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Protein

Low affinity sodium-glucose cotransporter

Gene

Slc5a4a

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Sodium-dependent glucose transporter.By similarity

GO - Molecular functioni

  • hydrogen ion transmembrane transporter activity Source: MGI
  • symporter activity Source: UniProtKB-KW

GO - Biological processi

  • carbohydrate transport Source: UniProtKB-KW
  • hydrogen ion transmembrane transport Source: GOC
  • proton transport Source: MGI
  • sodium ion transport Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Ion transport, Sodium transport, Sugar transport, Symport, Transport

Keywords - Ligandi

Sodium

Names & Taxonomyi

Protein namesi
Recommended name:
Low affinity sodium-glucose cotransporter
Alternative name(s):
Sodium/glucose cotransporter 3
Short name:
Na(+)/glucose cotransporter 3
Solute carrier family 5 member 4
Gene namesi
Name:Slc5a4a
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:1927848. Slc5a4a.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 2828CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei29 – 4719HelicalSequence AnalysisAdd
BLAST
Topological domaini48 – 6417ExtracellularSequence AnalysisAdd
BLAST
Transmembranei65 – 8521HelicalSequence AnalysisAdd
BLAST
Topological domaini86 – 10520CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei106 – 12621HelicalSequence AnalysisAdd
BLAST
Topological domaini127 – 17145ExtracellularSequence AnalysisAdd
BLAST
Transmembranei172 – 19120HelicalSequence AnalysisAdd
BLAST
Topological domaini192 – 20817CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei209 – 22921HelicalSequence AnalysisAdd
BLAST
Topological domaini230 – 27041ExtracellularSequence AnalysisAdd
BLAST
Transmembranei271 – 29121HelicalSequence AnalysisAdd
BLAST
Topological domaini292 – 31423CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei315 – 33420HelicalSequence AnalysisAdd
BLAST
Topological domaini335 – 42389ExtracellularSequence AnalysisAdd
BLAST
Transmembranei424 – 44320HelicalSequence AnalysisAdd
BLAST
Topological domaini444 – 45512CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei456 – 47621HelicalSequence AnalysisAdd
BLAST
Topological domaini477 – 52650ExtracellularSequence AnalysisAdd
BLAST
Transmembranei527 – 54721HelicalSequence AnalysisAdd
BLAST
Topological domaini548 – 63487CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei635 – 65521HelicalSequence AnalysisAdd
BLAST

GO - Cellular componenti

  • integral component of membrane Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 656656Low affinity sodium-glucose cotransporterPRO_0000105377Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi248 – 2481N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

PRIDEiQ9ET37.

PTM databases

PhosphoSiteiQ9ET37.

Expressioni

Gene expression databases

CleanExiMM_SLC5A4A.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000020450.

Structurei

3D structure databases

ProteinModelPortaliQ9ET37.
SMRiQ9ET37. Positions 28-497.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG4146.
HOGENOMiHOG000025422.
HOVERGENiHBG052859.
InParanoidiQ9ET37.
PhylomeDBiQ9ET37.

Family and domain databases

InterProiIPR001734. Na/solute_symporter.
IPR018212. Na/solute_symporter_CS.
IPR019900. Na/solute_symporter_subgr.
[Graphical view]
PANTHERiPTHR11819. PTHR11819. 1 hit.
PfamiPF00474. SSF. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00813. sss. 1 hit.
PROSITEiPS00457. NA_SOLUT_SYMP_2. 1 hit.
PS50283. NA_SOLUT_SYMP_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9ET37-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASTASVSTS TASSELSSLS NNINNAADIS VIVIYFVVVM AVGVWAMLKT
60 70 80 90 100
NRSTVGGFFL AGRSMTWWPM GASLFASNIG SGHFVGLAGT GAASGIAVTA
110 120 130 140 150
FESHSFALLL VLGWIFVPIY IKAGVMTMPE YLKKRFGGKR LQIYLSILFL
160 170 180 190 200
FICVILTISA DIFSGAIFIK LALGLNLYLA ILILLAITAI FTITGGLASV
210 220 230 240 250
IYTDTVQAVI MLVGSFILMV FAFVEVGGYE SFTEKFMNAI PSVVEGDNLT
260 270 280 290 300
INSRCYTPQP DSFHIFRDPV TGDIPWPGTA FGMPITALWY WCINQVIVQR
310 320 330 340 350
CLCGKNLSHV KAACILCGYL KLLPLFFMVM PGMISRILYT DMVACVVPSE
360 370 380 390 400
CVKHCGVDVG CTNYAYPMLV LKLMPPGLRG LMLSVMLASL MSSLTSVFNS
410 420 430 440 450
ASTLFTIDLY TKIRKKASER ELLIAGRLFV SVLIVTSILW VPIVEVSQGG
460 470 480 490 500
QLVHYTEAIS SYLGPPIAAV FLVAVFCKRA NEQGAFWGLM VGLVMGLIRM
510 520 530 540 550
IAEFSYGTGS CLAPSSCPKI ICGVHYLYFA IILFFVCILV ILGVSYLTKP
560 570 580 590 600
IPDVHLHRLC WALRNSKEER IDLDAEDKEE NGADDRTEED QTEKPRGCLK
610 620 630 640 650
KTCDLFCGLQ RAEFKLTKVE EEALTDTTEK PFWRTVMNVN VILLLAVAAF

FYGYFA
Length:656
Mass (Da):71,838
Last modified:March 1, 2001 - v1
Checksum:iA6668E815204D39B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF251267 mRNA. Translation: AAG01741.1.
CCDSiCCDS35941.1.
UniGeneiMm.154797.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF251267 mRNA. Translation: AAG01741.1.
CCDSiCCDS35941.1.
UniGeneiMm.154797.

3D structure databases

ProteinModelPortaliQ9ET37.
SMRiQ9ET37. Positions 28-497.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000020450.

PTM databases

PhosphoSiteiQ9ET37.

Proteomic databases

PRIDEiQ9ET37.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

MGIiMGI:1927848. Slc5a4a.

Phylogenomic databases

eggNOGiCOG4146.
HOGENOMiHOG000025422.
HOVERGENiHBG052859.
InParanoidiQ9ET37.
PhylomeDBiQ9ET37.

Miscellaneous databases

PROiQ9ET37.
SOURCEiSearch...

Gene expression databases

CleanExiMM_SLC5A4A.

Family and domain databases

InterProiIPR001734. Na/solute_symporter.
IPR018212. Na/solute_symporter_CS.
IPR019900. Na/solute_symporter_subgr.
[Graphical view]
PANTHERiPTHR11819. PTHR11819. 1 hit.
PfamiPF00474. SSF. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00813. sss. 1 hit.
PROSITEiPS00457. NA_SOLUT_SYMP_2. 1 hit.
PS50283. NA_SOLUT_SYMP_3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Chromosome evolution: the junction of mammalian chromosomes in the formation of mouse chromosome 10."
    Pletcher M.T., Roe B.A., Chen F., Do T., Do A., Malaj E., Reeves R.H.
    Genome Res. 10:1463-1467(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: 129/Sv.

Entry informationi

Entry nameiSC5A4_MOUSE
AccessioniPrimary (citable) accession number: Q9ET37
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 26, 2001
Last sequence update: March 1, 2001
Last modified: June 24, 2015
This is version 92 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.