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Protein

General transcription factor II-I

Gene

Gtf2i

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Interacts with the basal transcription machinery by coordinating the formation of a multiprotein complex at the C-FOS promoter, and linking specific signal responsive activator complexes. Promotes the formation of stable high-order complexes of SRF and PHOX1 and interacts cooperatively with PHOX1 to promote serum-inducible transcription of a reporter gene deriven by the C-FOS serum response element (SRE). Acts as a coregulator for USF1 by binding independently two promoter elements, a pyrimidine-rich initiator (Inr) and an upstream E-box (By similarity). Required for the formation of functional ARID3A DNA-binding complexes and for activation of immunoglobulin heavy-chain transcription upon B-lymphocyte activation.By similarity1 Publication

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
General transcription factor II-I
Short name:
GTFII-I
Short name:
TFII-I
Alternative name(s):
Bruton tyrosine kinase-associated protein 135
Short name:
BAP-135
Short name:
BTK-associated protein 135
Gene namesi
Name:Gtf2i
Synonyms:Bap135, Diws1t
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 5

Organism-specific databases

MGIiMGI:1202722. Gtf2i.

Subcellular locationi

GO - Cellular componenti

  • cell projection Source: MGI
  • cytoplasm Source: GO_Central
  • membrane Source: MGI
  • neuronal cell body Source: MGI
  • nucleoplasm Source: MGI
  • nucleus Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00000838732 – 998General transcription factor II-IAdd BLAST997

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineBy similarity1
Modified residuei19PhosphoserineBy similarity1
Cross-linki86Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki94Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei103PhosphoserineBy similarity1
Modified residuei130N6-acetyllysine; alternateCombined sources1
Cross-linki130Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateBy similarity
Modified residuei207PhosphoserineBy similarity1
Modified residuei210PhosphoserineBy similarity1
Modified residuei214PhosphoserineBy similarity1
Cross-linki221Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1)By similarity
Cross-linki221Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei248Phosphotyrosine; by BTKBy similarity1
Modified residuei317Phosphotyrosine; by BTKBy similarity1
Cross-linki325Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki343Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei353N6-acetyllysine; alternateCombined sources1
Cross-linki353Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateBy similarity
Modified residuei398Phosphotyrosine; by BTKBy similarity1
Modified residuei412Phosphoserine; by PKG/PRKG1By similarity1
Modified residuei450N6-acetyllysineCombined sources1
Cross-linki456Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki488Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei503Phosphotyrosine; by BTKBy similarity1
Modified residuei517PhosphoserineBy similarity1
Modified residuei556PhosphothreonineCombined sources1
Modified residuei558PhosphothreonineCombined sources1
Cross-linki561Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki660Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki664Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei668PhosphoserineBy similarity1
Modified residuei674PhosphoserineBy similarity1
Modified residuei715N6-acetyllysine; alternateCombined sources1
Cross-linki715Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateBy similarity
Modified residuei722PhosphoserineBy similarity1
Modified residuei784Phosphoserine; by PKG/PRKG1By similarity1
Cross-linki816Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei823PhosphoserineBy similarity1
Cross-linki991Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1)By similarity
Cross-linki991Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity

Post-translational modificationi

Transiently phosphorylated on tyrosine residues by BTK in response to B-cell receptor stimulation. Phosphorylation on Tyr-248 and Tyr-398, and perhaps, on Tyr-503 contributes to BTK-mediated transcriptional activation (By similarity).By similarity
Sumoylated.By similarity

Keywords - PTMi

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

PaxDbiQ9ESZ8.
PeptideAtlasiQ9ESZ8.
PRIDEiQ9ESZ8.

PTM databases

iPTMnetiQ9ESZ8.
PhosphoSitePlusiQ9ESZ8.

Expressioni

Tissue specificityi

Ubiquitous.

Gene expression databases

BgeeiENSMUSG00000060261.
CleanExiMM_GTF2I.
ExpressionAtlasiQ9ESZ8. baseline and differential.
GenevisibleiQ9ESZ8. MM.

Interactioni

Subunit structurei

Homodimer (Potential). Interacts with SRF and PHOX1. Binds a pyrimidine-rich initiator (Inr) and a recognition site (E-box) for upstream stimulatory factor 1 (USF1). Associates with the PH domain of Bruton's tyrosine kinase (BTK) (By similarity). May be a component of a BHC histone deacetylase complex that contains HDAC1, HDAC2, HMG20B/BRAF35, KDM1A, RCOR1/CoREST, PHF21A/BHC80, ZMYM2, ZNF217, ZMYM3, GSE1 and GTF2I. Interacts with BTK and ARID3A. Interacts with isoform beta of PRKG1 (By similarity).By similarityCurated

GO - Molecular functioni

  • mitogen-activated protein kinase binding Source: MGI

Protein-protein interaction databases

BioGridi200113. 3 interactors.
IntActiQ9ESZ8. 6 interactors.
MINTiMINT-4097022.
STRINGi10090.ENSMUSP00000049625.

Structurei

Secondary structure

1998
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi733 – 749Combined sources17
Helixi759 – 764Combined sources6
Turni766 – 768Combined sources3
Beta strandi769 – 773Combined sources5
Turni783 – 785Combined sources3
Helixi788 – 796Combined sources9
Turni797 – 800Combined sources4
Beta strandi802 – 806Combined sources5
Helixi808 – 810Combined sources3
Helixi812 – 817Combined sources6

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1Q60NMR-A733-818[»]
ProteinModelPortaliQ9ESZ8.
SMRiQ9ESZ8.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9ESZ8.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati103 – 197GTF2I-like 1Add BLAST95
Repeati352 – 446GTF2I-like 2Add BLAST95
Repeati457 – 551GTF2I-like 3Add BLAST95
Repeati562 – 656GTF2I-like 4Add BLAST95
Repeati724 – 818GTF2I-like 5Add BLAST95
Repeati859 – 953GTF2I-like 6Add BLAST95

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi319 – 326Nuclear localization signalSequence analysis8

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi329 – 337Poly-Pro9

Sequence similaritiesi

Belongs to the TFII-I family.PROSITE-ProRule annotation
Contains 6 GTF2I-like repeats.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiENOG410IEPZ. Eukaryota.
ENOG41100H8. LUCA.
GeneTreeiENSGT00530000063863.
HOVERGENiHBG051856.
InParanoidiQ9ESZ8.
KOiK03121.
OMAiMPPGVAF.
OrthoDBiEOG091G01ZC.
PhylomeDBiQ9ESZ8.
TreeFamiTF352524.

Family and domain databases

Gene3Di3.90.1460.10. 6 hits.
InterProiIPR004212. GTF2I.
IPR016659. TF_II-I.
[Graphical view]
PfamiPF02946. GTF2I. 6 hits.
[Graphical view]
PIRSFiPIRSF016441. TF_II-I. 1 hit.
SUPFAMiSSF117773. SSF117773. 6 hits.
PROSITEiPS51139. GTF2I. 6 hits.
[Graphical view]

Sequences (6)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 6 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9ESZ8-1) [UniParc]FASTAAdd to basket
Also known as: Gamma

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAQVVMSALP AEDEESSESR MVVTFLMSAL ESMCKELAKS KAEVACIAVY
60 70 80 90 100
ETDVFVVGTE RGRAFVNTRK DFQKDFVKYC VEEEEKAAEM HKMKSTTQAN
110 120 130 140 150
RMSVDAVEIE TLRKTVEDYF CFCYGKALGK STVVPVPYEK MLRDQSAVVV
160 170 180 190 200
QGLPEGVAFK HPEHYDLATL KWILENKAGI SFIIKRPFLE PKKHLGGRVL
210 220 230 240 250
AAEAERSMLS PSGSCGPIKV KTEPTEDSGI SLEMAAVTVK EESEDPDYYQ
260 270 280 290 300
YNIQGPSETD GVDEKLPLSK ALQGSHHSSE GNEGTEVEVP AEDSTQHVPS
310 320 330 340 350
ETSEDPEVEV TIEDDDYSPP TKRLKSTEPP PPPPVPEPAN AGKRKVREFN
360 370 380 390 400
FEKWNARITD LRKQVEELFE RKYAQAIKAK GPVTIPYPLF QSHVEDLYVE
410 420 430 440 450
GLPEGIPFRR PSTYGIPRLE RILLAKERIR FVIKKHELLN STREDLQLDK
460 470 480 490 500
PASGVKEEWY ARITKLRKMV DQLFCKKFAE ALGSTEAKAV PYQKFEAHPN
510 520 530 540 550
DLYVEGLPEN IPFRSPSWYG IPRLEKIIQV GNRIKFVIKR PELLTHSTTE
560 570 580 590 600
VTQPRTNTPV KEDWNVRITK LRKQVEEIFN LKFAQALGLT EAVKVPYPVF
610 620 630 640 650
ESNPEFLYVE GLPEGIPFRS PTWFGIPRLE RIVRGSNKIK FVVKKPELVV
660 670 680 690 700
SYLPPGMASK INTKALQSPK RPRSPGSNSK VPEIEVTVEG PNNSSPQTSA
710 720 730 740 750
VRTPTQTNGS NVPFKPRGRE FSFEAWNAKI TDLKQKVENL FNEKCGEALG
760 770 780 790 800
LKQAVKVPFA LFESFPEDFY VEGLPEGVPF RRPSTFGIPR LEKILRNKAK
810 820 830 840 850
IKFIIKKPEM FETAIKESTS SKSPPRKINS SPNVNTTASG VEDLNIIQVT
860 870 880 890 900
IPDDDNERLS KVEKARQLRE QVNDLFSRKF GEAIGMGFPV KVPYRKITIN
910 920 930 940 950
PGCVVVDGMP PGVSFKAPSY LEISSMRRIL DSAEFIKFTV IRPFPGLVIN
960 970 980 990
NQLVDQNESE GPVIQESAEA SQLEVPVTEE IKETDGSSQI KQEPDPTW
Length:998
Mass (Da):112,265
Last modified:December 15, 2003 - v3
Checksum:i3BC228A2F4F880CF
GO
Isoform 2 (identifier: Q9ESZ8-2) [UniParc]FASTAAdd to basket
Also known as: Beta, Long

The sequence of this isoform differs from the canonical sequence as follows:
     255-273: Missing.

Show »
Length:979
Mass (Da):110,299
Checksum:iE001EB13BE19A81F
GO
Isoform 3 (identifier: Q9ESZ8-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     255-292: Missing.

Show »
Length:960
Mass (Da):108,365
Checksum:i80E39FB7F85C4A93
GO
Isoform 4 (identifier: Q9ESZ8-4) [UniParc]FASTAAdd to basket
Also known as: Delta, Short

The sequence of this isoform differs from the canonical sequence as follows:
     255-273: Missing.
     293-313: Missing.

Show »
Length:958
Mass (Da):107,989
Checksum:iBC47CBD9FC28F4BD
GO
Isoform 5 (identifier: Q9ESZ8-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     255-313: Missing.

Show »
Length:939
Mass (Da):106,055
Checksum:iDC04C876B09F26FA
GO
Isoform 6 (identifier: Q9ESZ8-6) [UniParc]FASTAAdd to basket
Also known as: Alpha

The sequence of this isoform differs from the canonical sequence as follows:
     293-313: Missing.

Show »
Length:977
Mass (Da):109,955
Checksum:i013875885B7085A1
GO

Sequence cautioni

The sequence BAB28803 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti5V → A in AAC53569 (PubMed:9521869).Curated1
Sequence conflicti62G → R in AAC53569 (PubMed:9521869).Curated1
Sequence conflicti127 – 130ALGK → NTAL in BAB24743 (PubMed:16141072).Curated4
Sequence conflicti254Q → QA (PubMed:9521869).Curated1
Sequence conflicti261G → D (PubMed:9521869).Curated1
Sequence conflicti266L → Q (PubMed:9521869).Curated1
Sequence conflicti271 – 272AL → PM (PubMed:9521869).Curated2
Sequence conflicti314D → G (Ref. 6) Curated1
Sequence conflicti334Missing in AAC53569 (PubMed:9521869).Curated1
Sequence conflicti538I → T in AAC53569 (PubMed:9521869).Curated1
Sequence conflicti607L → C in AAC53569 (PubMed:9521869).Curated1
Sequence conflicti621P → L in AAC53569 (PubMed:9521869).Curated1
Sequence conflicti691P → L in AAC02990 (Ref. 2) Curated1
Sequence conflicti691P → L in AAC02991 (Ref. 2) Curated1
Sequence conflicti748A → T in AAC53569 (PubMed:9521869).Curated1
Sequence conflicti826R → IFLSG in BAB28803 (PubMed:16141072).Curated1
Sequence conflicti966E → Q in BAB28803 (PubMed:16141072).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_003871255 – 313Missing in isoform 5. 1 PublicationAdd BLAST59
Alternative sequenceiVSP_003870255 – 292Missing in isoform 3. 1 PublicationAdd BLAST38
Alternative sequenceiVSP_003869255 – 273Missing in isoform 2 and isoform 4. 3 PublicationsAdd BLAST19
Alternative sequenceiVSP_003872293 – 313Missing in isoform 4 and isoform 6. 3 PublicationsAdd BLAST21

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF017085 mRNA. Translation: AAC53569.1.
AF043219 mRNA. Translation: AAC02990.1.
AF043220 mRNA. Translation: AAC02991.1.
AF325177 Genomic DNA. No translation available.
AY030290 mRNA. Translation: AAK49785.1.
AY030291 mRNA. Translation: AAK49786.1.
AY030292 mRNA. Translation: AAK49787.1.
AY030293 mRNA. Translation: AAK49788.1.
BC053044 mRNA. Translation: AAH53044.1.
AK006796 mRNA. Translation: BAB24743.1.
AK013348 mRNA. Translation: BAB28803.2. Different initiation.
AF289666 Genomic DNA. Translation: AAF99338.1.
CCDSiCCDS39299.1. [Q9ESZ8-2]
CCDS39300.1. [Q9ESZ8-6]
CCDS39301.1. [Q9ESZ8-1]
CCDS57386.1. [Q9ESZ8-4]
PIRiT03763.
RefSeqiNP_001074215.1. NM_001080746.2. [Q9ESZ8-1]
NP_001074216.1. NM_001080747.2. [Q9ESZ8-6]
NP_001074217.1. NM_001080748.2. [Q9ESZ8-4]
NP_034495.2. NM_010365.4. [Q9ESZ8-2]
XP_017176169.1. XM_017320680.1. [Q9ESZ8-2]
XP_017176170.1. XM_017320681.1. [Q9ESZ8-4]
UniGeneiMm.261570.
Mm.412191.
Mm.466495.

Genome annotation databases

EnsembliENSMUST00000059042; ENSMUSP00000049625; ENSMUSG00000060261. [Q9ESZ8-1]
ENSMUST00000082057; ENSMUSP00000080714; ENSMUSG00000060261. [Q9ESZ8-6]
ENSMUST00000111261; ENSMUSP00000106892; ENSMUSG00000060261. [Q9ESZ8-2]
ENSMUST00000173888; ENSMUSP00000133969; ENSMUSG00000060261. [Q9ESZ8-5]
ENSMUST00000174155; ENSMUSP00000133566; ENSMUSG00000060261. [Q9ESZ8-1]
ENSMUST00000174354; ENSMUSP00000134440; ENSMUSG00000060261. [Q9ESZ8-2]
ENSMUST00000174513; ENSMUSP00000133489; ENSMUSG00000060261. [Q9ESZ8-4]
ENSMUST00000174772; ENSMUSP00000133740; ENSMUSG00000060261. [Q9ESZ8-6]
GeneIDi14886.
KEGGimmu:14886.
UCSCiuc008zvj.3. mouse. [Q9ESZ8-1]
uc008zvk.3. mouse. [Q9ESZ8-2]
uc008zvl.3. mouse. [Q9ESZ8-6]
uc008zvm.3. mouse. [Q9ESZ8-4]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF017085 mRNA. Translation: AAC53569.1.
AF043219 mRNA. Translation: AAC02990.1.
AF043220 mRNA. Translation: AAC02991.1.
AF325177 Genomic DNA. No translation available.
AY030290 mRNA. Translation: AAK49785.1.
AY030291 mRNA. Translation: AAK49786.1.
AY030292 mRNA. Translation: AAK49787.1.
AY030293 mRNA. Translation: AAK49788.1.
BC053044 mRNA. Translation: AAH53044.1.
AK006796 mRNA. Translation: BAB24743.1.
AK013348 mRNA. Translation: BAB28803.2. Different initiation.
AF289666 Genomic DNA. Translation: AAF99338.1.
CCDSiCCDS39299.1. [Q9ESZ8-2]
CCDS39300.1. [Q9ESZ8-6]
CCDS39301.1. [Q9ESZ8-1]
CCDS57386.1. [Q9ESZ8-4]
PIRiT03763.
RefSeqiNP_001074215.1. NM_001080746.2. [Q9ESZ8-1]
NP_001074216.1. NM_001080747.2. [Q9ESZ8-6]
NP_001074217.1. NM_001080748.2. [Q9ESZ8-4]
NP_034495.2. NM_010365.4. [Q9ESZ8-2]
XP_017176169.1. XM_017320680.1. [Q9ESZ8-2]
XP_017176170.1. XM_017320681.1. [Q9ESZ8-4]
UniGeneiMm.261570.
Mm.412191.
Mm.466495.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1Q60NMR-A733-818[»]
ProteinModelPortaliQ9ESZ8.
SMRiQ9ESZ8.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi200113. 3 interactors.
IntActiQ9ESZ8. 6 interactors.
MINTiMINT-4097022.
STRINGi10090.ENSMUSP00000049625.

PTM databases

iPTMnetiQ9ESZ8.
PhosphoSitePlusiQ9ESZ8.

Proteomic databases

PaxDbiQ9ESZ8.
PeptideAtlasiQ9ESZ8.
PRIDEiQ9ESZ8.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000059042; ENSMUSP00000049625; ENSMUSG00000060261. [Q9ESZ8-1]
ENSMUST00000082057; ENSMUSP00000080714; ENSMUSG00000060261. [Q9ESZ8-6]
ENSMUST00000111261; ENSMUSP00000106892; ENSMUSG00000060261. [Q9ESZ8-2]
ENSMUST00000173888; ENSMUSP00000133969; ENSMUSG00000060261. [Q9ESZ8-5]
ENSMUST00000174155; ENSMUSP00000133566; ENSMUSG00000060261. [Q9ESZ8-1]
ENSMUST00000174354; ENSMUSP00000134440; ENSMUSG00000060261. [Q9ESZ8-2]
ENSMUST00000174513; ENSMUSP00000133489; ENSMUSG00000060261. [Q9ESZ8-4]
ENSMUST00000174772; ENSMUSP00000133740; ENSMUSG00000060261. [Q9ESZ8-6]
GeneIDi14886.
KEGGimmu:14886.
UCSCiuc008zvj.3. mouse. [Q9ESZ8-1]
uc008zvk.3. mouse. [Q9ESZ8-2]
uc008zvl.3. mouse. [Q9ESZ8-6]
uc008zvm.3. mouse. [Q9ESZ8-4]

Organism-specific databases

CTDi2969.
MGIiMGI:1202722. Gtf2i.

Phylogenomic databases

eggNOGiENOG410IEPZ. Eukaryota.
ENOG41100H8. LUCA.
GeneTreeiENSGT00530000063863.
HOVERGENiHBG051856.
InParanoidiQ9ESZ8.
KOiK03121.
OMAiMPPGVAF.
OrthoDBiEOG091G01ZC.
PhylomeDBiQ9ESZ8.
TreeFamiTF352524.

Miscellaneous databases

ChiTaRSiGtf2i. mouse.
EvolutionaryTraceiQ9ESZ8.
PROiQ9ESZ8.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000060261.
CleanExiMM_GTF2I.
ExpressionAtlasiQ9ESZ8. baseline and differential.
GenevisibleiQ9ESZ8. MM.

Family and domain databases

Gene3Di3.90.1460.10. 6 hits.
InterProiIPR004212. GTF2I.
IPR016659. TF_II-I.
[Graphical view]
PfamiPF02946. GTF2I. 6 hits.
[Graphical view]
PIRSFiPIRSF016441. TF_II-I. 1 hit.
SUPFAMiSSF117773. SSF117773. 6 hits.
PROSITEiPS51139. GTF2I. 6 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiGTF2I_MOUSE
AccessioniPrimary (citable) accession number: Q9ESZ8
Secondary accession number(s): O54700
, O55030, O55031, Q8VHD1, Q8VHD2, Q8VHD3, Q8VHD4, Q9CSB5, Q9D9K9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 13, 2001
Last sequence update: December 15, 2003
Last modified: November 2, 2016
This is version 138 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.