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Q9ET39

- SLAF6_MOUSE

UniProt

Q9ET39 - SLAF6_MOUSE

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Protein

SLAM family member 6

Gene

Slamf6

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli

Functioni

May rather modulate immune responses. Triggers cytolytic activity only in natural killer cells (NK) expressing high surface densities of natural cytotoxicity receptors.1 Publication

GO - Molecular functioni

  1. receptor activity Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Receptor

Names & Taxonomyi

Protein namesi
Recommended name:
SLAM family member 6
Alternative name(s):
Lymphocyte antigen 108
CD_antigen: CD352
Gene namesi
Name:Slamf6
Synonyms:Ly108
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 1

Organism-specific databases

MGIiMGI:1353620. Slamf6.

Subcellular locationi

GO - Cellular componenti

  1. extracellular vesicular exosome Source: Ensembl
  2. integral component of plasma membrane Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 3030Sequence AnalysisAdd
BLAST
Chaini31 – 351321SLAM family member 6PRO_0000014962Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi82 – 821N-linked (GlcNAc...)Sequence Analysis
Glycosylationi101 – 1011N-linked (GlcNAc...)Sequence Analysis
Glycosylationi112 – 1121N-linked (GlcNAc...)Sequence Analysis
Glycosylationi152 – 1521N-linked (GlcNAc...)Sequence Analysis
Glycosylationi159 – 1591N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi162 ↔ 229PROSITE-ProRule annotation
Disulfide bondi168 ↔ 210PROSITE-ProRule annotation
Glycosylationi172 – 1721N-linked (GlcNAc...)Sequence Analysis
Glycosylationi186 – 1861N-linked (GlcNAc...)Sequence Analysis
Glycosylationi193 – 1931N-linked (GlcNAc...)Sequence Analysis
Glycosylationi218 – 2181N-linked (GlcNAc...)Sequence Analysis
Modified residuei319 – 3191PhosphotyrosineBy similarity

Post-translational modificationi

Phosphorylated.By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

MaxQBiQ9ET39.
PRIDEiQ9ET39.

PTM databases

PhosphoSiteiQ9ET39.

Expressioni

Tissue specificityi

Expressed on hematopoietic cells.

Gene expression databases

BgeeiQ9ET39.
CleanExiMM_SLAMF6.
ExpressionAtlasiQ9ET39. baseline and differential.
GenevestigatoriQ9ET39.

Interactioni

Subunit structurei

Homodimer. Interacts with PTN6 and, upon phosphorylation, with PTN11 and SH2D1A/SAP (By similarity).By similarity

Structurei

3D structure databases

ProteinModelPortaliQ9ET39.
SMRiQ9ET39. Positions 39-230.
ModBaseiSearch...
MobiDBiSearch...

Topological domain

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini31 – 239209ExtracellularSequence AnalysisAdd
BLAST
Topological domaini263 – 35189CytoplasmicSequence AnalysisAdd
BLAST

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei240 – 26223HelicalSequence AnalysisAdd
BLAST

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini36 – 13095Ig-like V-typeAdd
BLAST
Domaini147 – 21064Ig-like C2-typeAdd
BLAST

Sequence similaritiesi

Keywords - Domaini

Immunoglobulin domain, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG45125.
GeneTreeiENSGT00530000063114.
HOGENOMiHOG000059581.
HOVERGENiHBG055054.
InParanoidiQ9ET39.
KOiK16852.
OMAiEIHLTCS.
OrthoDBiEOG77HDFC.
PhylomeDBiQ9ET39.
TreeFamiTF334964.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR013106. Ig_V-set.
IPR015631. SLAM_fam_rcpts.
[Graphical view]
PANTHERiPTHR12080. PTHR12080. 1 hit.
PfamiPF07686. V-set. 1 hit.
[Graphical view]
SMARTiSM00409. IG. 1 hit.
[Graphical view]
PROSITEiPS50835. IG_LIKE. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q9ET39-1) [UniParc]FASTAAdd to Basket

Also known as: Ly108s

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAVSRAPAPD SACQRMVWLF PLVFCLGSGS EVSQSSSDPQ LMNGVLGESA
60 70 80 90 100
VLPLKLPAGK IANIIIWNYE WEASQVTALV INLSNPESPQ IMNTDVKKRL
110 120 130 140 150
NITQSYSLQI SNLTMADTGS YTAQITTKDS EVITFKYILR VFERLGNLET
160 170 180 190 200
TNYTLLLENG TCQIHLACVL KNQSQTVSVE WQATGNISLG GPNVTIFWDP
210 220 230 240 250
RNSGDQTYVC RAKNAVSNLS VSVSTQSLCK GVLTNPPWNA VWFMTTISII
260 270 280 290 300
SAVILIFVCW SIHVWKRRGS LPLTSQHPES SQSTDGPGSP GNTVYAQVTR
310 320 330 340 350
PMQEMKIPKP IKNDSMTIYS IVNHSREETV ALTGYNQPIT LKVNTLINYN

S
Length:351
Mass (Da):38,638
Last modified:March 1, 2001 - v1
Checksum:iA8DD9EBF650FB431
GO
Isoform 2 (identifier: Q9ET39-2) [UniParc]FASTAAdd to Basket

Also known as: Ly108l

The sequence of this isoform differs from the canonical sequence as follows:
     328-331: ETVA → AEYS
     332-351: Missing.

Show »
Length:331
Mass (Da):36,440
Checksum:i7E1A056C8C0A716A
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei328 – 3314ETVA → AEYS in isoform 2. 1 PublicationVSP_010404
Alternative sequencei332 – 35120Missing in isoform 2. 1 PublicationVSP_010405Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF248635 mRNA. Translation: AAG01737.1.
AF248636 mRNA. Translation: AAG01738.1.
BC030031 mRNA. Translation: AAH30031.1.
CCDSiCCDS15504.1. [Q9ET39-2]
RefSeqiNP_109635.1. NM_030710.2. [Q9ET39-2]
XP_006496948.1. XM_006496885.1. [Q9ET39-1]
UniGeneiMm.486404.

Genome annotation databases

EnsembliENSMUST00000171330; ENSMUSP00000130610; ENSMUSG00000015314. [Q9ET39-2]
GeneIDi30925.
KEGGimmu:30925.
UCSCiuc007dph.1. mouse. [Q9ET39-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF248635 mRNA. Translation: AAG01737.1 .
AF248636 mRNA. Translation: AAG01738.1 .
BC030031 mRNA. Translation: AAH30031.1 .
CCDSi CCDS15504.1. [Q9ET39-2 ]
RefSeqi NP_109635.1. NM_030710.2. [Q9ET39-2 ]
XP_006496948.1. XM_006496885.1. [Q9ET39-1 ]
UniGenei Mm.486404.

3D structure databases

ProteinModelPortali Q9ET39.
SMRi Q9ET39. Positions 39-230.
ModBasei Search...
MobiDBi Search...

PTM databases

PhosphoSitei Q9ET39.

Proteomic databases

MaxQBi Q9ET39.
PRIDEi Q9ET39.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000171330 ; ENSMUSP00000130610 ; ENSMUSG00000015314 . [Q9ET39-2 ]
GeneIDi 30925.
KEGGi mmu:30925.
UCSCi uc007dph.1. mouse. [Q9ET39-1 ]

Organism-specific databases

CTDi 114836.
MGIi MGI:1353620. Slamf6.

Phylogenomic databases

eggNOGi NOG45125.
GeneTreei ENSGT00530000063114.
HOGENOMi HOG000059581.
HOVERGENi HBG055054.
InParanoidi Q9ET39.
KOi K16852.
OMAi EIHLTCS.
OrthoDBi EOG77HDFC.
PhylomeDBi Q9ET39.
TreeFami TF334964.

Miscellaneous databases

NextBioi 307320.
PROi Q9ET39.
SOURCEi Search...

Gene expression databases

Bgeei Q9ET39.
CleanExi MM_SLAMF6.
ExpressionAtlasi Q9ET39. baseline and differential.
Genevestigatori Q9ET39.

Family and domain databases

Gene3Di 2.60.40.10. 1 hit.
InterProi IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR013106. Ig_V-set.
IPR015631. SLAM_fam_rcpts.
[Graphical view ]
PANTHERi PTHR12080. PTHR12080. 1 hit.
Pfami PF07686. V-set. 1 hit.
[Graphical view ]
SMARTi SM00409. IG. 1 hit.
[Graphical view ]
PROSITEi PS50835. IG_LIKE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Ly108: a new member of the mouse CD2 family of cell surface proteins."
    Peck S.R., Ruley H.E.
    Immunogenetics 52:63-72(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2).
    Strain: C57BL/6.
    Tissue: Spleen.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Thymus.
  3. "Homotypic interactions mediated by Slamf1 and Slamf6 receptors control NKT cell lineage development."
    Griewank K., Borowski C., Rietdijk S., Wang N., Julien A., Wei D.G., Mamchak A.A., Terhorst C., Bendelac A.
    Immunity 27:751-762(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.

Entry informationi

Entry nameiSLAF6_MOUSE
AccessioniPrimary (citable) accession number: Q9ET39
Secondary accession number(s): Q9ET40
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 24, 2004
Last sequence update: March 1, 2001
Last modified: October 29, 2014
This is version 111 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3