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Q9ET39

- SLAF6_MOUSE

UniProt

Q9ET39 - SLAF6_MOUSE

Protein

SLAM family member 6

Gene

Slamf6

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 110 (01 Oct 2014)
      Sequence version 1 (01 Mar 2001)
      Previous versions | rss
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    Functioni

    May rather modulate immune responses. Triggers cytolytic activity only in natural killer cells (NK) expressing high surface densities of natural cytotoxicity receptors.1 Publication

    GO - Molecular functioni

    1. receptor activity Source: InterPro

    Keywords - Molecular functioni

    Receptor

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    SLAM family member 6
    Alternative name(s):
    Lymphocyte antigen 108
    CD_antigen: CD352
    Gene namesi
    Name:Slamf6
    Synonyms:Ly108
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 1

    Organism-specific databases

    MGIiMGI:1353620. Slamf6.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of plasma membrane Source: MGI

    Keywords - Cellular componenti

    Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 3030Sequence AnalysisAdd
    BLAST
    Chaini31 – 351321SLAM family member 6PRO_0000014962Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi82 – 821N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi101 – 1011N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi112 – 1121N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi152 – 1521N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi159 – 1591N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi162 ↔ 229PROSITE-ProRule annotation
    Disulfide bondi168 ↔ 210PROSITE-ProRule annotation
    Glycosylationi172 – 1721N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi186 – 1861N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi193 – 1931N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi218 – 2181N-linked (GlcNAc...)Sequence Analysis
    Modified residuei319 – 3191PhosphotyrosineBy similarity

    Post-translational modificationi

    Phosphorylated.By similarity

    Keywords - PTMi

    Disulfide bond, Glycoprotein, Phosphoprotein

    Proteomic databases

    MaxQBiQ9ET39.
    PRIDEiQ9ET39.

    PTM databases

    PhosphoSiteiQ9ET39.

    Expressioni

    Tissue specificityi

    Expressed on hematopoietic cells.

    Gene expression databases

    ArrayExpressiQ9ET39.
    BgeeiQ9ET39.
    CleanExiMM_SLAMF6.
    GenevestigatoriQ9ET39.

    Interactioni

    Subunit structurei

    Homodimer. Interacts with PTN6 and, upon phosphorylation, with PTN11 and SH2D1A/SAP By similarity.By similarity

    Structurei

    3D structure databases

    ProteinModelPortaliQ9ET39.
    SMRiQ9ET39. Positions 39-230.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini31 – 239209ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini263 – 35189CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei240 – 26223HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini36 – 13095Ig-like V-typeAdd
    BLAST
    Domaini147 – 21064Ig-like C2-typeAdd
    BLAST

    Sequence similaritiesi

    Keywords - Domaini

    Immunoglobulin domain, Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG45125.
    GeneTreeiENSGT00530000063114.
    HOGENOMiHOG000059581.
    HOVERGENiHBG055054.
    InParanoidiQ9ET39.
    KOiK16852.
    OMAiEIHLTCS.
    OrthoDBiEOG77HDFC.
    PhylomeDBiQ9ET39.
    TreeFamiTF334964.

    Family and domain databases

    Gene3Di2.60.40.10. 1 hit.
    InterProiIPR007110. Ig-like_dom.
    IPR013783. Ig-like_fold.
    IPR003599. Ig_sub.
    IPR013106. Ig_V-set.
    IPR015631. SLAM_fam_rcpts.
    [Graphical view]
    PANTHERiPTHR12080. PTHR12080. 1 hit.
    PfamiPF07686. V-set. 1 hit.
    [Graphical view]
    SMARTiSM00409. IG. 1 hit.
    [Graphical view]
    PROSITEiPS50835. IG_LIKE. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q9ET39-1) [UniParc]FASTAAdd to Basket

    Also known as: Ly108s

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MAVSRAPAPD SACQRMVWLF PLVFCLGSGS EVSQSSSDPQ LMNGVLGESA    50
    VLPLKLPAGK IANIIIWNYE WEASQVTALV INLSNPESPQ IMNTDVKKRL 100
    NITQSYSLQI SNLTMADTGS YTAQITTKDS EVITFKYILR VFERLGNLET 150
    TNYTLLLENG TCQIHLACVL KNQSQTVSVE WQATGNISLG GPNVTIFWDP 200
    RNSGDQTYVC RAKNAVSNLS VSVSTQSLCK GVLTNPPWNA VWFMTTISII 250
    SAVILIFVCW SIHVWKRRGS LPLTSQHPES SQSTDGPGSP GNTVYAQVTR 300
    PMQEMKIPKP IKNDSMTIYS IVNHSREETV ALTGYNQPIT LKVNTLINYN 350
    S 351
    Length:351
    Mass (Da):38,638
    Last modified:March 1, 2001 - v1
    Checksum:iA8DD9EBF650FB431
    GO
    Isoform 2 (identifier: Q9ET39-2) [UniParc]FASTAAdd to Basket

    Also known as: Ly108l

    The sequence of this isoform differs from the canonical sequence as follows:
         328-331: ETVA → AEYS
         332-351: Missing.

    Show »
    Length:331
    Mass (Da):36,440
    Checksum:i7E1A056C8C0A716A
    GO

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei328 – 3314ETVA → AEYS in isoform 2. 1 PublicationVSP_010404
    Alternative sequencei332 – 35120Missing in isoform 2. 1 PublicationVSP_010405Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF248635 mRNA. Translation: AAG01737.1.
    AF248636 mRNA. Translation: AAG01738.1.
    BC030031 mRNA. Translation: AAH30031.1.
    CCDSiCCDS15504.1. [Q9ET39-2]
    RefSeqiNP_109635.1. NM_030710.2. [Q9ET39-2]
    XP_006496948.1. XM_006496885.1. [Q9ET39-1]
    UniGeneiMm.486404.

    Genome annotation databases

    EnsembliENSMUST00000171330; ENSMUSP00000130610; ENSMUSG00000015314. [Q9ET39-2]
    GeneIDi30925.
    KEGGimmu:30925.
    UCSCiuc007dph.1. mouse. [Q9ET39-1]

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF248635 mRNA. Translation: AAG01737.1 .
    AF248636 mRNA. Translation: AAG01738.1 .
    BC030031 mRNA. Translation: AAH30031.1 .
    CCDSi CCDS15504.1. [Q9ET39-2 ]
    RefSeqi NP_109635.1. NM_030710.2. [Q9ET39-2 ]
    XP_006496948.1. XM_006496885.1. [Q9ET39-1 ]
    UniGenei Mm.486404.

    3D structure databases

    ProteinModelPortali Q9ET39.
    SMRi Q9ET39. Positions 39-230.
    ModBasei Search...
    MobiDBi Search...

    PTM databases

    PhosphoSitei Q9ET39.

    Proteomic databases

    MaxQBi Q9ET39.
    PRIDEi Q9ET39.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000171330 ; ENSMUSP00000130610 ; ENSMUSG00000015314 . [Q9ET39-2 ]
    GeneIDi 30925.
    KEGGi mmu:30925.
    UCSCi uc007dph.1. mouse. [Q9ET39-1 ]

    Organism-specific databases

    CTDi 114836.
    MGIi MGI:1353620. Slamf6.

    Phylogenomic databases

    eggNOGi NOG45125.
    GeneTreei ENSGT00530000063114.
    HOGENOMi HOG000059581.
    HOVERGENi HBG055054.
    InParanoidi Q9ET39.
    KOi K16852.
    OMAi EIHLTCS.
    OrthoDBi EOG77HDFC.
    PhylomeDBi Q9ET39.
    TreeFami TF334964.

    Miscellaneous databases

    NextBioi 307320.
    PROi Q9ET39.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q9ET39.
    Bgeei Q9ET39.
    CleanExi MM_SLAMF6.
    Genevestigatori Q9ET39.

    Family and domain databases

    Gene3Di 2.60.40.10. 1 hit.
    InterProi IPR007110. Ig-like_dom.
    IPR013783. Ig-like_fold.
    IPR003599. Ig_sub.
    IPR013106. Ig_V-set.
    IPR015631. SLAM_fam_rcpts.
    [Graphical view ]
    PANTHERi PTHR12080. PTHR12080. 1 hit.
    Pfami PF07686. V-set. 1 hit.
    [Graphical view ]
    SMARTi SM00409. IG. 1 hit.
    [Graphical view ]
    PROSITEi PS50835. IG_LIKE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Ly108: a new member of the mouse CD2 family of cell surface proteins."
      Peck S.R., Ruley H.E.
      Immunogenetics 52:63-72(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2).
      Strain: C57BL/6.
      Tissue: Spleen.
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Thymus.
    3. "Homotypic interactions mediated by Slamf1 and Slamf6 receptors control NKT cell lineage development."
      Griewank K., Borowski C., Rietdijk S., Wang N., Julien A., Wei D.G., Mamchak A.A., Terhorst C., Bendelac A.
      Immunity 27:751-762(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.

    Entry informationi

    Entry nameiSLAF6_MOUSE
    AccessioniPrimary (citable) accession number: Q9ET39
    Secondary accession number(s): Q9ET40
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 24, 2004
    Last sequence update: March 1, 2001
    Last modified: October 1, 2014
    This is version 110 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3