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Q9ET39 (SLAF6_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 106. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
SLAM family member 6
Alternative name(s):
Lymphocyte antigen 108
CD_antigen=CD352
Gene names
Name:Slamf6
Synonyms:Ly108
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length351 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

May rather modulate immune responses. Triggers cytolytic activity only in natural killer cells (NK) expressing high surface densities of natural cytotoxicity receptors. Ref.3

Subunit structure

Homodimer. Interacts with PTN6 and, upon phosphorylation, with PTN11 and SH2D1A/SAP By similarity.

Subcellular location

Cell membrane; Single-pass type I membrane protein Probable.

Tissue specificity

Expressed on hematopoietic cells.

Post-translational modification

Phosphorylated By similarity.

Sequence similarities

Contains 1 Ig-like (immunoglobulin-like) domain.

Ontologies

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q9ET39-1)

Also known as: Ly108s;

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q9ET39-2)

Also known as: Ly108l;

The sequence of this isoform differs from the canonical sequence as follows:
     328-331: ETVA → AEYS
     332-351: Missing.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 3030 Potential
Chain31 – 351321SLAM family member 6
PRO_0000014962

Regions

Topological domain31 – 239209Extracellular Potential
Transmembrane240 – 26223Helical; Potential
Topological domain263 – 35189Cytoplasmic Potential
Domain147 – 22276Ig-like

Amino acid modifications

Modified residue3191Phosphotyrosine By similarity
Glycosylation821N-linked (GlcNAc...) Potential
Glycosylation1011N-linked (GlcNAc...) Potential
Glycosylation1121N-linked (GlcNAc...) Potential
Glycosylation1521N-linked (GlcNAc...) Potential
Glycosylation1591N-linked (GlcNAc...) Potential
Glycosylation1721N-linked (GlcNAc...) Potential
Glycosylation1861N-linked (GlcNAc...) Potential
Glycosylation1931N-linked (GlcNAc...) Potential
Glycosylation2181N-linked (GlcNAc...) Potential
Disulfide bond162 ↔ 229 By similarity
Disulfide bond168 ↔ 210 By similarity

Natural variations

Alternative sequence328 – 3314ETVA → AEYS in isoform 2.
VSP_010404
Alternative sequence332 – 35120Missing in isoform 2.
VSP_010405

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 (Ly108s) [UniParc].

Last modified March 1, 2001. Version 1.
Checksum: A8DD9EBF650FB431

FASTA35138,638
        10         20         30         40         50         60 
MAVSRAPAPD SACQRMVWLF PLVFCLGSGS EVSQSSSDPQ LMNGVLGESA VLPLKLPAGK 

        70         80         90        100        110        120 
IANIIIWNYE WEASQVTALV INLSNPESPQ IMNTDVKKRL NITQSYSLQI SNLTMADTGS 

       130        140        150        160        170        180 
YTAQITTKDS EVITFKYILR VFERLGNLET TNYTLLLENG TCQIHLACVL KNQSQTVSVE 

       190        200        210        220        230        240 
WQATGNISLG GPNVTIFWDP RNSGDQTYVC RAKNAVSNLS VSVSTQSLCK GVLTNPPWNA 

       250        260        270        280        290        300 
VWFMTTISII SAVILIFVCW SIHVWKRRGS LPLTSQHPES SQSTDGPGSP GNTVYAQVTR 

       310        320        330        340        350 
PMQEMKIPKP IKNDSMTIYS IVNHSREETV ALTGYNQPIT LKVNTLINYN S 

« Hide

Isoform 2 (Ly108l) [UniParc].

Checksum: 7E1A056C8C0A716A
Show »

FASTA33136,440

References

« Hide 'large scale' references
[1]"Ly108: a new member of the mouse CD2 family of cell surface proteins."
Peck S.R., Ruley H.E.
Immunogenetics 52:63-72(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2).
Strain: C57BL/6.
Tissue: Spleen.
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
Tissue: Thymus.
[3]"Homotypic interactions mediated by Slamf1 and Slamf6 receptors control NKT cell lineage development."
Griewank K., Borowski C., Rietdijk S., Wang N., Julien A., Wei D.G., Mamchak A.A., Terhorst C., Bendelac A.
Immunity 27:751-762(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF248635 mRNA. Translation: AAG01737.1.
AF248636 mRNA. Translation: AAG01738.1.
BC030031 mRNA. Translation: AAH30031.1.
RefSeqNP_109635.1. NM_030710.2.
XP_006496948.1. XM_006496885.1.
UniGeneMm.486404.

3D structure databases

ProteinModelPortalQ9ET39.
SMRQ9ET39. Positions 39-230.
ModBaseSearch...
MobiDBSearch...

PTM databases

PhosphoSiteQ9ET39.

Proteomic databases

PRIDEQ9ET39.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000171330; ENSMUSP00000130610; ENSMUSG00000015314. [Q9ET39-2]
GeneID30925.
KEGGmmu:30925.
UCSCuc007dph.1. mouse. [Q9ET39-1]

Organism-specific databases

CTD114836.
MGIMGI:1353620. Slamf6.

Phylogenomic databases

eggNOGNOG45125.
GeneTreeENSGT00530000063114.
HOGENOMHOG000059581.
HOVERGENHBG055054.
InParanoidQ9ET39.
KOK16852.
OMAEIHLTCS.
OrthoDBEOG77HDFC.
PhylomeDBQ9ET39.
TreeFamTF334964.

Gene expression databases

ArrayExpressQ9ET39.
BgeeQ9ET39.
CleanExMM_SLAMF6.
GenevestigatorQ9ET39.

Family and domain databases

Gene3D2.60.40.10. 1 hit.
InterProIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR013106. Ig_V-set.
IPR015631. SLAM_fam_rcpts.
[Graphical view]
PANTHERPTHR12080. PTHR12080. 1 hit.
PfamPF07686. V-set. 1 hit.
[Graphical view]
SMARTSM00409. IG. 1 hit.
[Graphical view]
PROSITEPS50835. IG_LIKE. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio307320.
PROQ9ET39.
SOURCESearch...

Entry information

Entry nameSLAF6_MOUSE
AccessionPrimary (citable) accession number: Q9ET39
Secondary accession number(s): Q9ET40
Entry history
Integrated into UniProtKB/Swiss-Prot: May 24, 2004
Last sequence update: March 1, 2001
Last modified: April 16, 2014
This is version 106 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot