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Q9ESW8

- PGPI_MOUSE

UniProt

Q9ESW8 - PGPI_MOUSE

Protein

Pyroglutamyl-peptidase 1

Gene

Pgpep1

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 113 (01 Oct 2014)
      Sequence version 1 (01 Mar 2001)
      Previous versions | rss
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    Functioni

    Removes 5-oxoproline from various penultimate amino acid residues except L-proline.By similarity

    Catalytic activityi

    Release of an N-terminal pyroglutamyl group from a polypeptide, the second amino acid generally not being Pro.PROSITE-ProRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei85 – 851By similarity
    Active sitei149 – 1491By similarity
    Active sitei168 – 1681By similarity

    GO - Molecular functioni

    1. cysteine-type peptidase activity Source: UniProtKB-KW
    2. peptidase activity Source: MGI

    GO - Biological processi

    1. proteolysis Source: MGI

    Keywords - Molecular functioni

    Hydrolase, Protease, Thiol protease

    Enzyme and pathway databases

    BRENDAi3.4.19.3. 3474.
    SABIO-RKQ9ESW8.

    Protein family/group databases

    MEROPSiC15.010.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Pyroglutamyl-peptidase 1 (EC:3.4.19.3)
    Alternative name(s):
    5-oxoprolyl-peptidase
    Pyroglutamyl aminopeptidase I
    Short name:
    PAP-I
    Pyroglutamyl-peptidase I
    Short name:
    PGP-I
    Pyrrolidone-carboxylate peptidase
    Gene namesi
    Name:Pgpep1
    Synonyms:Pgpi
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 8

    Organism-specific databases

    MGIiMGI:1913772. Pgpep1.

    Subcellular locationi

    Cytoplasm By similarity

    GO - Cellular componenti

    1. cytosol Source: Ensembl

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 209209Pyroglutamyl-peptidase 1PRO_0000184762Add
    BLAST

    Proteomic databases

    MaxQBiQ9ESW8.
    PaxDbiQ9ESW8.
    PRIDEiQ9ESW8.

    PTM databases

    PhosphoSiteiQ9ESW8.

    Expressioni

    Gene expression databases

    BgeeiQ9ESW8.
    CleanExiMM_PGPEP1.
    GenevestigatoriQ9ESW8.

    Interactioni

    Subunit structurei

    Monomer.By similarity

    Protein-protein interaction databases

    STRINGi10090.ENSMUSP00000070778.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9ESW8.
    SMRiQ9ESW8. Positions 3-172.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the peptidase C15 family.Curated

    Phylogenomic databases

    eggNOGiCOG2039.
    GeneTreeiENSGT00390000015368.
    HOGENOMiHOG000007775.
    HOVERGENiHBG019147.
    InParanoidiQ9ESW8.
    KOiK01304.
    OMAiTVNASWV.
    OrthoDBiEOG7VDXQV.
    PhylomeDBiQ9ESW8.
    TreeFamiTF313278.

    Family and domain databases

    Gene3Di3.40.630.20. 1 hit.
    InterProiIPR000816. Peptidase_C15.
    IPR016125. Peptidase_C15-like.
    [Graphical view]
    PANTHERiPTHR23402. PTHR23402. 1 hit.
    PfamiPF01470. Peptidase_C15. 1 hit.
    [Graphical view]
    PIRSFiPIRSF015592. Prld-crbxl_pptds. 1 hit.
    PRINTSiPR00706. PYROGLUPTASE.
    PROSITEiPS01334. PYRASE_CYS. 1 hit.
    PS01333. PYRASE_GLU. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9ESW8-1 [UniParc]FASTAAdd to Basket

    « Hide

    MEQPRKAVVV TGFGPFGEHT VNASWIAVQE LEKLGLGDSV DLHVYEIPVE    50
    YQTVQRLIPA LWEKHSPQLV VHVGVSGMAT TVTLEKCGHN KGYKGLDNCR 100
    FCPGSQCCVE DGPESIDSII DMDAVCKRVT TLGLDVSVTI SQDAGRYLCD 150
    FTYYTSLYQG RGRSAFVHVP PLGKPYNADQ LGRALRAIIE EMLGVLEQAE 200
    GDISCCRQL 209
    Length:209
    Mass (Da):22,934
    Last modified:March 1, 2001 - v1
    Checksum:iF8CD222CD61AE853
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ278829 mRNA. Translation: CAC03615.1.
    AK003373 mRNA. Translation: BAB22746.1.
    AK012658 mRNA. Translation: BAB28388.1.
    AK047835 mRNA. Translation: BAC33170.1.
    AK049632 mRNA. Translation: BAC33848.1.
    BC051938 mRNA. Translation: AAH51938.1.
    CCDSiCCDS22377.1.
    RefSeqiNP_075706.1. NM_023217.4.
    UniGeneiMm.154906.
    Mm.372568.
    Mm.487385.

    Genome annotation databases

    EnsembliENSMUST00000070173; ENSMUSP00000070778; ENSMUSG00000056204.
    GeneIDi66522.
    KEGGimmu:66522.
    UCSCiuc009mbc.2. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ278829 mRNA. Translation: CAC03615.1 .
    AK003373 mRNA. Translation: BAB22746.1 .
    AK012658 mRNA. Translation: BAB28388.1 .
    AK047835 mRNA. Translation: BAC33170.1 .
    AK049632 mRNA. Translation: BAC33848.1 .
    BC051938 mRNA. Translation: AAH51938.1 .
    CCDSi CCDS22377.1.
    RefSeqi NP_075706.1. NM_023217.4.
    UniGenei Mm.154906.
    Mm.372568.
    Mm.487385.

    3D structure databases

    ProteinModelPortali Q9ESW8.
    SMRi Q9ESW8. Positions 3-172.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10090.ENSMUSP00000070778.

    Protein family/group databases

    MEROPSi C15.010.

    PTM databases

    PhosphoSitei Q9ESW8.

    Proteomic databases

    MaxQBi Q9ESW8.
    PaxDbi Q9ESW8.
    PRIDEi Q9ESW8.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000070173 ; ENSMUSP00000070778 ; ENSMUSG00000056204 .
    GeneIDi 66522.
    KEGGi mmu:66522.
    UCSCi uc009mbc.2. mouse.

    Organism-specific databases

    CTDi 54858.
    MGIi MGI:1913772. Pgpep1.

    Phylogenomic databases

    eggNOGi COG2039.
    GeneTreei ENSGT00390000015368.
    HOGENOMi HOG000007775.
    HOVERGENi HBG019147.
    InParanoidi Q9ESW8.
    KOi K01304.
    OMAi TVNASWV.
    OrthoDBi EOG7VDXQV.
    PhylomeDBi Q9ESW8.
    TreeFami TF313278.

    Enzyme and pathway databases

    BRENDAi 3.4.19.3. 3474.
    SABIO-RK Q9ESW8.

    Miscellaneous databases

    NextBioi 321928.
    PROi Q9ESW8.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q9ESW8.
    CleanExi MM_PGPEP1.
    Genevestigatori Q9ESW8.

    Family and domain databases

    Gene3Di 3.40.630.20. 1 hit.
    InterProi IPR000816. Peptidase_C15.
    IPR016125. Peptidase_C15-like.
    [Graphical view ]
    PANTHERi PTHR23402. PTHR23402. 1 hit.
    Pfami PF01470. Peptidase_C15. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF015592. Prld-crbxl_pptds. 1 hit.
    PRINTSi PR00706. PYROGLUPTASE.
    PROSITEi PS01334. PYRASE_CYS. 1 hit.
    PS01333. PYRASE_GLU. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Pyroglutamyl-peptidase I: cloning, sequencing, and characterisation of the recombinant human enzyme."
      Dando P.M., Fortunato M., Strand G.B., Smith T.S., Barrett A.J.
      Protein Expr. Purif. 28:111-119(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J.
      Tissue: Embryo, Head and Spinal cord.
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6.
      Tissue: Brain.

    Entry informationi

    Entry nameiPGPI_MOUSE
    AccessioniPrimary (citable) accession number: Q9ESW8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 20, 2001
    Last sequence update: March 1, 2001
    Last modified: October 1, 2014
    This is version 113 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. Peptidase families
      Classification of peptidase families and list of entries
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3