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Protein

Claudin-19

Gene

Cldn19

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.By similarity

GO - Molecular functioni

  • identical protein binding Source: UniProtKB
  • structural molecule activity Source: MGI

GO - Biological processi

  • apical junction assembly Source: MGI
  • calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules Source: UniProtKB
  • neuronal action potential propagation Source: MGI
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Claudin-19
Gene namesi
Name:Cldn19
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 4

Organism-specific databases

MGIiMGI:3033992. Cldn19.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 7CytoplasmicSequence analysis7
Transmembranei8 – 28HelicalSequence analysisAdd BLAST21
Topological domaini29 – 81ExtracellularSequence analysisAdd BLAST53
Transmembranei82 – 102HelicalSequence analysisAdd BLAST21
Topological domaini103 – 117CytoplasmicSequence analysisAdd BLAST15
Transmembranei118 – 138HelicalSequence analysisAdd BLAST21
Topological domaini139 – 160ExtracellularSequence analysisAdd BLAST22
Transmembranei161 – 181HelicalSequence analysisAdd BLAST21
Topological domaini182 – 224CytoplasmicSequence analysisAdd BLAST43

GO - Cellular componenti

  • apical junction complex Source: MGI
  • basolateral plasma membrane Source: MGI
  • bicellular tight junction Source: UniProtKB
  • cell junction Source: MGI
  • cytoplasm Source: MGI
  • integral component of membrane Source: UniProtKB-KW
  • nucleus Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cell membrane, Membrane, Tight junction

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001447821 – 224Claudin-19Add BLAST224

Proteomic databases

PaxDbiQ9ET38.
PRIDEiQ9ET38.

PTM databases

PhosphoSitePlusiQ9ET38.

Expressioni

Gene expression databases

BgeeiENSMUSG00000066058.
CleanExiMM_CLDN19.
ExpressionAtlasiQ9ET38. baseline and differential.
GenevisibleiQ9ET38. MM.

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

DIPiDIP-42881N.
IntActiQ9ET38. 1 interactor.
MINTiMINT-1771795.
STRINGi10090.ENSMUSP00000081334.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3X29X-ray3.70A/C1-185[»]
ProteinModelPortaliQ9ET38.
SMRiQ9ET38.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the claudin family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IG5H. Eukaryota.
ENOG410Y143. LUCA.
GeneTreeiENSGT00760000118928.
HOGENOMiHOG000220937.
HOVERGENiHBG000643.
InParanoidiQ9ET38.
KOiK06087.
OMAiNSPQPYR.
OrthoDBiEOG091G0MX2.
PhylomeDBiQ9ET38.
TreeFamiTF331936.

Family and domain databases

InterProiIPR006187. Claudin.
IPR017974. Claudin_CS.
IPR004031. PMP22/EMP/MP20/Claudin.
[Graphical view]
PANTHERiPTHR12002. PTHR12002. 1 hit.
PfamiPF00822. PMP22_Claudin. 1 hit.
[Graphical view]
PROSITEiPS01346. CLAUDIN. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9ET38-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MANSGLQLLG YFLALGGWVG IIASTALPQW KQSSYAGDAI ITAVGLYEGL
60 70 80 90 100
WMSCASQSTG QVQCKLYDSL LALDGHIQSA RALMVVAVLL GFVAMVLSVV
110 120 130 140 150
GMKCTRVGDS NPTAKSRVAI SGGALFLLAG LCTLTAVSWY ATLVTQEFFN
160 170 180 190 200
PSTPVNARYE FGPALFVGWA SAGLAMLGGS FLCCTCPEPE RANSIPQPYR
210 220
SGPSTAAREP VVKLPASVKG PLGV
Length:224
Mass (Da):23,343
Last modified:May 24, 2004 - v3
Checksum:i4282BE63C4D8BCD2
GO
Isoform 2 (identifier: Q9ET38-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     210-224: PVVKLPASVKGPLGV → YV

Show »
Length:211
Mass (Da):22,163
Checksum:iA13E7C81F091D242
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_010343210 – 224PVVKL…GPLGV → YV in isoform 2. 1 PublicationAdd BLAST15

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF486651 mRNA. Translation: AAM12735.2.
AK032743 mRNA. Translation: BAC28005.1.
AF249889 mRNA. Translation: AAF98323.1.
CCDSiCCDS18577.1. [Q9ET38-1]
CCDS18578.1. [Q9ET38-2]
RefSeqiNP_001033679.1. NM_001038590.1. [Q9ET38-1]
NP_694745.1. NM_153105.7. [Q9ET38-2]
UniGeneiMm.130701.

Genome annotation databases

EnsembliENSMUST00000084309; ENSMUSP00000081334; ENSMUSG00000066058. [Q9ET38-1]
ENSMUST00000094823; ENSMUSP00000092418; ENSMUSG00000066058. [Q9ET38-2]
GeneIDi242653.
KEGGimmu:242653.
UCSCiuc008uls.1. mouse. [Q9ET38-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF486651 mRNA. Translation: AAM12735.2.
AK032743 mRNA. Translation: BAC28005.1.
AF249889 mRNA. Translation: AAF98323.1.
CCDSiCCDS18577.1. [Q9ET38-1]
CCDS18578.1. [Q9ET38-2]
RefSeqiNP_001033679.1. NM_001038590.1. [Q9ET38-1]
NP_694745.1. NM_153105.7. [Q9ET38-2]
UniGeneiMm.130701.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3X29X-ray3.70A/C1-185[»]
ProteinModelPortaliQ9ET38.
SMRiQ9ET38.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-42881N.
IntActiQ9ET38. 1 interactor.
MINTiMINT-1771795.
STRINGi10090.ENSMUSP00000081334.

PTM databases

PhosphoSitePlusiQ9ET38.

Proteomic databases

PaxDbiQ9ET38.
PRIDEiQ9ET38.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000084309; ENSMUSP00000081334; ENSMUSG00000066058. [Q9ET38-1]
ENSMUST00000094823; ENSMUSP00000092418; ENSMUSG00000066058. [Q9ET38-2]
GeneIDi242653.
KEGGimmu:242653.
UCSCiuc008uls.1. mouse. [Q9ET38-1]

Organism-specific databases

CTDi149461.
MGIiMGI:3033992. Cldn19.

Phylogenomic databases

eggNOGiENOG410IG5H. Eukaryota.
ENOG410Y143. LUCA.
GeneTreeiENSGT00760000118928.
HOGENOMiHOG000220937.
HOVERGENiHBG000643.
InParanoidiQ9ET38.
KOiK06087.
OMAiNSPQPYR.
OrthoDBiEOG091G0MX2.
PhylomeDBiQ9ET38.
TreeFamiTF331936.

Miscellaneous databases

PROiQ9ET38.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000066058.
CleanExiMM_CLDN19.
ExpressionAtlasiQ9ET38. baseline and differential.
GenevisibleiQ9ET38. MM.

Family and domain databases

InterProiIPR006187. Claudin.
IPR017974. Claudin_CS.
IPR004031. PMP22/EMP/MP20/Claudin.
[Graphical view]
PANTHERiPTHR12002. PTHR12002. 1 hit.
PfamiPF00822. PMP22_Claudin. 1 hit.
[Graphical view]
PROSITEiPS01346. CLAUDIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCLD19_MOUSE
AccessioniPrimary (citable) accession number: Q9ET38
Secondary accession number(s): Q8R4B7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 10, 2002
Last sequence update: May 24, 2004
Last modified: November 2, 2016
This is version 110 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.