Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Dipeptidyl peptidase 2

Gene

Dpp7

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Plays an important role in the degradation of some oligopeptides.

Catalytic activityi

Release of an N-terminal dipeptide, Xaa-Yaa-|-, preferentially when Yaa is Ala or Pro. Substrates are oligopeptides, preferentially tripeptides.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei172Charge relay systemSequence analysis1
Active sitei428Charge relay systemSequence analysis1
Active sitei453Charge relay systemSequence analysis1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Aminopeptidase, Hydrolase, Protease, Serine protease

Enzyme and pathway databases

ReactomeiR-MMU-6798695. Neutrophil degranulation.

Protein family/group databases

ESTHERimouse-dpp2. Prolylcarboxypeptidase.
MEROPSiS28.002.

Names & Taxonomyi

Protein namesi
Recommended name:
Dipeptidyl peptidase 2 (EC:3.4.14.2)
Alternative name(s):
Dipeptidyl aminopeptidase II
Dipeptidyl peptidase 7
Dipeptidyl peptidase II
Short name:
DPP II
Quiescent cell proline dipeptidase
Gene namesi
Name:Dpp7
Synonyms:Dpp2, Qpp
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:1933213. Dpp7.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasmic vesicle, Lysosome, Secreted

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL3259501.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 33Sequence analysisAdd BLAST33
PropeptideiPRO_000002731634 – 36By similarity3
ChainiPRO_000002731737 – 506Dipeptidyl peptidase 2Add BLAST470

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi60N-linked (GlcNAc...)Sequence analysis1
Glycosylationi96N-linked (GlcNAc...)Sequence analysis1
Glycosylationi325N-linked (GlcNAc...)Sequence analysis1
Glycosylationi366N-linked (GlcNAc...)Sequence analysis1
Glycosylationi373N-linked (GlcNAc...)Sequence analysis1
Glycosylationi438N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Glycoprotein, Zymogen

Proteomic databases

EPDiQ9ET22.
MaxQBiQ9ET22.
PaxDbiQ9ET22.
PeptideAtlasiQ9ET22.
PRIDEiQ9ET22.

PTM databases

iPTMnetiQ9ET22.
PhosphoSitePlusiQ9ET22.

Expressioni

Gene expression databases

BgeeiENSMUSG00000026958.
CleanExiMM_DPP7.
GenevisibleiQ9ET22. MM.

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

IntActiQ9ET22. 1 interactor.
MINTiMINT-4118228.
STRINGi10090.ENSMUSP00000028332.

Structurei

3D structure databases

ProteinModelPortaliQ9ET22.
SMRiQ9ET22.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase S28 family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG2183. Eukaryota.
ENOG410Y38A. LUCA.
GeneTreeiENSGT00530000063027.
HOGENOMiHOG000238311.
HOVERGENiHBG005526.
InParanoidiQ9ET22.
KOiK01276.
OMAiRWEFGTC.
OrthoDBiEOG091G056F.
TreeFamiTF314414.

Family and domain databases

Gene3Di3.40.50.1820. 1 hit.
InterProiIPR029058. AB_hydrolase.
IPR008758. Peptidase_S28.
[Graphical view]
PfamiPF05577. Peptidase_S28. 1 hit.
[Graphical view]
SUPFAMiSSF53474. SSF53474. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9ET22-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNFHPCYPVD HGVPSWILVL LLSLGLCNLQ ARADRVLDPD FHENYFEQYM
60 70 80 90 100
DHFNFESFGN KTFGQRFLVS DKFWKMGEGP IFFYTGNEGD IWSFANNSGF
110 120 130 140 150
MVELAAQQEA LLVFAEHRYY GKSLPFGVQS TQRGYTQLLT VEQALADFAV
160 170 180 190 200
LLQALRQDLG VHDAPTIAFG GSYGGMLSAY MRMKYPHLVA GALAASAPVV
210 220 230 240 250
AVAGLGDSYQ FFRDVTADFY GQSPKCAQAV RDAFQQIKDL FLQGAYDTIS
260 270 280 290 300
QNFGTCQSLS SPKDLTQLFG FARNAFTVLA MMDYPYPTDF LGPLPANPVK
310 320 330 340 350
VGCQRLLNEG QRIMGLRALA GLVYNSSGTE PCYDIYRLYQ SCADPTGCGT
360 370 380 390 400
GSDARAWDYQ ACTEINLTFD SNNVTDMFPE IPFSEELRQQ YCLDTWGVWP
410 420 430 440 450
RQDWLQTSFW GGDLKAASNI IFSNGDLDPW AGGGIQSNLS TSVIAVTIQG
460 470 480 490 500
GAHHLDLRAS NSEDPPSVVE VRKLESTLIR EWVAAARLKQ PAMPRWPGPK

KQHPSR
Length:506
Mass (Da):56,254
Last modified:July 27, 2011 - v2
Checksum:i3A4ECAA3DD4EF7D4
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti497P → L in AAG01154 (Ref. 1) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF285235 mRNA. Translation: AAG01154.1.
AL732557 Genomic DNA. Translation: CAM25607.1.
CH466542 Genomic DNA. Translation: EDL08237.1.
BC027205 mRNA. Translation: AAH27205.1.
CCDSiCCDS15766.1.
RefSeqiNP_114031.2. NM_031843.2.
UniGeneiMm.21440.

Genome annotation databases

EnsembliENSMUST00000028332; ENSMUSP00000028332; ENSMUSG00000026958.
GeneIDi83768.
KEGGimmu:83768.
UCSCiuc008irq.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF285235 mRNA. Translation: AAG01154.1.
AL732557 Genomic DNA. Translation: CAM25607.1.
CH466542 Genomic DNA. Translation: EDL08237.1.
BC027205 mRNA. Translation: AAH27205.1.
CCDSiCCDS15766.1.
RefSeqiNP_114031.2. NM_031843.2.
UniGeneiMm.21440.

3D structure databases

ProteinModelPortaliQ9ET22.
SMRiQ9ET22.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ9ET22. 1 interactor.
MINTiMINT-4118228.
STRINGi10090.ENSMUSP00000028332.

Chemistry databases

ChEMBLiCHEMBL3259501.

Protein family/group databases

ESTHERimouse-dpp2. Prolylcarboxypeptidase.
MEROPSiS28.002.

PTM databases

iPTMnetiQ9ET22.
PhosphoSitePlusiQ9ET22.

Proteomic databases

EPDiQ9ET22.
MaxQBiQ9ET22.
PaxDbiQ9ET22.
PeptideAtlasiQ9ET22.
PRIDEiQ9ET22.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000028332; ENSMUSP00000028332; ENSMUSG00000026958.
GeneIDi83768.
KEGGimmu:83768.
UCSCiuc008irq.1. mouse.

Organism-specific databases

CTDi29952.
MGIiMGI:1933213. Dpp7.

Phylogenomic databases

eggNOGiKOG2183. Eukaryota.
ENOG410Y38A. LUCA.
GeneTreeiENSGT00530000063027.
HOGENOMiHOG000238311.
HOVERGENiHBG005526.
InParanoidiQ9ET22.
KOiK01276.
OMAiRWEFGTC.
OrthoDBiEOG091G056F.
TreeFamiTF314414.

Enzyme and pathway databases

ReactomeiR-MMU-6798695. Neutrophil degranulation.

Miscellaneous databases

ChiTaRSiDpp7. mouse.
PROiQ9ET22.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000026958.
CleanExiMM_DPP7.
GenevisibleiQ9ET22. MM.

Family and domain databases

Gene3Di3.40.50.1820. 1 hit.
InterProiIPR029058. AB_hydrolase.
IPR008758. Peptidase_S28.
[Graphical view]
PfamiPF05577. Peptidase_S28. 1 hit.
[Graphical view]
SUPFAMiSSF53474. SSF53474. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiDPP2_MOUSE
AccessioniPrimary (citable) accession number: Q9ET22
Secondary accession number(s): Q8R082
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: July 27, 2011
Last modified: November 30, 2016
This is version 115 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. Peptidase families
    Classification of peptidase families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.