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Protein

DNA repair protein XRCC1

Gene

Xrcc1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Involved in DNA single-strand break repair by mediating the assembly of DNA break repair protein complexes. Probably during DNA repair, negatively regulates ADP-ribose levels by modulating ADP-ribosyltransferase PARP1 activity.By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processDNA damage, DNA repair

Enzyme and pathway databases

ReactomeiR-RNO-110381 Resolution of AP sites via the single-nucleotide replacement pathway
R-RNO-5649702 APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway
R-RNO-5685939 HDR through MMEJ (alt-NHEJ)
R-RNO-6782210 Gap-filling DNA repair synthesis and ligation in TC-NER

Names & Taxonomyi

Protein namesi
Recommended name:
DNA repair protein XRCC1
Alternative name(s):
X-ray repair cross-complementing protein 1
Gene namesi
Name:Xrcc1
Synonyms:Xrcc-1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 1

Organism-specific databases

RGDi619823 Xrcc1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000660461 – 631DNA repair protein XRCC1Add BLAST631

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei142PhosphoserineBy similarity1
Cross-linki178Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1); alternateBy similarity
Cross-linki178Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateBy similarity
Modified residuei206PhosphoserineBy similarity1
Modified residuei228PhosphoserineBy similarity1
Modified residuei261PhosphoserineBy similarity1
Modified residuei281PhosphothreonineBy similarity1
Modified residuei371Phosphoserine; by PRKDCBy similarity1
Modified residuei408PhosphoserineBy similarity1
Modified residuei409PhosphoserineBy similarity1
Modified residuei410PhosphoserineBy similarity1
Modified residuei445PhosphoserineBy similarity1
Modified residuei446PhosphoserineCombined sources1
Modified residuei452PhosphothreonineCombined sources1
Modified residuei456PhosphothreonineBy similarity1
Modified residuei460PhosphoserineBy similarity1
Modified residuei484PhosphoserineCombined sources1
Modified residuei487PhosphothreonineCombined sources1
Modified residuei517PhosphoserineBy similarity1
Modified residuei518PhosphothreonineBy similarity1
Modified residuei522PhosphothreonineBy similarity1

Post-translational modificationi

Phosphorylation of Ser-371 causes dimer dissociation. Phosphorylation by CK2 promotes interaction with APTX and APLF (By similarity).By similarity
Sumoylated.By similarity

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

PaxDbiQ9ESZ0
PRIDEiQ9ESZ0

PTM databases

iPTMnetiQ9ESZ0
PhosphoSitePlusiQ9ESZ0

Expressioni

Gene expression databases

BgeeiENSRNOG00000019915
GenevisibleiQ9ESZ0 RN

Interactioni

Subunit structurei

Homodimer. Interacts with polynucleotide kinase (PNK), DNA polymerase-beta (POLB) and DNA ligase III (LIG3). Interacts with APTX and APLF. Interacts with APEX1; the interaction is induced by SIRT1 and increases with the acetylated form of APEX1 (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000027057

Structurei

3D structure databases

ProteinModelPortaliQ9ESZ0
SMRiQ9ESZ0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini315 – 403BRCT 1PROSITE-ProRule annotationAdd BLAST89
Domaini536 – 627BRCT 2PROSITE-ProRule annotationAdd BLAST92

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG3226 Eukaryota
ENOG410ZE1H LUCA
GeneTreeiENSGT00390000004140
HOGENOMiHOG000111006
HOVERGENiHBG052992
InParanoidiQ9ESZ0
KOiK10803
OMAiSCNEKQK
OrthoDBiEOG091G0KP0
PhylomeDBiQ9ESZ0

Family and domain databases

CDDicd00027 BRCT, 2 hits
Gene3Di2.60.120.260, 1 hit
3.40.50.10190, 2 hits
InterProiView protein in InterPro
IPR001357 BRCT_dom
IPR036420 BRCT_dom_sf
IPR008979 Galactose-bd-like_sf
IPR002706 Xrcc1_N
PfamiView protein in Pfam
PF00533 BRCT, 1 hit
PF16589 BRCT_2, 1 hit
PF01834 XRCC1_N, 1 hit
SMARTiView protein in SMART
SM00292 BRCT, 2 hits
SUPFAMiSSF49785 SSF49785, 1 hit
SSF52113 SSF52113, 2 hits
PROSITEiView protein in PROSITE
PS50172 BRCT, 2 hits

Sequencei

Sequence statusi: Complete.

Q9ESZ0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPEISLRHVV SCSSQDSTHR AENLLKADTY RKWRSAKAGE KTISVVLQLE
60 70 80 90 100
KEEQIHSVDI GNDGSAFVEV LVGSSAGGAT AGEQDYEVLL VTSSFMSPSE
110 120 130 140 150
SRSGSNPNRV RIFGPDKLVR AAAEKRWDRV KIVCSQPYSK DSPYGLSFVK
160 170 180 190 200
FHSPPDKDEA EAPSQKVTVT KLGQFRVKEE DDSANSLRPG ALFFNRINKA
210 220 230 240 250
ASASASDPAG PSYAAATLQA SSAASSASPV PKVGGSSSKL QEPPKGKRKL
260 270 280 290 300
DLGLEDKKPP SKPSAGPPAP KRPKLPVPSR TPAATPASTP AQKAVPGKPR
310 320 330 340 350
GEGTEPRGAR AGPQELGKIL QGVVVVLSGF QNPFRSELRD KALELGAKYR
360 370 380 390 400
PDWTPDSTHL ICAFANTPKY SQVLGLGGRI VRKEWVLDCY RMRRRLPSRR
410 420 430 440 450
YLMAGLGSSS EDEGDSHSES GEDEAPKLPR KRPQPKAKTQ AAGPSSPPRP
460 470 480 490 500
PTPEETKAPS PGPQDNSDTD GEQSEGRDNG AEDSGDTEDE LRRVAKQREQ
510 520 530 540 550
RQPPAPEENG EDPYAGSTDE NTDSEAPSEA DLPIPELPDF FQGKHFFLYG
560 570 580 590 600
EFPGDERRKL IRYVTAFNGE LEDYMSDRVQ FVITAQEWDP NFEEALMENP
610 620 630
SLAFVRPRWI YSCNEKQKLL PHQLYGVVPQ A
Length:631
Mass (Da):68,836
Last modified:December 20, 2005 - v2
Checksum:iBB5A2FD89E0D0B38
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti228S → L in AAG02212 (Ref. 1) Curated1
Sequence conflicti257K → S in AAG02212 (Ref. 1) Curated1
Sequence conflicti268 – 270PAP → AAL in AAG02212 (Ref. 1) Curated3

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF290895 mRNA Translation: AAG02212.1
BC070894 mRNA Translation: AAH70894.1
RefSeqiNP_445887.1, NM_053435.1
UniGeneiRn.13754

Genome annotation databases

EnsembliENSRNOT00000027057; ENSRNOP00000027057; ENSRNOG00000019915
GeneIDi84495
KEGGirno:84495
UCSCiRGD:619823 rat

Similar proteinsi

Entry informationi

Entry nameiXRCC1_RAT
AccessioniPrimary (citable) accession number: Q9ESZ0
Secondary accession number(s): Q6IRJ9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 20, 2005
Last sequence update: December 20, 2005
Last modified: May 23, 2018
This is version 115 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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