Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

Q9ET37 (SC5A4_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 87. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Low affinity sodium-glucose cotransporter
Alternative name(s):
Sodium/glucose cotransporter 3
Short name=Na(+)/glucose cotransporter 3
Solute carrier family 5 member 4
Gene names
Name:Slc5a4a
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length656 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Sodium-dependent glucose transporter By similarity.

Subcellular location

Membrane; Multi-pass membrane protein.

Sequence similarities

Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family. [View classification]

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 656656Low affinity sodium-glucose cotransporter
PRO_0000105377

Regions

Topological domain1 – 2828Cytoplasmic Potential
Transmembrane29 – 4719Helical; Potential
Topological domain48 – 6417Extracellular Potential
Transmembrane65 – 8521Helical; Potential
Topological domain86 – 10520Cytoplasmic Potential
Transmembrane106 – 12621Helical; Potential
Topological domain127 – 17145Extracellular Potential
Transmembrane172 – 19120Helical; Potential
Topological domain192 – 20817Cytoplasmic Potential
Transmembrane209 – 22921Helical; Potential
Topological domain230 – 27041Extracellular Potential
Transmembrane271 – 29121Helical; Potential
Topological domain292 – 31423Cytoplasmic Potential
Transmembrane315 – 33420Helical; Potential
Topological domain335 – 42389Extracellular Potential
Transmembrane424 – 44320Helical; Potential
Topological domain444 – 45512Cytoplasmic Potential
Transmembrane456 – 47621Helical; Potential
Topological domain477 – 52650Extracellular Potential
Transmembrane527 – 54721Helical; Potential
Topological domain548 – 63487Cytoplasmic Potential
Transmembrane635 – 65521Helical; Potential

Amino acid modifications

Glycosylation2481N-linked (GlcNAc...) Potential

Sequences

Sequence LengthMass (Da)Tools
Q9ET37 [UniParc].

Last modified March 1, 2001. Version 1.
Checksum: A6668E815204D39B

FASTA65671,838
        10         20         30         40         50         60 
MASTASVSTS TASSELSSLS NNINNAADIS VIVIYFVVVM AVGVWAMLKT NRSTVGGFFL 

        70         80         90        100        110        120 
AGRSMTWWPM GASLFASNIG SGHFVGLAGT GAASGIAVTA FESHSFALLL VLGWIFVPIY 

       130        140        150        160        170        180 
IKAGVMTMPE YLKKRFGGKR LQIYLSILFL FICVILTISA DIFSGAIFIK LALGLNLYLA 

       190        200        210        220        230        240 
ILILLAITAI FTITGGLASV IYTDTVQAVI MLVGSFILMV FAFVEVGGYE SFTEKFMNAI 

       250        260        270        280        290        300 
PSVVEGDNLT INSRCYTPQP DSFHIFRDPV TGDIPWPGTA FGMPITALWY WCINQVIVQR 

       310        320        330        340        350        360 
CLCGKNLSHV KAACILCGYL KLLPLFFMVM PGMISRILYT DMVACVVPSE CVKHCGVDVG 

       370        380        390        400        410        420 
CTNYAYPMLV LKLMPPGLRG LMLSVMLASL MSSLTSVFNS ASTLFTIDLY TKIRKKASER 

       430        440        450        460        470        480 
ELLIAGRLFV SVLIVTSILW VPIVEVSQGG QLVHYTEAIS SYLGPPIAAV FLVAVFCKRA 

       490        500        510        520        530        540 
NEQGAFWGLM VGLVMGLIRM IAEFSYGTGS CLAPSSCPKI ICGVHYLYFA IILFFVCILV 

       550        560        570        580        590        600 
ILGVSYLTKP IPDVHLHRLC WALRNSKEER IDLDAEDKEE NGADDRTEED QTEKPRGCLK 

       610        620        630        640        650 
KTCDLFCGLQ RAEFKLTKVE EEALTDTTEK PFWRTVMNVN VILLLAVAAF FYGYFA 

« Hide

References

[1]"Chromosome evolution: the junction of mammalian chromosomes in the formation of mouse chromosome 10."
Pletcher M.T., Roe B.A., Chen F., Do T., Do A., Malaj E., Reeves R.H.
Genome Res. 10:1463-1467(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: 129/Sv.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF251267 mRNA. Translation: AAG01741.1.
UniGeneMm.154797.

3D structure databases

ProteinModelPortalQ9ET37.
SMRQ9ET37. Positions 25-553.
ModBaseSearch...
MobiDBSearch...

PTM databases

PhosphoSiteQ9ET37.

Proteomic databases

PRIDEQ9ET37.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Organism-specific databases

MGIMGI:1927848. Slc5a4a.

Phylogenomic databases

eggNOGCOG4146.
HOGENOMHOG000025422.
HOVERGENHBG052859.
InParanoidQ9ET37.
PhylomeDBQ9ET37.

Gene expression databases

CleanExMM_SLC5A4A.
GenevestigatorQ9ET37.

Family and domain databases

InterProIPR001734. Na/solute_symporter.
IPR018212. Na/solute_symporter_CS.
IPR019900. Na/solute_symporter_subgr.
[Graphical view]
PANTHERPTHR11819. PTHR11819. 1 hit.
PfamPF00474. SSF. 1 hit.
[Graphical view]
TIGRFAMsTIGR00813. sss. 1 hit.
PROSITEPS00457. NA_SOLUT_SYMP_2. 1 hit.
PS50283. NA_SOLUT_SYMP_3. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

PROQ9ET37.
SOURCESearch...

Entry information

Entry nameSC5A4_MOUSE
AccessionPrimary (citable) accession number: Q9ET37
Entry history
Integrated into UniProtKB/Swiss-Prot: September 26, 2001
Last sequence update: March 1, 2001
Last modified: April 16, 2014
This is version 87 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot