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Protein

Tumor necrosis factor receptor superfamily member 13B

Gene

Tnfrsf13b

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Receptor for TNFSF13/APRIL and TNFSF13B/TALL1/BAFF/BLYS that binds both ligands with similar high affinity. Mediates calcineurin-dependent activation of NF-AT, as well as activation of NF-kappa-B and AP-1. Involved in the stimulation of B- and T-cell function and the regulation of humoral immunity (By similarity).By similarity2 Publications

GO - Molecular functioni

GO - Biological processi

  • adaptive immune response Source: UniProtKB-KW
  • B cell homeostasis Source: MGI
  • cell surface receptor signaling pathway Source: GO_Central
  • hematopoietic progenitor cell differentiation Source: MGI
  • negative regulation of B cell proliferation Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Receptor

Keywords - Biological processi

Adaptive immunity, Immunity

Enzyme and pathway databases

ReactomeiR-MMU-5669034. TNFs bind their physiological receptors.

Names & Taxonomyi

Protein namesi
Recommended name:
Tumor necrosis factor receptor superfamily member 13B
Alternative name(s):
Transmembrane activator and CAML interactor
CD_antigen: CD267
Gene namesi
Name:Tnfrsf13b
Synonyms:Taci
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:1889411. Tnfrsf13b.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 128128ExtracellularSequence analysisAdd
BLAST
Transmembranei129 – 14921Helical; Signal-anchor for type III membrane proteinSequence analysisAdd
BLAST
Topological domaini150 – 249100CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

  • external side of plasma membrane Source: MGI
  • integral component of plasma membrane Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 249249Tumor necrosis factor receptor superfamily member 13BPRO_0000058932Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi6 ↔ 19By similarity
Disulfide bondi22 ↔ 34By similarity
Disulfide bondi26 ↔ 38By similarity
Disulfide bondi43 ↔ 58By similarity
Disulfide bondi61 ↔ 72By similarity
Disulfide bondi65 ↔ 76By similarity

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiQ9ET35.
PRIDEiQ9ET35.

PTM databases

iPTMnetiQ9ET35.
PhosphoSiteiQ9ET35.

Expressioni

Gene expression databases

BgeeiENSMUSG00000010142.
ExpressionAtlasiQ9ET35. baseline and differential.
GenevisibleiQ9ET35. MM.

Interactioni

Subunit structurei

Binds TRAF2, TRAF5 and TRAF6. Binds the NH2-terminal domain of CAMLG with its C-terminus (By similarity).By similarity

Protein-protein interaction databases

IntActiQ9ET35. 6 interactions.
STRINGi10090.ENSMUSP00000010286.

Structurei

3D structure databases

ProteinModelPortaliQ9ET35.
SMRiQ9ET35. Positions 43-77.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati5 – 3834TNFR-Cys 1Add
BLAST
Repeati42 – 7635TNFR-Cys 2Add
BLAST

Sequence similaritiesi

Contains 2 TNFR-Cys repeats.Curated

Keywords - Domaini

Repeat, Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IHJ8. Eukaryota.
ENOG410Z545. LUCA.
GeneTreeiENSGT00390000013910.
HOGENOMiHOG000273905.
HOVERGENiHBG058015.
InParanoidiQ9ET35.
KOiK05150.
OMAiCHTRTTV.
OrthoDBiEOG091G0ISO.
PhylomeDBiQ9ET35.
TreeFamiTF337993.

Family and domain databases

InterProiIPR015384. TACI_Cys-rich-dom.
IPR022317. TNFR_13B.
[Graphical view]
PfamiPF09305. TACI-CRD2. 1 hit.
[Graphical view]
PRINTSiPR01963. TNFACTORR13B.

Sequencei

Sequence statusi: Complete.

Q9ET35-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAMAFCPKDQ YWDSSRKSCV SCALTCSQRS QRTCTDFCKF INCRKEQGRY
60 70 80 90 100
YDHLLGACVS CDSTCTQHPQ QCAHFCEKRP RSQANLQPEL GRPQAGEVEV
110 120 130 140 150
RSDNSGRHQG SEHGPGLRLS SDQLTLYCTL GVCLCAIFCC FLVALASFLR
160 170 180 190 200
RRGEPLPSQP AGPRGSQANS PHAHRPVTEA CDEVTASPQP VETCSFCFPE
210 220 230 240
RSSPTQESAP RSLGIHGFAG TAAPQPCMRA TVGGLGVLRA STGDARPAT
Length:249
Mass (Da):26,947
Last modified:March 1, 2001 - v1
Checksum:iCB2F2D61C2931D81
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti137 – 1371I → F in BAB23457 (PubMed:16141072).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF257673 mRNA. Translation: AAG00081.1.
AK004668 mRNA. Translation: BAB23457.1.
CCDSiCCDS24806.1.
RefSeqiNP_067324.1. NM_021349.1.
XP_006533914.1. XM_006533851.2.
XP_006533915.1. XM_006533852.2.
UniGeneiMm.265915.

Genome annotation databases

EnsembliENSMUST00000010286; ENSMUSP00000010286; ENSMUSG00000010142.
ENSMUST00000101103; ENSMUSP00000098662; ENSMUSG00000010142.
GeneIDi57916.
KEGGimmu:57916.
UCSCiuc007jha.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF257673 mRNA. Translation: AAG00081.1.
AK004668 mRNA. Translation: BAB23457.1.
CCDSiCCDS24806.1.
RefSeqiNP_067324.1. NM_021349.1.
XP_006533914.1. XM_006533851.2.
XP_006533915.1. XM_006533852.2.
UniGeneiMm.265915.

3D structure databases

ProteinModelPortaliQ9ET35.
SMRiQ9ET35. Positions 43-77.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ9ET35. 6 interactions.
STRINGi10090.ENSMUSP00000010286.

PTM databases

iPTMnetiQ9ET35.
PhosphoSiteiQ9ET35.

Proteomic databases

PaxDbiQ9ET35.
PRIDEiQ9ET35.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000010286; ENSMUSP00000010286; ENSMUSG00000010142.
ENSMUST00000101103; ENSMUSP00000098662; ENSMUSG00000010142.
GeneIDi57916.
KEGGimmu:57916.
UCSCiuc007jha.1. mouse.

Organism-specific databases

CTDi23495.
MGIiMGI:1889411. Tnfrsf13b.

Phylogenomic databases

eggNOGiENOG410IHJ8. Eukaryota.
ENOG410Z545. LUCA.
GeneTreeiENSGT00390000013910.
HOGENOMiHOG000273905.
HOVERGENiHBG058015.
InParanoidiQ9ET35.
KOiK05150.
OMAiCHTRTTV.
OrthoDBiEOG091G0ISO.
PhylomeDBiQ9ET35.
TreeFamiTF337993.

Enzyme and pathway databases

ReactomeiR-MMU-5669034. TNFs bind their physiological receptors.

Miscellaneous databases

PROiQ9ET35.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000010142.
ExpressionAtlasiQ9ET35. baseline and differential.
GenevisibleiQ9ET35. MM.

Family and domain databases

InterProiIPR015384. TACI_Cys-rich-dom.
IPR022317. TNFR_13B.
[Graphical view]
PfamiPF09305. TACI-CRD2. 1 hit.
[Graphical view]
PRINTSiPR01963. TNFACTORR13B.
ProtoNetiSearch...

Entry informationi

Entry nameiTR13B_MOUSE
AccessioniPrimary (citable) accession number: Q9ET35
Secondary accession number(s): Q9DBZ3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 27, 2002
Last sequence update: March 1, 2001
Last modified: September 7, 2016
This is version 105 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.