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Q9ET37

- SC5A4_MOUSE

UniProt

Q9ET37 - SC5A4_MOUSE

Protein

Low affinity sodium-glucose cotransporter

Gene

Slc5a4a

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 90 (01 Oct 2014)
      Sequence version 1 (01 Mar 2001)
      Previous versions | rss
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    Functioni

    Sodium-dependent glucose transporter.By similarity

    GO - Molecular functioni

    1. hydrogen ion transmembrane transporter activity Source: MGI
    2. symporter activity Source: UniProtKB-KW

    GO - Biological processi

    1. carbohydrate transport Source: UniProtKB-KW
    2. hydrogen ion transmembrane transport Source: GOC
    3. proton transport Source: MGI
    4. sodium ion transport Source: UniProtKB-KW

    Keywords - Biological processi

    Ion transport, Sodium transport, Sugar transport, Symport, Transport

    Keywords - Ligandi

    Sodium

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Low affinity sodium-glucose cotransporter
    Alternative name(s):
    Sodium/glucose cotransporter 3
    Short name:
    Na(+)/glucose cotransporter 3
    Solute carrier family 5 member 4
    Gene namesi
    Name:Slc5a4a
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Unplaced

    Organism-specific databases

    MGIiMGI:1927848. Slc5a4a.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: MGI

    Keywords - Cellular componenti

    Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 656656Low affinity sodium-glucose cotransporterPRO_0000105377Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi248 – 2481N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    PRIDEiQ9ET37.

    PTM databases

    PhosphoSiteiQ9ET37.

    Expressioni

    Gene expression databases

    CleanExiMM_SLC5A4A.
    GenevestigatoriQ9ET37.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9ET37.
    SMRiQ9ET37. Positions 28-497.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 2828CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini48 – 6417ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini86 – 10520CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini127 – 17145ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini192 – 20817CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini230 – 27041ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini292 – 31423CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini335 – 42389ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini444 – 45512CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini477 – 52650ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini548 – 63487CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei29 – 4719HelicalSequence AnalysisAdd
    BLAST
    Transmembranei65 – 8521HelicalSequence AnalysisAdd
    BLAST
    Transmembranei106 – 12621HelicalSequence AnalysisAdd
    BLAST
    Transmembranei172 – 19120HelicalSequence AnalysisAdd
    BLAST
    Transmembranei209 – 22921HelicalSequence AnalysisAdd
    BLAST
    Transmembranei271 – 29121HelicalSequence AnalysisAdd
    BLAST
    Transmembranei315 – 33420HelicalSequence AnalysisAdd
    BLAST
    Transmembranei424 – 44320HelicalSequence AnalysisAdd
    BLAST
    Transmembranei456 – 47621HelicalSequence AnalysisAdd
    BLAST
    Transmembranei527 – 54721HelicalSequence AnalysisAdd
    BLAST
    Transmembranei635 – 65521HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG4146.
    HOGENOMiHOG000025422.
    HOVERGENiHBG052859.
    InParanoidiQ9ET37.
    PhylomeDBiQ9ET37.

    Family and domain databases

    InterProiIPR001734. Na/solute_symporter.
    IPR018212. Na/solute_symporter_CS.
    IPR019900. Na/solute_symporter_subgr.
    [Graphical view]
    PANTHERiPTHR11819. PTHR11819. 1 hit.
    PfamiPF00474. SSF. 1 hit.
    [Graphical view]
    TIGRFAMsiTIGR00813. sss. 1 hit.
    PROSITEiPS00457. NA_SOLUT_SYMP_2. 1 hit.
    PS50283. NA_SOLUT_SYMP_3. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9ET37-1 [UniParc]FASTAAdd to Basket

    « Hide

    MASTASVSTS TASSELSSLS NNINNAADIS VIVIYFVVVM AVGVWAMLKT    50
    NRSTVGGFFL AGRSMTWWPM GASLFASNIG SGHFVGLAGT GAASGIAVTA 100
    FESHSFALLL VLGWIFVPIY IKAGVMTMPE YLKKRFGGKR LQIYLSILFL 150
    FICVILTISA DIFSGAIFIK LALGLNLYLA ILILLAITAI FTITGGLASV 200
    IYTDTVQAVI MLVGSFILMV FAFVEVGGYE SFTEKFMNAI PSVVEGDNLT 250
    INSRCYTPQP DSFHIFRDPV TGDIPWPGTA FGMPITALWY WCINQVIVQR 300
    CLCGKNLSHV KAACILCGYL KLLPLFFMVM PGMISRILYT DMVACVVPSE 350
    CVKHCGVDVG CTNYAYPMLV LKLMPPGLRG LMLSVMLASL MSSLTSVFNS 400
    ASTLFTIDLY TKIRKKASER ELLIAGRLFV SVLIVTSILW VPIVEVSQGG 450
    QLVHYTEAIS SYLGPPIAAV FLVAVFCKRA NEQGAFWGLM VGLVMGLIRM 500
    IAEFSYGTGS CLAPSSCPKI ICGVHYLYFA IILFFVCILV ILGVSYLTKP 550
    IPDVHLHRLC WALRNSKEER IDLDAEDKEE NGADDRTEED QTEKPRGCLK 600
    KTCDLFCGLQ RAEFKLTKVE EEALTDTTEK PFWRTVMNVN VILLLAVAAF 650
    FYGYFA 656
    Length:656
    Mass (Da):71,838
    Last modified:March 1, 2001 - v1
    Checksum:iA6668E815204D39B
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF251267 mRNA. Translation: AAG01741.1.
    CCDSiCCDS35941.1.
    UniGeneiMm.154797.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF251267 mRNA. Translation: AAG01741.1 .
    CCDSi CCDS35941.1.
    UniGenei Mm.154797.

    3D structure databases

    ProteinModelPortali Q9ET37.
    SMRi Q9ET37. Positions 28-497.
    ModBasei Search...
    MobiDBi Search...

    PTM databases

    PhosphoSitei Q9ET37.

    Proteomic databases

    PRIDEi Q9ET37.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Organism-specific databases

    MGIi MGI:1927848. Slc5a4a.

    Phylogenomic databases

    eggNOGi COG4146.
    HOGENOMi HOG000025422.
    HOVERGENi HBG052859.
    InParanoidi Q9ET37.
    PhylomeDBi Q9ET37.

    Miscellaneous databases

    PROi Q9ET37.
    SOURCEi Search...

    Gene expression databases

    CleanExi MM_SLC5A4A.
    Genevestigatori Q9ET37.

    Family and domain databases

    InterProi IPR001734. Na/solute_symporter.
    IPR018212. Na/solute_symporter_CS.
    IPR019900. Na/solute_symporter_subgr.
    [Graphical view ]
    PANTHERi PTHR11819. PTHR11819. 1 hit.
    Pfami PF00474. SSF. 1 hit.
    [Graphical view ]
    TIGRFAMsi TIGR00813. sss. 1 hit.
    PROSITEi PS00457. NA_SOLUT_SYMP_2. 1 hit.
    PS50283. NA_SOLUT_SYMP_3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Chromosome evolution: the junction of mammalian chromosomes in the formation of mouse chromosome 10."
      Pletcher M.T., Roe B.A., Chen F., Do T., Do A., Malaj E., Reeves R.H.
      Genome Res. 10:1463-1467(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: 129/Sv.

    Entry informationi

    Entry nameiSC5A4_MOUSE
    AccessioniPrimary (citable) accession number: Q9ET37
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 26, 2001
    Last sequence update: March 1, 2001
    Last modified: October 1, 2014
    This is version 90 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3