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Protein

Transcription factor Sp6

Gene

Sp6

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Promotes cell proliferation.1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri254 – 278C2H2-type 1PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri284 – 308C2H2-type 2PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri314 – 336C2H2-type 3PROSITE-ProRule annotationAdd BLAST23

GO - Molecular functioni

GO - Biological processi

  • positive regulation of cell proliferation Source: MGI
  • regulation of odontogenesis Source: MGI
  • regulation of transcription by RNA polymerase II Source: GO_Central
  • transcription by RNA polymerase II Source: MGI

Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Transcription factor Sp6
Alternative name(s):
Epiprofin
Krueppel-like factor 14
Gene namesi
Name:Sp6
Synonyms:Epfn, Klf14
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:1932575 Sp6

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000471491 – 376Transcription factor Sp6Add BLAST376

Proteomic databases

MaxQBiQ9ESX2
PaxDbiQ9ESX2
PRIDEiQ9ESX2

PTM databases

iPTMnetiQ9ESX2
PhosphoSitePlusiQ9ESX2

Expressioni

Tissue specificityi

Ubiquitous. Preferentially expressed by proliferating epithelial cells of teeth, hair follicles and limbs.1 Publication

Gene expression databases

BgeeiENSMUSG00000038560
CleanExiMM_KLF14
MM_SP6
ExpressionAtlasiQ9ESX2 baseline and differential
GenevisibleiQ9ESX2 MM

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000039307

Structurei

3D structure databases

ProteinModelPortaliQ9ESX2
SMRiQ9ESX2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri254 – 278C2H2-type 1PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri284 – 308C2H2-type 2PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri314 – 336C2H2-type 3PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00760000118984
HOGENOMiHOG000231067
HOVERGENiHBG102037
InParanoidiQ9ESX2
KOiK09196
OMAiHPGTEDG
OrthoDBiEOG091G0HX6
PhylomeDBiQ9ESX2
TreeFamiTF315506

Family and domain databases

InterProiView protein in InterPro
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
SMARTiView protein in SMART
SM00355 ZnF_C2H2, 3 hits
SUPFAMiSSF57667 SSF57667, 2 hits
PROSITEiView protein in PROSITE
PS00028 ZINC_FINGER_C2H2_1, 3 hits
PS50157 ZINC_FINGER_C2H2_2, 3 hits

Sequencei

Sequence statusi: Complete.

Q9ESX2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLTAVCGSLG SQHTDAPHAS PPRLDLQPLQ TYQGHTSPEA GDYPSPLQPG
60 70 80 90 100
ELQSLPLGPE VDFSQGYELP GASSRVTCED LESDSPLAPG PFSKLLQPDM
110 120 130 140 150
SHHYESWFRP THPGTEDGSW WDLHPGTSWM DLPHTQGALT SPGHPGALQP
160 170 180 190 200
ALGGYVGDHQ LCAPPPHPHP HHLLPAAGGQ HLLGPPDGAK ALEAAAQESQ
210 220 230 240 250
GLDSSLDAAS RPKGSRRSVP RSSGQTVCRC PNCLEAERLG APCGPDGGKK
260 270 280 290 300
KHLHNCHIPG CGKAYAKTSH LKAHLRWHSG DRPFVCNWLF CGKRFTRSDE
310 320 330 340 350
LQRHLQTHTG TKKFPCAVCS RVFMRSDHLA KHMKTHEGAK EEAAAAAQGE
360 370
GKAGGVVEPP GGKGKREAEG SSASSN
Length:376
Mass (Da):40,016
Last modified:November 22, 2005 - v2
Checksum:iDA41AFF6FB6593A1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY338955 mRNA Translation: AAR01258.1
AJ275988 mRNA Translation: CAC06698.1
CCDSiCCDS25309.1
RefSeqiNP_112460.1, NM_031183.2
XP_006534594.1, XM_006534531.3
UniGeneiMm.156282
Mm.476096

Genome annotation databases

EnsembliENSMUST00000047997; ENSMUSP00000039307; ENSMUSG00000038560
ENSMUST00000107622; ENSMUSP00000103248; ENSMUSG00000038560
GeneIDi83395
KEGGimmu:83395
UCSCiuc007ldh.2 mouse

Similar proteinsi

Entry informationi

Entry nameiSP6_MOUSE
AccessioniPrimary (citable) accession number: Q9ESX2
Secondary accession number(s): Q6VM22
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 2, 2001
Last sequence update: November 22, 2005
Last modified: March 28, 2018
This is version 133 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome