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Q9ESZ8

- GTF2I_MOUSE

UniProt

Q9ESZ8 - GTF2I_MOUSE

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Protein

General transcription factor II-I

Gene
Gtf2i, Bap135, Diws1t
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Interacts with the basal transcription machinery by coordinating the formation of a multiprotein complex at the C-FOS promoter, and linking specific signal responsive activator complexes. Promotes the formation of stable high-order complexes of SRF and PHOX1 and interacts cooperatively with PHOX1 to promote serum-inducible transcription of a reporter gene deriven by the C-FOS serum response element (SRE). Acts as a coregulator for USF1 by binding independently two promoter elements, a pyrimidine-rich initiator (Inr) and an upstream E-box By similarity. Required for the formation of functional ARID3A DNA-binding complexes and for activation of immunoglobulin heavy-chain transcription upon B-lymphocyte activation.1 Publication

GO - Molecular functioni

  1. DNA binding Source: UniProtKB-KW
  2. mitogen-activated protein kinase binding Source: MGI
  3. protein binding Source: MGI

GO - Biological processi

  1. negative regulation of angiogenesis Source: Ensembl
  2. negative regulation of cytosolic calcium ion concentration Source: Ensembl
  3. regulation of transcription, DNA-templated Source: UniProtKB-KW
  4. transcription, DNA-templated Source: UniProtKB-KW
  5. transition between slow and fast fiber Source: MGI
Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
General transcription factor II-I
Short name:
GTFII-I
Short name:
TFII-I
Alternative name(s):
Bruton tyrosine kinase-associated protein 135
Short name:
BAP-135
Short name:
BTK-associated protein 135
Gene namesi
Name:Gtf2i
Synonyms:Bap135, Diws1t
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 5

Organism-specific databases

MGIiMGI:1202722. Gtf2i.

Subcellular locationi

Cytoplasm. Nucleus
Note: Colocalizes with BTK in the cytoplasm By similarity.

GO - Cellular componenti

  1. cell projection Source: MGI
  2. cytoplasm Source: UniProtKB-SubCell
  3. neuronal cell body Source: MGI
  4. nucleus Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed By similarity
Chaini2 – 998997General transcription factor II-IPRO_0000083873Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylalanine By similarity
Modified residuei103 – 1031Phosphoserine By similarity
Modified residuei130 – 1301N6-acetyllysine1 Publication
Modified residuei207 – 2071Phosphoserine By similarity
Modified residuei210 – 2101Phosphoserine By similarity
Modified residuei248 – 2481Phosphotyrosine; by BTK By similarity
Modified residuei317 – 3171Phosphotyrosine; by BTK By similarity
Modified residuei353 – 3531N6-acetyllysine1 Publication
Modified residuei398 – 3981Phosphotyrosine; by BTK By similarity
Modified residuei412 – 4121Phosphoserine; by PKG/PRKG1 By similarity
Modified residuei450 – 4501N6-acetyllysine1 Publication
Modified residuei503 – 5031Phosphotyrosine; by BTK By similarity
Modified residuei558 – 5581Phosphothreonine By similarity
Modified residuei668 – 6681Phosphoserine By similarity
Modified residuei715 – 7151N6-acetyllysine1 Publication
Modified residuei784 – 7841Phosphoserine; by PKG/PRKG1 By similarity
Modified residuei823 – 8231Phosphoserine By similarity

Post-translational modificationi

Transiently phosphorylated on tyrosine residues by BTK in response to B-cell receptor stimulation. Phosphorylation on Tyr-248 and Tyr-398, and perhaps, on Tyr-503 contributes to BTK-mediated transcriptional activation By similarity.
Sumoylated By similarity.

Keywords - PTMi

Acetylation, Phosphoprotein, Ubl conjugation

Proteomic databases

MaxQBiQ9ESZ8.
PaxDbiQ9ESZ8.
PRIDEiQ9ESZ8.

PTM databases

PhosphoSiteiQ9ESZ8.

Expressioni

Tissue specificityi

Ubiquitous.

Gene expression databases

ArrayExpressiQ9ESZ8.
BgeeiQ9ESZ8.
CleanExiMM_GTF2I.
GenevestigatoriQ9ESZ8.

Interactioni

Subunit structurei

Homodimer Reviewed prediction. Interacts with SRF and PHOX1. Binds a pyrimidine-rich initiator (Inr) and a recognition site (E-box) for upstream stimulatory factor 1 (USF1). Associates with the PH domain of Bruton's tyrosine kinase (BTK) By similarity. May be a component of a BHC histone deacetylase complex that contains HDAC1, HDAC2, HMG20B/BRAF35, KDM1A, RCOR1/CoREST, PHF21A/BHC80, ZMYM2, ZNF217, ZMYM3, GSE1 and GTF2I. Interacts with BTK and ARID3A. Interacts with isoform beta of PRKG1 By similarity.1 Publication

Protein-protein interaction databases

BioGridi200113. 3 interactions.
IntActiQ9ESZ8. 5 interactions.
MINTiMINT-4097022.

Structurei

Secondary structure

1
998
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi733 – 74917
Helixi759 – 7646
Turni766 – 7683
Beta strandi769 – 7735
Turni783 – 7853
Helixi788 – 7969
Turni797 – 8004
Beta strandi802 – 8065
Helixi808 – 8103
Helixi812 – 8176

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1Q60NMR-A733-818[»]
ProteinModelPortaliQ9ESZ8.
SMRiQ9ESZ8. Positions 104-197, 359-454, 466-556, 571-649, 731-823, 854-954.

Miscellaneous databases

EvolutionaryTraceiQ9ESZ8.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati103 – 19795GTF2I-like 1Add
BLAST
Repeati352 – 44695GTF2I-like 2Add
BLAST
Repeati457 – 55195GTF2I-like 3Add
BLAST
Repeati562 – 65695GTF2I-like 4Add
BLAST
Repeati724 – 81895GTF2I-like 5Add
BLAST
Repeati859 – 95395GTF2I-like 6Add
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi319 – 3268Nuclear localization signal Reviewed prediction

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi329 – 3379Poly-Pro

Sequence similaritiesi

Belongs to the TFII-I family.
Contains 6 GTF2I-like repeats.

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiNOG29608.
GeneTreeiENSGT00530000063863.
HOVERGENiHBG051856.
InParanoidiQ9ESZ8.
KOiK03121.
OMAiMPPGVAF.
OrthoDBiEOG7RRF67.
PhylomeDBiQ9ESZ8.
TreeFamiTF352524.

Family and domain databases

Gene3Di3.90.1460.10. 6 hits.
InterProiIPR004212. GTF2I.
IPR016659. TF_II-I.
[Graphical view]
PfamiPF02946. GTF2I. 6 hits.
[Graphical view]
PIRSFiPIRSF016441. TF_II-I. 1 hit.
SUPFAMiSSF117773. SSF117773. 6 hits.
PROSITEiPS51139. GTF2I. 6 hits.
[Graphical view]

Sequences (6)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 6 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q9ESZ8-1) [UniParc]FASTAAdd to Basket

Also known as: Gamma

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MAQVVMSALP AEDEESSESR MVVTFLMSAL ESMCKELAKS KAEVACIAVY    50
ETDVFVVGTE RGRAFVNTRK DFQKDFVKYC VEEEEKAAEM HKMKSTTQAN 100
RMSVDAVEIE TLRKTVEDYF CFCYGKALGK STVVPVPYEK MLRDQSAVVV 150
QGLPEGVAFK HPEHYDLATL KWILENKAGI SFIIKRPFLE PKKHLGGRVL 200
AAEAERSMLS PSGSCGPIKV KTEPTEDSGI SLEMAAVTVK EESEDPDYYQ 250
YNIQGPSETD GVDEKLPLSK ALQGSHHSSE GNEGTEVEVP AEDSTQHVPS 300
ETSEDPEVEV TIEDDDYSPP TKRLKSTEPP PPPPVPEPAN AGKRKVREFN 350
FEKWNARITD LRKQVEELFE RKYAQAIKAK GPVTIPYPLF QSHVEDLYVE 400
GLPEGIPFRR PSTYGIPRLE RILLAKERIR FVIKKHELLN STREDLQLDK 450
PASGVKEEWY ARITKLRKMV DQLFCKKFAE ALGSTEAKAV PYQKFEAHPN 500
DLYVEGLPEN IPFRSPSWYG IPRLEKIIQV GNRIKFVIKR PELLTHSTTE 550
VTQPRTNTPV KEDWNVRITK LRKQVEEIFN LKFAQALGLT EAVKVPYPVF 600
ESNPEFLYVE GLPEGIPFRS PTWFGIPRLE RIVRGSNKIK FVVKKPELVV 650
SYLPPGMASK INTKALQSPK RPRSPGSNSK VPEIEVTVEG PNNSSPQTSA 700
VRTPTQTNGS NVPFKPRGRE FSFEAWNAKI TDLKQKVENL FNEKCGEALG 750
LKQAVKVPFA LFESFPEDFY VEGLPEGVPF RRPSTFGIPR LEKILRNKAK 800
IKFIIKKPEM FETAIKESTS SKSPPRKINS SPNVNTTASG VEDLNIIQVT 850
IPDDDNERLS KVEKARQLRE QVNDLFSRKF GEAIGMGFPV KVPYRKITIN 900
PGCVVVDGMP PGVSFKAPSY LEISSMRRIL DSAEFIKFTV IRPFPGLVIN 950
NQLVDQNESE GPVIQESAEA SQLEVPVTEE IKETDGSSQI KQEPDPTW 998
Length:998
Mass (Da):112,265
Last modified:December 15, 2003 - v3
Checksum:i3BC228A2F4F880CF
GO
Isoform 2 (identifier: Q9ESZ8-2) [UniParc]FASTAAdd to Basket

Also known as: Beta, Long

The sequence of this isoform differs from the canonical sequence as follows:
     255-273: Missing.

Show »
Length:979
Mass (Da):110,299
Checksum:iE001EB13BE19A81F
GO
Isoform 3 (identifier: Q9ESZ8-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     255-292: Missing.

Show »
Length:960
Mass (Da):108,365
Checksum:i80E39FB7F85C4A93
GO
Isoform 4 (identifier: Q9ESZ8-4) [UniParc]FASTAAdd to Basket

Also known as: Delta, Short

The sequence of this isoform differs from the canonical sequence as follows:
     255-273: Missing.
     293-313: Missing.

Show »
Length:958
Mass (Da):107,989
Checksum:iBC47CBD9FC28F4BD
GO
Isoform 5 (identifier: Q9ESZ8-5) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     255-313: Missing.

Show »
Length:939
Mass (Da):106,055
Checksum:iDC04C876B09F26FA
GO
Isoform 6 (identifier: Q9ESZ8-6) [UniParc]FASTAAdd to Basket

Also known as: Alpha

The sequence of this isoform differs from the canonical sequence as follows:
     293-313: Missing.

Show »
Length:977
Mass (Da):109,955
Checksum:i013875885B7085A1
GO

Sequence cautioni

The sequence BAB28803.2 differs from that shown. Reason: Erroneous initiation.

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei255 – 31359Missing in isoform 5. VSP_003871Add
BLAST
Alternative sequencei255 – 29238Missing in isoform 3. VSP_003870Add
BLAST
Alternative sequencei255 – 27319Missing in isoform 2 and isoform 4. VSP_003869Add
BLAST
Alternative sequencei293 – 31321Missing in isoform 4 and isoform 6. VSP_003872Add
BLAST

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti5 – 51V → A in AAC53569. 1 Publication
Sequence conflicti62 – 621G → R in AAC53569. 1 Publication
Sequence conflicti127 – 1304ALGK → NTAL in BAB24743. 1 Publication
Sequence conflicti254 – 2541Q → QA1 Publication
Sequence conflicti261 – 2611G → D1 Publication
Sequence conflicti266 – 2661L → Q1 Publication
Sequence conflicti271 – 2722AL → PM1 Publication
Sequence conflicti314 – 3141D → G1 Publication
Sequence conflicti334 – 3341Missing in AAC53569. 1 Publication
Sequence conflicti538 – 5381I → T in AAC53569. 1 Publication
Sequence conflicti607 – 6071L → C in AAC53569. 1 Publication
Sequence conflicti621 – 6211P → L in AAC53569. 1 Publication
Sequence conflicti691 – 6911P → L in AAC02990. 1 Publication
Sequence conflicti691 – 6911P → L in AAC02991. 1 Publication
Sequence conflicti748 – 7481A → T in AAC53569. 1 Publication
Sequence conflicti826 – 8261R → IFLSG in BAB28803. 1 Publication
Sequence conflicti966 – 9661E → Q in BAB28803. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF017085 mRNA. Translation: AAC53569.1.
AF043219 mRNA. Translation: AAC02990.1.
AF043220 mRNA. Translation: AAC02991.1.
AF325177 Genomic DNA. No translation available.
AY030290 mRNA. Translation: AAK49785.1.
AY030291 mRNA. Translation: AAK49786.1.
AY030292 mRNA. Translation: AAK49787.1.
AY030293 mRNA. Translation: AAK49788.1.
BC053044 mRNA. Translation: AAH53044.1.
AK006796 mRNA. Translation: BAB24743.1.
AK013348 mRNA. Translation: BAB28803.2. Different initiation.
AF289666 Genomic DNA. Translation: AAF99338.1.
CCDSiCCDS39299.1. [Q9ESZ8-2]
CCDS39300.1. [Q9ESZ8-6]
CCDS39301.1. [Q9ESZ8-1]
CCDS57386.1. [Q9ESZ8-4]
PIRiT03763.
RefSeqiNP_001074215.1. NM_001080746.2. [Q9ESZ8-1]
NP_001074216.1. NM_001080747.2. [Q9ESZ8-6]
NP_001074217.1. NM_001080748.2. [Q9ESZ8-4]
NP_034495.2. NM_010365.4. [Q9ESZ8-2]
UniGeneiMm.261570.
Mm.412191.
Mm.466495.

Genome annotation databases

EnsembliENSMUST00000059042; ENSMUSP00000049625; ENSMUSG00000060261. [Q9ESZ8-1]
ENSMUST00000082057; ENSMUSP00000080714; ENSMUSG00000060261. [Q9ESZ8-6]
ENSMUST00000111261; ENSMUSP00000106892; ENSMUSG00000060261. [Q9ESZ8-2]
ENSMUST00000173888; ENSMUSP00000133969; ENSMUSG00000060261. [Q9ESZ8-5]
ENSMUST00000174155; ENSMUSP00000133566; ENSMUSG00000060261. [Q9ESZ8-1]
ENSMUST00000174354; ENSMUSP00000134440; ENSMUSG00000060261. [Q9ESZ8-2]
ENSMUST00000174513; ENSMUSP00000133489; ENSMUSG00000060261. [Q9ESZ8-4]
ENSMUST00000174772; ENSMUSP00000133740; ENSMUSG00000060261. [Q9ESZ8-6]
GeneIDi14886.
KEGGimmu:14886.
UCSCiuc008zvj.2. mouse. [Q9ESZ8-1]
uc008zvk.2. mouse. [Q9ESZ8-2]
uc008zvl.2. mouse. [Q9ESZ8-6]
uc008zvm.2. mouse. [Q9ESZ8-4]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF017085 mRNA. Translation: AAC53569.1 .
AF043219 mRNA. Translation: AAC02990.1 .
AF043220 mRNA. Translation: AAC02991.1 .
AF325177 Genomic DNA. No translation available.
AY030290 mRNA. Translation: AAK49785.1 .
AY030291 mRNA. Translation: AAK49786.1 .
AY030292 mRNA. Translation: AAK49787.1 .
AY030293 mRNA. Translation: AAK49788.1 .
BC053044 mRNA. Translation: AAH53044.1 .
AK006796 mRNA. Translation: BAB24743.1 .
AK013348 mRNA. Translation: BAB28803.2 . Different initiation.
AF289666 Genomic DNA. Translation: AAF99338.1 .
CCDSi CCDS39299.1. [Q9ESZ8-2 ]
CCDS39300.1. [Q9ESZ8-6 ]
CCDS39301.1. [Q9ESZ8-1 ]
CCDS57386.1. [Q9ESZ8-4 ]
PIRi T03763.
RefSeqi NP_001074215.1. NM_001080746.2. [Q9ESZ8-1 ]
NP_001074216.1. NM_001080747.2. [Q9ESZ8-6 ]
NP_001074217.1. NM_001080748.2. [Q9ESZ8-4 ]
NP_034495.2. NM_010365.4. [Q9ESZ8-2 ]
UniGenei Mm.261570.
Mm.412191.
Mm.466495.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1Q60 NMR - A 733-818 [» ]
ProteinModelPortali Q9ESZ8.
SMRi Q9ESZ8. Positions 104-197, 359-454, 466-556, 571-649, 731-823, 854-954.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 200113. 3 interactions.
IntActi Q9ESZ8. 5 interactions.
MINTi MINT-4097022.

PTM databases

PhosphoSitei Q9ESZ8.

Proteomic databases

MaxQBi Q9ESZ8.
PaxDbi Q9ESZ8.
PRIDEi Q9ESZ8.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000059042 ; ENSMUSP00000049625 ; ENSMUSG00000060261 . [Q9ESZ8-1 ]
ENSMUST00000082057 ; ENSMUSP00000080714 ; ENSMUSG00000060261 . [Q9ESZ8-6 ]
ENSMUST00000111261 ; ENSMUSP00000106892 ; ENSMUSG00000060261 . [Q9ESZ8-2 ]
ENSMUST00000173888 ; ENSMUSP00000133969 ; ENSMUSG00000060261 . [Q9ESZ8-5 ]
ENSMUST00000174155 ; ENSMUSP00000133566 ; ENSMUSG00000060261 . [Q9ESZ8-1 ]
ENSMUST00000174354 ; ENSMUSP00000134440 ; ENSMUSG00000060261 . [Q9ESZ8-2 ]
ENSMUST00000174513 ; ENSMUSP00000133489 ; ENSMUSG00000060261 . [Q9ESZ8-4 ]
ENSMUST00000174772 ; ENSMUSP00000133740 ; ENSMUSG00000060261 . [Q9ESZ8-6 ]
GeneIDi 14886.
KEGGi mmu:14886.
UCSCi uc008zvj.2. mouse. [Q9ESZ8-1 ]
uc008zvk.2. mouse. [Q9ESZ8-2 ]
uc008zvl.2. mouse. [Q9ESZ8-6 ]
uc008zvm.2. mouse. [Q9ESZ8-4 ]

Organism-specific databases

CTDi 2969.
MGIi MGI:1202722. Gtf2i.

Phylogenomic databases

eggNOGi NOG29608.
GeneTreei ENSGT00530000063863.
HOVERGENi HBG051856.
InParanoidi Q9ESZ8.
KOi K03121.
OMAi MPPGVAF.
OrthoDBi EOG7RRF67.
PhylomeDBi Q9ESZ8.
TreeFami TF352524.

Miscellaneous databases

ChiTaRSi GTF2I. mouse.
EvolutionaryTracei Q9ESZ8.
NextBioi 287171.
PROi Q9ESZ8.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q9ESZ8.
Bgeei Q9ESZ8.
CleanExi MM_GTF2I.
Genevestigatori Q9ESZ8.

Family and domain databases

Gene3Di 3.90.1460.10. 6 hits.
InterProi IPR004212. GTF2I.
IPR016659. TF_II-I.
[Graphical view ]
Pfami PF02946. GTF2I. 6 hits.
[Graphical view ]
PIRSFi PIRSF016441. TF_II-I. 1 hit.
SUPFAMi SSF117773. SSF117773. 6 hits.
PROSITEi PS51139. GTF2I. 6 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "A mouse single-copy gene, Gtf2i, the homolog of human GTF2I, that is duplicated in the Williams-Beuren syndrome deletion region."
    Wang Y.-K., Perez-Jurado L.A., Francke U.
    Genomics 48:163-170(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1; 2; 3; 4 AND 5).
    Tissue: Brain.
  2. "Cloning and expression of two forms of mouse TFII-I."
    Johansson E., Hjortsberg K., Roy A.L., Thelander L.
    Submitted (JAN-1998) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 2 AND 4).
    Strain: C57BL/Kaplan.
    Tissue: T-cell lymphoma.
  3. "Genomic organization of the genes Gtf2ird1, Gtf2i, and Ncf1 at the mouse chromosome 5 region syntenic to the human chromosome 7q11.23 Williams syndrome critical region."
    Bayarsaihan D., Dunai J., Greally J.M., Kawasaki K., Sumiyama K., Enkhmandakh B., Shimizu N., Ruddle F.H.
    Genomics 79:137-143(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] (ISOFORMS 1; 2; 4 AND 6).
    Strain: 129/SvJ.
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Strain: C57BL/6.
    Tissue: Brain.
  5. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-130 AND 719-998.
    Strain: C57BL/6J.
    Tissue: Embryo and Testis.
  6. Green E.D.
    Submitted (JUL-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE OF 1-314 (ISOFORM 2).
    Strain: 129/Sv.
  7. "Induction of immunoglobulin heavy-chain transcription through the transcription factor Bright requires TFII-I."
    Rajaiya J., Nixon J.C., Ayers N., Desgranges Z.P., Roy A.L., Webb C.F.
    Mol. Cell. Biol. 26:4758-4768(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH ARID3A AND BTK, FUNCTION.
  8. "SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways."
    Park J., Chen Y., Tishkoff D.X., Peng C., Tan M., Dai L., Xie Z., Zhang Y., Zwaans B.M., Skinner M.E., Lombard D.B., Zhao Y.
    Mol. Cell 50:919-930(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-130; LYS-353; LYS-450 AND LYS-715, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Embryonic fibroblast.
  9. Cited for: STRUCTURE BY NMR OF 733-818.

Entry informationi

Entry nameiGTF2I_MOUSE
AccessioniPrimary (citable) accession number: Q9ESZ8
Secondary accession number(s): O54700
, O55030, O55031, Q8VHD1, Q8VHD2, Q8VHD3, Q8VHD4, Q9CSB5, Q9D9K9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 13, 2001
Last sequence update: December 15, 2003
Last modified: July 9, 2014
This is version 119 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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