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Protein

DNA repair protein XRCC1

Gene

Xrcc1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Corrects defective DNA strand-break repair and sister chromatid exchange following treatment with ionizing radiation and alkylating agents.By similarity

GO - Molecular functioni

GO - Biological processi

  • base-excision repair Source: RGD
  • cellular response to DNA damage stimulus Source: RGD
  • hippocampus development Source: Ensembl
  • response to drug Source: RGD
  • response to hypoxia Source: RGD
  • response to organic substance Source: RGD
  • single strand break repair Source: InterPro
Complete GO annotation...

Keywords - Biological processi

DNA damage, DNA repair

Enzyme and pathway databases

ReactomeiR-RNO-110381. Resolution of AP sites via the single-nucleotide replacement pathway.
R-RNO-5649702. APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway.
R-RNO-5685939. HDR through MMEJ (alt-NHEJ).
R-RNO-6782210. Gap-filling DNA repair synthesis and ligation in TC-NER.

Names & Taxonomyi

Protein namesi
Recommended name:
DNA repair protein XRCC1
Alternative name(s):
X-ray repair cross-complementing protein 1
Gene namesi
Name:Xrcc1
Synonyms:Xrcc-1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 1

Organism-specific databases

RGDi619823. Xrcc1.

Subcellular locationi

GO - Cellular componenti

  • nucleus Source: RGD
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000660461 – 631DNA repair protein XRCC1Add BLAST631

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei142PhosphoserineBy similarity1
Cross-linki178Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1)By similarity
Cross-linki178Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei206PhosphoserineBy similarity1
Modified residuei228PhosphoserineBy similarity1
Modified residuei261PhosphoserineBy similarity1
Modified residuei281PhosphothreonineBy similarity1
Modified residuei371Phosphoserine; by PRKDCBy similarity1
Modified residuei408PhosphoserineBy similarity1
Modified residuei409PhosphoserineBy similarity1
Modified residuei410PhosphoserineBy similarity1
Modified residuei445PhosphoserineBy similarity1
Modified residuei446PhosphoserineCombined sources1
Modified residuei452PhosphothreonineCombined sources1
Modified residuei456PhosphothreonineBy similarity1
Modified residuei460PhosphoserineBy similarity1
Modified residuei484PhosphoserineCombined sources1
Modified residuei487PhosphothreonineCombined sources1
Modified residuei517PhosphoserineBy similarity1
Modified residuei518PhosphothreonineBy similarity1
Modified residuei522PhosphothreonineBy similarity1

Post-translational modificationi

Phosphorylation of Ser-371 causes dimer dissociation. Phosphorylation by CK2 promotes interaction with APTX and APLF (By similarity).By similarity
Sumoylated.By similarity

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

PaxDbiQ9ESZ0.
PRIDEiQ9ESZ0.

PTM databases

iPTMnetiQ9ESZ0.
PhosphoSitePlusiQ9ESZ0.

Expressioni

Gene expression databases

BgeeiENSRNOG00000019915.
GenevisibleiQ9ESZ0. RN.

Interactioni

Subunit structurei

Homodimer. Interacts with polynucleotide kinase (PNK), DNA polymerase-beta (POLB) and DNA ligase III (LIG3). Interacts with APTX and APLF. Interacts with APEX1; the interaction is induced by SIRT1 and increases with the acetylated form of APEX1 (By similarity).By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000027057.

Structurei

3D structure databases

ProteinModelPortaliQ9ESZ0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini315 – 403BRCT 1PROSITE-ProRule annotationAdd BLAST89
Domaini536 – 627BRCT 2PROSITE-ProRule annotationAdd BLAST92

Sequence similaritiesi

Contains 2 BRCT domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG3226. Eukaryota.
ENOG410ZE1H. LUCA.
GeneTreeiENSGT00390000004140.
HOGENOMiHOG000111006.
HOVERGENiHBG052992.
InParanoidiQ9ESZ0.
KOiK10803.
OMAiSCNEKQK.
OrthoDBiEOG091G0KP0.
PhylomeDBiQ9ESZ0.

Family and domain databases

CDDicd00027. BRCT. 2 hits.
Gene3Di2.60.120.260. 1 hit.
3.40.50.10190. 2 hits.
InterProiIPR001357. BRCT_dom.
IPR008979. Galactose-bd-like.
IPR002706. Xrcc1_N.
[Graphical view]
PfamiPF00533. BRCT. 1 hit.
PF16589. BRCT_2. 1 hit.
PF01834. XRCC1_N. 1 hit.
[Graphical view]
SMARTiSM00292. BRCT. 2 hits.
[Graphical view]
SUPFAMiSSF49785. SSF49785. 1 hit.
SSF52113. SSF52113. 2 hits.
PROSITEiPS50172. BRCT. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9ESZ0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPEISLRHVV SCSSQDSTHR AENLLKADTY RKWRSAKAGE KTISVVLQLE
60 70 80 90 100
KEEQIHSVDI GNDGSAFVEV LVGSSAGGAT AGEQDYEVLL VTSSFMSPSE
110 120 130 140 150
SRSGSNPNRV RIFGPDKLVR AAAEKRWDRV KIVCSQPYSK DSPYGLSFVK
160 170 180 190 200
FHSPPDKDEA EAPSQKVTVT KLGQFRVKEE DDSANSLRPG ALFFNRINKA
210 220 230 240 250
ASASASDPAG PSYAAATLQA SSAASSASPV PKVGGSSSKL QEPPKGKRKL
260 270 280 290 300
DLGLEDKKPP SKPSAGPPAP KRPKLPVPSR TPAATPASTP AQKAVPGKPR
310 320 330 340 350
GEGTEPRGAR AGPQELGKIL QGVVVVLSGF QNPFRSELRD KALELGAKYR
360 370 380 390 400
PDWTPDSTHL ICAFANTPKY SQVLGLGGRI VRKEWVLDCY RMRRRLPSRR
410 420 430 440 450
YLMAGLGSSS EDEGDSHSES GEDEAPKLPR KRPQPKAKTQ AAGPSSPPRP
460 470 480 490 500
PTPEETKAPS PGPQDNSDTD GEQSEGRDNG AEDSGDTEDE LRRVAKQREQ
510 520 530 540 550
RQPPAPEENG EDPYAGSTDE NTDSEAPSEA DLPIPELPDF FQGKHFFLYG
560 570 580 590 600
EFPGDERRKL IRYVTAFNGE LEDYMSDRVQ FVITAQEWDP NFEEALMENP
610 620 630
SLAFVRPRWI YSCNEKQKLL PHQLYGVVPQ A
Length:631
Mass (Da):68,836
Last modified:December 20, 2005 - v2
Checksum:iBB5A2FD89E0D0B38
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti228S → L in AAG02212 (Ref. 1) Curated1
Sequence conflicti257K → S in AAG02212 (Ref. 1) Curated1
Sequence conflicti268 – 270PAP → AAL in AAG02212 (Ref. 1) Curated3

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF290895 mRNA. Translation: AAG02212.1.
BC070894 mRNA. Translation: AAH70894.1.
RefSeqiNP_445887.1. NM_053435.1.
UniGeneiRn.13754.

Genome annotation databases

EnsembliENSRNOT00000027057; ENSRNOP00000027057; ENSRNOG00000019915.
GeneIDi84495.
KEGGirno:84495.
UCSCiRGD:619823. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF290895 mRNA. Translation: AAG02212.1.
BC070894 mRNA. Translation: AAH70894.1.
RefSeqiNP_445887.1. NM_053435.1.
UniGeneiRn.13754.

3D structure databases

ProteinModelPortaliQ9ESZ0.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000027057.

PTM databases

iPTMnetiQ9ESZ0.
PhosphoSitePlusiQ9ESZ0.

Proteomic databases

PaxDbiQ9ESZ0.
PRIDEiQ9ESZ0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000027057; ENSRNOP00000027057; ENSRNOG00000019915.
GeneIDi84495.
KEGGirno:84495.
UCSCiRGD:619823. rat.

Organism-specific databases

CTDi7515.
RGDi619823. Xrcc1.

Phylogenomic databases

eggNOGiKOG3226. Eukaryota.
ENOG410ZE1H. LUCA.
GeneTreeiENSGT00390000004140.
HOGENOMiHOG000111006.
HOVERGENiHBG052992.
InParanoidiQ9ESZ0.
KOiK10803.
OMAiSCNEKQK.
OrthoDBiEOG091G0KP0.
PhylomeDBiQ9ESZ0.

Enzyme and pathway databases

ReactomeiR-RNO-110381. Resolution of AP sites via the single-nucleotide replacement pathway.
R-RNO-5649702. APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway.
R-RNO-5685939. HDR through MMEJ (alt-NHEJ).
R-RNO-6782210. Gap-filling DNA repair synthesis and ligation in TC-NER.

Miscellaneous databases

PROiQ9ESZ0.

Gene expression databases

BgeeiENSRNOG00000019915.
GenevisibleiQ9ESZ0. RN.

Family and domain databases

CDDicd00027. BRCT. 2 hits.
Gene3Di2.60.120.260. 1 hit.
3.40.50.10190. 2 hits.
InterProiIPR001357. BRCT_dom.
IPR008979. Galactose-bd-like.
IPR002706. Xrcc1_N.
[Graphical view]
PfamiPF00533. BRCT. 1 hit.
PF16589. BRCT_2. 1 hit.
PF01834. XRCC1_N. 1 hit.
[Graphical view]
SMARTiSM00292. BRCT. 2 hits.
[Graphical view]
SUPFAMiSSF49785. SSF49785. 1 hit.
SSF52113. SSF52113. 2 hits.
PROSITEiPS50172. BRCT. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiXRCC1_RAT
AccessioniPrimary (citable) accession number: Q9ESZ0
Secondary accession number(s): Q6IRJ9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 20, 2005
Last sequence update: December 20, 2005
Last modified: November 30, 2016
This is version 104 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.