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Protein

Tumor necrosis factor receptor superfamily member 13B

Gene

Tnfrsf13b

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Receptor for TNFSF13/APRIL and TNFSF13B/TALL1/BAFF/BLYS that binds both ligands with similar high affinity. Mediates calcineurin-dependent activation of NF-AT, as well as activation of NF-kappa-B and AP-1. Involved in the stimulation of B- and T-cell function and the regulation of humoral immunity (By similarity).By similarity2 Publications

GO - Biological processi

  • adaptive immune response Source: UniProtKB-KW
  • B cell homeostasis Source: MGI
  • cell surface receptor signaling pathway Source: GO_Central
  • hematopoietic progenitor cell differentiation Source: MGI
  • negative regulation of B cell proliferation Source: MGI

Keywordsi

Molecular functionReceptor
Biological processAdaptive immunity, Immunity

Enzyme and pathway databases

ReactomeiR-MMU-5669034 TNFs bind their physiological receptors

Names & Taxonomyi

Protein namesi
Recommended name:
Tumor necrosis factor receptor superfamily member 13B
Alternative name(s):
Transmembrane activator and CAML interactor
CD_antigen: CD267
Gene namesi
Name:Tnfrsf13b
Synonyms:Taci
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:1889411 Tnfrsf13b

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 128ExtracellularSequence analysisAdd BLAST128
Transmembranei129 – 149Helical; Signal-anchor for type III membrane proteinSequence analysisAdd BLAST21
Topological domaini150 – 249CytoplasmicSequence analysisAdd BLAST100

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000589321 – 249Tumor necrosis factor receptor superfamily member 13BAdd BLAST249

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi6 ↔ 19By similarity
Disulfide bondi22 ↔ 34By similarity
Disulfide bondi26 ↔ 38By similarity
Disulfide bondi43 ↔ 58By similarity
Disulfide bondi61 ↔ 72By similarity
Disulfide bondi65 ↔ 76By similarity

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiQ9ET35
PRIDEiQ9ET35

PTM databases

iPTMnetiQ9ET35
PhosphoSitePlusiQ9ET35

Expressioni

Gene expression databases

BgeeiENSMUSG00000010142
ExpressionAtlasiQ9ET35 baseline and differential
GenevisibleiQ9ET35 MM

Interactioni

Subunit structurei

Binds TRAF2, TRAF5 and TRAF6. Binds the NH2-terminal domain of CAMLG with its C-terminus (By similarity).By similarity

Protein-protein interaction databases

IntActiQ9ET35, 6 interactors
STRINGi10090.ENSMUSP00000010286

Structurei

3D structure databases

ProteinModelPortaliQ9ET35
SMRiQ9ET35
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati5 – 38TNFR-Cys 1Add BLAST34
Repeati42 – 76TNFR-Cys 2Add BLAST35

Keywords - Domaini

Repeat, Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IHJ8 Eukaryota
ENOG410Z545 LUCA
GeneTreeiENSGT00390000013910
HOGENOMiHOG000273905
HOVERGENiHBG058015
InParanoidiQ9ET35
KOiK05150
OMAiCHTRTTV
OrthoDBiEOG091G0ISO
PhylomeDBiQ9ET35
TreeFamiTF337993

Family and domain databases

CDDicd13415 TNFRSF13B, 1 hit
InterProiView protein in InterPro
IPR015384 TACI_Cys-rich-dom
IPR022317 TNFR_13B
PANTHERiPTHR15511 PTHR15511, 1 hit
PfamiView protein in Pfam
PF09305 TACI-CRD2, 1 hit
PRINTSiPR01963 TNFACTORR13B

Sequencei

Sequence statusi: Complete.

Q9ET35-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAMAFCPKDQ YWDSSRKSCV SCALTCSQRS QRTCTDFCKF INCRKEQGRY
60 70 80 90 100
YDHLLGACVS CDSTCTQHPQ QCAHFCEKRP RSQANLQPEL GRPQAGEVEV
110 120 130 140 150
RSDNSGRHQG SEHGPGLRLS SDQLTLYCTL GVCLCAIFCC FLVALASFLR
160 170 180 190 200
RRGEPLPSQP AGPRGSQANS PHAHRPVTEA CDEVTASPQP VETCSFCFPE
210 220 230 240
RSSPTQESAP RSLGIHGFAG TAAPQPCMRA TVGGLGVLRA STGDARPAT
Length:249
Mass (Da):26,947
Last modified:March 1, 2001 - v1
Checksum:iCB2F2D61C2931D81
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti137I → F in BAB23457 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF257673 mRNA Translation: AAG00081.1
AK004668 mRNA Translation: BAB23457.1
CCDSiCCDS24806.1
RefSeqiNP_067324.1, NM_021349.1
XP_006533914.1, XM_006533851.3
XP_006533915.1, XM_006533852.3
UniGeneiMm.265915

Genome annotation databases

EnsembliENSMUST00000010286; ENSMUSP00000010286; ENSMUSG00000010142
ENSMUST00000101103; ENSMUSP00000098662; ENSMUSG00000010142
GeneIDi57916
KEGGimmu:57916
UCSCiuc007jha.1 mouse

Similar proteinsi

Entry informationi

Entry nameiTR13B_MOUSE
AccessioniPrimary (citable) accession number: Q9ET35
Secondary accession number(s): Q9DBZ3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 27, 2002
Last sequence update: March 1, 2001
Last modified: May 23, 2018
This is version 113 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

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