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Protein

Peptidase inhibitor 16

Gene

Pi16

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

May inhibit cardiomyocyte growth.1 Publication

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionProtease inhibitor

Names & Taxonomyi

Protein namesi
Recommended name:
Peptidase inhibitor 16
Short name:
PI-16
Alternative name(s):
Cysteine-rich protease inhibitor
Gene namesi
Name:Pi16
Synonyms:Cripi
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:1921366. Pi16.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 20By similarityAdd BLAST20
ChainiPRO_000028763421 – 489Peptidase inhibitor 16Add BLAST469

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi107N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi438N-linked (GlcNAc...) asparagineSequence analysis1

Post-translational modificationi

N-glycosylated.1 Publication

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ9ET66.
PeptideAtlasiQ9ET66.
PRIDEiQ9ET66.

PTM databases

PhosphoSitePlusiQ9ET66.

Expressioni

Tissue specificityi

Expressed strongly in aorta and skin, and weakly in adipose tissue (at protein level). In heart, found in the extracellular space surrounding cardiomyocytes (at protein level).1 Publication

Inductioni

Up-regulated in a mouse model of heart failure.1 Publication

Gene expression databases

CleanExiMM_PI16.

Interactioni

Subunit structurei

Interacts with PSP94/MSMB.By similarity

Structurei

3D structure databases

ProteinModelPortaliQ9ET66.
SMRiQ9ET66.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini30 – 158SCPAdd BLAST129

Sequence similaritiesi

Belongs to the CRISP family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG3017. Eukaryota.
COG2340. LUCA.
HOGENOMiHOG000036879.
HOVERGENiHBG104077.
InParanoidiQ9ET66.
KOiK20412.
PhylomeDBiQ9ET66.

Family and domain databases

CDDicd05559. SCP_HrTT-1. 1 hit.
Gene3Di3.40.33.10. 1 hit.
InterProiView protein in InterPro
IPR001283. Allrgn_V5/Tpx1.
IPR018244. Allrgn_V5/Tpx1_CS.
IPR014044. CAP_domain.
IPR035940. CAP_sf.
IPR034124. SCP_PI16-like.
PANTHERiPTHR10334. PTHR10334. 1 hit.
PfamiView protein in Pfam
PF00188. CAP. 1 hit.
PRINTSiPR00837. V5TPXLIKE.
SMARTiView protein in SMART
SM00198. SCP. 1 hit.
SUPFAMiSSF55797. SSF55797. 1 hit.
PROSITEiView protein in PROSITE
PS01009. CRISP_1. 1 hit.
PS01010. CRISP_2. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9ET66-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MLPPPLLLLL LLIATGPTTA LTEDEKQTMV DLHNQYRAQV SPPASDMLQM
60 70 80 90 100
RWDDELAAFA KAYAQKCVWG HNKERGRRGE NLFAITDEGM DVPLAVGNWH
110 120 130 140 150
EEHEYYNFST ATCDPNQMCG HYTQVVWSKT ERIGCGSHFC ETLQGVEEAN
160 170 180 190 200
IHLLVCNYEP PGNVKGRKPY QEGTPCSQCP LGYSCENSLC EPMRNPEKAQ
210 220 230 240 250
DSPPRVTEVP STRATEAPSS RETGTPSLAT SETLHFSVTK VSDSLATESS
260 270 280 290 300
PAVETKAPSS LATEGPSSMA TEAQAFVTEV PLVSARHMQP SVDEGPVNFL
310 320 330 340 350
TSTHIPVPKS MDEEASKSSA TSVSPKKSLY PKMSLTESGE SVPQIQEEAE
360 370 380 390 400
PKDELSEPEA ILPEAEAAPT EAEVELREPE AESPKAESPE AEAESPLSSE
410 420 430 440 450
ALVPVLPAQE RGGQKASLEH SGHPASPSLP TFPSASGNAT GGRTLALQSS
460 470 480
WTGAENPEKA DWDLKNSAHV WGPFLGLLLP SLLLLAGMV
Length:489
Mass (Da):52,665
Last modified:March 1, 2001 - v1
Checksum:i01C2009712E3C76D
GO
Isoform 2 (identifier: Q9ET66-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     191-452: Missing.

Show »
Length:227
Mass (Da):25,280
Checksum:iFE79BC4DEC8CEBA2
GO

Sequence cautioni

The sequence AAH39124 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti239T → I in BAB03398 (Ref. 1) Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_025575191 – 452Missing in isoform 2. 1 PublicationAdd BLAST262

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB046537 mRNA. Translation: BAB03398.1.
AB046539 Genomic DNA. Translation: BAB03453.1.
AY301264 Genomic DNA. Translation: AAP45197.1.
BC039124 mRNA. Translation: AAH39124.1. Different initiation.
BC118026 mRNA. Translation: AAI18027.1.
RefSeqiNP_076223.3. NM_023734.3.
UniGeneiMm.30950.

Genome annotation databases

GeneIDi74116.
KEGGimmu:74116.

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiPI16_MOUSE
AccessioniPrimary (citable) accession number: Q9ET66
Secondary accession number(s): Q148Q6, Q8CHU4, Q9JJ56
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 15, 2007
Last sequence update: March 1, 2001
Last modified: October 25, 2017
This is version 100 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families