, Lysine biosynthesisUniRule annotation, Methionine biosynthesisUniRule annotation, Threonine biosynthesisUniRule annotation

    Keywords - Ligandi

    NADPUniRule annotation

    Enzyme and pathway databases

    BioCyciYPES214092:GKDD-3924-MONOMER.
    UniPathwayiUPA00034; UER00016.
    UPA00050; UER00463.
    UPA00051; UER00464.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Aspartate-semialdehyde dehydrogenaseUniRule annotation (EC:1.2.1.11UniRule annotation)
    Short name:
    ASA dehydrogenaseUniRule annotation
    Short name:
    ASADHUniRule annotation
    Alternative name(s):
    Aspartate-beta-semialdehyde dehydrogenaseUniRule annotation
    Gene namesi
    Name:asdUniRule annotationImported
    Synonyms:asd2Imported
    Ordered Locus Names:y3880Imported, YP_3311Imported, YPO3949Imported
    OrganismiYersinia pestisImported
    Taxonomic identifieri632 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeYersinia
    ProteomesiUP000001019: Chromosome

    Subcellular locationi

    GO - Cellular componenti

    1. cytoplasm Source: InterPro

    Interactioni

    Subunit structurei

    Homodimer.UniRule annotation

    Protein-protein interaction databases

    STRINGi214092.YPO3949.

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the aspartate-semialdehyde dehydrogenase family.UniRule annotation

    Phylogenomic databases

    HOGENOMiHOG000161376.
    KOiK00133.
    OMAiLASHNEW.
    OrthoDBiEOG67X1PS.

    Family and domain databases

    Gene3Di3.40.50.720. 1 hit.
    HAMAPiMF_02121. ASADH.
    InterProiIPR000319. Asp-semialdehyde_DH_CS.
    IPR011534. Asp_ADH_gamma-type.
    IPR012080. Asp_semialdehyde_DH.
    IPR016040. NAD(P)-bd_dom.
    IPR000534. Semialdehyde_DH_NAD-bd.
    IPR012280. Semialdhyde_DH_dimer_dom.
    [Graphical view]
    PfamiPF01118. Semialdhyde_dh. 1 hit.
    PF02774. Semialdhyde_dhC. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000148. ASA_dh. 1 hit.
    SMARTiSM00859. Semialdhyde_dh. 1 hit.
    [Graphical view]
    TIGRFAMsiTIGR01745. asd_gamma. 1 hit.
    PROSITEiPS01103. ASD. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9ETB0-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKNVGFIGWR GMVGSVLMQR MIEERDFDGI RPVFFSTSQH GQAAPAFAGH    50
    QGTLQDAYDI DALSALDIII TCQGGDYTNQ IYPKLREIGW QGYWIDAASS 100
    LRMQDDTIII LDPVNHDVIK QGLDKGIKTF AGGNCTVSLM LMSLGGLFAN 150
    NLVEWASVAT YQAASGGGAR HMRELLTQMG MLHAGVAKEL QDPASAILDI 200
    ERKVTSTTRS GTLPTDNFGV PLAGSLIPWI DKALDNGQSR EEWKGQAETN 250
    KILSTSTLIP VDGLCVRVGA LRCHSQAFTL KLKKDVPLAE IEQMLATHND 300
    WVRVIPNDRE LSMRELTPAA VTGTLNTPVG RLRKLNMGPE YLSAFTVGDQ 350
    LLWGAAEPLR RMLRILL 367
    Length:367
    Mass (Da):40,191
    Last modified:March 1, 2001 - v1
    Checksum:iEFFEE5C4625B6DE4
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF282318 Genomic DNA. Translation: AAG22007.1.
    AE009952 Genomic DNA. Translation: AAM87425.1.
    AE017042 Genomic DNA. Translation: AAS63476.1.
    AL590842 Genomic DNA. Translation: CAL22530.1.
    PIRiAG0480.
    RefSeqiNP_671174.1. NC_004088.1.
    NP_994599.1. NC_005810.1.
    YP_002348820.1. NC_003143.1.

    Genome annotation databases

    EnsemblBacteriaiAAM87425; AAM87425; y3880.
    AAS63476; AAS63476; YP_3311.
    GeneIDi1148827.
    1176788.
    2763780.
    KEGGiype:YPO3949.
    ypk:y3880.
    ypm:YP_3311.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF282318 Genomic DNA. Translation: AAG22007.1 .
    AE009952 Genomic DNA. Translation: AAM87425.1 .
    AE017042 Genomic DNA. Translation: AAS63476.1 .
    AL590842 Genomic DNA. Translation: CAL22530.1 .
    PIRi AG0480.
    RefSeqi NP_671174.1. NC_004088.1.
    NP_994599.1. NC_005810.1.
    YP_002348820.1. NC_003143.1.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 214092.YPO3949.

    Protocols and materials databases

    DNASUi 1148827.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAM87425 ; AAM87425 ; y3880 .
    AAS63476 ; AAS63476 ; YP_3311 .
    GeneIDi 1148827.
    1176788.
    2763780.
    KEGGi ype:YPO3949.
    ypk:y3880.
    ypm:YP_3311.

    Phylogenomic databases

    HOGENOMi HOG000161376.
    KOi K00133.
    OMAi LASHNEW.
    OrthoDBi EOG67X1PS.

    Enzyme and pathway databases

    UniPathwayi UPA00034 ; UER00016 .
    UPA00050 ; UER00463 .
    UPA00051 ; UER00464 .
    BioCyci YPES214092:GKDD-3924-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.720. 1 hit.
    HAMAPi MF_02121. ASADH.
    InterProi IPR000319. Asp-semialdehyde_DH_CS.
    IPR011534. Asp_ADH_gamma-type.
    IPR012080. Asp_semialdehyde_DH.
    IPR016040. NAD(P)-bd_dom.
    IPR000534. Semialdehyde_DH_NAD-bd.
    IPR012280. Semialdhyde_DH_dimer_dom.
    [Graphical view ]
    Pfami PF01118. Semialdhyde_dh. 1 hit.
    PF02774. Semialdhyde_dhC. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000148. ASA_dh. 1 hit.
    SMARTi SM00859. Semialdhyde_dh. 1 hit.
    [Graphical view ]
    TIGRFAMsi TIGR01745. asd_gamma. 1 hit.
    PROSITEi PS01103. ASD. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Genetic relatedness of Yersinia."
      Lindler L.E., Popek M., Huang X.
      Submitted (JUN-2000) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: KIMImported.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: CO92Imported.
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: KIMImported.
    4. "Annotation and evolutionary relationships of a small regulatory RNA gene micF and its target ompF in Yersinia species."
      Delihas N.
      BMC Microbiol. 3:13-13(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: CO92Imported.
    5. "Complete genome sequence of Yersinia pestis strain 91001, an isolate avirulent to humans."
      Song Y., Tong Z., Wang J., Wang L., Guo Z., Han Y., Zhang J., Pei D., Zhou D., Qin H., Pang X., Han Y., Zhai J., Li M., Cui B., Qi Z., Jin L., Dai R.
      , Chen F., Li S., Ye C., Du Z., Lin W., Wang J., Yu J., Yang H., Wang J., Huang P., Yang R.
      DNA Res. 11:179-197(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 91001Imported and 91001 / Biovar MediaevalisImported.
    6. "Genetics of metabolic variations between Yersinia pestis biovars and the proposal of a new biovar, microtus."
      Zhou D., Tong Z., Song Y., Han Y., Pei D., Pang X., Zhai J., Li M., Cui B., Qi Z., Jin L., Dai R., Du Z., Wang J., Guo Z., Wang J., Huang P., Yang R.
      J. Bacteriol. 186:5147-5152(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: 91001Imported.

    Entry informationi

    Entry nameiQ9ETB0_YERPE
    AccessioniPrimary (citable) accession number: Q9ETB0
    Secondary accession number(s): Q74QZ1, Q7CFY8
    Entry historyi
    Integrated into UniProtKB/TrEMBL: March 1, 2001
    Last sequence update: March 1, 2001
    Last modified: October 1, 2014
    This is version 110 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteomeImported

    External Data

    Dasty 3