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Protein

Krueppel-like factor 2

Gene

Klf2

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Transcription factor that binds to the CACCC box in the promoter of target genes such as HBB/beta globin or NOV and activates their transcription.By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri268 – 29225C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri298 – 32225C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri328 – 35023C2H2-type 3PROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Activator

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Krueppel-like factor 2
Alternative name(s):
Lung krueppel-like factor
Gene namesi
Name:Klf2
Synonyms:Lklf
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 16

Organism-specific databases

RGDi1359220. Klf2.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 351351Krueppel-like factor 2PRO_0000047164Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei171 – 1711PhosphothreonineCombined sources
Modified residuei240 – 2401PhosphothreonineCombined sources
Modified residuei243 – 2431PhosphoserineBy similarity

Post-translational modificationi

Ubiquitinated. Polyubiquitination involves WWP1 and leads to proteasomal degradation of this protein (By similarity).By similarity

Keywords - PTMi

Phosphoprotein, Ubl conjugation

Proteomic databases

PaxDbiQ9ET58.
PRIDEiQ9ET58.

PTM databases

iPTMnetiQ9ET58.

Expressioni

Gene expression databases

GenevisibleiQ9ET58. RN.

Interactioni

Subunit structurei

Interacts with WWP1.By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000019052.

Structurei

3D structure databases

ProteinModelPortaliQ9ET58.
SMRiQ9ET58. Positions 268-350.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni110 – 264155Interaction with WWP1By similarityAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi60 – 7011Poly-ProAdd
BLAST
Compositional biasi165 – 1684Poly-Pro
Compositional biasi224 – 2274Poly-Ala

Sequence similaritiesi

Contains 3 C2H2-type zinc fingers.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri268 – 29225C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri298 – 32225C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri328 – 35023C2H2-type 3PROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00760000118998.
HOGENOMiHOG000060173.
HOVERGENiHBG006220.
InParanoidiQ9ET58.
KOiK17845.
OMAiFYYPEPG.
OrthoDBiEOG747PJ4.
PhylomeDBiQ9ET58.
TreeFamiTF350556.

Family and domain databases

Gene3Di3.30.160.60. 3 hits.
InterProiIPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF00096. zf-C2H2. 1 hit.
[Graphical view]
SMARTiSM00355. ZnF_C2H2. 3 hits.
[Graphical view]
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 3 hits.
PS50157. ZINC_FINGER_C2H2_2. 3 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9ET58-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MALSEPILPS FATFASPCER GLQERWPRNE PEAGSTDEDL NSVLDFILSM
60 70 80 90 100
GLDGLGAENP PEPPPQPPPP AFYYPEPGAP PPYGTPAAGL GTELLRPDLD
110 120 130 140 150
APQGPALHGR FLLAPPGRLV KAEPPEVDGG GYGCAAGLAR GPRGLKLEGA
160 170 180 190 200
LGATGACMRG PAGRPPPPSD TPPLSPDGPP RLPAPGPRNP FPPPFGPGPS
210 220 230 240 250
FGGPGPALHY GPPAPGAFGL FDDAAAALGL APPATRGLLT PPSSPLELLE
260 270 280 290 300
AKPKRGRRSW PRKRAATHTC SYTNCGKTYT KSSHLKAHLR THTGEKPYHC
310 320 330 340 350
NWDGCGWKFA RSDELTRHYR KHTGHRPFQC HLCDRAFSRS DHLALHMKRH

M
Length:351
Mass (Da):37,313
Last modified:March 1, 2001 - v1
Checksum:i2E4EB6B0577A53A4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF181251 Genomic DNA. Translation: AAG02141.1.
RefSeqiNP_001007685.1. NM_001007684.1.
UniGeneiRn.92653.

Genome annotation databases

EnsembliENSRNOT00000019052; ENSRNOP00000019052; ENSRNOG00000014205.
GeneIDi306330.
KEGGirno:306330.
UCSCiRGD:1359220. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF181251 Genomic DNA. Translation: AAG02141.1.
RefSeqiNP_001007685.1. NM_001007684.1.
UniGeneiRn.92653.

3D structure databases

ProteinModelPortaliQ9ET58.
SMRiQ9ET58. Positions 268-350.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000019052.

PTM databases

iPTMnetiQ9ET58.

Proteomic databases

PaxDbiQ9ET58.
PRIDEiQ9ET58.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000019052; ENSRNOP00000019052; ENSRNOG00000014205.
GeneIDi306330.
KEGGirno:306330.
UCSCiRGD:1359220. rat.

Organism-specific databases

CTDi10365.
RGDi1359220. Klf2.

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00760000118998.
HOGENOMiHOG000060173.
HOVERGENiHBG006220.
InParanoidiQ9ET58.
KOiK17845.
OMAiFYYPEPG.
OrthoDBiEOG747PJ4.
PhylomeDBiQ9ET58.
TreeFamiTF350556.

Miscellaneous databases

PROiQ9ET58.

Gene expression databases

GenevisibleiQ9ET58. RN.

Family and domain databases

Gene3Di3.30.160.60. 3 hits.
InterProiIPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF00096. zf-C2H2. 1 hit.
[Graphical view]
SMARTiSM00355. ZnF_C2H2. 3 hits.
[Graphical view]
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 3 hits.
PS50157. ZINC_FINGER_C2H2_2. 3 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The gene for the transcription factor LKLF is developmentally expressed in rat T cells and is not defective in lymphopenic diabetes-prone BB rats."
    Haag F., Bartels K., Rothenburg S., Stahmer I., Thiele H.-G., Koch-Nolte F.
    Submitted (AUG-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: Brown Norway/SsNHsd.
  2. "Quantitative maps of protein phosphorylation sites across 14 different rat organs and tissues."
    Lundby A., Secher A., Lage K., Nordsborg N.B., Dmytriyev A., Lundby C., Olsen J.V.
    Nat. Commun. 3:876-876(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-171 AND THR-240, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiKLF2_RAT
AccessioniPrimary (citable) accession number: Q9ET58
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 23, 2002
Last sequence update: March 1, 2001
Last modified: June 8, 2016
This is version 112 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.