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Q9ET37

- SC5A4_MOUSE

UniProt

Q9ET37 - SC5A4_MOUSE

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Protein
Low affinity sodium-glucose cotransporter
Gene
Slc5a4a
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Sodium-dependent glucose transporter By similarity.

GO - Molecular functioni

  1. hydrogen ion transmembrane transporter activity Source: MGI
  2. symporter activity Source: UniProtKB-KW

GO - Biological processi

  1. carbohydrate transport Source: UniProtKB-KW
  2. hydrogen ion transmembrane transport Source: GOC
  3. proton transport Source: MGI
  4. sodium ion transport Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Ion transport, Sodium transport, Sugar transport, Symport, Transport

Keywords - Ligandi

Sodium

Names & Taxonomyi

Protein namesi
Recommended name:
Low affinity sodium-glucose cotransporter
Alternative name(s):
Sodium/glucose cotransporter 3
Short name:
Na(+)/glucose cotransporter 3
Solute carrier family 5 member 4
Gene namesi
Name:Slc5a4a
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Unplaced

Organism-specific databases

MGIiMGI:1927848. Slc5a4a.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 2828Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei29 – 4719Helical; Reviewed prediction
Add
BLAST
Topological domaini48 – 6417Extracellular Reviewed prediction
Add
BLAST
Transmembranei65 – 8521Helical; Reviewed prediction
Add
BLAST
Topological domaini86 – 10520Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei106 – 12621Helical; Reviewed prediction
Add
BLAST
Topological domaini127 – 17145Extracellular Reviewed prediction
Add
BLAST
Transmembranei172 – 19120Helical; Reviewed prediction
Add
BLAST
Topological domaini192 – 20817Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei209 – 22921Helical; Reviewed prediction
Add
BLAST
Topological domaini230 – 27041Extracellular Reviewed prediction
Add
BLAST
Transmembranei271 – 29121Helical; Reviewed prediction
Add
BLAST
Topological domaini292 – 31423Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei315 – 33420Helical; Reviewed prediction
Add
BLAST
Topological domaini335 – 42389Extracellular Reviewed prediction
Add
BLAST
Transmembranei424 – 44320Helical; Reviewed prediction
Add
BLAST
Topological domaini444 – 45512Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei456 – 47621Helical; Reviewed prediction
Add
BLAST
Topological domaini477 – 52650Extracellular Reviewed prediction
Add
BLAST
Transmembranei527 – 54721Helical; Reviewed prediction
Add
BLAST
Topological domaini548 – 63487Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei635 – 65521Helical; Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 656656Low affinity sodium-glucose cotransporter
PRO_0000105377Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi248 – 2481N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Glycoprotein

Proteomic databases

PRIDEiQ9ET37.

PTM databases

PhosphoSiteiQ9ET37.

Expressioni

Gene expression databases

CleanExiMM_SLC5A4A.
GenevestigatoriQ9ET37.

Structurei

3D structure databases

ProteinModelPortaliQ9ET37.
SMRiQ9ET37. Positions 28-497.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG4146.
HOGENOMiHOG000025422.
HOVERGENiHBG052859.
InParanoidiQ9ET37.
PhylomeDBiQ9ET37.

Family and domain databases

InterProiIPR001734. Na/solute_symporter.
IPR018212. Na/solute_symporter_CS.
IPR019900. Na/solute_symporter_subgr.
[Graphical view]
PANTHERiPTHR11819. PTHR11819. 1 hit.
PfamiPF00474. SSF. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00813. sss. 1 hit.
PROSITEiPS00457. NA_SOLUT_SYMP_2. 1 hit.
PS50283. NA_SOLUT_SYMP_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9ET37-1 [UniParc]FASTAAdd to Basket

« Hide

MASTASVSTS TASSELSSLS NNINNAADIS VIVIYFVVVM AVGVWAMLKT    50
NRSTVGGFFL AGRSMTWWPM GASLFASNIG SGHFVGLAGT GAASGIAVTA 100
FESHSFALLL VLGWIFVPIY IKAGVMTMPE YLKKRFGGKR LQIYLSILFL 150
FICVILTISA DIFSGAIFIK LALGLNLYLA ILILLAITAI FTITGGLASV 200
IYTDTVQAVI MLVGSFILMV FAFVEVGGYE SFTEKFMNAI PSVVEGDNLT 250
INSRCYTPQP DSFHIFRDPV TGDIPWPGTA FGMPITALWY WCINQVIVQR 300
CLCGKNLSHV KAACILCGYL KLLPLFFMVM PGMISRILYT DMVACVVPSE 350
CVKHCGVDVG CTNYAYPMLV LKLMPPGLRG LMLSVMLASL MSSLTSVFNS 400
ASTLFTIDLY TKIRKKASER ELLIAGRLFV SVLIVTSILW VPIVEVSQGG 450
QLVHYTEAIS SYLGPPIAAV FLVAVFCKRA NEQGAFWGLM VGLVMGLIRM 500
IAEFSYGTGS CLAPSSCPKI ICGVHYLYFA IILFFVCILV ILGVSYLTKP 550
IPDVHLHRLC WALRNSKEER IDLDAEDKEE NGADDRTEED QTEKPRGCLK 600
KTCDLFCGLQ RAEFKLTKVE EEALTDTTEK PFWRTVMNVN VILLLAVAAF 650
FYGYFA 656
Length:656
Mass (Da):71,838
Last modified:March 1, 2001 - v1
Checksum:iA6668E815204D39B
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF251267 mRNA. Translation: AAG01741.1.
CCDSiCCDS35941.1.
UniGeneiMm.154797.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF251267 mRNA. Translation: AAG01741.1 .
CCDSi CCDS35941.1.
UniGenei Mm.154797.

3D structure databases

ProteinModelPortali Q9ET37.
SMRi Q9ET37. Positions 28-497.
ModBasei Search...
MobiDBi Search...

PTM databases

PhosphoSitei Q9ET37.

Proteomic databases

PRIDEi Q9ET37.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Organism-specific databases

MGIi MGI:1927848. Slc5a4a.

Phylogenomic databases

eggNOGi COG4146.
HOGENOMi HOG000025422.
HOVERGENi HBG052859.
InParanoidi Q9ET37.
PhylomeDBi Q9ET37.

Miscellaneous databases

PROi Q9ET37.
SOURCEi Search...

Gene expression databases

CleanExi MM_SLC5A4A.
Genevestigatori Q9ET37.

Family and domain databases

InterProi IPR001734. Na/solute_symporter.
IPR018212. Na/solute_symporter_CS.
IPR019900. Na/solute_symporter_subgr.
[Graphical view ]
PANTHERi PTHR11819. PTHR11819. 1 hit.
Pfami PF00474. SSF. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR00813. sss. 1 hit.
PROSITEi PS00457. NA_SOLUT_SYMP_2. 1 hit.
PS50283. NA_SOLUT_SYMP_3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Chromosome evolution: the junction of mammalian chromosomes in the formation of mouse chromosome 10."
    Pletcher M.T., Roe B.A., Chen F., Do T., Do A., Malaj E., Reeves R.H.
    Genome Res. 10:1463-1467(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: 129/Sv.

Entry informationi

Entry nameiSC5A4_MOUSE
AccessioniPrimary (citable) accession number: Q9ET37
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 26, 2001
Last sequence update: March 1, 2001
Last modified: July 9, 2014
This is version 89 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi