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Q9ETB0

- Q9ETB0_YERPE

UniProt

Q9ETB0 - Q9ETB0_YERPE

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Protein

Aspartate-semialdehyde dehydrogenase

Gene
asd, asd2, y3880, YP_3311, YPO3949
Organism
Yersinia pestis
Status
Unreviewed - Annotation score: 4 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the NADPH-dependent formation of L-aspartate-semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl-4-phosphate By similarity.UniRule annotation

Catalytic activityi

L-aspartate 4-semialdehyde + phosphate + NADP+ = L-4-aspartyl phosphate + NADPH.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei73 – 731NADP By similarityUniRule annotation
Binding sitei102 – 1021Phosphate By similarityUniRule annotation
Active sitei135 – 1351Acyl-thioester intermediate By similarityUniRule annotation
Binding sitei162 – 1621Substrate By similarityUniRule annotation
Binding sitei193 – 1931NADP; via carbonyl oxygen By similarityUniRule annotation
Binding sitei241 – 2411Substrate By similarityUniRule annotation
Binding sitei244 – 2441Phosphate By similarityUniRule annotation
Binding sitei267 – 2671Substrate By similarityUniRule annotation
Active sitei274 – 2741Proton acceptor By similarityUniRule annotation
Binding sitei350 – 3501NADP By similarityUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi10 – 134NADP By similarityUniRule annotation
Nucleotide bindingi37 – 382NADP By similarityUniRule annotation
Nucleotide bindingi165 – 1662NADP By similarityUniRule annotation

GO - Molecular functioni

  1. aspartate-semialdehyde dehydrogenase activity Source: UniProtKB-HAMAP
  2. N-acetyl-gamma-glutamyl-phosphate reductase activity Source: InterPro
  3. NAD binding Source: InterPro
  4. NADP binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. 'de novo' L-methionine biosynthetic process Source: UniProtKB-HAMAP
  2. diaminopimelate biosynthetic process Source: UniProtKB-HAMAP
  3. isoleucine biosynthetic process Source: InterPro
  4. lysine biosynthetic process via diaminopimelate Source: UniProtKB-HAMAP
  5. threonine biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

OxidoreductaseUniRule annotation

Keywords - Biological processi

Amino-acid biosynthesis, Diaminopimelate biosynthesisUniRule annotation, Lysine biosynthesisUniRule annotation, Methionine biosynthesisUniRule annotation, Threonine biosynthesisUniRule annotation

Keywords - Ligandi

NADPUniRule annotation

Enzyme and pathway databases

BioCyciYPES214092:GKDD-3924-MONOMER.
UniPathwayiUPA00034; UER00016.
UPA00050; UER00463.
UPA00051; UER00464.

Names & Taxonomyi

Protein namesi
Recommended name:
Aspartate-semialdehyde dehydrogenaseUniRule annotation (EC:1.2.1.11UniRule annotation)
Short name:
ASA dehydrogenaseUniRule annotation
Short name:
ASADHUniRule annotation
Alternative name(s):
Aspartate-beta-semialdehyde dehydrogenase
Gene namesi
Name:asdUniRule annotationImported
Synonyms:asd2Imported
Ordered Locus Names:y3880Imported, YP_3311Imported, YPO3949Imported
OrganismiYersinia pestisImported
Taxonomic identifieri632 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeYersinia
ProteomesiUP000000815: Chromosome, UP000002490: Chromosome

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: InterPro
Complete GO annotation...

Interactioni

Subunit structurei

Homodimer By similarity.UniRule annotation

Protein-protein interaction databases

STRINGi214092.YPO3949.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

HOGENOMiHOG000161376.
KOiK00133.
OMAiLASHNEW.
OrthoDBiEOG67X1PS.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
HAMAPiMF_02121. ASADH.
InterProiIPR000319. Asp-semialdehyde_DH_CS.
IPR011534. Asp_ADH_gamma-type.
IPR012080. Asp_semialdehyde_DH.
IPR016040. NAD(P)-bd_dom.
IPR000534. Semialdehyde_DH_NAD-bd.
IPR012280. Semialdhyde_DH_dimer_dom.
[Graphical view]
PfamiPF01118. Semialdhyde_dh. 1 hit.
PF02774. Semialdhyde_dhC. 1 hit.
[Graphical view]
PIRSFiPIRSF000148. ASA_dh. 1 hit.
SMARTiSM00859. Semialdhyde_dh. 1 hit.
[Graphical view]
TIGRFAMsiTIGR01745. asd_gamma. 1 hit.
PROSITEiPS01103. ASD. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9ETB0-1 [UniParc]FASTAAdd to Basket

« Hide

MKNVGFIGWR GMVGSVLMQR MIEERDFDGI RPVFFSTSQH GQAAPAFAGH    50
QGTLQDAYDI DALSALDIII TCQGGDYTNQ IYPKLREIGW QGYWIDAASS 100
LRMQDDTIII LDPVNHDVIK QGLDKGIKTF AGGNCTVSLM LMSLGGLFAN 150
NLVEWASVAT YQAASGGGAR HMRELLTQMG MLHAGVAKEL QDPASAILDI 200
ERKVTSTTRS GTLPTDNFGV PLAGSLIPWI DKALDNGQSR EEWKGQAETN 250
KILSTSTLIP VDGLCVRVGA LRCHSQAFTL KLKKDVPLAE IEQMLATHND 300
WVRVIPNDRE LSMRELTPAA VTGTLNTPVG RLRKLNMGPE YLSAFTVGDQ 350
LLWGAAEPLR RMLRILL 367
Length:367
Mass (Da):40,191
Last modified:March 1, 2001 - v1
Checksum:iEFFEE5C4625B6DE4
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF282318 Genomic DNA. Translation: AAG22007.1.
AE009952 Genomic DNA. Translation: AAM87425.1.
AE017042 Genomic DNA. Translation: AAS63476.1.
AL590842 Genomic DNA. Translation: CAL22530.1.
PIRiAG0480.
RefSeqiNP_671174.1. NC_004088.1.
NP_994599.1. NC_005810.1.
YP_002348820.1. NC_003143.1.

Genome annotation databases

EnsemblBacteriaiAAM87425; AAM87425; y3880.
AAS63476; AAS63476; YP_3311.
GeneIDi1148827.
1176788.
2763780.
KEGGiype:YPO3949.
ypk:y3880.
ypm:YP_3311.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF282318 Genomic DNA. Translation: AAG22007.1 .
AE009952 Genomic DNA. Translation: AAM87425.1 .
AE017042 Genomic DNA. Translation: AAS63476.1 .
AL590842 Genomic DNA. Translation: CAL22530.1 .
PIRi AG0480.
RefSeqi NP_671174.1. NC_004088.1.
NP_994599.1. NC_005810.1.
YP_002348820.1. NC_003143.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 214092.YPO3949.

Protocols and materials databases

DNASUi 1148827.
Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAM87425 ; AAM87425 ; y3880 .
AAS63476 ; AAS63476 ; YP_3311 .
GeneIDi 1148827.
1176788.
2763780.
KEGGi ype:YPO3949.
ypk:y3880.
ypm:YP_3311.

Phylogenomic databases

HOGENOMi HOG000161376.
KOi K00133.
OMAi LASHNEW.
OrthoDBi EOG67X1PS.

Enzyme and pathway databases

UniPathwayi UPA00034 ; UER00016 .
UPA00050 ; UER00463 .
UPA00051 ; UER00464 .
BioCyci YPES214092:GKDD-3924-MONOMER.

Family and domain databases

Gene3Di 3.40.50.720. 1 hit.
HAMAPi MF_02121. ASADH.
InterProi IPR000319. Asp-semialdehyde_DH_CS.
IPR011534. Asp_ADH_gamma-type.
IPR012080. Asp_semialdehyde_DH.
IPR016040. NAD(P)-bd_dom.
IPR000534. Semialdehyde_DH_NAD-bd.
IPR012280. Semialdhyde_DH_dimer_dom.
[Graphical view ]
Pfami PF01118. Semialdhyde_dh. 1 hit.
PF02774. Semialdhyde_dhC. 1 hit.
[Graphical view ]
PIRSFi PIRSF000148. ASA_dh. 1 hit.
SMARTi SM00859. Semialdhyde_dh. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR01745. asd_gamma. 1 hit.
PROSITEi PS01103. ASD. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Genetic relatedness of Yersinia."
    Lindler L.E., Popek M., Huang X.
    Submitted (JUN-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: KIMImported.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: CO-92 / Biovar Orientalis and CO92Imported.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: KIMImported and KIM10+ / Biovar Mediaevalis.
  4. "Annotation and evolutionary relationships of a small regulatory RNA gene micF and its target ompF in Yersinia species."
    Delihas N.
    BMC Microbiol. 3:13-13(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: CO92Imported.
  5. "Complete genome sequence of Yersinia pestis strain 91001, an isolate avirulent to humans."
    Song Y., Tong Z., Wang J., Wang L., Guo Z., Han Y., Zhang J., Pei D., Zhou D., Qin H., Pang X., Han Y., Zhai J., Li M., Cui B., Qi Z., Jin L., Dai R.
    , Chen F., Li S., Ye C., Du Z., Lin W., Wang J., Yu J., Yang H., Wang J., Huang P., Yang R.
    DNA Res. 11:179-197(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 91001Imported and 91001 / Biovar Mediaevalis.
  6. "Genetics of metabolic variations between Yersinia pestis biovars and the proposal of a new biovar, microtus."
    Zhou D., Tong Z., Song Y., Han Y., Pei D., Pang X., Zhai J., Li M., Cui B., Qi Z., Jin L., Dai R., Du Z., Wang J., Guo Z., Wang J., Huang P., Yang R.
    J. Bacteriol. 186:5147-5152(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: 91001Imported.

Entry informationi

Entry nameiQ9ETB0_YERPE
AccessioniPrimary (citable) accession number: Q9ETB0
Secondary accession number(s): Q74QZ1, Q7CFY8
Entry historyi
Integrated into UniProtKB/TrEMBL: March 1, 2001
Last sequence update: March 1, 2001
Last modified: July 9, 2014
This is version 109 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

External Data

Dasty 3

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