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Q9ESZ8

- GTF2I_MOUSE

UniProt

Q9ESZ8 - GTF2I_MOUSE

Protein

General transcription factor II-I

Gene

Gtf2i

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 120 (01 Oct 2014)
      Sequence version 3 (15 Dec 2003)
      Previous versions | rss
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    Functioni

    Interacts with the basal transcription machinery by coordinating the formation of a multiprotein complex at the C-FOS promoter, and linking specific signal responsive activator complexes. Promotes the formation of stable high-order complexes of SRF and PHOX1 and interacts cooperatively with PHOX1 to promote serum-inducible transcription of a reporter gene deriven by the C-FOS serum response element (SRE). Acts as a coregulator for USF1 by binding independently two promoter elements, a pyrimidine-rich initiator (Inr) and an upstream E-box By similarity. Required for the formation of functional ARID3A DNA-binding complexes and for activation of immunoglobulin heavy-chain transcription upon B-lymphocyte activation.By similarity1 Publication

    GO - Molecular functioni

    1. DNA binding Source: UniProtKB-KW
    2. mitogen-activated protein kinase binding Source: MGI
    3. protein binding Source: MGI

    GO - Biological processi

    1. negative regulation of angiogenesis Source: Ensembl
    2. negative regulation of cytosolic calcium ion concentration Source: Ensembl
    3. regulation of transcription, DNA-templated Source: UniProtKB-KW
    4. transcription, DNA-templated Source: UniProtKB-KW
    5. transition between slow and fast fiber Source: MGI

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    General transcription factor II-I
    Short name:
    GTFII-I
    Short name:
    TFII-I
    Alternative name(s):
    Bruton tyrosine kinase-associated protein 135
    Short name:
    BAP-135
    Short name:
    BTK-associated protein 135
    Gene namesi
    Name:Gtf2i
    Synonyms:Bap135, Diws1t
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 5

    Organism-specific databases

    MGIiMGI:1202722. Gtf2i.

    Subcellular locationi

    Cytoplasm. Nucleus
    Note: Colocalizes with BTK in the cytoplasm.By similarity

    GO - Cellular componenti

    1. cell projection Source: MGI
    2. cytoplasm Source: UniProtKB-SubCell
    3. neuronal cell body Source: MGI
    4. nucleus Source: MGI

    Keywords - Cellular componenti

    Cytoplasm, Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11RemovedBy similarity
    Chaini2 – 998997General transcription factor II-IPRO_0000083873Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei2 – 21N-acetylalanineBy similarity
    Modified residuei103 – 1031PhosphoserineBy similarity
    Modified residuei130 – 1301N6-acetyllysine1 Publication
    Modified residuei207 – 2071PhosphoserineBy similarity
    Modified residuei210 – 2101PhosphoserineBy similarity
    Modified residuei248 – 2481Phosphotyrosine; by BTKBy similarity
    Modified residuei317 – 3171Phosphotyrosine; by BTKBy similarity
    Modified residuei353 – 3531N6-acetyllysine1 Publication
    Modified residuei398 – 3981Phosphotyrosine; by BTKBy similarity
    Modified residuei412 – 4121Phosphoserine; by PKG/PRKG1By similarity
    Modified residuei450 – 4501N6-acetyllysine1 Publication
    Modified residuei503 – 5031Phosphotyrosine; by BTKBy similarity
    Modified residuei558 – 5581PhosphothreonineBy similarity
    Modified residuei668 – 6681PhosphoserineBy similarity
    Modified residuei715 – 7151N6-acetyllysine1 Publication
    Modified residuei784 – 7841Phosphoserine; by PKG/PRKG1By similarity
    Modified residuei823 – 8231PhosphoserineBy similarity

    Post-translational modificationi

    Transiently phosphorylated on tyrosine residues by BTK in response to B-cell receptor stimulation. Phosphorylation on Tyr-248 and Tyr-398, and perhaps, on Tyr-503 contributes to BTK-mediated transcriptional activation By similarity.By similarity
    Sumoylated.By similarity

    Keywords - PTMi

    Acetylation, Phosphoprotein, Ubl conjugation

    Proteomic databases

    MaxQBiQ9ESZ8.
    PaxDbiQ9ESZ8.
    PRIDEiQ9ESZ8.

    PTM databases

    PhosphoSiteiQ9ESZ8.

    Expressioni

    Tissue specificityi

    Ubiquitous.

    Gene expression databases

    ArrayExpressiQ9ESZ8.
    BgeeiQ9ESZ8.
    CleanExiMM_GTF2I.
    GenevestigatoriQ9ESZ8.

    Interactioni

    Subunit structurei

    Homodimer Potential. Interacts with SRF and PHOX1. Binds a pyrimidine-rich initiator (Inr) and a recognition site (E-box) for upstream stimulatory factor 1 (USF1). Associates with the PH domain of Bruton's tyrosine kinase (BTK) By similarity. May be a component of a BHC histone deacetylase complex that contains HDAC1, HDAC2, HMG20B/BRAF35, KDM1A, RCOR1/CoREST, PHF21A/BHC80, ZMYM2, ZNF217, ZMYM3, GSE1 and GTF2I. Interacts with BTK and ARID3A. Interacts with isoform beta of PRKG1 By similarity.By similarityCurated

    Protein-protein interaction databases

    BioGridi200113. 3 interactions.
    IntActiQ9ESZ8. 5 interactions.
    MINTiMINT-4097022.

    Structurei

    Secondary structure

    1
    998
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Helixi733 – 74917
    Helixi759 – 7646
    Turni766 – 7683
    Beta strandi769 – 7735
    Turni783 – 7853
    Helixi788 – 7969
    Turni797 – 8004
    Beta strandi802 – 8065
    Helixi808 – 8103
    Helixi812 – 8176

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    1Q60NMR-A733-818[»]
    ProteinModelPortaliQ9ESZ8.
    SMRiQ9ESZ8. Positions 104-197, 359-454, 466-556, 571-649, 731-823, 854-954.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiQ9ESZ8.

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Repeati103 – 19795GTF2I-like 1Add
    BLAST
    Repeati352 – 44695GTF2I-like 2Add
    BLAST
    Repeati457 – 55195GTF2I-like 3Add
    BLAST
    Repeati562 – 65695GTF2I-like 4Add
    BLAST
    Repeati724 – 81895GTF2I-like 5Add
    BLAST
    Repeati859 – 95395GTF2I-like 6Add
    BLAST

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi319 – 3268Nuclear localization signalSequence Analysis

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi329 – 3379Poly-Pro

    Sequence similaritiesi

    Belongs to the TFII-I family.PROSITE-ProRule annotation
    Contains 6 GTF2I-like repeats.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat

    Phylogenomic databases

    eggNOGiNOG29608.
    GeneTreeiENSGT00530000063863.
    HOVERGENiHBG051856.
    InParanoidiQ9ESZ8.
    KOiK03121.
    OMAiMPPGVAF.
    OrthoDBiEOG7RRF67.
    PhylomeDBiQ9ESZ8.
    TreeFamiTF352524.

    Family and domain databases

    Gene3Di3.90.1460.10. 6 hits.
    InterProiIPR004212. GTF2I.
    IPR016659. TF_II-I.
    [Graphical view]
    PfamiPF02946. GTF2I. 6 hits.
    [Graphical view]
    PIRSFiPIRSF016441. TF_II-I. 1 hit.
    SUPFAMiSSF117773. SSF117773. 6 hits.
    PROSITEiPS51139. GTF2I. 6 hits.
    [Graphical view]

    Sequences (6)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 6 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q9ESZ8-1) [UniParc]FASTAAdd to Basket

    Also known as: Gamma

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MAQVVMSALP AEDEESSESR MVVTFLMSAL ESMCKELAKS KAEVACIAVY    50
    ETDVFVVGTE RGRAFVNTRK DFQKDFVKYC VEEEEKAAEM HKMKSTTQAN 100
    RMSVDAVEIE TLRKTVEDYF CFCYGKALGK STVVPVPYEK MLRDQSAVVV 150
    QGLPEGVAFK HPEHYDLATL KWILENKAGI SFIIKRPFLE PKKHLGGRVL 200
    AAEAERSMLS PSGSCGPIKV KTEPTEDSGI SLEMAAVTVK EESEDPDYYQ 250
    YNIQGPSETD GVDEKLPLSK ALQGSHHSSE GNEGTEVEVP AEDSTQHVPS 300
    ETSEDPEVEV TIEDDDYSPP TKRLKSTEPP PPPPVPEPAN AGKRKVREFN 350
    FEKWNARITD LRKQVEELFE RKYAQAIKAK GPVTIPYPLF QSHVEDLYVE 400
    GLPEGIPFRR PSTYGIPRLE RILLAKERIR FVIKKHELLN STREDLQLDK 450
    PASGVKEEWY ARITKLRKMV DQLFCKKFAE ALGSTEAKAV PYQKFEAHPN 500
    DLYVEGLPEN IPFRSPSWYG IPRLEKIIQV GNRIKFVIKR PELLTHSTTE 550
    VTQPRTNTPV KEDWNVRITK LRKQVEEIFN LKFAQALGLT EAVKVPYPVF 600
    ESNPEFLYVE GLPEGIPFRS PTWFGIPRLE RIVRGSNKIK FVVKKPELVV 650
    SYLPPGMASK INTKALQSPK RPRSPGSNSK VPEIEVTVEG PNNSSPQTSA 700
    VRTPTQTNGS NVPFKPRGRE FSFEAWNAKI TDLKQKVENL FNEKCGEALG 750
    LKQAVKVPFA LFESFPEDFY VEGLPEGVPF RRPSTFGIPR LEKILRNKAK 800
    IKFIIKKPEM FETAIKESTS SKSPPRKINS SPNVNTTASG VEDLNIIQVT 850
    IPDDDNERLS KVEKARQLRE QVNDLFSRKF GEAIGMGFPV KVPYRKITIN 900
    PGCVVVDGMP PGVSFKAPSY LEISSMRRIL DSAEFIKFTV IRPFPGLVIN 950
    NQLVDQNESE GPVIQESAEA SQLEVPVTEE IKETDGSSQI KQEPDPTW 998
    Length:998
    Mass (Da):112,265
    Last modified:December 15, 2003 - v3
    Checksum:i3BC228A2F4F880CF
    GO
    Isoform 2 (identifier: Q9ESZ8-2) [UniParc]FASTAAdd to Basket

    Also known as: Beta, Long

    The sequence of this isoform differs from the canonical sequence as follows:
         255-273: Missing.

    Show »
    Length:979
    Mass (Da):110,299
    Checksum:iE001EB13BE19A81F
    GO
    Isoform 3 (identifier: Q9ESZ8-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         255-292: Missing.

    Show »
    Length:960
    Mass (Da):108,365
    Checksum:i80E39FB7F85C4A93
    GO
    Isoform 4 (identifier: Q9ESZ8-4) [UniParc]FASTAAdd to Basket

    Also known as: Delta, Short

    The sequence of this isoform differs from the canonical sequence as follows:
         255-273: Missing.
         293-313: Missing.

    Show »
    Length:958
    Mass (Da):107,989
    Checksum:iBC47CBD9FC28F4BD
    GO
    Isoform 5 (identifier: Q9ESZ8-5) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         255-313: Missing.

    Show »
    Length:939
    Mass (Da):106,055
    Checksum:iDC04C876B09F26FA
    GO
    Isoform 6 (identifier: Q9ESZ8-6) [UniParc]FASTAAdd to Basket

    Also known as: Alpha

    The sequence of this isoform differs from the canonical sequence as follows:
         293-313: Missing.

    Show »
    Length:977
    Mass (Da):109,955
    Checksum:i013875885B7085A1
    GO

    Sequence cautioni

    The sequence BAB28803.2 differs from that shown. Reason: Erroneous initiation.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti5 – 51V → A in AAC53569. (PubMed:9521869)Curated
    Sequence conflicti62 – 621G → R in AAC53569. (PubMed:9521869)Curated
    Sequence conflicti127 – 1304ALGK → NTAL in BAB24743. (PubMed:16141072)Curated
    Sequence conflicti254 – 2541Q → QA(PubMed:9521869)Curated
    Sequence conflicti261 – 2611G → D(PubMed:9521869)Curated
    Sequence conflicti266 – 2661L → Q(PubMed:9521869)Curated
    Sequence conflicti271 – 2722AL → PM(PubMed:9521869)Curated
    Sequence conflicti314 – 3141D → G1 PublicationCurated
    Sequence conflicti334 – 3341Missing in AAC53569. (PubMed:9521869)Curated
    Sequence conflicti538 – 5381I → T in AAC53569. (PubMed:9521869)Curated
    Sequence conflicti607 – 6071L → C in AAC53569. (PubMed:9521869)Curated
    Sequence conflicti621 – 6211P → L in AAC53569. (PubMed:9521869)Curated
    Sequence conflicti691 – 6911P → L in AAC02990. 1 PublicationCurated
    Sequence conflicti691 – 6911P → L in AAC02991. 1 PublicationCurated
    Sequence conflicti748 – 7481A → T in AAC53569. (PubMed:9521869)Curated
    Sequence conflicti826 – 8261R → IFLSG in BAB28803. (PubMed:16141072)Curated
    Sequence conflicti966 – 9661E → Q in BAB28803. (PubMed:16141072)Curated

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei255 – 31359Missing in isoform 5. 1 PublicationVSP_003871Add
    BLAST
    Alternative sequencei255 – 29238Missing in isoform 3. 1 PublicationVSP_003870Add
    BLAST
    Alternative sequencei255 – 27319Missing in isoform 2 and isoform 4. 3 PublicationsVSP_003869Add
    BLAST
    Alternative sequencei293 – 31321Missing in isoform 4 and isoform 6. 3 PublicationsVSP_003872Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF017085 mRNA. Translation: AAC53569.1.
    AF043219 mRNA. Translation: AAC02990.1.
    AF043220 mRNA. Translation: AAC02991.1.
    AF325177 Genomic DNA. No translation available.
    AY030290 mRNA. Translation: AAK49785.1.
    AY030291 mRNA. Translation: AAK49786.1.
    AY030292 mRNA. Translation: AAK49787.1.
    AY030293 mRNA. Translation: AAK49788.1.
    BC053044 mRNA. Translation: AAH53044.1.
    AK006796 mRNA. Translation: BAB24743.1.
    AK013348 mRNA. Translation: BAB28803.2. Different initiation.
    AF289666 Genomic DNA. Translation: AAF99338.1.
    CCDSiCCDS39299.1. [Q9ESZ8-2]
    CCDS39300.1. [Q9ESZ8-6]
    CCDS39301.1. [Q9ESZ8-1]
    CCDS57386.1. [Q9ESZ8-4]
    PIRiT03763.
    RefSeqiNP_001074215.1. NM_001080746.2. [Q9ESZ8-1]
    NP_001074216.1. NM_001080747.2. [Q9ESZ8-6]
    NP_001074217.1. NM_001080748.2. [Q9ESZ8-4]
    NP_034495.2. NM_010365.4. [Q9ESZ8-2]
    UniGeneiMm.261570.
    Mm.412191.
    Mm.466495.

    Genome annotation databases

    EnsembliENSMUST00000059042; ENSMUSP00000049625; ENSMUSG00000060261. [Q9ESZ8-1]
    ENSMUST00000082057; ENSMUSP00000080714; ENSMUSG00000060261. [Q9ESZ8-6]
    ENSMUST00000111261; ENSMUSP00000106892; ENSMUSG00000060261. [Q9ESZ8-2]
    ENSMUST00000173888; ENSMUSP00000133969; ENSMUSG00000060261. [Q9ESZ8-5]
    ENSMUST00000174155; ENSMUSP00000133566; ENSMUSG00000060261. [Q9ESZ8-1]
    ENSMUST00000174354; ENSMUSP00000134440; ENSMUSG00000060261. [Q9ESZ8-2]
    ENSMUST00000174513; ENSMUSP00000133489; ENSMUSG00000060261. [Q9ESZ8-4]
    ENSMUST00000174772; ENSMUSP00000133740; ENSMUSG00000060261. [Q9ESZ8-6]
    GeneIDi14886.
    KEGGimmu:14886.
    UCSCiuc008zvj.2. mouse. [Q9ESZ8-1]
    uc008zvk.2. mouse. [Q9ESZ8-2]
    uc008zvl.2. mouse. [Q9ESZ8-6]
    uc008zvm.2. mouse. [Q9ESZ8-4]

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF017085 mRNA. Translation: AAC53569.1 .
    AF043219 mRNA. Translation: AAC02990.1 .
    AF043220 mRNA. Translation: AAC02991.1 .
    AF325177 Genomic DNA. No translation available.
    AY030290 mRNA. Translation: AAK49785.1 .
    AY030291 mRNA. Translation: AAK49786.1 .
    AY030292 mRNA. Translation: AAK49787.1 .
    AY030293 mRNA. Translation: AAK49788.1 .
    BC053044 mRNA. Translation: AAH53044.1 .
    AK006796 mRNA. Translation: BAB24743.1 .
    AK013348 mRNA. Translation: BAB28803.2 . Different initiation.
    AF289666 Genomic DNA. Translation: AAF99338.1 .
    CCDSi CCDS39299.1. [Q9ESZ8-2 ]
    CCDS39300.1. [Q9ESZ8-6 ]
    CCDS39301.1. [Q9ESZ8-1 ]
    CCDS57386.1. [Q9ESZ8-4 ]
    PIRi T03763.
    RefSeqi NP_001074215.1. NM_001080746.2. [Q9ESZ8-1 ]
    NP_001074216.1. NM_001080747.2. [Q9ESZ8-6 ]
    NP_001074217.1. NM_001080748.2. [Q9ESZ8-4 ]
    NP_034495.2. NM_010365.4. [Q9ESZ8-2 ]
    UniGenei Mm.261570.
    Mm.412191.
    Mm.466495.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    1Q60 NMR - A 733-818 [» ]
    ProteinModelPortali Q9ESZ8.
    SMRi Q9ESZ8. Positions 104-197, 359-454, 466-556, 571-649, 731-823, 854-954.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 200113. 3 interactions.
    IntActi Q9ESZ8. 5 interactions.
    MINTi MINT-4097022.

    PTM databases

    PhosphoSitei Q9ESZ8.

    Proteomic databases

    MaxQBi Q9ESZ8.
    PaxDbi Q9ESZ8.
    PRIDEi Q9ESZ8.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000059042 ; ENSMUSP00000049625 ; ENSMUSG00000060261 . [Q9ESZ8-1 ]
    ENSMUST00000082057 ; ENSMUSP00000080714 ; ENSMUSG00000060261 . [Q9ESZ8-6 ]
    ENSMUST00000111261 ; ENSMUSP00000106892 ; ENSMUSG00000060261 . [Q9ESZ8-2 ]
    ENSMUST00000173888 ; ENSMUSP00000133969 ; ENSMUSG00000060261 . [Q9ESZ8-5 ]
    ENSMUST00000174155 ; ENSMUSP00000133566 ; ENSMUSG00000060261 . [Q9ESZ8-1 ]
    ENSMUST00000174354 ; ENSMUSP00000134440 ; ENSMUSG00000060261 . [Q9ESZ8-2 ]
    ENSMUST00000174513 ; ENSMUSP00000133489 ; ENSMUSG00000060261 . [Q9ESZ8-4 ]
    ENSMUST00000174772 ; ENSMUSP00000133740 ; ENSMUSG00000060261 . [Q9ESZ8-6 ]
    GeneIDi 14886.
    KEGGi mmu:14886.
    UCSCi uc008zvj.2. mouse. [Q9ESZ8-1 ]
    uc008zvk.2. mouse. [Q9ESZ8-2 ]
    uc008zvl.2. mouse. [Q9ESZ8-6 ]
    uc008zvm.2. mouse. [Q9ESZ8-4 ]

    Organism-specific databases

    CTDi 2969.
    MGIi MGI:1202722. Gtf2i.

    Phylogenomic databases

    eggNOGi NOG29608.
    GeneTreei ENSGT00530000063863.
    HOVERGENi HBG051856.
    InParanoidi Q9ESZ8.
    KOi K03121.
    OMAi MPPGVAF.
    OrthoDBi EOG7RRF67.
    PhylomeDBi Q9ESZ8.
    TreeFami TF352524.

    Miscellaneous databases

    ChiTaRSi GTF2I. mouse.
    EvolutionaryTracei Q9ESZ8.
    NextBioi 287171.
    PROi Q9ESZ8.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q9ESZ8.
    Bgeei Q9ESZ8.
    CleanExi MM_GTF2I.
    Genevestigatori Q9ESZ8.

    Family and domain databases

    Gene3Di 3.90.1460.10. 6 hits.
    InterProi IPR004212. GTF2I.
    IPR016659. TF_II-I.
    [Graphical view ]
    Pfami PF02946. GTF2I. 6 hits.
    [Graphical view ]
    PIRSFi PIRSF016441. TF_II-I. 1 hit.
    SUPFAMi SSF117773. SSF117773. 6 hits.
    PROSITEi PS51139. GTF2I. 6 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "A mouse single-copy gene, Gtf2i, the homolog of human GTF2I, that is duplicated in the Williams-Beuren syndrome deletion region."
      Wang Y.-K., Perez-Jurado L.A., Francke U.
      Genomics 48:163-170(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1; 2; 3; 4 AND 5).
      Tissue: Brain.
    2. "Cloning and expression of two forms of mouse TFII-I."
      Johansson E., Hjortsberg K., Roy A.L., Thelander L.
      Submitted (JAN-1998) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 2 AND 4).
      Strain: C57BL/Kaplan.
      Tissue: T-cell lymphoma.
    3. "Genomic organization of the genes Gtf2ird1, Gtf2i, and Ncf1 at the mouse chromosome 5 region syntenic to the human chromosome 7q11.23 Williams syndrome critical region."
      Bayarsaihan D., Dunai J., Greally J.M., Kawasaki K., Sumiyama K., Enkhmandakh B., Shimizu N., Ruddle F.H.
      Genomics 79:137-143(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] (ISOFORMS 1; 2; 4 AND 6).
      Strain: 129/SvJ.
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Strain: C57BL/6.
      Tissue: Brain.
    5. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-130 AND 719-998.
      Strain: C57BL/6J.
      Tissue: Embryo and Testis.
    6. Green E.D.
      Submitted (JUL-2000) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE OF 1-314 (ISOFORM 2).
      Strain: 129/Sv.
    7. "Induction of immunoglobulin heavy-chain transcription through the transcription factor Bright requires TFII-I."
      Rajaiya J., Nixon J.C., Ayers N., Desgranges Z.P., Roy A.L., Webb C.F.
      Mol. Cell. Biol. 26:4758-4768(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH ARID3A AND BTK, FUNCTION.
    8. "SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways."
      Park J., Chen Y., Tishkoff D.X., Peng C., Tan M., Dai L., Xie Z., Zhang Y., Zwaans B.M., Skinner M.E., Lombard D.B., Zhao Y.
      Mol. Cell 50:919-930(2013) [PubMed] [Europe PMC] [Abstract]
      Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-130; LYS-353; LYS-450 AND LYS-715, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Embryonic fibroblast.
    9. Cited for: STRUCTURE BY NMR OF 733-818.

    Entry informationi

    Entry nameiGTF2I_MOUSE
    AccessioniPrimary (citable) accession number: Q9ESZ8
    Secondary accession number(s): O54700
    , O55030, O55031, Q8VHD1, Q8VHD2, Q8VHD3, Q8VHD4, Q9CSB5, Q9D9K9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 13, 2001
    Last sequence update: December 15, 2003
    Last modified: October 1, 2014
    This is version 120 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3