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Protein

Claudin-12

Gene

Cldn12

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Claudin-12
Gene namesi
Name:Cldn12
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 5

Organism-specific databases

MGIiMGI:1929288. Cldn12.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 10CytoplasmicSequence analysis10
Transmembranei11 – 31HelicalSequence analysisAdd BLAST21
Topological domaini32 – 87ExtracellularSequence analysisAdd BLAST56
Transmembranei88 – 108HelicalSequence analysisAdd BLAST21
Topological domaini109 – 135CytoplasmicSequence analysisAdd BLAST27
Transmembranei136 – 156HelicalSequence analysisAdd BLAST21
Topological domaini157 – 174ExtracellularSequence analysisAdd BLAST18
Transmembranei175 – 195HelicalSequence analysisAdd BLAST21
Topological domaini196 – 244CytoplasmicSequence analysisAdd BLAST49

GO - Cellular componenti

  • bicellular tight junction Source: UniProtKB
  • cell periphery Source: MGI
  • integral component of membrane Source: UniProtKB-KW
  • lateral plasma membrane Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cell membrane, Membrane, Tight junction

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001447661 – 244Claudin-12Add BLAST244

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei228PhosphoserineBy similarity1
Modified residuei231PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ9ET43.
PeptideAtlasiQ9ET43.
PRIDEiQ9ET43.

PTM databases

iPTMnetiQ9ET43.
PhosphoSitePlusiQ9ET43.

Expressioni

Gene expression databases

BgeeiENSMUSG00000046798.
CleanExiMM_CLDN12.
GenevisibleiQ9ET43. MM.

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000061928.

Structurei

3D structure databases

ProteinModelPortaliQ9ET43.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the claudin family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IE44. Eukaryota.
ENOG410ZR1K. LUCA.
GeneTreeiENSGT00400000022250.
HOGENOMiHOG000036050.
HOVERGENiHBG050986.
InParanoidiQ9ET43.
OMAiFYNTHLN.
OrthoDBiEOG091G0E18.
PhylomeDBiQ9ET43.
TreeFamiTF331972.

Family and domain databases

InterProiIPR013287. Claudin12.
IPR017974. Claudin_CS.
[Graphical view]
PRINTSiPR01872. CLAUDIN12.
PROSITEiPS01346. CLAUDIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9ET43-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGCRDVHAAT VLSFLCGIAS VAGLFAGTLL PNWRKLRLIT FNRNEKNLTI
60 70 80 90 100
YTGLWVKCAR YDGSSDCLMY DRTWYLSVDQ LDLRVLQFAL PLSIVIAMGA
110 120 130 140 150
LLLCLIGMCN TAFNSSVPNI KLAKCLVNSA GCHLVAGLLF FLAGTVSLSP
160 170 180 190 200
SIWAIFYNSH LNRKFEPVFT FDYAVFVTIA SSGGLFMTAL LLFVWYCACK
210 220 230 240
SLSSPFWQPL YSHAPGMHTY SQPYSSRSRL SAIEIDIPVV SHST
Length:244
Mass (Da):26,995
Last modified:May 16, 2003 - v2
Checksum:i5A49F3BD7C25C87E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK039672 mRNA. Translation: BAC30414.1.
AK049331 mRNA. Translation: BAC33687.1.
AK132155 mRNA. Translation: BAE21001.1.
AK166110 mRNA. Translation: BAE38577.1.
BC024057 mRNA. Translation: AAH24057.1.
AF247664 mRNA. Translation: AAF98801.1.
CCDSiCCDS19074.1.
RefSeqiNP_001180588.1. NM_001193659.1.
NP_001180589.1. NM_001193660.1.
NP_001180590.1. NM_001193661.1.
NP_075028.1. NM_022890.2.
XP_006503661.1. XM_006503598.3.
XP_011238975.1. XM_011240673.2.
XP_011238976.1. XM_011240674.1.
UniGeneiMm.40132.

Genome annotation databases

EnsembliENSMUST00000060947; ENSMUSP00000061928; ENSMUSG00000046798.
ENSMUST00000115445; ENSMUSP00000111105; ENSMUSG00000046798.
ENSMUST00000115446; ENSMUSP00000111106; ENSMUSG00000046798.
ENSMUST00000179804; ENSMUSP00000136988; ENSMUSG00000046798.
GeneIDi64945.
KEGGimmu:64945.
UCSCiuc008wip.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK039672 mRNA. Translation: BAC30414.1.
AK049331 mRNA. Translation: BAC33687.1.
AK132155 mRNA. Translation: BAE21001.1.
AK166110 mRNA. Translation: BAE38577.1.
BC024057 mRNA. Translation: AAH24057.1.
AF247664 mRNA. Translation: AAF98801.1.
CCDSiCCDS19074.1.
RefSeqiNP_001180588.1. NM_001193659.1.
NP_001180589.1. NM_001193660.1.
NP_001180590.1. NM_001193661.1.
NP_075028.1. NM_022890.2.
XP_006503661.1. XM_006503598.3.
XP_011238975.1. XM_011240673.2.
XP_011238976.1. XM_011240674.1.
UniGeneiMm.40132.

3D structure databases

ProteinModelPortaliQ9ET43.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000061928.

PTM databases

iPTMnetiQ9ET43.
PhosphoSitePlusiQ9ET43.

Proteomic databases

PaxDbiQ9ET43.
PeptideAtlasiQ9ET43.
PRIDEiQ9ET43.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000060947; ENSMUSP00000061928; ENSMUSG00000046798.
ENSMUST00000115445; ENSMUSP00000111105; ENSMUSG00000046798.
ENSMUST00000115446; ENSMUSP00000111106; ENSMUSG00000046798.
ENSMUST00000179804; ENSMUSP00000136988; ENSMUSG00000046798.
GeneIDi64945.
KEGGimmu:64945.
UCSCiuc008wip.2. mouse.

Organism-specific databases

CTDi9069.
MGIiMGI:1929288. Cldn12.

Phylogenomic databases

eggNOGiENOG410IE44. Eukaryota.
ENOG410ZR1K. LUCA.
GeneTreeiENSGT00400000022250.
HOGENOMiHOG000036050.
HOVERGENiHBG050986.
InParanoidiQ9ET43.
OMAiFYNTHLN.
OrthoDBiEOG091G0E18.
PhylomeDBiQ9ET43.
TreeFamiTF331972.

Miscellaneous databases

PROiQ9ET43.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000046798.
CleanExiMM_CLDN12.
GenevisibleiQ9ET43. MM.

Family and domain databases

InterProiIPR013287. Claudin12.
IPR017974. Claudin_CS.
[Graphical view]
PRINTSiPR01872. CLAUDIN12.
PROSITEiPS01346. CLAUDIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCLD12_MOUSE
AccessioniPrimary (citable) accession number: Q9ET43
Secondary accession number(s): Q3TM65, Q8BH13
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 10, 2002
Last sequence update: May 16, 2003
Last modified: November 2, 2016
This is version 102 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.