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Q9ESW8

- PGPI_MOUSE

UniProt

Q9ESW8 - PGPI_MOUSE

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Protein

Pyroglutamyl-peptidase 1

Gene

Pgpep1

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

Removes 5-oxoproline from various penultimate amino acid residues except L-proline.By similarity

Catalytic activityi

Release of an N-terminal pyroglutamyl group from a polypeptide, the second amino acid generally not being Pro.PROSITE-ProRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei85 – 851By similarity
Active sitei149 – 1491By similarity
Active sitei168 – 1681By similarity

GO - Molecular functioni

  1. cysteine-type peptidase activity Source: UniProtKB-KW
  2. peptidase activity Source: MGI
  3. pyroglutamyl-peptidase activity Source: InterPro

GO - Biological processi

  1. proteolysis Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease, Thiol protease

Enzyme and pathway databases

BRENDAi3.4.19.3. 3474.
SABIO-RKQ9ESW8.

Protein family/group databases

MEROPSiC15.010.

Names & Taxonomyi

Protein namesi
Recommended name:
Pyroglutamyl-peptidase 1 (EC:3.4.19.3)
Alternative name(s):
5-oxoprolyl-peptidase
Pyroglutamyl aminopeptidase I
Short name:
PAP-I
Pyroglutamyl-peptidase I
Short name:
PGP-I
Pyrrolidone-carboxylate peptidase
Gene namesi
Name:Pgpep1
Synonyms:Pgpi
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 8

Organism-specific databases

MGIiMGI:1913772. Pgpep1.

Subcellular locationi

Cytoplasm By similarity

GO - Cellular componenti

  1. cytosol Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 209209Pyroglutamyl-peptidase 1PRO_0000184762Add
BLAST

Proteomic databases

MaxQBiQ9ESW8.
PaxDbiQ9ESW8.
PRIDEiQ9ESW8.

PTM databases

PhosphoSiteiQ9ESW8.

Expressioni

Gene expression databases

BgeeiQ9ESW8.
CleanExiMM_PGPEP1.
GenevestigatoriQ9ESW8.

Interactioni

Subunit structurei

Monomer.By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000070778.

Structurei

3D structure databases

ProteinModelPortaliQ9ESW8.
SMRiQ9ESW8. Positions 3-172.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase C15 family.Curated

Phylogenomic databases

eggNOGiCOG2039.
GeneTreeiENSGT00390000015368.
HOGENOMiHOG000007775.
HOVERGENiHBG019147.
InParanoidiQ9ESW8.
KOiK01304.
OMAiTVNASWV.
OrthoDBiEOG7VDXQV.
PhylomeDBiQ9ESW8.
TreeFamiTF313278.

Family and domain databases

Gene3Di3.40.630.20. 1 hit.
InterProiIPR000816. Peptidase_C15.
IPR016125. Peptidase_C15-like.
IPR029761. PGP-I_metazoa.
[Graphical view]
PANTHERiPTHR23402. PTHR23402. 1 hit.
PTHR23402:SF11. PTHR23402:SF11. 1 hit.
PfamiPF01470. Peptidase_C15. 1 hit.
[Graphical view]
PIRSFiPIRSF015592. Prld-crbxl_pptds. 1 hit.
PRINTSiPR00706. PYROGLUPTASE.
PROSITEiPS01334. PYRASE_CYS. 1 hit.
PS01333. PYRASE_GLU. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9ESW8-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MEQPRKAVVV TGFGPFGEHT VNASWIAVQE LEKLGLGDSV DLHVYEIPVE
60 70 80 90 100
YQTVQRLIPA LWEKHSPQLV VHVGVSGMAT TVTLEKCGHN KGYKGLDNCR
110 120 130 140 150
FCPGSQCCVE DGPESIDSII DMDAVCKRVT TLGLDVSVTI SQDAGRYLCD
160 170 180 190 200
FTYYTSLYQG RGRSAFVHVP PLGKPYNADQ LGRALRAIIE EMLGVLEQAE

GDISCCRQL
Length:209
Mass (Da):22,934
Last modified:March 1, 2001 - v1
Checksum:iF8CD222CD61AE853
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ278829 mRNA. Translation: CAC03615.1.
AK003373 mRNA. Translation: BAB22746.1.
AK012658 mRNA. Translation: BAB28388.1.
AK047835 mRNA. Translation: BAC33170.1.
AK049632 mRNA. Translation: BAC33848.1.
BC051938 mRNA. Translation: AAH51938.1.
CCDSiCCDS22377.1.
RefSeqiNP_075706.1. NM_023217.4.
UniGeneiMm.154906.
Mm.372568.
Mm.487385.

Genome annotation databases

EnsembliENSMUST00000070173; ENSMUSP00000070778; ENSMUSG00000056204.
GeneIDi66522.
KEGGimmu:66522.
UCSCiuc009mbc.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ278829 mRNA. Translation: CAC03615.1 .
AK003373 mRNA. Translation: BAB22746.1 .
AK012658 mRNA. Translation: BAB28388.1 .
AK047835 mRNA. Translation: BAC33170.1 .
AK049632 mRNA. Translation: BAC33848.1 .
BC051938 mRNA. Translation: AAH51938.1 .
CCDSi CCDS22377.1.
RefSeqi NP_075706.1. NM_023217.4.
UniGenei Mm.154906.
Mm.372568.
Mm.487385.

3D structure databases

ProteinModelPortali Q9ESW8.
SMRi Q9ESW8. Positions 3-172.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10090.ENSMUSP00000070778.

Protein family/group databases

MEROPSi C15.010.

PTM databases

PhosphoSitei Q9ESW8.

Proteomic databases

MaxQBi Q9ESW8.
PaxDbi Q9ESW8.
PRIDEi Q9ESW8.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000070173 ; ENSMUSP00000070778 ; ENSMUSG00000056204 .
GeneIDi 66522.
KEGGi mmu:66522.
UCSCi uc009mbc.2. mouse.

Organism-specific databases

CTDi 54858.
MGIi MGI:1913772. Pgpep1.

Phylogenomic databases

eggNOGi COG2039.
GeneTreei ENSGT00390000015368.
HOGENOMi HOG000007775.
HOVERGENi HBG019147.
InParanoidi Q9ESW8.
KOi K01304.
OMAi TVNASWV.
OrthoDBi EOG7VDXQV.
PhylomeDBi Q9ESW8.
TreeFami TF313278.

Enzyme and pathway databases

BRENDAi 3.4.19.3. 3474.
SABIO-RK Q9ESW8.

Miscellaneous databases

NextBioi 321928.
PROi Q9ESW8.
SOURCEi Search...

Gene expression databases

Bgeei Q9ESW8.
CleanExi MM_PGPEP1.
Genevestigatori Q9ESW8.

Family and domain databases

Gene3Di 3.40.630.20. 1 hit.
InterProi IPR000816. Peptidase_C15.
IPR016125. Peptidase_C15-like.
IPR029761. PGP-I_metazoa.
[Graphical view ]
PANTHERi PTHR23402. PTHR23402. 1 hit.
PTHR23402:SF11. PTHR23402:SF11. 1 hit.
Pfami PF01470. Peptidase_C15. 1 hit.
[Graphical view ]
PIRSFi PIRSF015592. Prld-crbxl_pptds. 1 hit.
PRINTSi PR00706. PYROGLUPTASE.
PROSITEi PS01334. PYRASE_CYS. 1 hit.
PS01333. PYRASE_GLU. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Pyroglutamyl-peptidase I: cloning, sequencing, and characterisation of the recombinant human enzyme."
    Dando P.M., Fortunato M., Strand G.B., Smith T.S., Barrett A.J.
    Protein Expr. Purif. 28:111-119(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Embryo, Head and Spinal cord.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6.
    Tissue: Brain.

Entry informationi

Entry nameiPGPI_MOUSE
AccessioniPrimary (citable) accession number: Q9ESW8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 20, 2001
Last sequence update: March 1, 2001
Last modified: October 29, 2014
This is version 114 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. Peptidase families
    Classification of peptidase families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3