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Protein

Solute carrier family 5 member 4A

Gene

Slc5a4a

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Has sugar-induced sodium-independent electrogenic activity. Generation of glucose-induced inward currents is pH-dependent, with activity in acidic conditions (pH 5) but not neutral conditions. Does not have sugar transport activity.1 Publication

Enzyme regulationi

Not inhibited by phlorizin.1 Publication

GO - Molecular functioni

GO - Biological processi

  • glucose transmembrane transport Source: GO_Central
  • proton transport Source: MGI
  • sodium ion transport Source: GO_Central

Names & Taxonomyi

Protein namesi
Recommended name:
Solute carrier family 5 member 4AImported
Gene namesi
Name:Slc5a4aImported
Synonyms:Sglt3a1 Publication
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:1927848. Slc5a4a.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 28CytoplasmicSequence analysisAdd BLAST28
Transmembranei29 – 47HelicalSequence analysisAdd BLAST19
Topological domaini48 – 64ExtracellularSequence analysisAdd BLAST17
Transmembranei65 – 85HelicalSequence analysisAdd BLAST21
Topological domaini86 – 105CytoplasmicSequence analysisAdd BLAST20
Transmembranei106 – 126HelicalSequence analysisAdd BLAST21
Topological domaini127 – 171ExtracellularSequence analysisAdd BLAST45
Transmembranei172 – 191HelicalSequence analysisAdd BLAST20
Topological domaini192 – 208CytoplasmicSequence analysisAdd BLAST17
Transmembranei209 – 229HelicalSequence analysisAdd BLAST21
Topological domaini230 – 270ExtracellularSequence analysisAdd BLAST41
Transmembranei271 – 291HelicalSequence analysisAdd BLAST21
Topological domaini292 – 314CytoplasmicSequence analysisAdd BLAST23
Transmembranei315 – 334HelicalSequence analysisAdd BLAST20
Topological domaini335 – 423ExtracellularSequence analysisAdd BLAST89
Transmembranei424 – 443HelicalSequence analysisAdd BLAST20
Topological domaini444 – 455CytoplasmicSequence analysisAdd BLAST12
Transmembranei456 – 476HelicalSequence analysisAdd BLAST21
Topological domaini477 – 526ExtracellularSequence analysisAdd BLAST50
Transmembranei527 – 547HelicalSequence analysisAdd BLAST21
Topological domaini548 – 634CytoplasmicSequence analysisAdd BLAST87
Transmembranei635 – 655HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi457E → Q: Confers sodium-dependent sugar transport activity not found in the wild type protein. 1 Publication1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001053771 – 656Solute carrier family 5 member 4AAdd BLAST656

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi248N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ9ET37.
PRIDEiQ9ET37.

PTM databases

iPTMnetiQ9ET37.
PhosphoSitePlusiQ9ET37.

Expressioni

Tissue specificityi

Expressed in small intestine.1 Publication

Gene expression databases

CleanExiMM_SLC5A4A.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000020450.

Structurei

3D structure databases

ProteinModelPortaliQ9ET37.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IP49. Eukaryota.
COG4146. LUCA.
HOGENOMiHOG000025422.
HOVERGENiHBG052859.
InParanoidiQ9ET37.
PhylomeDBiQ9ET37.

Family and domain databases

Gene3Di1.20.1730.10. 1 hit.
InterProiView protein in InterPro
IPR038377. Na/Glc_symporter_sf.
IPR001734. Na/solute_symporter.
IPR018212. Na/solute_symporter_CS.
PfamiView protein in Pfam
PF00474. SSF. 1 hit.
TIGRFAMsiTIGR00813. sss. 1 hit.
PROSITEiView protein in PROSITE
PS00457. NA_SOLUT_SYMP_2. 1 hit.
PS50283. NA_SOLUT_SYMP_3. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9ET37-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASTASVSTS TASSELSSLS NNINNAADIS VIVIYFVVVM AVGVWAMLKT
60 70 80 90 100
NRSTVGGFFL AGRSMTWWPM GASLFASNIG SGHFVGLAGT GAASGIAVTA
110 120 130 140 150
FESHSFALLL VLGWIFVPIY IKAGVMTMPE YLKKRFGGKR LQIYLSILFL
160 170 180 190 200
FICVILTISA DIFSGAIFIK LALGLNLYLA ILILLAITAI FTITGGLASV
210 220 230 240 250
IYTDTVQAVI MLVGSFILMV FAFVEVGGYE SFTEKFMNAI PSVVEGDNLT
260 270 280 290 300
INSRCYTPQP DSFHIFRDPV TGDIPWPGTA FGMPITALWY WCINQVIVQR
310 320 330 340 350
CLCGKNLSHV KAACILCGYL KLLPLFFMVM PGMISRILYT DMVACVVPSE
360 370 380 390 400
CVKHCGVDVG CTNYAYPMLV LKLMPPGLRG LMLSVMLASL MSSLTSVFNS
410 420 430 440 450
ASTLFTIDLY TKIRKKASER ELLIAGRLFV SVLIVTSILW VPIVEVSQGG
460 470 480 490 500
QLVHYTEAIS SYLGPPIAAV FLVAVFCKRA NEQGAFWGLM VGLVMGLIRM
510 520 530 540 550
IAEFSYGTGS CLAPSSCPKI ICGVHYLYFA IILFFVCILV ILGVSYLTKP
560 570 580 590 600
IPDVHLHRLC WALRNSKEER IDLDAEDKEE NGADDRTEED QTEKPRGCLK
610 620 630 640 650
KTCDLFCGLQ RAEFKLTKVE EEALTDTTEK PFWRTVMNVN VILLLAVAAF

FYGYFA
Length:656
Mass (Da):71,838
Last modified:March 1, 2001 - v1
Checksum:iA6668E815204D39B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF251267 mRNA. Translation: AAG01741.1.
CCDSiCCDS35941.1.
UniGeneiMm.154797.

Similar proteinsi

Entry informationi

Entry nameiS5A4A_MOUSE
AccessioniPrimary (citable) accession number: Q9ET37
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 26, 2001
Last sequence update: March 1, 2001
Last modified: March 28, 2018
This is version 102 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome