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Protein

Low affinity sodium-glucose cotransporter

Gene

Slc5a4a

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Sodium-dependent glucose transporter.By similarity

GO - Molecular functioni

GO - Biological processi

  • glucose transmembrane transport Source: GO_Central
  • proton transport Source: MGI
  • sodium ion transport Source: GO_Central
Complete GO annotation...

Keywords - Biological processi

Ion transport, Sodium transport, Sugar transport, Symport, Transport

Keywords - Ligandi

Sodium

Names & Taxonomyi

Protein namesi
Recommended name:
Low affinity sodium-glucose cotransporter
Alternative name(s):
Sodium/glucose cotransporter 3
Short name:
Na(+)/glucose cotransporter 3
Solute carrier family 5 member 4
Gene namesi
Name:Slc5a4a
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:1927848. Slc5a4a.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 28CytoplasmicSequence analysisAdd BLAST28
Transmembranei29 – 47HelicalSequence analysisAdd BLAST19
Topological domaini48 – 64ExtracellularSequence analysisAdd BLAST17
Transmembranei65 – 85HelicalSequence analysisAdd BLAST21
Topological domaini86 – 105CytoplasmicSequence analysisAdd BLAST20
Transmembranei106 – 126HelicalSequence analysisAdd BLAST21
Topological domaini127 – 171ExtracellularSequence analysisAdd BLAST45
Transmembranei172 – 191HelicalSequence analysisAdd BLAST20
Topological domaini192 – 208CytoplasmicSequence analysisAdd BLAST17
Transmembranei209 – 229HelicalSequence analysisAdd BLAST21
Topological domaini230 – 270ExtracellularSequence analysisAdd BLAST41
Transmembranei271 – 291HelicalSequence analysisAdd BLAST21
Topological domaini292 – 314CytoplasmicSequence analysisAdd BLAST23
Transmembranei315 – 334HelicalSequence analysisAdd BLAST20
Topological domaini335 – 423ExtracellularSequence analysisAdd BLAST89
Transmembranei424 – 443HelicalSequence analysisAdd BLAST20
Topological domaini444 – 455CytoplasmicSequence analysisAdd BLAST12
Transmembranei456 – 476HelicalSequence analysisAdd BLAST21
Topological domaini477 – 526ExtracellularSequence analysisAdd BLAST50
Transmembranei527 – 547HelicalSequence analysisAdd BLAST21
Topological domaini548 – 634CytoplasmicSequence analysisAdd BLAST87
Transmembranei635 – 655HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

  • integral component of membrane Source: MGI
  • integral component of plasma membrane Source: GO_Central
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001053771 – 656Low affinity sodium-glucose cotransporterAdd BLAST656

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi248N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ9ET37.
PRIDEiQ9ET37.

PTM databases

iPTMnetiQ9ET37.
PhosphoSitePlusiQ9ET37.

Expressioni

Gene expression databases

CleanExiMM_SLC5A4A.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000020450.

Structurei

3D structure databases

ProteinModelPortaliQ9ET37.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IP49. Eukaryota.
COG4146. LUCA.
HOGENOMiHOG000025422.
HOVERGENiHBG052859.
InParanoidiQ9ET37.
PhylomeDBiQ9ET37.

Family and domain databases

InterProiIPR001734. Na/solute_symporter.
IPR018212. Na/solute_symporter_CS.
[Graphical view]
PANTHERiPTHR11819. PTHR11819. 1 hit.
PfamiPF00474. SSF. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00813. sss. 1 hit.
PROSITEiPS00457. NA_SOLUT_SYMP_2. 1 hit.
PS50283. NA_SOLUT_SYMP_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9ET37-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASTASVSTS TASSELSSLS NNINNAADIS VIVIYFVVVM AVGVWAMLKT
60 70 80 90 100
NRSTVGGFFL AGRSMTWWPM GASLFASNIG SGHFVGLAGT GAASGIAVTA
110 120 130 140 150
FESHSFALLL VLGWIFVPIY IKAGVMTMPE YLKKRFGGKR LQIYLSILFL
160 170 180 190 200
FICVILTISA DIFSGAIFIK LALGLNLYLA ILILLAITAI FTITGGLASV
210 220 230 240 250
IYTDTVQAVI MLVGSFILMV FAFVEVGGYE SFTEKFMNAI PSVVEGDNLT
260 270 280 290 300
INSRCYTPQP DSFHIFRDPV TGDIPWPGTA FGMPITALWY WCINQVIVQR
310 320 330 340 350
CLCGKNLSHV KAACILCGYL KLLPLFFMVM PGMISRILYT DMVACVVPSE
360 370 380 390 400
CVKHCGVDVG CTNYAYPMLV LKLMPPGLRG LMLSVMLASL MSSLTSVFNS
410 420 430 440 450
ASTLFTIDLY TKIRKKASER ELLIAGRLFV SVLIVTSILW VPIVEVSQGG
460 470 480 490 500
QLVHYTEAIS SYLGPPIAAV FLVAVFCKRA NEQGAFWGLM VGLVMGLIRM
510 520 530 540 550
IAEFSYGTGS CLAPSSCPKI ICGVHYLYFA IILFFVCILV ILGVSYLTKP
560 570 580 590 600
IPDVHLHRLC WALRNSKEER IDLDAEDKEE NGADDRTEED QTEKPRGCLK
610 620 630 640 650
KTCDLFCGLQ RAEFKLTKVE EEALTDTTEK PFWRTVMNVN VILLLAVAAF

FYGYFA
Length:656
Mass (Da):71,838
Last modified:March 1, 2001 - v1
Checksum:iA6668E815204D39B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF251267 mRNA. Translation: AAG01741.1.
CCDSiCCDS35941.1.
UniGeneiMm.154797.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF251267 mRNA. Translation: AAG01741.1.
CCDSiCCDS35941.1.
UniGeneiMm.154797.

3D structure databases

ProteinModelPortaliQ9ET37.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000020450.

PTM databases

iPTMnetiQ9ET37.
PhosphoSitePlusiQ9ET37.

Proteomic databases

PaxDbiQ9ET37.
PRIDEiQ9ET37.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

MGIiMGI:1927848. Slc5a4a.

Phylogenomic databases

eggNOGiENOG410IP49. Eukaryota.
COG4146. LUCA.
HOGENOMiHOG000025422.
HOVERGENiHBG052859.
InParanoidiQ9ET37.
PhylomeDBiQ9ET37.

Miscellaneous databases

PROiQ9ET37.
SOURCEiSearch...

Gene expression databases

CleanExiMM_SLC5A4A.

Family and domain databases

InterProiIPR001734. Na/solute_symporter.
IPR018212. Na/solute_symporter_CS.
[Graphical view]
PANTHERiPTHR11819. PTHR11819. 1 hit.
PfamiPF00474. SSF. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00813. sss. 1 hit.
PROSITEiPS00457. NA_SOLUT_SYMP_2. 1 hit.
PS50283. NA_SOLUT_SYMP_3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSC5A4_MOUSE
AccessioniPrimary (citable) accession number: Q9ET37
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 26, 2001
Last sequence update: March 1, 2001
Last modified: November 2, 2016
This is version 98 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.