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Protein
Submitted name:

TRPC6 cation channel, putative alternative splice variant gpTRPC6a

Gene

trp6

Organism
Cavia porcellus (Guinea pig)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Ion channelSAAS annotation

Keywords - Biological processi

Ion transport, Transport

Names & Taxonomyi

Protein namesi
Submitted name:
TRPC6 cation channel, putative alternative splice variant gpTRPC6aImported
Gene namesi
Name:trp6Imported
OrganismiCavia porcellus (Guinea pig)Imported
Taxonomic identifieri10141 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaHystricognathiCaviidaeCavia

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei318 – 33720HelicalSequence analysisAdd
BLAST
Transmembranei357 – 37620HelicalSequence analysisAdd
BLAST
Transmembranei404 – 42219HelicalSequence analysisAdd
BLAST
Transmembranei442 – 46120HelicalSequence analysisAdd
BLAST
Transmembranei507 – 52822HelicalSequence analysisAdd
BLAST
Transmembranei548 – 57023HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

Interactioni

Protein-protein interaction databases

STRINGi10141.ENSCPOP00000005008.

Structurei

3D structure databases

ProteinModelPortaliQ9ESX8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini19 – 6951ANK_REP_REGIONInterPro annotationAdd
BLAST
Domaini132 – 16433ANK_REP_REGIONInterPro annotationAdd
BLAST

Sequence similaritiesi

Belongs to the transient receptor (TC 1.A.4) family. [View classification]SAAS annotation
Contains 1 ANK repeat.UniRule annotation

Keywords - Domaini

ANK repeatUniRule annotationSAAS annotation, RepeatSAAS annotation, Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

eggNOGiKOG3609. Eukaryota.
ENOG410XQ0Y. LUCA.
HOGENOMiHOG000020590.
HOVERGENiHBG068337.

Family and domain databases

Gene3Di1.25.40.20. 1 hit.
InterProiIPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
IPR005821. Ion_trans_dom.
IPR004729. TRP_channel.
IPR013555. TRP_dom.
IPR005462. TRPC6_channel.
IPR002153. TRPC_channel.
[Graphical view]
PANTHERiPTHR10117. PTHR10117. 1 hit.
PTHR10117:SF7. PTHR10117:SF7. 1 hit.
PfamiPF12796. Ank_2. 1 hit.
PF00520. Ion_trans. 1 hit.
PF08344. TRP_2. 1 hit.
[Graphical view]
PRINTSiPR01647. TRPCHANNEL6.
SMARTiSM00248. ANK. 3 hits.
[Graphical view]
SUPFAMiSSF48403. SSF48403. 1 hit.
TIGRFAMsiTIGR00870. trp. 1 hit.
PROSITEiPS50297. ANK_REP_REGION. 2 hits.
PS50088. ANK_REPEAT. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9ESX8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFNDHSTTLS IEEERFLDAA EYGNIPVVRK MLEECLSLNV NCVDYMGQNA
60 70 80 90 100
LQLAVANEHL EITELLLKKE NLSRVGDALL LAISKGYVRI VEAILSHPAF
110 120 130 140 150
AEGKRLATSL SQSELQQDDF YAYDEDGTRF SHDVTPIILA AHCQEYEIVH
160 170 180 190 200
TLLRKGARIE RPHDYFCKCS ECNQKQKHDS FSHSRSRINA YKGLASPAYL
210 220 230 240 250
SLSSEDPVMT ALELSNELAV LANIEKEFKN DYKKLSMQCK DFVVGLLDLC
260 270 280 290 300
RNTEEVEAIL NGDIETCQPG DQGRPNLSRL KLAIKYEVKK FVAHPNCQQQ
310 320 330 340 350
LLSIWYENLS GLRQQTMAVK FLVVLGVAIG LPFLALIYWC APCSKMGKIM
360 370 380 390 400
RGPFMKFVAH AASFTIFLGL LVMNAADRFE GTKLRPNETS TDNAKQLFRM
410 420 430 440 450
KTSCFSWMEM LIISWVIGMV WAECKEIWAQ GPKEYLFELW NMLDFGMLAI
460 470 480 490 500
FAASFIARFM AFWHASKAQS IIDANDTLKD LTKVTLGEDV KYYNLARIKW
510 520 530 540 550
DPSDPQIISE GLYAIAVVLS FSRIAYILPA NESFGPLQIS LGRTVKDIFK
560 570 580 590
FMVIFIMVFV AFMIGMFNLY SHYIGAKQNE AFTTYVISDV LTMEIAD
Length:597
Mass (Da):67,673
Last modified:March 1, 2001 - v1
Checksum:i575B7F8D734105D9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ293895 mRNA. Translation: CAC06426.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ293895 mRNA. Translation: CAC06426.1.

3D structure databases

ProteinModelPortaliQ9ESX8.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10141.ENSCPOP00000005008.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

eggNOGiKOG3609. Eukaryota.
ENOG410XQ0Y. LUCA.
HOGENOMiHOG000020590.
HOVERGENiHBG068337.

Family and domain databases

Gene3Di1.25.40.20. 1 hit.
InterProiIPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
IPR005821. Ion_trans_dom.
IPR004729. TRP_channel.
IPR013555. TRP_dom.
IPR005462. TRPC6_channel.
IPR002153. TRPC_channel.
[Graphical view]
PANTHERiPTHR10117. PTHR10117. 1 hit.
PTHR10117:SF7. PTHR10117:SF7. 1 hit.
PfamiPF12796. Ank_2. 1 hit.
PF00520. Ion_trans. 1 hit.
PF08344. TRP_2. 1 hit.
[Graphical view]
PRINTSiPR01647. TRPCHANNEL6.
SMARTiSM00248. ANK. 3 hits.
[Graphical view]
SUPFAMiSSF48403. SSF48403. 1 hit.
TIGRFAMsiTIGR00870. trp. 1 hit.
PROSITEiPS50297. ANK_REP_REGION. 2 hits.
PS50088. ANK_REPEAT. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiQ9ESX8_CAVPO
AccessioniPrimary (citable) accession number: Q9ESX8
Entry historyi
Integrated into UniProtKB/TrEMBL: March 1, 2001
Last sequence update: March 1, 2001
Last modified: September 7, 2016
This is version 81 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.