Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Complement component C1q receptor

Gene

Cd93

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Receptor (or element of a larger receptor complex) for C1q, mannose-binding lectin (MBL2) and pulmonary surfactant protein A (SPA). May mediate the enhancement of phagocytosis in monocytes and macrophages upon interaction with soluble defense collagens. May play a role in intercellular adhesion.

GO - Molecular functioni

GO - Biological processi

  • single organismal cell-cell adhesion Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Receptor

Keywords - Biological processi

Cell adhesion

Keywords - Ligandi

Lectin

Names & Taxonomyi

Protein namesi
Recommended name:
Complement component C1q receptor
Alternative name(s):
C1q/MBL/SPA receptor
Short name:
C1qR(p)
Short name:
C1qRp
Cell surface antigen AA4
Complement component 1 q subcomponent receptor 1
CD_antigen: CD93
Gene namesi
Name:Cd93
Synonyms:C1qr1, C1qrp
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi621251. Cd93.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini24 – 571ExtracellularSequence analysisAdd BLAST548
Transmembranei572 – 592HelicalSequence analysisAdd BLAST21
Topological domaini593 – 643CytoplasmicSequence analysisAdd BLAST51

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 23Sequence analysisAdd BLAST23
ChainiPRO_000001736924 – 643Complement component C1q receptorAdd BLAST620

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi140 ↔ 164By similarity
Disulfide bondi261 ↔ 272By similarity
Disulfide bondi268 ↔ 282By similarity
Disulfide bondi284 ↔ 297By similarity
Disulfide bondi303 ↔ 314By similarity
Disulfide bondi308 ↔ 325By similarity
Glycosylationi322N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi327 ↔ 340By similarity
Disulfide bondi346 ↔ 355By similarity
Disulfide bondi351 ↔ 364By similarity
Disulfide bondi366 ↔ 380By similarity
Disulfide bondi386 ↔ 397By similarity
Disulfide bondi393 ↔ 406By similarity
Disulfide bondi408 ↔ 422By similarity
Disulfide bondi428 ↔ 437By similarity
Disulfide bondi433 ↔ 446By similarity
Disulfide bondi448 ↔ 461By similarity
Glycosylationi498N-linked (GlcNAc...)Sequence analysis1
Modified residuei618PhosphoserineCombined sources1
Modified residuei635PhosphotyrosineBy similarity1

Post-translational modificationi

N- and O-glycosylated.By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiQ9ET61.
PRIDEiQ9ET61.

PTM databases

iPTMnetiQ9ET61.
PhosphoSitePlusiQ9ET61.

Expressioni

Tissue specificityi

Widely expressed. Highly expressed in lung and heart. Expressed at lower level in brain, thymus, liver, spleen, intestine, kidney, adrenal gland, muscle and testis. Expressed on endothelial cells, platelets, undifferentiated monocytes and circulating natural killer cells.

Gene expression databases

BgeeiENSRNOG00000024799.

Interactioni

Subunit structurei

Interacts with C1QBP; the association may represent a cell surface C1q receptor.By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000034001.

Structurei

3D structure databases

ProteinModelPortaliQ9ET61.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini31 – 173C-type lectinPROSITE-ProRule annotationAdd BLAST143
Domaini257 – 298EGF-like 1PROSITE-ProRule annotationAdd BLAST42
Domaini299 – 341EGF-like 2PROSITE-ProRule annotationAdd BLAST43
Domaini342 – 381EGF-like 3; calcium-bindingPROSITE-ProRule annotationAdd BLAST40
Domaini382 – 423EGF-like 4; calcium-bindingPROSITE-ProRule annotationAdd BLAST42
Domaini424 – 462EGF-like 5; calcium-bindingPROSITE-ProRule annotationAdd BLAST39

Sequence similaritiesi

Contains 1 C-type lectin domain.PROSITE-ProRule annotation
Contains 5 EGF-like domains.PROSITE-ProRule annotation

Keywords - Domaini

EGF-like domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IJQN. Eukaryota.
ENOG410ZKXP. LUCA.
HOVERGENiHBG050751.
InParanoidiQ9ET61.
KOiK06702.
PhylomeDBiQ9ET61.

Family and domain databases

Gene3Di3.10.100.10. 2 hits.
InterProiIPR001304. C-type_lectin-like.
IPR016186. C-type_lectin-like/link.
IPR026823. cEGF.
IPR016187. CTDL_fold.
IPR001881. EGF-like_Ca-bd_dom.
IPR013032. EGF-like_CS.
IPR000742. EGF-like_dom.
IPR000152. EGF-type_Asp/Asn_hydroxyl_site.
IPR018097. EGF_Ca-bd_CS.
IPR009030. Growth_fac_rcpt_.
[Graphical view]
PfamiPF12662. cEGF. 1 hit.
PF07645. EGF_CA. 2 hits.
PF00059. Lectin_C. 1 hit.
[Graphical view]
SMARTiSM00034. CLECT. 1 hit.
SM00181. EGF. 5 hits.
SM00179. EGF_CA. 5 hits.
[Graphical view]
SUPFAMiSSF56436. SSF56436. 1 hit.
SSF57184. SSF57184. 1 hit.
PROSITEiPS00010. ASX_HYDROXYL. 3 hits.
PS50041. C_TYPE_LECTIN_2. 1 hit.
PS01186. EGF_2. 3 hits.
PS50026. EGF_3. 4 hits.
PS01187. EGF_CA. 3 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9ET61-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVTSTGLLLL LGLLGQLWAG AAADSEAVVC EGTACYTAHW GKLSAAEAQH
60 70 80 90 100
RCNENGGNLA TVKSEEEARH VQEALAQLLK TKAPSETKIG KFWIGLQREK
110 120 130 140 150
GKCTYHDLPM KGFSWVGGGE DTTYSNWYKA SKSSCISKRC VSLILDLSLK
160 170 180 190 200
PHPSHLPKWH ESPCGTPDAP GNSIEGFLCK FNFKGMCSPL ALGGPGQLTY
210 220 230 240 250
TTPFQATTSS LKAVPFASVA NVVCGDEAES KTNYYLCKET TAGVFHWGSS
260 270 280 290 300
GPLCVSPKFG CSFNNGGCQQ DCFEGGDGSF RCGCRPGFRL LDDLVTCASR
310 320 330 340 350
NPCSSNPCTG GGMCHSVPLS ENYTCHCPRG YQLDSSQVHC VDIDECEDSP
360 370 380 390 400
CDQECINTPG GFHCECWVGY QSSGSKEEAC EDVDECTAAY SPCAQGCTNT
410 420 430 440 450
DGSFYCSCKE GYIMSGEDST QCEDIDECLG NPCDTLCINT DGSFRCGCPA
460 470 480 490 500
GFELAPNGVS CTRGSMFSEL PARPPQKEDK GDGKESTVPL TEMPGSLNGS
510 520 530 540 550
KDVSNRAQTT DLSIQSDSST ASVPLEIEVS SEASDVWLDL GTYLPTTSGH
560 570 580 590 600
SQPTHEDSVP AHSDSDTDGQ KLLLFYILGT VVAISLLLAL ALGLLIYLKR
610 620 630 640
KAKKEEIKEK KAQNAADSYS WIPERAESRA PENQYSPTPG TDC
Length:643
Mass (Da):68,782
Last modified:March 1, 2001 - v1
Checksum:i9AE4C933AD943DB6
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti417E → K in AAF80402 (PubMed:10934210).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF136537 mRNA. Translation: AAG01572.1.
AF160978 mRNA. Translation: AAF80402.1.
RefSeqiNP_445835.1. NM_053383.1.
UniGeneiRn.162695.

Genome annotation databases

GeneIDi84398.
KEGGirno:84398.
UCSCiRGD:621251. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF136537 mRNA. Translation: AAG01572.1.
AF160978 mRNA. Translation: AAF80402.1.
RefSeqiNP_445835.1. NM_053383.1.
UniGeneiRn.162695.

3D structure databases

ProteinModelPortaliQ9ET61.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000034001.

PTM databases

iPTMnetiQ9ET61.
PhosphoSitePlusiQ9ET61.

Proteomic databases

PaxDbiQ9ET61.
PRIDEiQ9ET61.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi84398.
KEGGirno:84398.
UCSCiRGD:621251. rat.

Organism-specific databases

CTDi22918.
RGDi621251. Cd93.

Phylogenomic databases

eggNOGiENOG410IJQN. Eukaryota.
ENOG410ZKXP. LUCA.
HOVERGENiHBG050751.
InParanoidiQ9ET61.
KOiK06702.
PhylomeDBiQ9ET61.

Miscellaneous databases

PROiQ9ET61.

Gene expression databases

BgeeiENSRNOG00000024799.

Family and domain databases

Gene3Di3.10.100.10. 2 hits.
InterProiIPR001304. C-type_lectin-like.
IPR016186. C-type_lectin-like/link.
IPR026823. cEGF.
IPR016187. CTDL_fold.
IPR001881. EGF-like_Ca-bd_dom.
IPR013032. EGF-like_CS.
IPR000742. EGF-like_dom.
IPR000152. EGF-type_Asp/Asn_hydroxyl_site.
IPR018097. EGF_Ca-bd_CS.
IPR009030. Growth_fac_rcpt_.
[Graphical view]
PfamiPF12662. cEGF. 1 hit.
PF07645. EGF_CA. 2 hits.
PF00059. Lectin_C. 1 hit.
[Graphical view]
SMARTiSM00034. CLECT. 1 hit.
SM00181. EGF. 5 hits.
SM00179. EGF_CA. 5 hits.
[Graphical view]
SUPFAMiSSF56436. SSF56436. 1 hit.
SSF57184. SSF57184. 1 hit.
PROSITEiPS00010. ASX_HYDROXYL. 3 hits.
PS50041. C_TYPE_LECTIN_2. 1 hit.
PS01186. EGF_2. 3 hits.
PS50026. EGF_3. 4 hits.
PS01187. EGF_CA. 3 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiC1QR1_RAT
AccessioniPrimary (citable) accession number: Q9ET61
Secondary accession number(s): Q9JIZ6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 20, 2002
Last sequence update: March 1, 2001
Last modified: November 30, 2016
This is version 115 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.