Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Transcription factor Sp6

Gene

Sp6

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Promotes cell proliferation.1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri254 – 278C2H2-type 1PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri284 – 308C2H2-type 2PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri314 – 336C2H2-type 3PROSITE-ProRule annotationAdd BLAST23

GO - Molecular functioni

  • DNA binding Source: MGI
  • metal ion binding Source: UniProtKB-KW

GO - Biological processi

  • positive regulation of cell proliferation Source: MGI
  • regulation of odontogenesis Source: MGI
  • regulation of transcription, DNA-templated Source: UniProtKB-KW
  • transcription from RNA polymerase II promoter Source: MGI
Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Transcription factor Sp6
Alternative name(s):
Epiprofin
Krueppel-like factor 14
Gene namesi
Name:Sp6
Synonyms:Epfn, Klf14
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:1932575. Sp6.

Subcellular locationi

GO - Cellular componenti

  • cytosol Source: Ensembl
  • nucleus Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000471491 – 376Transcription factor Sp6Add BLAST376

Proteomic databases

MaxQBiQ9ESX2.
PaxDbiQ9ESX2.
PRIDEiQ9ESX2.

PTM databases

iPTMnetiQ9ESX2.
PhosphoSitePlusiQ9ESX2.

Expressioni

Tissue specificityi

Ubiquitous. Preferentially expressed by proliferating epithelial cells of teeth, hair follicles and limbs.1 Publication

Gene expression databases

BgeeiENSMUSG00000038560.
CleanExiMM_KLF14.
MM_SP6.
ExpressionAtlasiQ9ESX2. baseline and differential.
GenevisibleiQ9ESX2. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000039307.

Structurei

3D structure databases

ProteinModelPortaliQ9ESX2.
SMRiQ9ESX2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Contains 3 C2H2-type zinc fingers.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri254 – 278C2H2-type 1PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri284 – 308C2H2-type 2PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri314 – 336C2H2-type 3PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00760000118984.
HOGENOMiHOG000231067.
HOVERGENiHBG102037.
InParanoidiQ9ESX2.
KOiK09196.
OMAiTEDGSWW.
OrthoDBiEOG091G0HX6.
PhylomeDBiQ9ESX2.
TreeFamiTF315506.

Family and domain databases

Gene3Di3.30.160.60. 3 hits.
InterProiIPR030450. Sp1_fam.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PANTHERiPTHR23235. PTHR23235. 1 hit.
PfamiPF00096. zf-C2H2. 2 hits.
[Graphical view]
SMARTiSM00355. ZnF_C2H2. 3 hits.
[Graphical view]
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 3 hits.
PS50157. ZINC_FINGER_C2H2_2. 3 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9ESX2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLTAVCGSLG SQHTDAPHAS PPRLDLQPLQ TYQGHTSPEA GDYPSPLQPG
60 70 80 90 100
ELQSLPLGPE VDFSQGYELP GASSRVTCED LESDSPLAPG PFSKLLQPDM
110 120 130 140 150
SHHYESWFRP THPGTEDGSW WDLHPGTSWM DLPHTQGALT SPGHPGALQP
160 170 180 190 200
ALGGYVGDHQ LCAPPPHPHP HHLLPAAGGQ HLLGPPDGAK ALEAAAQESQ
210 220 230 240 250
GLDSSLDAAS RPKGSRRSVP RSSGQTVCRC PNCLEAERLG APCGPDGGKK
260 270 280 290 300
KHLHNCHIPG CGKAYAKTSH LKAHLRWHSG DRPFVCNWLF CGKRFTRSDE
310 320 330 340 350
LQRHLQTHTG TKKFPCAVCS RVFMRSDHLA KHMKTHEGAK EEAAAAAQGE
360 370
GKAGGVVEPP GGKGKREAEG SSASSN
Length:376
Mass (Da):40,016
Last modified:November 22, 2005 - v2
Checksum:iDA41AFF6FB6593A1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY338955 mRNA. Translation: AAR01258.1.
AJ275988 mRNA. Translation: CAC06698.1.
CCDSiCCDS25309.1.
RefSeqiNP_112460.1. NM_031183.2.
XP_006534594.1. XM_006534531.3.
UniGeneiMm.156282.
Mm.476096.

Genome annotation databases

EnsembliENSMUST00000047997; ENSMUSP00000039307; ENSMUSG00000038560.
ENSMUST00000107622; ENSMUSP00000103248; ENSMUSG00000038560.
GeneIDi83395.
KEGGimmu:83395.
UCSCiuc007ldh.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY338955 mRNA. Translation: AAR01258.1.
AJ275988 mRNA. Translation: CAC06698.1.
CCDSiCCDS25309.1.
RefSeqiNP_112460.1. NM_031183.2.
XP_006534594.1. XM_006534531.3.
UniGeneiMm.156282.
Mm.476096.

3D structure databases

ProteinModelPortaliQ9ESX2.
SMRiQ9ESX2.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000039307.

PTM databases

iPTMnetiQ9ESX2.
PhosphoSitePlusiQ9ESX2.

Proteomic databases

MaxQBiQ9ESX2.
PaxDbiQ9ESX2.
PRIDEiQ9ESX2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000047997; ENSMUSP00000039307; ENSMUSG00000038560.
ENSMUST00000107622; ENSMUSP00000103248; ENSMUSG00000038560.
GeneIDi83395.
KEGGimmu:83395.
UCSCiuc007ldh.2. mouse.

Organism-specific databases

CTDi80320.
MGIiMGI:1932575. Sp6.

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00760000118984.
HOGENOMiHOG000231067.
HOVERGENiHBG102037.
InParanoidiQ9ESX2.
KOiK09196.
OMAiTEDGSWW.
OrthoDBiEOG091G0HX6.
PhylomeDBiQ9ESX2.
TreeFamiTF315506.

Miscellaneous databases

PROiQ9ESX2.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000038560.
CleanExiMM_KLF14.
MM_SP6.
ExpressionAtlasiQ9ESX2. baseline and differential.
GenevisibleiQ9ESX2. MM.

Family and domain databases

Gene3Di3.30.160.60. 3 hits.
InterProiIPR030450. Sp1_fam.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PANTHERiPTHR23235. PTHR23235. 1 hit.
PfamiPF00096. zf-C2H2. 2 hits.
[Graphical view]
SMARTiSM00355. ZnF_C2H2. 3 hits.
[Graphical view]
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 3 hits.
PS50157. ZINC_FINGER_C2H2_2. 3 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSP6_MOUSE
AccessioniPrimary (citable) accession number: Q9ESX2
Secondary accession number(s): Q6VM22
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 2, 2001
Last sequence update: November 22, 2005
Last modified: November 2, 2016
This is version 127 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.