Q9ESZ8 (GTF2I_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
General transcription factor II-I
Short name=GTFII-I
Short name=TFII-I

Alternative name(s):
Bruton tyrosine kinase-associated protein 135
Short name=BAP-135
Short name=BTK-associated protein 135

Gene names

Name:	Gtf2i
Synonyms:	Bap135, Diws1t

Organism

Mus musculus (Mouse)

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	998 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Interacts with the basal transcription machinery by coordinating the formation of a multiprotein complex at the C-FOS promoter, and linking specific signal responsive activator complexes. Promotes the formation of stable high-order complexes of SRF and PHOX1 and interacts cooperatively with PHOX1 to promote serum-inducible transcription of a reporter gene deriven by the C-FOS serum response element (SRE). Acts as a coregulator for USF1 by binding independently two promoter elements, a pyrimidine-rich initiator (Inr) and an upstream E-box By similarity. Required for the formation of functional ARID3A DNA-binding complexes and for activation of immunoglobulin heavy-chain transcription upon B-lymphocyte activation. Ref.7
Subunit structure	Homodimer Potential. Interacts with SRF and PHOX1. Binds a pyrimidine-rich initiator (Inr) and a recognition site (E-box) for upstream stimulatory factor 1 (USF1). Associates with the PH domain of Bruton's tyrosine kinase (BTK) By similarity. May be a component of a BHC histone deacetylase complex that contains HDAC1, HDAC2, HMG20B/BRAF35, KDM1A, RCOR1/CoREST, PHF21A/BHC80, ZMYM2, ZNF217, ZMYM3, GSE1 and GTF2I. Interacts with BTK and ARID3A. Interacts with isoform beta of PRKG1 By similarity. Ref.7
Subcellular location	Cytoplasm. Nucleus. Note: Colocalizes with BTK in the cytoplasm By similarity.
Tissue specificity	Ubiquitous.
Post-translational modification	Transiently phosphorylated on tyrosine residues by BTK in response to B-cell receptor stimulation. Phosphorylation on Tyr-248 and Tyr-398, and perhaps, on Tyr-503 contributes to BTK-mediated transcriptional activation By similarity. Sumoylated By similarity.
Sequence similarities	Belongs to the TFII-I family. Contains 6 GTF2I-like repeats.
Sequence caution	The sequence BAB28803.2 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
Biological process	Transcription Transcription regulation
Cellular component	Cytoplasm Nucleus
Coding sequence diversity	Alternative splicing
Domain	Repeat
Ligand	DNA-binding
PTM	Acetylation Phosphoprotein Ubl conjugation
Technical term	3D-structure Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	embryo development Inferred from mutant phenotype. Source: MGI regulation of transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cell projection Inferred from direct assay. Source: MGI cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell neuronal cell body Inferred from direct assay. Source: MGI nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	DNA binding Inferred from electronic annotation. Source: UniProtKB-KW mitogen-activated protein kinase binding Inferred from direct assay. Source: MGI
Complete GO annotation...

Alternative products

This entry describes 6 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q9ESZ8-1)

Also known as: Gamma;

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q9ESZ8-2)

Also known as: Beta; Long;

The sequence of this isoform differs from the canonical sequence as follows:
     255-273: Missing.

Isoform 3 (identifier: Q9ESZ8-3)

The sequence of this isoform differs from the canonical sequence as follows:
     255-292: Missing.

Isoform 4 (identifier: Q9ESZ8-4)

Also known as: Delta; Short;

The sequence of this isoform differs from the canonical sequence as follows:
     255-273: Missing.
     293-313: Missing.

Isoform 5 (identifier: Q9ESZ8-5)

The sequence of this isoform differs from the canonical sequence as follows:
     255-313: Missing.

Isoform 6 (identifier: Q9ESZ8-6)

Also known as: Alpha;

The sequence of this isoform differs from the canonical sequence as follows:
     293-313: Missing.

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Initiator methionine

1

1

Removed By similarity

Chain

2 – 998

997

General transcription factor II-I

PRO_0000083873

Regions

Repeat

103 – 197

95

GTF2I-like 1

Repeat

352 – 446

95

GTF2I-like 2

Repeat

457 – 551

95

GTF2I-like 3

Repeat

562 – 656

95

GTF2I-like 4

Repeat

724 – 818

95

GTF2I-like 5

Repeat

859 – 953

95

GTF2I-like 6

Motif

319 – 326

8

Nuclear localization signal Potential

Compositional bias

329 – 337

9

Poly-Pro

Amino acid modifications

Modified residue

2

1

N-acetylalanine By similarity

Modified residue

103

1

Phosphoserine By similarity

Modified residue

207

1

Phosphoserine By similarity

Modified residue

210

1

Phosphoserine By similarity

Modified residue

248

1

Phosphotyrosine; by BTK By similarity

Modified residue

317

1

Phosphotyrosine; by BTK By similarity

Modified residue

398

1

Phosphotyrosine; by BTK By similarity

Modified residue

412

1

Phosphoserine; by PKG/PRKG1 By similarity

Modified residue

503

1

Phosphotyrosine; by BTK By similarity

Modified residue

515

1

Phosphoserine By similarity

Modified residue

517

1

Phosphoserine By similarity

Modified residue

558

1

Phosphothreonine By similarity

Modified residue

668

1

Phosphoserine By similarity

Modified residue

674

1

Phosphoserine By similarity

Modified residue

679

1

Phosphoserine By similarity

Modified residue

687

1

Phosphothreonine By similarity

Modified residue

784

1

Phosphoserine; by PKG/PRKG1 By similarity

Modified residue

823

1

Phosphoserine By similarity

Natural variations

Alternative sequence

255 – 313

59

Missing in isoform 5.

VSP_003871

Alternative sequence

255 – 292

38

Missing in isoform 3.

VSP_003870

Alternative sequence

255 – 273

19

Missing in isoform 2 and isoform 4.

VSP_003869

Alternative sequence

293 – 313

21

Missing in isoform 4 and isoform 6.

VSP_003872

Experimental info

Sequence conflict

5

1

V → A in AAC53569. Ref.1

Sequence conflict

62

1

G → R in AAC53569. Ref.1

Sequence conflict

127 – 130

4

ALGK → NTAL in BAB24743. Ref.5

Sequence conflict

254

1

Q → QA Ref.1

Sequence conflict

261

1

G → D Ref.1

Sequence conflict

266

1

L → Q Ref.1

Sequence conflict

271 – 272

2

AL → PM Ref.1

Sequence conflict

314

1

D → G Ref.6

Sequence conflict

334

1

Missing in AAC53569. Ref.1

Sequence conflict

538

1

I → T in AAC53569. Ref.1

Sequence conflict

607

1

L → C in AAC53569. Ref.1

Sequence conflict

621

1

P → L in AAC53569. Ref.1

Sequence conflict

691

1

P → L in AAC02990. Ref.2

Sequence conflict

691

1

P → L in AAC02991. Ref.2

Sequence conflict

748

1

A → T in AAC53569. Ref.1

Sequence conflict

826

1

R → IFLSG in BAB28803. Ref.5

Sequence conflict

966

1

E → Q in BAB28803. Ref.5

Secondary structure

1

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

998

Helix Strand Turn

Details...

Helix

733 – 749

17

Helix

759 – 764

6

Turn

766 – 768

3

Beta strand

769 – 773

5

Turn

783 – 785

3

Helix

788 – 796

9

Turn

797 – 800

4

Beta strand

802 – 806

5

Helix

808 – 810

3

Helix

812 – 817

6

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 (Gamma) [UniParc]. Last modified December 15, 2003. Version 3. Checksum: 3BC228A2F4F880CF	FASTA	998	112,265
	10 20 30 40 50 60 MAQVVMSALP AEDEESSESR MVVTFLMSAL ESMCKELAKS KAEVACIAVY ETDVFVVGTE 70 80 90 100 110 120 RGRAFVNTRK DFQKDFVKYC VEEEEKAAEM HKMKSTTQAN RMSVDAVEIE TLRKTVEDYF 130 140 150 160 170 180 CFCYGKALGK STVVPVPYEK MLRDQSAVVV QGLPEGVAFK HPEHYDLATL KWILENKAGI 190 200 210 220 230 240 SFIIKRPFLE PKKHLGGRVL AAEAERSMLS PSGSCGPIKV KTEPTEDSGI SLEMAAVTVK 250 260 270 280 290 300 EESEDPDYYQ YNIQGPSETD GVDEKLPLSK ALQGSHHSSE GNEGTEVEVP AEDSTQHVPS 310 320 330 340 350 360 ETSEDPEVEV TIEDDDYSPP TKRLKSTEPP PPPPVPEPAN AGKRKVREFN FEKWNARITD 370 380 390 400 410 420 LRKQVEELFE RKYAQAIKAK GPVTIPYPLF QSHVEDLYVE GLPEGIPFRR PSTYGIPRLE 430 440 450 460 470 480 RILLAKERIR FVIKKHELLN STREDLQLDK PASGVKEEWY ARITKLRKMV DQLFCKKFAE 490 500 510 520 530 540 ALGSTEAKAV PYQKFEAHPN DLYVEGLPEN IPFRSPSWYG IPRLEKIIQV GNRIKFVIKR 550 560 570 580 590 600 PELLTHSTTE VTQPRTNTPV KEDWNVRITK LRKQVEEIFN LKFAQALGLT EAVKVPYPVF 610 620 630 640 650 660 ESNPEFLYVE GLPEGIPFRS PTWFGIPRLE RIVRGSNKIK FVVKKPELVV SYLPPGMASK 670 680 690 700 710 720 INTKALQSPK RPRSPGSNSK VPEIEVTVEG PNNSSPQTSA VRTPTQTNGS NVPFKPRGRE 730 740 750 760 770 780 FSFEAWNAKI TDLKQKVENL FNEKCGEALG LKQAVKVPFA LFESFPEDFY VEGLPEGVPF 790 800 810 820 830 840 RRPSTFGIPR LEKILRNKAK IKFIIKKPEM FETAIKESTS SKSPPRKINS SPNVNTTASG 850 860 870 880 890 900 VEDLNIIQVT IPDDDNERLS KVEKARQLRE QVNDLFSRKF GEAIGMGFPV KVPYRKITIN 910 920 930 940 950 960 PGCVVVDGMP PGVSFKAPSY LEISSMRRIL DSAEFIKFTV IRPFPGLVIN NQLVDQNESE 970 980 990 GPVIQESAEA SQLEVPVTEE IKETDGSSQI KQEPDPTW
	Isoform 2 (Beta) (Long) [UniParc]. Checksum: E001EB13BE19A81F	FASTA	979	110,299
	10 20 30 40 50 60 MAQVVMSALP AEDEESSESR MVVTFLMSAL ESMCKELAKS KAEVACIAVY ETDVFVVGTE 70 80 90 100 110 120 RGRAFVNTRK DFQKDFVKYC VEEEEKAAEM HKMKSTTQAN RMSVDAVEIE TLRKTVEDYF 130 140 150 160 170 180 CFCYGKALGK STVVPVPYEK MLRDQSAVVV QGLPEGVAFK HPEHYDLATL KWILENKAGI 190 200 210 220 230 240 SFIIKRPFLE PKKHLGGRVL AAEAERSMLS PSGSCGPIKV KTEPTEDSGI SLEMAAVTVK 250 260 270 280 290 300 EESEDPDYYQ YNIQGSHHSS EGNEGTEVEV PAEDSTQHVP SETSEDPEVE VTIEDDDYSP 310 320 330 340 350 360 PTKRLKSTEP PPPPPVPEPA NAGKRKVREF NFEKWNARIT DLRKQVEELF ERKYAQAIKA 370 380 390 400 410 420 KGPVTIPYPL FQSHVEDLYV EGLPEGIPFR RPSTYGIPRL ERILLAKERI RFVIKKHELL 430 440 450 460 470 480 NSTREDLQLD KPASGVKEEW YARITKLRKM VDQLFCKKFA EALGSTEAKA VPYQKFEAHP 490 500 510 520 530 540 NDLYVEGLPE NIPFRSPSWY GIPRLEKIIQ VGNRIKFVIK RPELLTHSTT EVTQPRTNTP 550 560 570 580 590 600 VKEDWNVRIT KLRKQVEEIF NLKFAQALGL TEAVKVPYPV FESNPEFLYV EGLPEGIPFR 610 620 630 640 650 660 SPTWFGIPRL ERIVRGSNKI KFVVKKPELV VSYLPPGMAS KINTKALQSP KRPRSPGSNS 670 680 690 700 710 720 KVPEIEVTVE GPNNSSPQTS AVRTPTQTNG SNVPFKPRGR EFSFEAWNAK ITDLKQKVEN 730 740 750 760 770 780 LFNEKCGEAL GLKQAVKVPF ALFESFPEDF YVEGLPEGVP FRRPSTFGIP RLEKILRNKA 790 800 810 820 830 840 KIKFIIKKPE MFETAIKEST SSKSPPRKIN SSPNVNTTAS GVEDLNIIQV TIPDDDNERL 850 860 870 880 890 900 SKVEKARQLR EQVNDLFSRK FGEAIGMGFP VKVPYRKITI NPGCVVVDGM PPGVSFKAPS 910 920 930 940 950 960 YLEISSMRRI LDSAEFIKFT VIRPFPGLVI NNQLVDQNES EGPVIQESAE ASQLEVPVTE 970 EIKETDGSSQ IKQEPDPTW
	Isoform 3 [UniParc]. Checksum: 80E39FB7F85C4A93	FASTA	960	108,365
	10 20 30 40 50 60 MAQVVMSALP AEDEESSESR MVVTFLMSAL ESMCKELAKS KAEVACIAVY ETDVFVVGTE 70 80 90 100 110 120 RGRAFVNTRK DFQKDFVKYC VEEEEKAAEM HKMKSTTQAN RMSVDAVEIE TLRKTVEDYF 130 140 150 160 170 180 CFCYGKALGK STVVPVPYEK MLRDQSAVVV QGLPEGVAFK HPEHYDLATL KWILENKAGI 190 200 210 220 230 240 SFIIKRPFLE PKKHLGGRVL AAEAERSMLS PSGSCGPIKV KTEPTEDSGI SLEMAAVTVK 250 260 270 280 290 300 EESEDPDYYQ YNIQDSTQHV PSETSEDPEV EVTIEDDDYS PPTKRLKSTE PPPPPPVPEP 310 320 330 340 350 360 ANAGKRKVRE FNFEKWNARI TDLRKQVEEL FERKYAQAIK AKGPVTIPYP LFQSHVEDLY 370 380 390 400 410 420 VEGLPEGIPF RRPSTYGIPR LERILLAKER IRFVIKKHEL LNSTREDLQL DKPASGVKEE 430 440 450 460 470 480 WYARITKLRK MVDQLFCKKF AEALGSTEAK AVPYQKFEAH PNDLYVEGLP ENIPFRSPSW 490 500 510 520 530 540 YGIPRLEKII QVGNRIKFVI KRPELLTHST TEVTQPRTNT PVKEDWNVRI TKLRKQVEEI 550 560 570 580 590 600 FNLKFAQALG LTEAVKVPYP VFESNPEFLY VEGLPEGIPF RSPTWFGIPR LERIVRGSNK 610 620 630 640 650 660 IKFVVKKPEL VVSYLPPGMA SKINTKALQS PKRPRSPGSN SKVPEIEVTV EGPNNSSPQT 670 680 690 700 710 720 SAVRTPTQTN GSNVPFKPRG REFSFEAWNA KITDLKQKVE NLFNEKCGEA LGLKQAVKVP 730 740 750 760 770 780 FALFESFPED FYVEGLPEGV PFRRPSTFGI PRLEKILRNK AKIKFIIKKP EMFETAIKES 790 800 810 820 830 840 TSSKSPPRKI NSSPNVNTTA SGVEDLNIIQ VTIPDDDNER LSKVEKARQL REQVNDLFSR 850 860 870 880 890 900 KFGEAIGMGF PVKVPYRKIT INPGCVVVDG MPPGVSFKAP SYLEISSMRR ILDSAEFIKF 910 920 930 940 950 960 TVIRPFPGLV INNQLVDQNE SEGPVIQESA EASQLEVPVT EEIKETDGSS QIKQEPDPTW
	Isoform 4 (Delta) (Short) [UniParc]. Checksum: BC47CBD9FC28F4BD	FASTA	958	107,989
	10 20 30 40 50 60 MAQVVMSALP AEDEESSESR MVVTFLMSAL ESMCKELAKS KAEVACIAVY ETDVFVVGTE 70 80 90 100 110 120 RGRAFVNTRK DFQKDFVKYC VEEEEKAAEM HKMKSTTQAN RMSVDAVEIE TLRKTVEDYF 130 140 150 160 170 180 CFCYGKALGK STVVPVPYEK MLRDQSAVVV QGLPEGVAFK HPEHYDLATL KWILENKAGI 190 200 210 220 230 240 SFIIKRPFLE PKKHLGGRVL AAEAERSMLS PSGSCGPIKV KTEPTEDSGI SLEMAAVTVK 250 260 270 280 290 300 EESEDPDYYQ YNIQGSHHSS EGNEGTEVEV PAEDDDYSPP TKRLKSTEPP PPPPVPEPAN 310 320 330 340 350 360 AGKRKVREFN FEKWNARITD LRKQVEELFE RKYAQAIKAK GPVTIPYPLF QSHVEDLYVE 370 380 390 400 410 420 GLPEGIPFRR PSTYGIPRLE RILLAKERIR FVIKKHELLN STREDLQLDK PASGVKEEWY 430 440 450 460 470 480 ARITKLRKMV DQLFCKKFAE ALGSTEAKAV PYQKFEAHPN DLYVEGLPEN IPFRSPSWYG 490 500 510 520 530 540 IPRLEKIIQV GNRIKFVIKR PELLTHSTTE VTQPRTNTPV KEDWNVRITK LRKQVEEIFN 550 560 570 580 590 600 LKFAQALGLT EAVKVPYPVF ESNPEFLYVE GLPEGIPFRS PTWFGIPRLE RIVRGSNKIK 610 620 630 640 650 660 FVVKKPELVV SYLPPGMASK INTKALQSPK RPRSPGSNSK VPEIEVTVEG PNNSSPQTSA 670 680 690 700 710 720 VRTPTQTNGS NVPFKPRGRE FSFEAWNAKI TDLKQKVENL FNEKCGEALG LKQAVKVPFA 730 740 750 760 770 780 LFESFPEDFY VEGLPEGVPF RRPSTFGIPR LEKILRNKAK IKFIIKKPEM FETAIKESTS 790 800 810 820 830 840 SKSPPRKINS SPNVNTTASG VEDLNIIQVT IPDDDNERLS KVEKARQLRE QVNDLFSRKF 850 860 870 880 890 900 GEAIGMGFPV KVPYRKITIN PGCVVVDGMP PGVSFKAPSY LEISSMRRIL DSAEFIKFTV 910 920 930 940 950 IRPFPGLVIN NQLVDQNESE GPVIQESAEA SQLEVPVTEE IKETDGSSQI KQEPDPTW
	Isoform 5 [UniParc]. Checksum: DC04C876B09F26FA	FASTA	939	106,055
	10 20 30 40 50 60 MAQVVMSALP AEDEESSESR MVVTFLMSAL ESMCKELAKS KAEVACIAVY ETDVFVVGTE 70 80 90 100 110 120 RGRAFVNTRK DFQKDFVKYC VEEEEKAAEM HKMKSTTQAN RMSVDAVEIE TLRKTVEDYF 130 140 150 160 170 180 CFCYGKALGK STVVPVPYEK MLRDQSAVVV QGLPEGVAFK HPEHYDLATL KWILENKAGI 190 200 210 220 230 240 SFIIKRPFLE PKKHLGGRVL AAEAERSMLS PSGSCGPIKV KTEPTEDSGI SLEMAAVTVK 250 260 270 280 290 300 EESEDPDYYQ YNIQDDDYSP PTKRLKSTEP PPPPPVPEPA NAGKRKVREF NFEKWNARIT 310 320 330 340 350 360 DLRKQVEELF ERKYAQAIKA KGPVTIPYPL FQSHVEDLYV EGLPEGIPFR RPSTYGIPRL 370 380 390 400 410 420 ERILLAKERI RFVIKKHELL NSTREDLQLD KPASGVKEEW YARITKLRKM VDQLFCKKFA 430 440 450 460 470 480 EALGSTEAKA VPYQKFEAHP NDLYVEGLPE NIPFRSPSWY GIPRLEKIIQ VGNRIKFVIK 490 500 510 520 530 540 RPELLTHSTT EVTQPRTNTP VKEDWNVRIT KLRKQVEEIF NLKFAQALGL TEAVKVPYPV 550 560 570 580 590 600 FESNPEFLYV EGLPEGIPFR SPTWFGIPRL ERIVRGSNKI KFVVKKPELV VSYLPPGMAS 610 620 630 640 650 660 KINTKALQSP KRPRSPGSNS KVPEIEVTVE GPNNSSPQTS AVRTPTQTNG SNVPFKPRGR 670 680 690 700 710 720 EFSFEAWNAK ITDLKQKVEN LFNEKCGEAL GLKQAVKVPF ALFESFPEDF YVEGLPEGVP 730 740 750 760 770 780 FRRPSTFGIP RLEKILRNKA KIKFIIKKPE MFETAIKEST SSKSPPRKIN SSPNVNTTAS 790 800 810 820 830 840 GVEDLNIIQV TIPDDDNERL SKVEKARQLR EQVNDLFSRK FGEAIGMGFP VKVPYRKITI 850 860 870 880 890 900 NPGCVVVDGM PPGVSFKAPS YLEISSMRRI LDSAEFIKFT VIRPFPGLVI NNQLVDQNES 910 920 930 EGPVIQESAE ASQLEVPVTE EIKETDGSSQ IKQEPDPTW
	Isoform 6 (Alpha) [UniParc]. Checksum: 013875885B7085A1	FASTA	977	109,955
	10 20 30 40 50 60 MAQVVMSALP AEDEESSESR MVVTFLMSAL ESMCKELAKS KAEVACIAVY ETDVFVVGTE 70 80 90 100 110 120 RGRAFVNTRK DFQKDFVKYC VEEEEKAAEM HKMKSTTQAN RMSVDAVEIE TLRKTVEDYF 130 140 150 160 170 180 CFCYGKALGK STVVPVPYEK MLRDQSAVVV QGLPEGVAFK HPEHYDLATL KWILENKAGI 190 200 210 220 230 240 SFIIKRPFLE PKKHLGGRVL AAEAERSMLS PSGSCGPIKV KTEPTEDSGI SLEMAAVTVK 250 260 270 280 290 300 EESEDPDYYQ YNIQGPSETD GVDEKLPLSK ALQGSHHSSE GNEGTEVEVP AEDDDYSPPT 310 320 330 340 350 360 KRLKSTEPPP PPPVPEPANA GKRKVREFNF EKWNARITDL RKQVEELFER KYAQAIKAKG 370 380 390 400 410 420 PVTIPYPLFQ SHVEDLYVEG LPEGIPFRRP STYGIPRLER ILLAKERIRF VIKKHELLNS 430 440 450 460 470 480 TREDLQLDKP ASGVKEEWYA RITKLRKMVD QLFCKKFAEA LGSTEAKAVP YQKFEAHPND 490 500 510 520 530 540 LYVEGLPENI PFRSPSWYGI PRLEKIIQVG NRIKFVIKRP ELLTHSTTEV TQPRTNTPVK 550 560 570 580 590 600 EDWNVRITKL RKQVEEIFNL KFAQALGLTE AVKVPYPVFE SNPEFLYVEG LPEGIPFRSP 610 620 630 640 650 660 TWFGIPRLER IVRGSNKIKF VVKKPELVVS YLPPGMASKI NTKALQSPKR PRSPGSNSKV 670 680 690 700 710 720 PEIEVTVEGP NNSSPQTSAV RTPTQTNGSN VPFKPRGREF SFEAWNAKIT DLKQKVENLF 730 740 750 760 770 780 NEKCGEALGL KQAVKVPFAL FESFPEDFYV EGLPEGVPFR RPSTFGIPRL EKILRNKAKI 790 800 810 820 830 840 KFIIKKPEMF ETAIKESTSS KSPPRKINSS PNVNTTASGV EDLNIIQVTI PDDDNERLSK 850 860 870 880 890 900 VEKARQLREQ VNDLFSRKFG EAIGMGFPVK VPYRKITINP GCVVVDGMPP GVSFKAPSYL 910 920 930 940 950 960 EISSMRRILD SAEFIKFTVI RPFPGLVINN QLVDQNESEG PVIQESAEAS QLEVPVTEEI 970 KETDGSSQIK QEPDPTW

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"A mouse single-copy gene, Gtf2i, the homolog of human GTF2I, that is duplicated in the Williams-Beuren syndrome deletion region." Wang Y.-K., Perez-Jurado L.A., Francke U. Genomics 48:163-170(1998) [PubMed: 9521869] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1; 2; 3; 4 AND 5). Tissue: Brain.
[2]	"Cloning and expression of two forms of mouse TFII-I." Johansson E., Hjortsberg K., Roy A.L., Thelander L. Submitted (JAN-1998) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 2 AND 4). Strain: C57BL/Kaplan. Tissue: T-cell lymphoma.
[3]	"Genomic organization of the genes Gtf2ird1, Gtf2i, and Ncf1 at the mouse chromosome 5 region syntenic to the human chromosome 7q11.23 Williams syndrome critical region." Bayarsaihan D., Dunai J., Greally J.M., Kawasaki K., Sumiyama K., Enkhmandakh B., Shimizu N., Ruddle F.H. Genomics 79:137-143(2002) [PubMed: 11827466] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] (ISOFORMS 1; 2; 4 AND 6). Strain: 129/SvJ.
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). Strain: C57BL/6. Tissue: Brain.
[5]	"The transcriptional landscape of the mammalian genome." Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y. Science 309:1559-1563(2005) [PubMed: 16141072] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-130 AND 719-998. Strain: C57BL/6J. Tissue: Embryo and Testis.
[6]	Green E.D. Submitted (JUL-2000) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE OF 1-314 (ISOFORM 2). Strain: 129/Sv.
[7]	"Induction of immunoglobulin heavy-chain transcription through the transcription factor Bright requires TFII-I." Rajaiya J., Nixon J.C., Ayers N., Desgranges Z.P., Roy A.L., Webb C.F. Mol. Cell. Biol. 26:4758-4768(2006) [PubMed: 16738337] [Abstract] Cited for: INTERACTION WITH ARID3A AND BTK, FUNCTION.
[8]	"Solution structure of the general transcription factor 2I domain in mouse TFII-I protein." Doi-Katayama Y., Hayashi F., Inoue M., Yabuki T., Aoki M., Seki E., Matsuda T., Kigawa T., Yoshida M., Shirouzu M., Terada T., Hayashizaki Y., Yokoyama S., Hirota H. Protein Sci. 16:1788-1792(2007) [PubMed: 17600150] [Abstract] Cited for: STRUCTURE BY NMR OF 733-818.
+	Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

AF017085 mRNA. Translation: AAC53569.1.
AF043219 mRNA. Translation: AAC02990.1.
AF043220 mRNA. Translation: AAC02991.1.
AF325177 Genomic DNA. No translation available.
AY030290 mRNA. Translation: AAK49785.1.
AY030291 mRNA. Translation: AAK49786.1.
AY030292 mRNA. Translation: AAK49787.1.
AY030293 mRNA. Translation: AAK49788.1.
BC053044 mRNA. Translation: AAH53044.1.
AK006796 mRNA. Translation: BAB24743.1.
AK013348 mRNA. Translation: BAB28803.2. Different initiation.
AF289666 Genomic DNA. Translation: AAF99338.1.

IPI

IPI00113686.
IPI00229535.
IPI00229536.
IPI00395163.
IPI00761775.
IPI00876528.

PIR

T03763.

RefSeq

NP_001074215.1. NM_001080746.1.
NP_001074216.1. NM_001080747.1.
NP_001074217.1. NM_001080748.1.
NP_001074218.1. NM_001080749.1.
NP_034495.2. NM_010365.3.

UniGene

Mm.261570.
Mm.412191.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
1Q60	NMR	-	A	733-818	[»]

ProteinModelPortal

Q9ESZ8.

SMR

Q9ESZ8. Positions 104-197, 359-454, 466-556, 571-649, 731-823, 854-954.

ModBase

Search...

Protein-protein interaction databases

STRING

Q9ESZ8.

PTM databases

PhosphoSite

Q9ESZ8.

Proteomic databases

PRIDE

Q9ESZ8.

Protocols and materials databases

StructuralBiologyKnowledgebase

Search...

Genome annotation databases

Ensembl

ENSMUST00000059042; ENSMUSP00000049625; ENSMUSG00000060261.
ENSMUST00000082057; ENSMUSP00000080714; ENSMUSG00000060261.
ENSMUST00000111259; ENSMUSP00000106890; ENSMUSG00000060261.
ENSMUST00000111260; ENSMUSP00000106891; ENSMUSG00000060261.
ENSMUST00000111261; ENSMUSP00000106892; ENSMUSG00000060261.
ENSMUST00000173888; ENSMUSP00000133969; ENSMUSG00000060261.
ENSMUST00000174155; ENSMUSP00000133566; ENSMUSG00000060261.
ENSMUST00000174354; ENSMUSP00000134440; ENSMUSG00000060261.
ENSMUST00000174513; ENSMUSP00000133489; ENSMUSG00000060261.
ENSMUST00000174772; ENSMUSP00000133740; ENSMUSG00000060261.

GeneID

14886.

KEGG

mmu:14886.

UCSC

uc008zvj.1. mouse.
uc008zvk.1. mouse.
uc008zvl.1. mouse.
uc008zvm.1. mouse.

Organism-specific databases

CTD

2969.

MGI

MGI:1202722. Gtf2i.

Phylogenomic databases

eggNOG

roNOG10935.

GeneTree

ENSGT00530000063863.

HOVERGEN

HBG051856.

InParanoid

Q9ESZ8.

OMA

FYVEGLP.

OrthoDB

EOG48WC18.

PhylomeDB

Q9ESZ8.

Gene expression databases

ArrayExpress

Q9ESZ8.

Bgee

Q9ESZ8.

CleanEx

MM_GTF2I.

Genevestigator

Q9ESZ8.

GermOnline

ENSMUSG00000060261. Mus musculus.

Family and domain databases

InterPro

IPR004212. GTF2I.
IPR016659. TF_II-I.
[Graphical view]

Gene3D

G3DSA:3.90.1460.10. GTF2I. 6 hits.

KO

K03121.

Pfam

PF02946. GTF2I. 6 hits.
[Graphical view]

PIRSF

PIRSF016441. TF_II-I. 1 hit.

SUPFAM

SSF117773. SSF117773. 6 hits.

PROSITE

PS51139. GTF2I. 6 hits.
[Graphical view]

ProtoNet

Search...

Other

NextBio

287171.

SOURCE

Search...

Entry information

Entry name

GTF2I_MOUSE

Accession

Primary (citable) accession number: Q9ESZ8
Secondary accession number(s): O54700 , O55030, O55031, Q8VHD1, Q8VHD2, Q8VHD3, Q8VHD4, Q9CSB5, Q9D9K9

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 13, 2001
Last sequence update:	December 15, 2003
Last modified:	January 25, 2012
This is version 100 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program