Q9ET39 (SLAF6_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
SLAM family member 6

Alternative name(s):
Lymphocyte antigen 108
CD_antigen=CD352

Gene names

Name:	Slamf6
Synonyms:	Ly108

Organism

Mus musculus (Mouse) [Reference proteome]

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	351 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	May rather modulate immune responses. Triggers cytolytic activity only in natural killer cells (NK) expressing high surface densities of natural cytotoxicity receptors. Ref.3
Subunit structure	Homodimer. Interacts with PTN6 and, upon phosphorylation, with PTN11 and SH2D1A/SAP By similarity.
Subcellular location	Cell membrane; Single-pass type I membrane protein Probable.
Tissue specificity	Expressed on hematopoietic cells.
Post-translational modification	Phosphorylated By similarity.
Sequence similarities	Contains 1 Ig-like (immunoglobulin-like) domain.

Ontologies

Keywords
Cellular component	Cell membrane Membrane
Coding sequence diversity	Alternative splicing
Domain	Immunoglobulin domain Signal Transmembrane Transmembrane helix
Molecular function	Receptor
PTM	Disulfide bond Glycoprotein Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular_component	integral to plasma membrane Inferred from sequence or structural similarity Ref.1. Source: MGI
Molecular_function	receptor activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q9ET39-1)

Also known as: Ly108s;

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q9ET39-2)

Also known as: Ly108l;

The sequence of this isoform differs from the canonical sequence as follows:
     328-331: ETVA → AEYS
     332-351: Missing.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 30	30	Potential
	Chain	31 – 351	321	SLAM family member 6		PRO_0000014962
Regions
	Topological domain	31 – 239	209	Extracellular Potential
	Transmembrane	240 – 262	23	Helical; Potential
	Topological domain	263 – 351	89	Cytoplasmic Potential
	Domain	147 – 222	76	Ig-like
Amino acid modifications
	Modified residue	319	1	Phosphotyrosine By similarity
	Glycosylation	82	1	N-linked (GlcNAc...) Potential
	Glycosylation	101	1	N-linked (GlcNAc...) Potential
	Glycosylation	112	1	N-linked (GlcNAc...) Potential
	Glycosylation	152	1	N-linked (GlcNAc...) Potential
	Glycosylation	159	1	N-linked (GlcNAc...) Potential
	Glycosylation	172	1	N-linked (GlcNAc...) Potential
	Glycosylation	186	1	N-linked (GlcNAc...) Potential
	Glycosylation	193	1	N-linked (GlcNAc...) Potential
	Glycosylation	218	1	N-linked (GlcNAc...) Potential
	Disulfide bond	162 ↔ 229		By similarity
	Disulfide bond	168 ↔ 210		By similarity
Natural variations
	Alternative sequence	328 – 331	4	ETVA → AEYS in isoform 2.		VSP_010404
	Alternative sequence	332 – 351	20	Missing in isoform 2.		VSP_010405

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 (Ly108s) [UniParc]. Last modified March 1, 2001. Version 1. Checksum: A8DD9EBF650FB431	FASTA	351	38,638
	10 20 30 40 50 60 MAVSRAPAPD SACQRMVWLF PLVFCLGSGS EVSQSSSDPQ LMNGVLGESA VLPLKLPAGK 70 80 90 100 110 120 IANIIIWNYE WEASQVTALV INLSNPESPQ IMNTDVKKRL NITQSYSLQI SNLTMADTGS 130 140 150 160 170 180 YTAQITTKDS EVITFKYILR VFERLGNLET TNYTLLLENG TCQIHLACVL KNQSQTVSVE 190 200 210 220 230 240 WQATGNISLG GPNVTIFWDP RNSGDQTYVC RAKNAVSNLS VSVSTQSLCK GVLTNPPWNA 250 260 270 280 290 300 VWFMTTISII SAVILIFVCW SIHVWKRRGS LPLTSQHPES SQSTDGPGSP GNTVYAQVTR 310 320 330 340 350 PMQEMKIPKP IKNDSMTIYS IVNHSREETV ALTGYNQPIT LKVNTLINYN S
	Isoform 2 (Ly108l) [UniParc]. Checksum: 7E1A056C8C0A716A	FASTA	331	36,440
	10 20 30 40 50 60 MAVSRAPAPD SACQRMVWLF PLVFCLGSGS EVSQSSSDPQ LMNGVLGESA VLPLKLPAGK 70 80 90 100 110 120 IANIIIWNYE WEASQVTALV INLSNPESPQ IMNTDVKKRL NITQSYSLQI SNLTMADTGS 130 140 150 160 170 180 YTAQITTKDS EVITFKYILR VFERLGNLET TNYTLLLENG TCQIHLACVL KNQSQTVSVE 190 200 210 220 230 240 WQATGNISLG GPNVTIFWDP RNSGDQTYVC RAKNAVSNLS VSVSTQSLCK GVLTNPPWNA 250 260 270 280 290 300 VWFMTTISII SAVILIFVCW SIHVWKRRGS LPLTSQHPES SQSTDGPGSP GNTVYAQVTR 310 320 330 PMQEMKIPKP IKNDSMTIYS IVNHSREAEY S

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Ly108: a new member of the mouse CD2 family of cell surface proteins." Peck S.R., Ruley H.E. Immunogenetics 52:63-72(2000) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2). Strain: C57BL/6. Tissue: Spleen.
[2]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). Tissue: Thymus.
[3]	"Homotypic interactions mediated by Slamf1 and Slamf6 receptors control NKT cell lineage development." Griewank K., Borowski C., Rietdijk S., Wang N., Julien A., Wei D.G., Mamchak A.A., Terhorst C., Bendelac A. Immunity 27:751-762(2007) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF248635 mRNA. Translation: AAG01737.1. AF248636 mRNA. Translation: AAG01738.1. BC030031 mRNA. Translation: AAH30031.1.
IPI	IPI00113541. IPI00131363.
RefSeq	NP_109635.1. NM_030710.2.
UniGene	Mm.486404.
3D structure databases
ProteinModelPortal	Q9ET39.
SMR	Q9ET39. Positions 39-230.
ModBase	Search...
PTM databases
PhosphoSite	Q9ET39.
Proteomic databases
PRIDE	Q9ET39.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSMUST00000171330; ENSMUSP00000130610; ENSMUSG00000015314.
GeneID	30925.
KEGG	mmu:30925.
Organism-specific databases
CTD	114836.
MGI	MGI:1353620. Slamf6.
Phylogenomic databases
eggNOG	NOG45125.
GeneTree	ENSGT00530000063114.
HOGENOM	HOG000059581.
HOVERGEN	HBG055054.
InParanoid	Q9ET39.
KO	K16852.
OMA	EIHLTCS.
OrthoDB	EOG483D5K.
Gene expression databases
ArrayExpress	Q9ET39.
Bgee	Q9ET39.
CleanEx	MM_SLAMF6.
Genevestigator	Q9ET39.
GermOnline	ENSMUSG00000015314. Mus musculus.
Family and domain databases
Gene3D	2.60.40.10. 1 hit.
InterPro	IPR007110. Ig-like_dom. IPR013783. Ig-like_fold. IPR003599. Ig_sub. IPR013106. Ig_V-set. IPR015631. SLAM_fam_rcpts. [Graphical view]
PANTHER	PTHR12080. PTHR12080. 1 hit.
Pfam	PF07686. V-set. 1 hit. [Graphical view]
SMART	SM00409. IG. 1 hit. [Graphical view]
PROSITE	PS50835. IG_LIKE. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	307320.
SOURCE	Search...

Entry information

Entry name

SLAF6_MOUSE

Accession

Primary (citable) accession number: Q9ET39
Secondary accession number(s): Q9ET40

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 24, 2004
Last sequence update:	March 1, 2001
Last modified:	May 1, 2013
This is version 97 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program